RGD Reference Report - Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease. - Rat Genome Database

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Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease.

Authors: Tsuji, S  Kobayashi, H  Uchida, Y  Ihara, Y  Miyatake, T 
Citation: Tsuji S, etal., EMBO J. 1992 Dec;11(13):4843-50.
RGD ID: 6480485
Pubmed: PMID:1464312   (View Abstract at PubMed)
PMCID: PMC556960   (View Article at PubMed Central)

In previous studies, we discovered a growth inhibitory factor (GIF) that was abundant in normal human brain, but greatly reduced in Alzheimer's disease (AD) brain. Molecular cloning of a full-length cDNA for human GIF revealed that the GIF had striking homology to metallothioneins. Furthermore, it was determined that the GIF gene was on chromosome 16, as are the metallothionein genes. GIF, in contrast to metallothioneins, was found to be expressed exclusively in the nervous system. The GIF protein produced by Escherichia coli harboring the GIF cDNA in a prokaryotic expression vector inhibited the growth of neonatal rat cortical neurons. These results indicate that GIF is a new member of the metallothionein family with distinct tissue-specific expression and functions. Northern blot analysis revealed that expression of the GIF mRNA is drastically decreased in AD brains. The result raises the possibility that down-regulation of the GIF gene in AD brain plays an important role in the pathogenesis of AD.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MT3HumanAlzheimer's disease  IEP mRNA:decreased expression:brainRGD 
Mt3RatAlzheimer's disease  ISOMT3 (Homo sapiens)mRNA:decreased expression:brainRGD 
Mt3MouseAlzheimer's disease  ISOMT3 (Homo sapiens)mRNA:decreased expression:brainRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mt3  (metallothionein 3)

Genes (Mus musculus)
Mt3  (metallothionein 3)

Genes (Homo sapiens)
MT3  (metallothionein 3)


Additional Information