RGD Reference Report - Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors. - Rat Genome Database

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Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors.

Authors: Koumura, A  Kakefuda, K  Honda, A  Ito, Y  Tsuruma, K  Shimazawa, M  Uchida, Y  Hozumi, I  Satoh, M  Inuzuka, T  Hara, H 
Citation: Koumura A, etal., Neurosci Lett. 2009 Dec 18;467(1):11-4. Epub 2009 Sep 30.
RGD ID: 6480520
Pubmed: PMID:19799968   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2009.09.051   (Journal Full-text)

Metallothioneins (MTs) are metal binding proteins and have four isoforms. MT-3, known as growth inhibitory factor (GIF), exists mainly in the central nervous system. It regulates zinc levels and exhibits a neuroprotective effect in the various types of brain diseases. However, the reports demonstrate that the relation between MT-3 and psychiatric disorder is still unknown. In the present study, the authors carried out behavioral tests on MT-3 knock-out (KO) mice. The duration of the MT-3 KO mice's social interactions were significantly shorter than that of the wild-type (WT) mice. The acoustic startle response of the MT-3 KO mice showed diminished prepulse inhibition (PPI) at all prepulse intensities. However, the locomotor activity tests of the MT-3 KO mice displayed normal circadian rhythm, activity, and habituation to a novel environment. In the novel object recognition test, the MT-3 KO mice exhibited normal memory. These findings indicate that abnormalities of psychological behavior were observed in the MT-3 KO mice. Further experiments will be needed to clarify the involvement of MT-3 in higher brain function.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MT3HumanNeurobehavioral Manifestations  ISOMt3 (Mus musculus) RGD 
Mt3RatNeurobehavioral Manifestations  ISOMt3 (Mus musculus) RGD 
Mt3MouseNeurobehavioral Manifestations  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mt3  (metallothionein 3)

Genes (Mus musculus)
Mt3  (metallothionein 3)

Genes (Homo sapiens)
MT3  (metallothionein 3)


Additional Information