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Gene: MT3 (metallothionein 3) Homo sapiens
Symbol: MT3
Name: metallothionein 3
Description: Exhibits drug binding activity; enzyme regulator activity; and transition metal ion binding activity. Involved in several processes, including cellular response to oxidative stress; regulation of cellular protein metabolic process; and regulation of necrotic cell death. Localizes to inclusion body and perinuclear region of cytoplasm. Implicated in Alzheimer's disease. Biomarker of Alzheimer's disease; amyotrophic lateral sclerosis; multiple system atrophy; and psychotic disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GIF; GIFB; GRIF; growth inhibitory factor; metallothionein 3 (growth inhibitory factor (neurotrophic)); metallothionein-3; metallothionein-III; MT-3; MT-III; ZnMT3
Mus musculus (house mouse) : Mt3 (metallothionein 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mt3 (metallothionein 3)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : MT3 (metallothionein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mt3 (metallothionein 3)
Sus scrofa (pig) : MT3 (metallothionein 3)
Chlorocebus sabaeus (African green monkey) : MT3 (metallothionein 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: GIF (Gene ID: 2694) and MT3 (Gene ID: 4504) share the GIF symbol/alias in common. GIF is a widely used alternative name for metallothionein 3 (MT3), which can be confused with the official symbol for GIF (gastric intrinsic factor, GeneID 2694). [01 Jun 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1656,589,074 - 56,591,088 (+)EnsemblGRCh38hg38GRCh38
GRCh381656,589,528 - 56,591,085 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371656,623,267 - 56,625,000 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,180,768 - 55,182,501 (+)NCBINCBI36hg18NCBI36
Build 341655,180,767 - 55,182,500NCBI
Celera1641,120,754 - 41,122,487 (+)NCBI
Cytogenetic Map16q13NCBI
HuRef1642,492,901 - 42,494,634 (+)NCBIHuRef
CHM1_11658,029,740 - 58,031,473 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MT3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730879
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.