MT3 (metallothionein 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: MT3 (metallothionein 3) Homo sapiens
Analyze
Symbol: MT3
Name: metallothionein 3
RGD ID: 730879
HGNC Page HGNC:7408
Description: Enables protein kinase activator activity and transition metal ion binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and protein stabilization. Located in inclusion body and perinuclear region of cytoplasm. Implicated in Alzheimer's disease. Biomarker of Alzheimer's disease; amyotrophic lateral sclerosis; multiple system atrophy; and psychotic disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GIF; GIFB; GRIF; growth inhibitory factor; metallothionein 3 (growth inhibitory factor (neurotrophic)); metallothionein-3; metallothionein-III; MT-3; MT-III; ZnMT3
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: GIF (Gene ID: 2694) and MT3 (Gene ID: 4504) share the GIF symbol/alias in common. GIF is a widely used alternative name for metallothionein 3 (MT3), which can be confused with the official symbol for GIF (gastric intrinsic factor, GeneID 2694). [01 Jun 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,589,528 - 56,591,085 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,589,074 - 56,591,088 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,623,440 - 56,624,997 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,180,768 - 55,182,501 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,180,767 - 55,182,500NCBI
Celera1641,120,754 - 41,122,487 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,492,901 - 42,494,634 (+)NCBIHuRef
CHM1_11658,029,740 - 58,031,473 (+)NCBICHM1_1
T2T-CHM13v2.01662,384,459 - 62,386,016 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-aminonicotinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
7,8-dihydro-8-oxoguanine  (EXP)
alachlor  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
coenzyme Q10  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
D-glucose  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichromium trioxide  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (EXP)
dithionitrobenzoic acid  (EXP)
doxorubicin  (EXP)
elemental selenium  (ISO)
entinostat  (EXP)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (EXP)
eugenol  (ISO)
fipronil  (EXP)
folic acid  (EXP,ISO)
fonofos  (EXP)
gallium nitrate  (EXP)
glucose  (EXP)
hydrogen peroxide  (EXP)
hydroxyl  (EXP)
iron(III) nitrilotriacetate  (EXP)
L-ascorbic acid  (EXP,ISO)
lead diacetate  (EXP,ISO)
LY294002  (EXP)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethylmaleimide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
naringin  (EXP)
nicotine  (ISO)
nitric oxide  (ISO)
nitrogen dioxide  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pinostrobin  (EXP)
platinum  (EXP)
platinum(0)  (EXP)
potassium dichromate  (ISO)
purine-6-thiol  (ISO)
quercetin  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
SB 203580  (EXP)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (EXP)
sodium arsenite  (EXP,ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
superoxide  (EXP)
tamibarotene  (EXP)
terbufos  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
triclosan  (EXP)
Tungsten carbide  (EXP)
valproic acid  (EXP)
vitamin E  (ISO)
wortmannin  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (IDA)
cellular detoxification  (IDA)
cellular response to cadmium ion  (IBA)
cellular response to copper ion  (IBA)
cellular response to hypoxia  (IEP)
cellular response to oxidative stress  (IEP)
cellular response to reactive oxygen species  (IDA)
cellular response to zinc ion  (IBA)
detoxification of cadmium ion  (ISO)
detoxification of copper ion  (IBA)
energy reserve metabolic process  (ISS)
intracellular monoatomic cation homeostasis  (ISO,NAS,TAS)
intracellular zinc ion homeostasis  (IBA,ISS)
leptin-mediated signaling pathway  (ISS)
negative regulation of apoptotic process  (ISO)
negative regulation of axon extension  (IDA)
negative regulation of cell growth  (IDA,IMP)
negative regulation of hydrogen peroxide catabolic process  (IEA,ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of neuron apoptotic process  (ISS)
negative regulation of neuron projection development  (TAS)
negative regulation of oxidoreductase activity  (IDA)
positive regulation of DNA-templated transcription  (IDA,ISS)
positive regulation of ERK1 and ERK2 cascade  (IBA,IDA,ISS)
positive regulation of gene expression  (IDA)
positive regulation of oxygen metabolic process  (ISS)
positive regulation of protein phosphorylation  (IDA)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (IDA)
protein stabilization  (IDA)
regulation of response to food  (ISS)
removal of superoxide radicals  (IDA)
response to hypoxia  (IDA)
response to oxidative stress  (ISO)
sequestering of metal ion  (ISO)
zinc ion transport  (ISS)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression of growth inhibitory factor (metallothionein-III) mRNA and protein following excitotoxic immature brain injury. Acarin L, etal., J Neuropathol Exp Neurol. 1999 Apr;58(4):389-97.
2. Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice. Byun HR, etal., Neurobiol Dis. 2011 Oct;44(1):125-32. Epub 2011 Jun 25.
3. Metallothionein (MT)-III: generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains. Carrasco J, etal., J Neurotrauma. 1999 Nov;16(11):1115-29.
4. Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays. Choi KH, etal., BMC Psychiatry. 2008 Nov 7;8:87.
5. Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF). Erickson JC, etal., Brain Res. 1994 Jun 27;649(1-2):297-304.
6. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
7. Tolerance of aged rat brains to mild hyperoxia: possible involvement of higher GIF content. Gomi F, etal., Brain Res. 2005 Feb 1;1033(1):113-6.
8. Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity. Honda A, etal., J Toxicol Sci. 2010 Apr;35(2):209-15.
9. Growth inhibitory factor (GIF) can protect from brain damage due to stab wounds in rat brain. Hozumi I, etal., Neurosci Lett. 2006 Mar 13;395(3):220-3. Epub 2005 Nov 28.
10. Patterns of growth inhibitory factor (GIF) and glial fibrillary acidic protein relative level changes differ following left middle cerebral artery occlusion in rats. Inuzuka T, etal., Brain Res. 1996 Feb 12;709(1):151-31.
11. Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis. Ishigaki S, etal., FEBS Lett. 2002 Nov 6;531(2):354-8.
12. Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia. Koumura A, etal., Brain Res. 2009 Oct 6;1292:148-54. Epub 2009 Jul 25.
13. Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors. Koumura A, etal., Neurosci Lett. 2009 Dec 18;467(1):11-4. Epub 2009 Sep 30.
14. Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo. Lanza C, etal., J Neurochem. 2009 Sep;110(5):1674-84. Epub 2009 Jul 8.
15. Expression of antioxidant molecules after peripheral nerve injury and regeneration. Lanza C, etal., J Neurosci Res. 2012 Apr;90(4):842-8. doi: 10.1002/jnr.22778. Epub 2012 Jan 18.
16. Metallothionein-3 and neuronal nitric oxide synthase levels in brains from the Tg2576 mouse model of Alzheimer's disease. Martin BL, etal., Mol Cell Biochem. 2006 Feb;283(1-2):129-37.
17. Age-related changes in expression of metallothionein-III in rat brain. Miyazaki I, etal., Neurosci Res. 2002 Aug;43(4):323-33.
18. Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus. Ni H, etal., Toxicol Lett. 2013 Feb 27;217(2):162-9. doi: 10.1016/j.toxlet.2012.12.010. Epub 2012 Dec 21.
19. Association of metallothionein-III with oligodendroglial cytoplasmic inclusions in multiple system atrophy. Pountney DL, etal., Neurotox Res. 2011 Jan;19(1):115-22. Epub 2009 Dec 29.
20. Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins. Puttaparthi K, etal., J Neurosci. 2002 Oct 15;22(20):8790-6.
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Growth inhibitory factor prevents degeneration of injured adult rat motoneurons. Sakamoto T, etal., Neuroreport. 2003 Dec 2;14(17):2147-51.
23. The unique N-terminal sequence of metallothionein-3 is required to regulate the choice between apoptotic or necrotic cell death of human proximal tubule cells exposed to Cd+2. Somji S, etal., Toxicol Sci. 2006 Apr;90(2):369-76. Epub 2005 Dec 30.
24. Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis. Tokuda E, etal., Toxicology. 2007 Jan 5;229(1-2):33-41. Epub 2006 Sep 29.
25. Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators. Tougu V, etal., J Neurochem. 2009 Sep;110(6):1784-95. Epub 2009 Jul 8.
26. Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease. Tsuji S, etal., EMBO J. 1992 Dec;11(13):4843-50.
27. Metallothionein-III deficiency exacerbates light-induced retinal degeneration. Tsuruma K, etal., Invest Ophthalmol Vis Sci. 2012 Nov 29;53(12):7896-903. doi: 10.1167/iovs.12-10165.
28. Peripheral nerve avulsion injuries as experimental models for adult motoneuron degeneration. Watabe K, etal., Neuropathology. 2005 Dec;25(4):371-80.
29. Metallothioneins and zinc dysregulation contribute to neurodevelopmental damage in a model of perinatal viral infection. Williams BL, etal., Brain Pathol. 2006 Jan;16(1):1-14.
30. Ischemia induces metallothionein III expression in neurons of rat brain. Yanagitani S, etal., Life Sci. 1999;64(8):707-15.
31. Regulation of metallothionein-3 mRNA by thyroid hormone in developing rat brain and primary cultures of rat astrocytes and neurons. Yeiser EC, etal., Brain Res Dev Brain Res. 1999 Jun 2;115(2):195-200.
Additional References at PubMed
PMID:1631128   PMID:1873033   PMID:7677777   PMID:8039715   PMID:8751715   PMID:9655243   PMID:10355541   PMID:10517878   PMID:11226237   PMID:11849386   PMID:11994011   PMID:12058024  
PMID:12067712   PMID:12072966   PMID:12111700   PMID:12187490   PMID:12383939   PMID:12477932   PMID:12538345   PMID:12539042   PMID:12763630   PMID:15129022   PMID:15190073   PMID:15342556  
PMID:15489334   PMID:16036436   PMID:16087360   PMID:16336778   PMID:16351731   PMID:16546755   PMID:16601975   PMID:16712791   PMID:16945328   PMID:17712581   PMID:18029348   PMID:18157556  
PMID:18182399   PMID:18206644   PMID:18208603   PMID:18295594   PMID:18533104   PMID:18554677   PMID:18757100   PMID:18782281   PMID:19425569   PMID:19490120   PMID:19536566   PMID:19578815  
PMID:19881214   PMID:20646067   PMID:20974010   PMID:21044950   PMID:21320589   PMID:21818286   PMID:21873635   PMID:22615124   PMID:23086305   PMID:23482768   PMID:23728617   PMID:23794209  
PMID:24222235   PMID:24242700   PMID:24859040   PMID:25290577   PMID:25803827   PMID:25933064   PMID:27049123   PMID:27840910   PMID:28538697   PMID:28545470   PMID:29524106   PMID:29808689  
PMID:30813460   PMID:31324867   PMID:32512576   PMID:33526321   PMID:33750814   PMID:35503771   PMID:36639030   PMID:38904023  


Genomics

Comparative Map Data
MT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,589,528 - 56,591,085 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,589,074 - 56,591,088 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,623,440 - 56,624,997 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,180,768 - 55,182,501 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,180,767 - 55,182,500NCBI
Celera1641,120,754 - 41,122,487 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,492,901 - 42,494,634 (+)NCBIHuRef
CHM1_11658,029,740 - 58,031,473 (+)NCBICHM1_1
T2T-CHM13v2.01662,384,459 - 62,386,016 (+)NCBIT2T-CHM13v2.0
Mt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,879,235 - 94,880,776 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,879,235 - 94,880,774 (+)EnsemblGRCm39 Ensembl
GRCm38894,152,607 - 94,154,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,152,607 - 94,154,146 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,676,507 - 96,678,048 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,041,873 - 97,043,260 (+)NCBIMGSCv36mm8
Celera898,484,267 - 98,485,940 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.29NCBI
Mt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,854,676 - 10,856,080 (-)NCBIGRCr8
mRatBN7.21910,848,754 - 10,850,158 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,848,755 - 10,850,158 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,816,785 - 10,818,191 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,583,639 - 11,585,045 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,870,637 - 10,872,043 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,324,708 - 11,326,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,324,698 - 11,326,139 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,300,014 - 11,301,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,284,554 - 11,286,402 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,289,380 - 11,291,228 (-)NCBI
Celera1910,734,686 - 10,736,090 (-)NCBICelera
Cytogenetic Map19p12NCBI
MT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,071,291 - 66,073,006 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11671,990,250 - 71,991,887 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,875,919 - 36,877,558 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,007,922 - 56,009,828 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,007,922 - 56,028,093 (+)NCBIpanpan1.1panPan2
MT-III
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,624,845 - 59,630,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,258,480 - 56,264,041 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,169,540 - 60,175,101 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,169,544 - 60,171,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,000,204 - 57,005,739 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,008,894 - 58,014,626 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,902,010 - 58,907,559 (-)NCBIUU_Cfam_GSD_1.0
Mt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,722,559 - 50,724,569 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364758,864,675 - 8,866,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364758,864,512 - 8,866,516 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,634,261 - 18,636,131 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,634,735 - 18,636,134 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,377,693 - 26,380,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,502,306 - 42,504,467 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604733,859,328 - 33,861,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in MT3
6 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q12.2-21(chr16:55457477-63841622)x1 copy number loss See cases [RCV000133738] Chr16:55457477..63841622 [GRCh38]
Chr16:55491389..63875526 [GRCh37]
Chr16:54048890..62433027 [NCBI36]
Chr16:16q12.2-21		 pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3		 pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Breast ductal adenocarcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3		 uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Breast ductal adenocarcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2		 likely pathogenic|uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p11.2-q21(chr16:34197492-64509054)x3 copy number gain See cases [RCV000511791] Chr16:34197492..64509054 [GRCh37]
Chr16:16p11.2-q21		 pathogenic
GRCh37/hg19 16q12.2-13(chr16:56492890-57056368)x3 copy number gain See cases [RCV000511577] Chr16:56492890..57056368 [GRCh37]
Chr16:16q12.2-13		 uncertain significance
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
NM_005954.4(MT3):c.104G>T (p.Cys35Phe) single nucleotide variant not specified [RCV004281716] Chr16:56590846 [GRCh38]
Chr16:56624758 [GRCh37]
Chr16:16q13		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
GRCh37/hg19 16q12.2-22.2(chr16:54416050-72453266)x3 copy number gain not provided [RCV000683820] Chr16:54416050..72453266 [GRCh37]
Chr16:16q12.2-22.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q12.2-21(chr16:53455650-64006604)x3 copy number gain not provided [RCV000848548] Chr16:53455650..64006604 [GRCh37]
Chr16:16q12.2-21		 uncertain significance
NM_005954.4(MT3):c.200G>A (p.Cys67Tyr) single nucleotide variant not provided [RCV000882178] Chr16:56590942 [GRCh38]
Chr16:56624854 [GRCh37]
Chr16:16q13		 benign
Single allele duplication not provided [RCV001542388] Chr16:46385317..61223349 [GRCh38]
Chr16:16q11.2-21		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46503968-90155062)x3 copy number gain not provided [RCV002221458] Chr16:46503968..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
NC_000016.9:g.(?_56226148)_(58768132_?)del deletion Bardet-Biedl syndrome [RCV003119976]|Early infantile epileptic encephalopathy with suppression bursts [RCV003109791] Chr16:56226148..58768132 [GRCh37]
Chr16:16q12.2-21		 pathogenic
Single allele deletion not provided [RCV002266766] Chr16:53818483..57631312 [GRCh38]
Chr16:16q12.2-21		 pathogenic
GRCh37/hg19 16q11.2-21(chr16:46503573-62203182)x3 copy number gain not provided [RCV002472562] Chr16:46503573..62203182 [GRCh37]
Chr16:16q11.2-21		 pathogenic
NM_005954.4(MT3):c.23G>A (p.Cys8Tyr) single nucleotide variant not specified [RCV004191602] Chr16:56589613 [GRCh38]
Chr16:56623525 [GRCh37]
Chr16:16q13		 uncertain significance
NM_005954.4(MT3):c.92A>G (p.Lys31Arg) single nucleotide variant not specified [RCV004192567] Chr16:56589930 [GRCh38]
Chr16:56623842 [GRCh37]
Chr16:16q13		 uncertain significance
NM_005954.4(MT3):c.119C>T (p.Ala40Val) single nucleotide variant not specified [RCV004117779] Chr16:56590861 [GRCh38]
Chr16:56624773 [GRCh37]
Chr16:16q13		 uncertain significance
GRCh37/hg19 16q12.2-22.1(chr16:55329260-67180113)x1 copy number loss not specified [RCV003987196] Chr16:55329260..67180113 [GRCh37]
Chr16:16q12.2-22.1		 pathogenic
NM_005954.4(MT3):c.175G>A (p.Ala59Thr) single nucleotide variant not specified [RCV004505931] Chr16:56590917 [GRCh38]
Chr16:56624829 [GRCh37]
Chr16:16q13		 uncertain significance
NC_000016.9:g.(?_56226148)_(57286179_?)del deletion not provided [RCV004582872] Chr16:56226148..57286179 [GRCh37]
Chr16:16q12.2-13		 pathogenic
NC_000016.9:g.(?_48799549)_(70756330_?)dup duplication Chromosome 16q12 duplication syndrome [RCV004595820] Chr16:48799549..70756330 [GRCh37]
Chr16:16q12.1-22.1		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1454
Count of miRNA genes:535
Interacting mature miRNAs:593
Transcripts:ENST00000200691, ENST00000561640, ENST00000565838, ENST00000566451, ENST00000566576, ENST00000570176
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G67938  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371656,624,640 - 56,625,074UniSTSGRCh37
Build 361655,182,141 - 55,182,575RGDNCBI36
Celera1641,122,127 - 41,122,561RGD
Cytogenetic Map16q13UniSTS
HuRef1642,494,274 - 42,494,708UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1194 2338 2766 2189 4707 1551 2032 468 1448 305 2066 6483 5895 17 3655 783 1651 1458 165

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_005954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC026461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI752092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI820409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP210917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB155600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB470290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ297144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M93311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S72043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X89604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000200691   ⟹   ENSP00000200691
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1656,589,528 - 56,591,085 (+)Ensembl
Ensembl Acc Id: ENST00000561640   ⟹   ENSP00000455353
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1656,589,074 - 56,591,075 (+)Ensembl
Ensembl Acc Id: ENST00000565838   ⟹   ENSP00000455980
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1656,589,074 - 56,591,078 (+)Ensembl
Ensembl Acc Id: ENST00000566451
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1656,589,536 - 56,591,085 (+)Ensembl
Ensembl Acc Id: ENST00000566576
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1656,589,545 - 56,591,088 (+)Ensembl
Ensembl Acc Id: ENST00000570176   ⟹   ENSP00000457164
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1656,589,540 - 56,590,366 (+)Ensembl
RefSeq Acc Id: NM_005954   ⟹   NP_005945
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381656,589,528 - 56,591,085 (+)NCBI
GRCh371656,623,267 - 56,625,000 (+)ENTREZGENE
Build 361655,180,768 - 55,182,501 (+)NCBI Archive
HuRef1642,492,901 - 42,494,634 (+)ENTREZGENE
CHM1_11658,029,740 - 58,031,473 (+)NCBI
T2T-CHM13v2.01662,384,459 - 62,386,016 (+)NCBI
Sequence:
RefSeq Acc Id: NP_005945   ⟸   NM_005954
- UniProtKB: Q2V574 (UniProtKB/Swiss-Prot),   P25713 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000200691   ⟸   ENST00000200691
Ensembl Acc Id: ENSP00000457164   ⟸   ENST00000570176
Ensembl Acc Id: ENSP00000455353   ⟸   ENST00000561640
Ensembl Acc Id: ENSP00000455980   ⟸   ENST00000565838

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25713-F1-model_v2 AlphaFold P25713 1-68 view protein structure

Promoters
RGD ID:7232263
Promoter ID:EPDNEW_H21877
Type:multiple initiation site
Name:MT3_1
Description:metallothionein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381656,589,528 - 56,589,588EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7408 AgrOrtholog
COSMIC MT3 COSMIC
Ensembl Genes ENSG00000087250 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000200691 ENTREZGENE
  ENST00000200691.5 UniProtKB/Swiss-Prot
  ENST00000561640.5 UniProtKB/TrEMBL
  ENST00000565838.5 UniProtKB/TrEMBL
  ENST00000570176.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000087250 GTEx
HGNC ID HGNC:7408 ENTREZGENE
Human Proteome Map MT3 Human Proteome Map
InterPro Metalthion_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_dom_sf_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert_metal_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4504 UniProtKB/Swiss-Prot
NCBI Gene 4504 ENTREZGENE
OMIM 139255 OMIM
PANTHER METALLOTHIONEIN-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallothio UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31216 PharmGKB
PRINTS MTVERTEBRATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE METALLOTHIONEIN_VRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57868 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H3BPK2_HUMAN UniProtKB/TrEMBL
  H3BQX6_HUMAN UniProtKB/TrEMBL
  H3BTG5_HUMAN UniProtKB/TrEMBL
  MT3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q2V574 ENTREZGENE
UniProt Secondary Q2V574 UniProtKB/Swiss-Prot