RGD Reference Report - Peripheral nerve avulsion injuries as experimental models for adult motoneuron degeneration. - Rat Genome Database

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Peripheral nerve avulsion injuries as experimental models for adult motoneuron degeneration.

Authors: Watabe, K  Hayashi, Y  Kawazoe, Y 
Citation: Watabe K, etal., Neuropathology. 2005 Dec;25(4):371-80.
RGD ID: 6480623
Pubmed: PMID:16382788   (View Abstract at PubMed)

We have used adult rat peripheral nerve avulsion models to evaluate the effects of neuroprotective molecules on motoneuron degeneration. The right facial nerves of adult Fischer 344 male rats were avulsed and adenoviral vectors encoding glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), transforming growth factor-beta2 (TGFbeta2), and growth inhibitory factor (GIF) were injected into the facial canal. The treatment with the vectors significantly prevented the loss of lesioned facial motoneurons, improved choline acetyltransferase (ChAT) immunoreactivity and suppressed the induction of nitric oxide synthase activity in these neurons. In separate experiments, animals were orally administered a solution of a neuroprotective compound T-588 after avulsion. Both free oral administration and oral tube administration of T-588 improved the survival of injured motoneurons and ameliorated their ChAT immunoreactivity. These results indicate that the gene transfer of GDNF, BDNF, TGFbeta2, and GIF and oral administration of T-588 may prevent the degeneration of motoneurons in adult humans with motoneuron injury and motor neuron diseases.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MT3Humanmotor neuron disease  ISOMt3 (Rattus norvegicus) RGD 
Mt3Ratmotor neuron disease  IMP  RGD 
Mt3Mousemotor neuron disease  ISOMt3 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mt3  (metallothionein 3)

Genes (Mus musculus)
Mt3  (metallothionein 3)

Genes (Homo sapiens)
MT3  (metallothionein 3)


Additional Information