RGD Reference Report - Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo.

Authors: Lanza, C  Morando, S  Voci, A  Canesi, L  Principato, MC  Serpero, LD  Mancardi, G  Uccelli, A  Vergani, L 
Citation: Lanza C, etal., J Neurochem. 2009 Sep;110(5):1674-84. Epub 2009 Jul 8.
RGD ID: 6484112
Pubmed: PMID:19619133   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1471-4159.2009.06268.x   (Journal Full-text)

Experimental autoimmune encephalomyelitis (EAE), an animal model for human multiple sclerosis, is characterized by demyelination, inflammation and neurodegeneration of CNS in which free radicals play a role. Recently, the efficacy of murine mesenchimal stem cells (MSCs) as treatment of EAE induced in mice by the encephalitogenic peptide MOG(35-55) was demonstrated. The present study analyzed some markers of oxidative stress, inflammation/degeneration and apoptosis such as metallothioneins (MTs), antioxidant enzymes (superoxide dismutase, catalase and glutathione-S-transferase), poly(ADP-ribose) polymerase-1 and p53 during EAE progression and following MSC treatment. Expression of the three brain MT isoforms increased significantly in EAE mice compared with healthy controls, but while expression of MT-1 and MT-3 increased along EAE course, MT-2 was up-regulated at the onset, but returned to levels similar to those of controls in chronic phase. The changes in the transcription and activity of the antioxidant enzymes and in expression of poly(ADP-ribose) polymerase-1 and p53 showed the same kinetics observed for MT-1 and MT-3 during EAE. Interestingly, i.v. administration of MSCs reduced the EAE-induced increases in levels/activities of all these proteins. These results support an antioxidant and neuroprotective activity for MSCs that was also confirmed in vitro on neuroblastoma cells exposed to an oxidative insult.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MT1EHumanExperimental Autoimmune Encephalomyelitis  ISOMt1 (Mus musculus)mRNA:increased expression:brain (mouse)RGD 
MT2AHumanExperimental Autoimmune Encephalomyelitis  ISOMt2 (Mus musculus)mRNA:increased expression:brain (mouse)RGD 
MT3HumanExperimental Autoimmune Encephalomyelitis  ISOMt3 (Mus musculus)mRNA:increased expression:brain (mouse)RGD 
Mt1RatExperimental Autoimmune Encephalomyelitis  ISOMt1 (Mus musculus)mRNA:increased expression:brain (mouse)RGD 
Mt1MouseExperimental Autoimmune Encephalomyelitis  IEP mRNA:increased expression:brain (mouse)RGD 
Mt2MouseExperimental Autoimmune Encephalomyelitis  IEP mRNA:increased expression:brain (mouse)RGD 
Mt2ARatExperimental Autoimmune Encephalomyelitis  ISOMt2 (Mus musculus)mRNA:increased expression:brain (mouse)RGD 
Mt3RatExperimental Autoimmune Encephalomyelitis  ISOMt3 (Mus musculus)mRNA:increased expression:brain (mouse)RGD 
Mt3MouseExperimental Autoimmune Encephalomyelitis  IEP mRNA:increased expression:brain (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mt1  (metallothionein 1)
Mt2A  (metallothionein 2A)
Mt3  (metallothionein 3)

Genes (Mus musculus)
Mt1  (metallothionein 1)
Mt2  (metallothionein 2)
Mt3  (metallothionein 3)

Genes (Homo sapiens)
MT1E  (metallothionein 1E)
MT2A  (metallothionein 2A)
MT3  (metallothionein 3)

Objects referenced in this article
Gene MT1A metallothionein 1A Homo sapiens

Additional Information