Mt3 (metallothionein 3) - Rat Genome Database

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Gene: Mt3 (metallothionein 3) Mus musculus
Analyze
Symbol: Mt3
Name: metallothionein 3
RGD ID: 1553329
MGI Page MGI
Description: Enables zinc ion binding activity. Involved in several processes, including divalent inorganic cation homeostasis; negative regulation of cell death; and regulation of macromolecule biosynthetic process. Acts upstream of or within cellular metal ion homeostasis and negative regulation of neurogenesis. Located in synaptic vesicle. Is expressed in brain; decidua; ganglia; ventral grey horn; and ventricular layer. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human MT3 (metallothionein 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GIF; growth inhibitory factor; metallothionein-3; metallothionein-III; Mt-3; MT-III
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,879,235 - 94,880,776 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,879,235 - 94,880,774 (+)EnsemblGRCm39 Ensembl
GRCm38894,152,607 - 94,154,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,152,607 - 94,154,146 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,676,507 - 96,678,048 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,041,873 - 97,043,260 (+)NCBIMGSCv36mm8
Celera898,484,267 - 98,485,940 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,7-dihydropurine-6-thione  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-aminonicotinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7,8-dihydro-8-oxoguanine  (ISO)
alachlor  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bifenthrin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
carbon nanotube  (EXP,ISO)
chlordecone  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichromium trioxide  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dithionitrobenzoic acid  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethylenediaminetetraacetic acid  (ISO)
eugenol  (EXP)
fipronil  (ISO)
folic acid  (EXP,ISO)
fonofos  (ISO)
glucose  (ISO)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
iron(III) nitrilotriacetate  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
LY294002  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP)
mercury(0)  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethylmaleimide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naringin  (ISO)
nicotine  (EXP)
nitric oxide  (ISO)
nitrogen dioxide  (ISO)
ozone  (EXP)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctanoic acid  (EXP)
platinum  (ISO)
platinum(0)  (ISO)
potassium dichromate  (ISO)
purine-6-thiol  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulforaphane  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
tamibarotene  (ISO)
terbufos  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thimerosal  (EXP)
triclosan  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
astrocyte development  (IDA)
brain development  (ISO)
cadmium ion homeostasis  (IMP)
cellular lipid catabolic process  (IMP)
cellular metal ion homeostasis  (IDA)
cellular response to cadmium ion  (ISO)
cellular response to copper ion  (IBA)
cellular response to hypoxia  (ISO)
cellular response to nitric oxide  (ISO)
cellular response to oxidative stress  (IDA)
cellular response to reactive oxygen species  (ISO)
cellular zinc ion homeostasis  (IDA,IMP)
cholesterol catabolic process  (IMP)
energy reserve metabolic process  (IMP)
ERK1 and ERK2 cascade  (ISO)
histone modification  (ISO)
leptin-mediated signaling pathway  (IMP)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of autophagy  (IMP)
negative regulation of axon extension  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cysteine-type endopeptidase activity  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (IMP)
negative regulation of hydrogen peroxide catabolic process  (ISO)
negative regulation of necrotic cell death  (IMP,ISO)
negative regulation of neurogenesis  (IDA)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of neuron death  (ISO)
negative regulation of oxidoreductase activity  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of catalytic activity  (IMP)
positive regulation of cell death  (IMP,ISO)
positive regulation of DNA-templated transcription  (IMP,ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,IMP,ISO)
positive regulation of gene expression  (IMP,ISO)
positive regulation of lysosomal membrane permeability  (IMP)
positive regulation of necrotic cell death  (ISO)
positive regulation of oxygen metabolic process  (IMP)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress  (ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
protein kinase B signaling  (ISO)
protein stabilization  (ISO)
regulation of protein glycosylation  (IMP)
regulation of response to food  (IMP)
removal of superoxide radicals  (ISO)
response to hypoxia  (ISO)
response to oxidative stress  (IMP)
zinc ion homeostasis  (ISO)
zinc ion transport  (IDA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Expression of growth inhibitory factor (metallothionein-III) mRNA and protein following excitotoxic immature brain injury. Acarin L, etal., J Neuropathol Exp Neurol. 1999 Apr;58(4):389-97.
2. Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice. Byun HR, etal., Neurobiol Dis. 2011 Oct;44(1):125-32. Epub 2011 Jun 25.
3. Metallothionein (MT)-III: generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains. Carrasco J, etal., J Neurotrauma. 1999 Nov;16(11):1115-29.
4. Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays. Choi KH, etal., BMC Psychiatry. 2008 Nov 7;8:87.
5. Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF). Erickson JC, etal., Brain Res. 1994 Jun 27;649(1-2):297-304.
6. Tolerance of aged rat brains to mild hyperoxia: possible involvement of higher GIF content. Gomi F, etal., Brain Res. 2005 Feb 1;1033(1):113-6.
7. Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity. Honda A, etal., J Toxicol Sci. 2010 Apr;35(2):209-15.
8. Growth inhibitory factor (GIF) can protect from brain damage due to stab wounds in rat brain. Hozumi I, etal., Neurosci Lett. 2006 Mar 13;395(3):220-3. Epub 2005 Nov 28.
9. Patterns of growth inhibitory factor (GIF) and glial fibrillary acidic protein relative level changes differ following left middle cerebral artery occlusion in rats. Inuzuka T, etal., Brain Res. 1996 Feb 12;709(1):151-31.
10. Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis. Ishigaki S, etal., FEBS Lett. 2002 Nov 6;531(2):354-8.
11. Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia. Koumura A, etal., Brain Res. 2009 Oct 6;1292:148-54. Epub 2009 Jul 25.
12. Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors. Koumura A, etal., Neurosci Lett. 2009 Dec 18;467(1):11-4. Epub 2009 Sep 30.
13. Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo. Lanza C, etal., J Neurochem. 2009 Sep;110(5):1674-84. Epub 2009 Jul 8.
14. Expression of antioxidant molecules after peripheral nerve injury and regeneration. Lanza C, etal., J Neurosci Res. 2012 Apr;90(4):842-8. doi: 10.1002/jnr.22778. Epub 2012 Jan 18.
15. Metallothionein-3 and neuronal nitric oxide synthase levels in brains from the Tg2576 mouse model of Alzheimer's disease. Martin BL, etal., Mol Cell Biochem. 2006 Feb;283(1-2):129-37.
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. Age-related changes in expression of metallothionein-III in rat brain. Miyazaki I, etal., Neurosci Res. 2002 Aug;43(4):323-33.
19. Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus. Ni H, etal., Toxicol Lett. 2013 Feb 27;217(2):162-9. doi: 10.1016/j.toxlet.2012.12.010. Epub 2012 Dec 21.
20. Association of metallothionein-III with oligodendroglial cytoplasmic inclusions in multiple system atrophy. Pountney DL, etal., Neurotox Res. 2011 Jan;19(1):115-22. Epub 2009 Dec 29.
21. Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteins. Puttaparthi K, etal., J Neurosci. 2002 Oct 15;22(20):8790-6.
22. Mouse MP Annotation Import Pipeline RGD automated import pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Growth inhibitory factor prevents degeneration of injured adult rat motoneurons. Sakamoto T, etal., Neuroreport. 2003 Dec 2;14(17):2147-51.
25. The unique N-terminal sequence of metallothionein-3 is required to regulate the choice between apoptotic or necrotic cell death of human proximal tubule cells exposed to Cd+2. Somji S, etal., Toxicol Sci. 2006 Apr;90(2):369-76. Epub 2005 Dec 30.
26. Metallothionein proteins expression, copper and zinc concentrations, and lipid peroxidation level in a rodent model for amyotrophic lateral sclerosis. Tokuda E, etal., Toxicology. 2007 Jan 5;229(1-2):33-41. Epub 2006 Sep 29.
27. Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators. Tougu V, etal., J Neurochem. 2009 Sep;110(6):1784-95. Epub 2009 Jul 8.
28. Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease. Tsuji S, etal., EMBO J. 1992 Dec;11(13):4843-50.
29. Metallothionein-III deficiency exacerbates light-induced retinal degeneration. Tsuruma K, etal., Invest Ophthalmol Vis Sci. 2012 Nov 29;53(12):7896-903. doi: 10.1167/iovs.12-10165.
30. Peripheral nerve avulsion injuries as experimental models for adult motoneuron degeneration. Watabe K, etal., Neuropathology. 2005 Dec;25(4):371-80.
31. Metallothioneins and zinc dysregulation contribute to neurodevelopmental damage in a model of perinatal viral infection. Williams BL, etal., Brain Pathol. 2006 Jan;16(1):1-14.
32. Ischemia induces metallothionein III expression in neurons of rat brain. Yanagitani S, etal., Life Sci. 1999;64(8):707-15.
33. Regulation of metallothionein-3 mRNA by thyroid hormone in developing rat brain and primary cultures of rat astrocytes and neurons. Yeiser EC, etal., Brain Res Dev Brain Res. 1999 Jun 2;115(2):195-200.
Additional References at PubMed
PMID:1631128   PMID:7655347   PMID:7673112   PMID:7878670   PMID:7931547   PMID:7979162   PMID:8003488   PMID:8039715   PMID:8600611   PMID:8720110   PMID:9006971   PMID:9379832  
PMID:9655243   PMID:9675420   PMID:10349636   PMID:10712606   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11560491   PMID:12130647   PMID:12466851   PMID:12477932   PMID:12714242  
PMID:12758064   PMID:12861386   PMID:14637104   PMID:15489334   PMID:15802640   PMID:16141072   PMID:16141073   PMID:17018872   PMID:17027170   PMID:17435258   PMID:19767621   PMID:20544854  
PMID:20851133   PMID:21267068   PMID:21359432   PMID:21677750   PMID:21873635   PMID:21900236   PMID:22722772   PMID:23962989   PMID:24464935   PMID:24479872   PMID:25054451   PMID:25189895  
PMID:26637294   PMID:27689697   PMID:28100752   PMID:28489004   PMID:29382714   PMID:31242420   PMID:32029749   PMID:32325033   PMID:32514052   PMID:34867993   PMID:35089129   PMID:35175194  


Genomics

Comparative Map Data
Mt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,879,235 - 94,880,776 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,879,235 - 94,880,774 (+)EnsemblGRCm39 Ensembl
GRCm38894,152,607 - 94,154,148 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,152,607 - 94,154,146 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,676,507 - 96,678,048 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,041,873 - 97,043,260 (+)NCBIMGSCv36mm8
Celera898,484,267 - 98,485,940 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.29NCBI
MT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,589,528 - 56,591,085 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1656,589,074 - 56,591,088 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,623,440 - 56,624,997 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,180,768 - 55,182,501 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,180,767 - 55,182,500NCBI
Celera1641,120,754 - 41,122,487 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,492,901 - 42,494,634 (+)NCBIHuRef
CHM1_11658,029,740 - 58,031,473 (+)NCBICHM1_1
T2T-CHM13v2.01662,384,459 - 62,386,016 (+)NCBIT2T-CHM13v2.0
Mt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21910,848,754 - 10,850,158 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,848,755 - 10,850,158 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,816,785 - 10,818,191 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01911,583,639 - 11,585,045 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01910,870,637 - 10,872,043 (-)NCBIRnor_WKY
Rnor_6.01911,324,708 - 11,326,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,324,698 - 11,326,139 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,300,014 - 11,301,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,284,554 - 11,286,402 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,289,380 - 11,291,228 (-)NCBI
Celera1910,734,686 - 10,736,090 (-)NCBICelera
Cytogenetic Map19p12NCBI
MT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11656,007,922 - 56,009,828 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,007,922 - 56,028,093 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01636,875,919 - 36,877,558 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MT-III
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,624,845 - 59,630,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,258,480 - 56,264,041 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,169,540 - 60,175,101 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,169,544 - 60,171,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,000,204 - 57,005,739 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,008,894 - 58,014,626 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,902,010 - 58,907,559 (-)NCBIUU_Cfam_GSD_1.0
Mt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,722,559 - 50,724,569 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364758,864,675 - 8,866,506 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364758,864,512 - 8,866,516 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,634,261 - 18,636,131 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,634,735 - 18,636,134 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,377,693 - 26,380,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,502,306 - 42,504,467 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604733,859,328 - 33,861,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:241
Count of miRNA genes:218
Interacting mature miRNAs:237
Transcripts:ENSMUST00000034211
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse

Markers in Region
Mt3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38894,152,329 - 94,152,449UniSTSGRCm38
MGSCv37896,676,229 - 96,676,349UniSTSGRCm37
Celera898,483,989 - 98,484,109UniSTS
Cytogenetic Map8C5UniSTS
cM Map845.0UniSTS
Mt3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB877752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC935161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M93310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S72046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034211   ⟹   ENSMUSP00000034211
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,879,235 - 94,880,774 (+)Ensembl
GRCm38.p6 Ensembl894,152,607 - 94,154,146 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211915   ⟹   ENSMUSP00000148383
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,879,374 - 94,880,613 (+)Ensembl
GRCm38.p6 Ensembl894,152,746 - 94,153,985 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211930   ⟹   ENSMUSP00000148345
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,879,374 - 94,880,044 (+)Ensembl
GRCm38.p6 Ensembl894,152,746 - 94,153,416 (+)Ensembl
RefSeq Acc Id: NM_013603   ⟹   NP_038631
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39894,879,235 - 94,880,776 (+)NCBI
GRCm38894,152,607 - 94,154,148 (+)ENTREZGENE
MGSCv37896,676,507 - 96,678,048 (+)RGD
Celera898,484,267 - 98,485,940 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038631   ⟸   NM_013603
- UniProtKB: P28184 (UniProtKB/Swiss-Prot),   Q3USP9 (UniProtKB/TrEMBL),   A0A8C6GAE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000148345   ⟸   ENSMUST00000211930
RefSeq Acc Id: ENSMUSP00000148383   ⟸   ENSMUST00000211915
RefSeq Acc Id: ENSMUSP00000034211   ⟸   ENSMUST00000034211

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28184-F1-model_v2 AlphaFold P28184 1-68 view protein structure

Promoters
RGD ID:8667899
Promoter ID:EPDNEW_M11974
Type:multiple initiation site
Name:Mt3_2
Description:Mus musculus metallothionein 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11975  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38894,152,627 - 94,152,687EPDNEW
RGD ID:8667887
Promoter ID:EPDNEW_M11975
Type:multiple initiation site
Name:Mt3_1
Description:Mus musculus metallothionein 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11974  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38894,152,745 - 94,152,805EPDNEW
RGD ID:6843497
Promoter ID:MM_KWN:55318
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_013603
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36896,676,386 - 96,676,886 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97173 AgrOrtholog
Ensembl Genes ENSMUSG00000031760 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034211 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000148345.2 UniProtKB/TrEMBL
  ENSMUSP00000148383.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034211 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000211915.2 UniProtKB/TrEMBL
  ENSMUST00000211930.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Metalthion UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_dom_sf_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert_metal_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17751 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97173 ENTREZGENE
NCBI Gene 17751 ENTREZGENE
PANTHER PTHR23299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallothio UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mt3 PhenoGen
PRINTS MTVERTEBRATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE METALLOTHIONEIN_VRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57868 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1D5RLF4_MOUSE UniProtKB/TrEMBL
  A0A1D5RLI5_MOUSE UniProtKB/TrEMBL
  A0A8C6GAE2 ENTREZGENE
  MT3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3USP9 ENTREZGENE, UniProtKB/TrEMBL