Ednrb (endothelin receptor type B) - Rat Genome Database
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Gene: Ednrb (endothelin receptor type B) Rattus norvegicus
Analyze
Symbol: Ednrb
Name: endothelin receptor type B
RGD ID: 2536
Description: Exhibits endothelin receptor activity and type 1 angiotensin receptor binding activity. Involved in several processes, including blood vessel diameter maintenance; enteric nervous system development; and positive regulation of penile erection. Localizes to membrane raft; nuclear membrane; and plasma membrane. Used to study several diseases, including artery disease (multiple); lymphopenia; megacolon (multiple); portal hypertension; and type 2 diabetes mellitus. Biomarker of asthma; hepatopulmonary syndrome; and hypertension. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg syndrome type 4A; Waardenburg's syndrome; and asthma. Orthologous to human EDNRB (endothelin receptor type B); PARTICIPATES IN calcium/calmodulin dependent kinase signaling pathway; endothelin signaling pathway; inflammatory response pathway; INTERACTS WITH (R)-noradrenaline; (S)-colchicine; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Ednra; endothelin B receptor; endothelin receptor; endothelin receptor non-selective type; endothelin-B receptor; ET-B; ET-BR; Etb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Ednrbsl  
Genetic Models: Sl LE/Hkv.AR-Ednrbsl F344.AR-Ednrbsl/Hkv AR-Ednrbsl/Hkv LE.AR-Ednrbsl/Okkm AR-Ednrbsl/Okkm
Is Marker For: Strains:   DA   SI-Tg(Ednrb)Ywa   Sl   LE.AR-Ednrbsl/Okkm   AR-Ednrbsl/Okkm  
QTLs:   Scl1   BpQTLcluster12   Bp126   Gluco31  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21580,640,839 - 80,672,115 (-)NCBI
Rnor_6.0 Ensembl1588,006,977 - 88,036,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01588,004,775 - 88,036,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01591,500,400 - 91,531,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41587,893,141 - 87,898,700 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11587,908,924 - 87,914,471 (-)NCBI
Celera1579,772,740 - 79,801,760 (-)NCBICelera
RH 3.4 Map15496.21RGD
Cytogenetic Map15q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP)
7-NITROINDAZOLE  (EXP)
8-bromo-3',5'-cyclic GMP  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
angiotensin II  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrasentan  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
celecoxib  (EXP)
chlorambucil  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
daunorubicin  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enrasentan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenoterol  (ISO)
folic acid  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
Ile(5)-angiotensin II  (EXP)
indometacin  (ISO)
isoprenaline  (EXP)
isoquinoline-1,5-diol  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (EXP)
nicotinic acid  (ISO)
nimesulide  (ISO)
nitric oxide  (EXP)
nitrites  (EXP)
nitrofen  (EXP)
nitroprusside  (EXP)
Nonylphenol  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paricalcitol  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phosphoramidon  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
picrotoxin  (EXP)
potassium chloride  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
rofecoxib  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
SB-239063  (EXP)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
staurosporine  (EXP)
Tanshinone I  (EXP)
telmisartan  (EXP)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
U-73122  (EXP)
udenafil  (EXP)
urethane  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vorinostat  (ISO)
wedelolactone  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
calcium-mediated signaling  (ISO,ISS)
cellular response to lipopolysaccharide  (IEP)
cGMP-mediated signaling  (IMP)
developmental pigmentation  (ISO)
endothelin receptor signaling pathway  (ISO)
enteric nervous system development  (IGI,ISO)
enteric smooth muscle cell differentiation  (ISO)
epithelial fluid transport  (IMP)
G protein-coupled receptor signaling pathway  (ISO)
macrophage chemotaxis  (ISO)
melanocyte differentiation  (IDA,ISO)
negative regulation of apoptotic process  (IGI,IMP)
negative regulation of cellular protein metabolic process  (ISO)
negative regulation of neuron maturation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neural crest cell migration  (ISO)
peripheral nervous system development  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IMP)
pigmentation  (IMP,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of penile erection  (IMP)
positive regulation of protein phosphorylation  (IDA)
positive regulation of renal sodium excretion  (IMP)
positive regulation of urine volume  (IMP)
posterior midgut development  (ISO)
regulation of blood pressure  (IMP,ISO)
regulation of epithelial cell proliferation  (IMP)
regulation of fever generation  (IMP)
regulation of pH  (ISO)
regulation of sensory perception of pain  (IMP)
response to endothelin  (IMP)
response to lipopolysaccharide  (IMP)
response to organic cyclic compound  (IEP)
response to pain  (IMP)
sensory perception of pain  (IMP)
vasoconstriction  (IMP,ISO)
vasodilation  (IMP)
vein smooth muscle contraction  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:1312429   PMID:1713452   PMID:2379821   PMID:8371713   PMID:8582288   PMID:8982507   PMID:9012511   PMID:10021336   PMID:10591209   PMID:10626068   PMID:11413164   PMID:11834512  
PMID:11897624   PMID:11910302   PMID:12088756   PMID:12164874   PMID:12207323   PMID:12421649   PMID:12441350   PMID:12668144   PMID:12686728   PMID:12713865   PMID:12750545   PMID:12813000  
PMID:12919946   PMID:14988072   PMID:15194452   PMID:15280069   PMID:15311109   PMID:15322542   PMID:15344879   PMID:15464196   PMID:15761039   PMID:15838256   PMID:15838268   PMID:15838271  
PMID:15838321   PMID:15838330   PMID:15838350   PMID:15838354   PMID:15838359   PMID:15838360   PMID:15838363   PMID:16144989   PMID:16341592   PMID:16463654   PMID:16806184   PMID:16947426  
PMID:17337507   PMID:17345093   PMID:17400719   PMID:17495482   PMID:17522762   PMID:17626731   PMID:17632282   PMID:17664390   PMID:17670915   PMID:17873013   PMID:17892518   PMID:18205269  
PMID:18242601   PMID:18281380   PMID:18287215   PMID:18424628   PMID:18469849   PMID:18516102   PMID:18518881   PMID:18524860   PMID:18547994   PMID:18567602   PMID:18758505   PMID:18793415  
PMID:19111903   PMID:19157542   PMID:19196949   PMID:19297422   PMID:19353416   PMID:19535675   PMID:19628575   PMID:19767294   PMID:19945955   PMID:20008273   PMID:20026178   PMID:20399772  
PMID:20716444   PMID:20844020   PMID:21035524   PMID:21228598   PMID:21428728   PMID:21536992   PMID:21801590   PMID:22007724   PMID:22198335   PMID:22198514   PMID:22258095   PMID:22391414  
PMID:22457360   PMID:22585122   PMID:22787113   PMID:22848635   PMID:22916224   PMID:22952915   PMID:23047940   PMID:23086942   PMID:23351051   PMID:23370722   PMID:23396520   PMID:23436727  
PMID:23599626   PMID:23646960   PMID:23875673   PMID:23988741   PMID:24144054   PMID:24462674   PMID:24467585   PMID:24503339   PMID:24582810   PMID:24731444   PMID:24779608   PMID:24815227  
PMID:24914193   PMID:24918345   PMID:25091502   PMID:25232999   PMID:25772258   PMID:25806822   PMID:25891848   PMID:26022359   PMID:26232046   PMID:26318480   PMID:26459423   PMID:26528589  
PMID:26776836   PMID:27017960   PMID:27582096   PMID:27697218   PMID:28012855   PMID:28236341   PMID:28356074   PMID:28623618   PMID:28701323   PMID:28757442   PMID:29115394   PMID:29351432  
PMID:30839511   PMID:31170185   PMID:32023824   PMID:33127751  


Genomics

Comparative Map Data
Ednrb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21580,640,839 - 80,672,115 (-)NCBI
Rnor_6.0 Ensembl1588,006,977 - 88,036,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01588,004,775 - 88,036,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01591,500,400 - 91,531,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41587,893,141 - 87,898,700 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11587,908,924 - 87,914,471 (-)NCBI
Celera1579,772,740 - 79,801,760 (-)NCBICelera
RH 3.4 Map15496.21RGD
Cytogenetic Map15q22NCBI
EDNRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1377,895,481 - 77,975,529 (-)EnsemblGRCh38hg38GRCh38
GRCh381377,895,481 - 77,975,527 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371378,469,616 - 78,549,662 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361377,367,617 - 77,447,665 (-)NCBINCBI36hg18NCBI36
Build 341377,368,543 - 77,390,935NCBI
Celera1359,367,540 - 59,390,895 (-)NCBI
Cytogenetic Map13q22.3NCBI
HuRef1359,168,348 - 59,248,390 (-)NCBIHuRef
CHM1_11378,436,966 - 78,516,998 (-)NCBICHM1_1
Ednrb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914104,052,051 - 104,083,248 (-)NCBIGRCm39mm39
GRCm39 Ensembl14104,052,061 - 104,081,838 (-)Ensembl
GRCm3814103,814,615 - 103,844,508 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14103,814,625 - 103,844,402 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714104,213,842 - 104,243,390 (-)NCBIGRCm37mm9NCBIm37
MGSCv3614102,700,305 - 102,729,375 (-)NCBImm8
Celera14102,434,540 - 102,464,042 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1453.05NCBI
Ednrb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540429,394,164 - 29,425,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540429,394,253 - 29,425,358 (+)NCBIChiLan1.0ChiLan1.0
EDNRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11378,153,026 - 78,177,281 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1378,153,020 - 78,177,286 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01359,112,349 - 59,136,615 (-)NCBIMhudiblu_PPA_v0panPan3
EDNRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2231,417,308 - 31,437,587 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12231,415,324 - 31,438,772 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ednrb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365113,446,864 - 3,478,434 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDNRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1150,072,554 - 50,102,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11150,073,300 - 50,102,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21154,689,465 - 54,718,898 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDNRB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1356,969,493 - 56,993,719 (-)NCBI
ChlSab1.1 Ensembl356,969,101 - 56,992,731 (-)Ensembl
Ednrb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475122,459,613 - 22,491,409 (+)NCBI

Position Markers
D15Mco2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01588,004,206 - 88,004,663NCBIRnor6.0
Rnor_6.01588,004,438 - 88,004,663NCBIRnor6.0
Rnor_5.01591,500,063 - 91,500,288UniSTSRnor5.0
Rnor_5.01591,499,831 - 91,500,288UniSTSRnor5.0
RGSC_v3.41587,890,619 - 87,890,845RGDRGSC3.4
RGSC_v3.41587,890,620 - 87,890,845UniSTSRGSC3.4
RGSC_v3.11587,906,399 - 87,906,625RGD
Celera1579,770,219 - 79,770,444UniSTS
Cytogenetic Map15q21-q22UniSTS
D15Mco3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01588,009,405 - 88,009,579NCBIRnor6.0
Rnor_5.01591,505,030 - 91,505,204UniSTSRnor5.0
RGSC_v3.41587,895,670 - 87,895,844UniSTSRGSC3.4
Celera1579,775,226 - 79,775,400UniSTS
Cytogenetic Map15q21-q22UniSTS
D15Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01588,012,000 - 88,012,247NCBIRnor6.0
Rnor_5.01591,507,625 - 91,507,872UniSTSRnor5.0
RGSC_v3.41587,898,265 - 87,898,512UniSTSRGSC3.4
Celera1579,777,821 - 79,778,067UniSTS
Cytogenetic Map15q21-q22UniSTS
D15Ulb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01588,010,417 - 88,010,700NCBIRnor6.0
Rnor_5.01591,506,042 - 91,506,325UniSTSRnor5.0
RGSC_v3.41587,896,682 - 87,896,965UniSTSRGSC3.4
Celera1579,776,238 - 79,776,521UniSTS
Cytogenetic Map15q21-q22UniSTS
PMC24270P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01588,007,314 - 88,007,525NCBIRnor6.0
Rnor_5.01591,502,939 - 91,503,150UniSTSRnor5.0
RGSC_v3.41587,893,496 - 87,893,707UniSTSRGSC3.4
Celera1579,773,095 - 79,773,306UniSTS
Cytogenetic Map15q21-q22UniSTS
AA818970  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01588,035,179 - 88,035,358NCBIRnor6.0
Rnor_5.01591,530,804 - 91,530,983UniSTSRnor5.0
Celera1579,800,585 - 79,800,764UniSTS
RH 3.4 Map15498.61UniSTS
Cytogenetic Map15q21-q22UniSTS
EDNRB-2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01588,012,396 - 88,013,824NCBIRnor6.0
Rnor_5.01591,508,021 - 91,509,449UniSTSRnor5.0
Celera1579,778,216 - 79,779,644UniSTS
Cytogenetic Map15q21-q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151851391388036354Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1526381041106550657Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1526381041106550657Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1526381041106550657Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)153321910189640841Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)153321910189640841Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)153321910189640841Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1543097470106550657Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)1561447766106447766Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)156259641099372139Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1562596410103164962Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1565520564110520564Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1575527634111246239Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1575761024109400896Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1581255292103165069Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1581255292109133904Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)1581255430103164962Rat
1581555Eae19Experimental allergic encephalomyelitis QTL 194.7nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)158394771498027710Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1583947714111246239Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1584050550111246239Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1584050550111246239Rat


Related Rat Strains
The following Strains have been annotated to Ednrb


Genetic Models
This gene Ednrb is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:153
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000014747
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 39 19 11 1 11 72 35 27 11
Low 2 4 38 30 18 30 8 10 2 13 8
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014747   ⟹   ENSRNOP00000014747
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1588,006,977 - 88,036,354 (-)Ensembl
RefSeq Acc Id: NM_017333   ⟹   NP_059029
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21580,643,025 - 80,672,115 (-)NCBI
Rnor_6.01588,006,959 - 88,036,354 (-)NCBI
Rnor_5.01591,500,400 - 91,531,979 (-)NCBI
RGSC_v3.41587,893,141 - 87,898,700 (-)RGD
Celera1579,772,740 - 79,801,760 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252431   ⟹   XP_006252493
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21580,640,839 - 80,671,537 (-)NCBI
Rnor_6.01588,004,775 - 88,036,106 (-)NCBI
Rnor_5.01591,500,400 - 91,531,979 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599786   ⟹   XP_017455275
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21580,640,839 - 80,671,517 (-)NCBI
Rnor_6.01588,004,775 - 88,036,106 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_059029   ⟸   NM_017333
- Peptide Label: precursor
- UniProtKB: P21451 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006252493   ⟸   XM_006252431
- Peptide Label: isoform X1
- UniProtKB: P21451 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455275   ⟸   XM_017599786
- Peptide Label: isoform X1
- UniProtKB: P21451 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014747   ⟸   ENSRNOT00000014747
Protein Domains
G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699864
Promoter ID:EPDNEW_R10387
Type:single initiation site
Name:Ednrb_1
Description:endothelin receptor type B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01588,036,356 - 88,036,416EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2536 AgrOrtholog
Ensembl Genes ENSRNOG00000010997 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000014747 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014747 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Endthln_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETB_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50672 UniProtKB/Swiss-Prot
NCBI Gene 50672 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB EDNRB RGD
PhenoGen Ednrb PhenoGen
PRINTS ENDOTHELINBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENDOTHELINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt EDNRB_RAT UniProtKB/Swiss-Prot
  F2W8B2_RAT UniProtKB/TrEMBL
  P21451 ENTREZGENE
  Q9R1M2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Ednrb  endothelin receptor type B      Symbol and Name updated 629477 APPROVED
2003-03-19 Ednrb  endothelin receptor type B  Etb  endothelin receptor  Data Merged 628472 PROVISIONAL
2002-08-07 Etb  endothelin receptor      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ednrb  endothelin receptor type B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of this gene in humans a leads to congental aganglionic megacolon or Hirschsprung disease, participates in deoxycorticosterone acetate (DOCA)-salt-induced hypertension, cardiovascular hypertrophy and renal damage 628459
gene_disease mutation of this gene in humans a leads to congental aganglionic megacolon or Hirschsprung disease, participates in deoxycorticosterone acetate (DOCA)-salt-induced hypertension, cardiovascular hypertrophy and renal damage 628515
gene_disease mutation of this gene in humans a leads to congental aganglionic megacolon or Hirschsprung disease, participates in deoxycorticosterone acetate (DOCA)-salt-induced hypertension, cardiovascular hypertrophy and renal damage 628516
gene_expression expressed in vascular and nonvascular tissues of the lung, brain and gut, mRNA first detected in the neural crest cells and in the wall of the forgut diverticulum. 628459
gene_expression expressed in vascular and nonvascular tissues of the lung, brain and gut, mRNA first detected in the neural crest cells and in the wall of the forgut diverticulum. 628515
gene_expression expressed in vascular and nonvascular tissues of the lung, brain and gut, mRNA first detected in the neural crest cells and in the wall of the forgut diverticulum. 628516
gene_expression not expressed in spontaneously hypertensive rat hearts but was expressed in salt-hypertensive sensitive and resistant rats fed a high-salt diet 1358986
gene_function induces inositol phosphate accumulation and calcium flux 61059
gene_mutations_overexpression deletion in this gene stops the receptor expression hence elevates endothelin 1 628459
gene_mutations_overexpression deletion in this gene stops the receptor expression hence elevates endothelin 1 628515
gene_mutations_overexpression deletion in this gene stops the receptor expression hence elevates endothelin 1 628516
gene_process involved in the development of two neural crest derived cells, epidermal melanocytes and entric neurons 628459
gene_process involved in the development of two neural crest derived cells, epidermal melanocytes and entric neurons 628515
gene_process involved in the development of two neural crest derived cells, epidermal melanocytes and entric neurons 628516
gene_process may be involved in congenital aganglionic megacolon and pigmentation abnormalities 628459
gene_process may be involved in congenital aganglionic megacolon and pigmentation abnormalities 628515
gene_process may be involved in congenital aganglionic megacolon and pigmentation abnormalities 628516