RGD Reference Report - Murine and rat cavernosal responses to endothelin-1 and urotensin-II Vasoactive Peptide Symposium. - Rat Genome Database

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Murine and rat cavernosal responses to endothelin-1 and urotensin-II Vasoactive Peptide Symposium.

Authors: Carneiro, FS  Carneiro, ZN  Giachini, FR  Lima, VV  Nogueira, E  Rainey, WE  Tostes, RC  Webb, RC 
Citation: Carneiro FS, etal., J Am Soc Hypertens. 2008 Nov;2(6):439-447.
RGD ID: 4892342
Pubmed: (View Article at PubMed) PMID:19884966
DOI: Full-text: DOI:10.1016/j.jash.2008.07.001

BACKGROUND: Endothelin-1 (ET-1) and urotensin-II (U-II) are the most potent constrictors of human vessels. Although the cavernosal tissue is higly responsive to ET-1, no information exists on the effects of U-II on cavernosal function. The aim of this study was to characterize ET-1 and U-II responses in corpora cavernosa from rats and mice. METHODS AND RESULTS: Male Wistar rats and C57/BL6 mice were used at 13 weeks. Cumulative concentration-response curves to ET-1, U-II and IRL-1620, an ET(B) agonist, were performed. ET-1 increased force generation in cavernosal strips from mice and rats, but no response to U-II was observed in the presence or absence of L-NAME, or in strips pre-stimulated with 20mM KCl. IRL-1620 did not induce cavernosal contraction even in presence of L-NAME, but induced a cavernosal relaxation which was greater in rats than mice. No relaxation responses to U-II were observed in cavernosal strips pre-contracted with phenylephrine. mRNA expression of ET-1, ET(A), ET(B) and U-II receptors, but not U-II was observed in cavernosal strips. CONCLUSION: ET-1, via ET(A) receptors activation, causes contractile responses in cavernosal strips from rats and mice whereas ET(B) receptor activation produces relaxation. Although the cavernosal tissue expresses U-II receptors, U-II does not induce contractile responses in corpora cavernosa from mice or rats.

Annotation

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Ednra  (endothelin receptor type A)
Ednrb  (endothelin receptor type B)


Additional Information