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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Myocardial Ischemia | | ISO | RGD:736543 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:16214533 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Myocardial Ischemia | | ISO | RGD:736543 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:16214533 | |
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# | Reference Title | Reference Citation |
1. | Dynamics of protein-tyrosine phosphatases in rat adipocytes. | Calera MR, etal., J Biol Chem. 2000 Mar 3;275(9):6308-12. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
4. | SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent. | Helmke S, etal., J Cell Sci. 1998 Aug;111 ( Pt 16):2465-75. |
5. | Gain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alpha. | Lei G, etal., EMBO J. 2002 Jun 17;21(12):2977-89. |
6. | Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels. | Lin D, etal., J Biol Chem. 2008 Mar 21;283(12):7674-81. Epub 2008 Jan 22. |
7. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
8. | cDNA cloning of rat LRP, a receptor like protein tyrosine phosphatase, and evidence for its gene regulation in cultured rat mesangial cells. | Moriyama T, etal., Biochem Biophys Res Commun 1992 Oct 15;188(1):34-9. |
9. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
10. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
11. | GOA pipeline | RGD automated data pipeline |
12. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
13. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
14. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
15. | Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2. | Su J, etal., J Biol Chem. 1994 Jul 22;269(29):18731-4. |
16. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
17. | Protein tyrosine phosphatase Alpha (PTP{alpha}) acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination. | Wang PS, etal., J Biol Chem. 2009 Oct 6. |
18. | Protein tyrosine-phosphatase expression profiling in gastric cancer tissues. | Wu CW, etal., Cancer Lett. 2006 Oct 8;242(1):95-103. doi: 10.1016/j.canlet.2005.10.046. Epub 2005 Dec 7. |
PMID:12826681 | PMID:12912911 | PMID:14733908 | PMID:15978577 | PMID:16899073 | PMID:18768480 | PMID:20458337 | PMID:23382219 |
Ptpra (Rattus norvegicus - Norway rat) |
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PTPRA (Homo sapiens - human) |
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Ptpra (Mus musculus - house mouse) |
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Ptpra (Chinchilla lanigera - long-tailed chinchilla) |
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PTPRA (Pan paniscus - bonobo/pygmy chimpanzee) |
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PTPRA (Canis lupus familiaris - dog) |
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Ptpra (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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PTPRA (Sus scrofa - pig) |
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PTPRA (Chlorocebus sabaeus - green monkey) |
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Ptpra (Heterocephalus glaber - naked mole-rat) |
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BE108511 |
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AU047115 |
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RH134950 |
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The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 43 | 56 | 40 | 19 | 40 | 6 | 6 | 74 | 35 | 38 | 11 | 6 |
Low | 1 | 1 | 1 | 2 | 5 | 3 | 2 | ||||||
Below cutoff |
RefSeq Transcripts | NM_012763 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006235006 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006235007 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039104340 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | BC081828 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
JACYVU010000118 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
L01702 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
U57500 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000055801 ⟹ ENSRNOP00000052657 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000080379 ⟹ ENSRNOP00000069583 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_012763 ⟹ NP_036895 | ||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006235006 ⟹ XP_006235068 | ||||||||||||||||
RefSeq Status: | |||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039104340 ⟹ XP_038960268 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_036895 | (Get FASTA) | NCBI Sequence Viewer |
XP_006235068 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038960268 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAA41983 | (Get FASTA) | NCBI Sequence Viewer |
AAB02230 | (Get FASTA) | NCBI Sequence Viewer | |
AAH81828 | (Get FASTA) | NCBI Sequence Viewer | |
Q03348 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_036895 ⟸ NM_012763 |
- Peptide Label: | precursor |
- UniProtKB: | Q66HJ7 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006235068 ⟸ XM_006235006 |
- Peptide Label: | isoform X1 |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000069583 ⟸ ENSRNOT00000080379 |
RefSeq Acc Id: | ENSRNOP00000052657 ⟸ ENSRNOT00000055801 |
RefSeq Acc Id: | XP_038960268 ⟸ XM_039104340 |
- Peptide Label: | isoform X1 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q03348-F1-model_v2 | AlphaFold | Q03348 | 1-796 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13692434 | ||||||||
Promoter ID: | EPDNEW_R2958 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Ptpra_1 | ||||||||
Description: | protein tyrosine phosphatase, receptor type, A | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
3 | 129571241 | 129571242 | T | C | snv | ACI/EurMcwi (MCW), ZFDM (KyushuU), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), GH/OmrMcwi (MCW), SBH/Ygl (MCW), SR/JrHsd (MCW), SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL), Crl:SD (UDEL), IS/Kyo (KyushuU), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), LE/Stm (KyushuU), HTX/Kyo (KyushuU), F344/NSlc (KyushuU), RCS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU), F344/Stm (KyushuU), HWY/Slc (KyushuU), F344/Jcl (KyushuU), BDIX/NemOda (KyushuU), DOB/Oda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), KFRS3B/Kyo (KyushuU), ZF (KyushuU), COP/CrCrl (MCW & UW) |
Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
3 | 118157700 | 118157701 | G | A | snv | SS/JrHsdMcwi (MCW) |
3 | 118158825 | 118158826 | T | C | snv | FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), SR/JrHsd (MCW), SHR/OlaIpcv (ICL), FHH/EurMcwi (MDC), SHRSP/Gcrc (MDC), ACI/N (KNAW), BUF/N (KNAW), F344/NRrrc (KNAW), LE/Stm (KNAW), M520/N (KNAW), MR/N (KNAW), WKY/N (KNAW), SHR/OlaIpcv (KNAW), COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW), ACI/EurMcwi (ICL), BBDP/WorN (ICL), F344/NCrl (ICL), FHH/EurMcwi (ICL), FHL/EurMcwi (ICL), LE/Stm (ICL), LEW/Crl (ICL), LEW/NCrl (ICL), MHS/Gib (ICL), MNS/Gib (ICL), SBH/Ygl (ICL), SHR/OlaIpcv (ICL), SHR/NHsd (ICL), SHRSP/Gcrc (ICL), SR/JrHsd (ICL), WAG/Rij (ICL), WKY/NCrl (ICL), WKY/Gcrc (ICL), WKY/NHsd (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), HCR/2Mco (UMich), LCR/2Mco (UMich), DA/BklArbNsi (ICAHN), F344/NHsd (ICAHN), ACI/EurMcwi (MCW) |
Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
3 | 117746512 | 117746513 | T | C | snv | BUF/N (2020), BXH3/CubMcwi (2020), HXB20/IpcvMcwi (2020), HXB2/IpcvMcwi (2019), LEXF3/Stm (2020), WKY/N (2020), M520/N (2020), MR/N (2020), SHRSP/A3NCrl (2019), SHR/OlalpcvMcwi (2019), WKY/NCrl (2019), LEXF4/Stm (2020) |
Database | Acc Id | Source(s) |
AGR Gene | RGD:3450 | AgrOrtholog |
BioCyc Gene | G2FUF-47855 | BioCyc |
Ensembl Genes | ENSRNOG00000021223 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000052657 | ENTREZGENE |
ENSRNOP00000052657.4 | UniProtKB/TrEMBL | |
ENSRNOP00000069583 | ENTREZGENE | |
ENSRNOP00000069583.2 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000055801 | ENTREZGENE |
ENSRNOT00000055801.5 | UniProtKB/TrEMBL | |
ENSRNOT00000080379 | ENTREZGENE | |
ENSRNOT00000080379.2 | UniProtKB/TrEMBL | |
Gene3D-CATH | 3.90.190.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IMAGE_CLONE | IMAGE:7107006 | IMAGE-MGC_LOAD |
InterPro | Prot-tyrosine_phosphatase-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTPase_domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Tyr_Pase_AS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Tyr_Pase_cat | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Tyr_Pase_rcpt_a/e-type | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Tyr_Pase_rcpt_alpha | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TYR_PHOSPHATASE_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:25167 | UniProtKB/TrEMBL |
MGC_CLONE | MGC:93561 | IMAGE-MGC_LOAD |
NCBI Gene | 25167 | ENTREZGENE |
PANTHER | PTHR19134:SF433 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Pfam | Y_phosphatase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Ptpra | PhenoGen |
PIRSF | PTPR_alpha | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTPR_alpha_epsilon | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PRINTS | PRTYPHPHTASE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | TYR_PHOSPHATASE_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TYR_PHOSPHATASE_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TYR_PHOSPHATASE_PTP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SMART | PTPc | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTPc_motif | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | SSF52799 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TIGR | TC229590 | |
UniProt | A0A0G2JVR0_RAT | UniProtKB/TrEMBL |
A0A8J8YBN3_RAT | UniProtKB/TrEMBL | |
PTPRA_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
Q66HJ7 | ENTREZGENE, UniProtKB/TrEMBL | |
UniProt Secondary | F1M833 | UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2002-06-10 | Ptpra | Protein tyrosine phosphatase, receptor type, A | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_domains | has two intracellular PTPase domains | 633823 |
gene_regulation | expression is inhibited by treatment with Il6 or Il1 | 633823 |