Ptpra (protein tyrosine phosphatase, receptor type, A)

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Gene: Ptpra (protein tyrosine phosphatase, receptor type, A) Rattus norvegicus

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Symbol:

Ptpra

Name:

protein tyrosine phosphatase, receptor type, A

RGD ID:

3450

Description:

Enables protein tyrosine phosphatase activity. Involved in oligodendrocyte differentiation and positive regulation of oligodendrocyte differentiation. Predicted to be located in focal adhesion and membrane. Predicted to be part of receptor complex. Predicted to be active in Schaffer collateral - CA1 synapse and synaptic membrane. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LRP; MGC93561; protein tyrosine phosphatase alpha; protein-tyrosine phosphatase alpha; R-PTP-alpha; receptor-type tyrosine-protein phosphatase alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Ptpra^{Tn(sb-T2/Bart3)2.261Mcwi}

Genetic Models:

F344-Ptpra^{Tn(sb-T2/Bart3)2.261Mcwi}

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	138,103,261 - 138,212,835 (+)	NCBI		GRCr8
mRatBN7.2	3	117,650,146 - 117,759,744 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	117,650,183 - 117,759,728 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	121,547,451 - 121,654,208 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	130,143,111 - 130,251,468 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	127,803,579 - 127,910,341 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	122,976,066 - 123,084,585 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	122,976,104 - 123,084,863 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	129,475,237 - 129,582,992 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	118,061,713 - 118,171,300 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	118,022,615 - 118,077,164 (+)	NCBI
Celera	3	116,464,194 - 116,570,590 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

dystonia 30 (ISO)

gastric adenocarcinoma (ISO)

genetic disease (ISO)

Huntington's disease-like 1 (ISO)

Myocardial Ischemia (ISO)

pantothenate kinase-associated neurodegeneration (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

atrazine (EXP,ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (EXP)

bisphenol A (EXP,ISO)

caffeine (ISO)

casticin (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

cocaine (ISO)

copper(II) sulfate (ISO)

dibutyl phthalate (EXP)

endosulfan (EXP)

ethanol (ISO)

fipronil (EXP)

folic acid (ISO)

geldanamycin (ISO)

genistein (ISO)

hydrogen peroxide (ISO)

ivermectin (ISO)

Mecamylamine (ISO)

menadione (ISO)

methylmercury chloride (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

nickel sulfate (ISO)

nicotine (ISO)

ozone (ISO)

paracetamol (EXP)

propiconazole (EXP)

resveratrol (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulfadimethoxine (EXP)

tamoxifen (ISO)

thapsigargin (ISO)

thimerosal (ISO)

thiram (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

tubocurarine (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

insulin receptor signaling pathway (IEA,ISO)

integrin-mediated signaling pathway (IEA,ISO,ISS)

modulation of chemical synaptic transmission (IEA,ISO)

oligodendrocyte differentiation (IEP)

positive regulation of oligodendrocyte differentiation (IMP)

protein dephosphorylation (IEA)

protein phosphorylation (ISO)

regulation of focal adhesion assembly (IEA,ISO,ISS)

Cellular Component

focal adhesion (IEA,ISO,ISS)

membrane (ISO)

plasma membrane (IEA)

receptor complex (IEA,ISO)

Schaffer collateral - CA1 synapse (IEA,ISO)

synaptic membrane (IEA,ISO)

Molecular Function

protein binding (IPI,ISO)

protein tyrosine phosphatase activity (IBA,IDA,IEA,ISO,ISS)

protein-containing complex binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Dynamics of protein-tyrosine phosphatases in rat adipocytes.	Calera MR, etal., J Biol Chem. 2000 Mar 3;275(9):6308-12.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent.	Helmke S, etal., J Cell Sci. 1998 Aug;111 ( Pt 16):2465-75.
5.	Gain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alpha.	Lei G, etal., EMBO J. 2002 Jun 17;21(12):2977-89.
6.	Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels.	Lin D, etal., J Biol Chem. 2008 Mar 21;283(12):7674-81. Epub 2008 Jan 22.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	cDNA cloning of rat LRP, a receptor like protein tyrosine phosphatase, and evidence for its gene regulation in cultured rat mesangial cells.	Moriyama T, etal., Biochem Biophys Res Commun 1992 Oct 15;188(1):34-9.
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15.	Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2.	Su J, etal., J Biol Chem. 1994 Jul 22;269(29):18731-4.
16.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17.	Protein tyrosine phosphatase Alpha (PTP{alpha}) acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination.	Wang PS, etal., J Biol Chem. 2009 Oct 6.
18.	Protein tyrosine-phosphatase expression profiling in gastric cancer tissues.	Wu CW, etal., Cancer Lett. 2006 Oct 8;242(1):95-103. doi: 10.1016/j.canlet.2005.10.046. Epub 2005 Dec 7.

Additional References at PubMed

PMID:12826681	PMID:12912911	PMID:14733908	PMID:15978577	PMID:16899073	PMID:18768480	PMID:20458337	PMID:23382219	PMID:25951993

Genomics

Comparative Map Data

Ptpra
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	138,103,261 - 138,212,835 (+)	NCBI		GRCr8
mRatBN7.2	3	117,650,146 - 117,759,744 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	117,650,183 - 117,759,728 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	121,547,451 - 121,654,208 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	130,143,111 - 130,251,468 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	127,803,579 - 127,910,341 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	122,976,066 - 123,084,585 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	122,976,104 - 123,084,863 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	129,475,237 - 129,582,992 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	118,061,713 - 118,171,300 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	118,022,615 - 118,077,164 (+)	NCBI
Celera	3	116,464,194 - 116,570,590 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

PTPRA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	2,864,184 - 3,038,669 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	2,873,420 - 3,039,076 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	2,844,830 - 3,019,315 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	2,792,841 - 2,967,315 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	2,851,852 - 2,967,314	NCBI
Celera	20	2,907,196 - 3,081,302 (+)	NCBI		Celera
Cytogenetic Map	20	p13	NCBI
HuRef	20	2,793,748 - 2,965,653 (+)	NCBI		HuRef
CHM1_1	20	2,844,843 - 3,014,144 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	2,895,030 - 3,069,415 (+)	NCBI		T2T-CHM13v2.0

Ptpra
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	130,292,198 - 130,396,220 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	130,292,198 - 130,398,044 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	130,450,278 - 130,554,300 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	130,450,278 - 130,556,124 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	130,276,014 - 130,380,036 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	130,194,915 - 130,245,464 (+)	NCBI		MGSCv36	mm8
Celera	2	131,674,730 - 131,778,720 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	63.23	NCBI

Ptpra
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	13,819,717 - 13,967,068 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	13,819,934 - 13,967,068 (+)	NCBI	ChiLan1.0	ChiLan1.0

PTPRA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	3,843,586 - 4,005,991 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	3,840,405 - 4,002,816 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	2,962,701 - 3,125,282 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	2,726,657 - 2,888,195 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	2,801,905 - 2,888,195 (+)	Ensembl	panpan1.1		panPan2

PTPRA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	18,224,355 - 18,395,650 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	18,224,801 - 18,296,350 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	18,052,684 - 18,223,899 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	18,643,403 - 18,815,534 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	18,643,403 - 18,815,666 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	18,236,577 - 18,408,752 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	18,349,051 - 18,519,508 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	18,677,051 - 18,848,067 (-)	NCBI		UU_Cfam_GSD_1.0

Ptpra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	167,313,690 - 167,441,022 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	15,744,205 - 15,872,995 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	15,745,054 - 15,872,377 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTPRA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	32,637,932 - 32,797,104 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	32,638,494 - 32,797,110 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	37,008,987 - 37,167,722 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTPRA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	33,559,634 - 33,724,446 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	33,559,697 - 33,722,137 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	10,789,232 - 10,956,158 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptpra
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	4,075,101 - 4,155,130 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	3,997,853 - 4,155,130 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ptpra
484 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	249
Count of miRNA genes:	171
Interacting mature miRNAs:	192
Transcripts:	ENSRNOT00000055801
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
1358204	Insglur1	Insulin/glucose ratio QTL 1	3.8		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	3	115638168	135181505	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	112287552	135181505	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat

Markers in Region

BE108511

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	117,759,831 - 117,760,025 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	123,084,673 - 123,084,866	NCBI	Rnor6.0
Rnor_5.0	3	129,582,801 - 129,582,994	UniSTS	Rnor5.0
RGSC_v3.4	3	118,171,401 - 118,171,594	UniSTS	RGSC3.4
Celera	3	116,570,691 - 116,570,884	UniSTS
RH 3.4 Map	3	1001.2	UniSTS
Cytogenetic Map	3	q36	UniSTS

AU047115

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	117,731,453 - 117,731,719 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	123,058,055 - 123,058,320	NCBI	Rnor6.0
Rnor_5.0	3	129,556,183 - 129,556,448	UniSTS	Rnor5.0
RGSC_v3.4	3	118,143,790 - 118,144,055	UniSTS	RGSC3.4
Celera	3	116,545,174 - 116,545,439	UniSTS
Cytogenetic Map	3	q36	UniSTS

RH134950

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	117,711,190 - 117,711,386 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	123,037,794 - 123,037,989	NCBI	Rnor6.0
Rnor_5.0	3	129,535,922 - 129,536,117	UniSTS	Rnor5.0
RGSC_v3.4	3	118,123,530 - 118,123,725	UniSTS	RGSC3.4
Celera	3	116,524,913 - 116,525,108	UniSTS
RH 3.4 Map	3	1000.7	UniSTS
Cytogenetic Map	3	q36	UniSTS

Genetic Models

This gene Ptpra is modified in the following models/strains:

F344-Ptpra^{Tn(sb-T2/Bart3)2.261Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006235006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006235007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081828	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L01702	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U57500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000055801 ⟹ ENSRNOP00000052657

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	117,650,183 - 117,759,728 (+)	Ensembl
Rnor_6.0 Ensembl	3	122,976,104 - 123,084,569 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000080379 ⟹ ENSRNOP00000069583

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	117,650,183 - 117,759,728 (+)	Ensembl
Rnor_6.0 Ensembl	3	123,031,307 - 123,084,863 (+)	Ensembl

RefSeq Acc Id:

NM_012763 ⟹ NP_036895

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	138,103,295 - 138,212,835 (+)	NCBI
mRatBN7.2	3	117,650,183 - 117,759,731 (+)	NCBI
Rnor_6.0	3	122,976,104 - 123,084,572 (+)	NCBI
Rnor_5.0	3	129,475,237 - 129,582,992 (+)	NCBI
RGSC_v3.4	3	118,061,713 - 118,171,300 (+)	RGD
Celera	3	116,464,194 - 116,570,590 (+)	RGD

Sequence:

show sequence

CGGCGAGTGAGGCGCTGACAGGGACTCACGGGGGCATCTTGCACAGACCCCTGGACCACGCCGC
CATCGCAGCCTCCCGCCCAGTCCTCTCTCTGCTGCTTCTCCTCGCCATGGAGGCGAGGCCGCCG
CCGCCGCCGCGGGGCTTCGAGCAGCGGACCGGGCGGCGGCCCTGAGGGGAGCGGCGGGCCGAGA
CGCCGCCGCGGTGCTGAGGCGGAGCTGCCGTGCGCGTCCCCCGCGGTCCCGCCCAGCGCCGGGC
TCGGTCAGCATGGATTCCTGGTTCATTCTTATCCTGTTTGGCAGTGGTCTAATACACATTAGTG
CCAACAACACTACTACAGTTTCACCTTCTTTAGGAACTACAAGATTAATTAAAACATCAACAAC
AGAATCGGCTAAGGAAGAGAATAAAACTTCAAATTCAACCTCTTCAGTAATTTCTCTTTCTGTG
ACACCAACATTCAGCCCAAATCTAACTCTGGAACCCACCTATGTGACTACTGTTAATTCTTCAC
ACTCTGACAATGGGACCAAGAGAGCAGCCAGCACGGAATCTGGAGGCACTACCATTTCACCAAA
CGGAACATACGGAACATGGCTTACTGATAACCAGTTCACGGATGCCAGAACAGAACCCTGGGAG
GGGAATTCCAGCACTGCAGCAACCACTCCAGAAACCTTCCCCCCTGCAGATGAGACACCAATCA
TTGCGGTGATGGTGGCCCTGTCCTCTCTGCTAGTAATTGTGTTTATTATTATAGTTCTGTACAT
GTTAAGGTTTAAGAAATACAAGCAAGCTGGGAGCCATTCCAATTCTTTCCGCCTGTCAAATGGC
CGCACAGAGGATGTGGAGCCCCAAAGTGTACCACTTCTGGCCAGGTCCCCGAGCACCAACAGGA
AGTTCCCACCACTGCCTGTGGACAAGCTGGAAGAGGAGATTAACCGGAGAATGGCTGATGACAA
TAAGCTCTTCAGAGAGGAATTCAACGCCCTCCCTGCCTGTCCAATCCAGGCCACCTGTGAGGCT
GCCTCCAAGGAAGAAAACAAGGAAAAAAACCGATATGTAAACATCCTGCCTTATGACCACTCCA
GAGTGCACCTGACGCCTGTGGAAGGGGTTCCAGATTCTGATTACATCAACGCCTCATTCATTAA
TGGCTACCAGGAAAAGAACAAATTCATTGCTGCACAAGGACCAAAAGAAGAAACGGTGAATGAT
TTCTGGAGAATGATATGGGAACAGAACACAGCCACCATTGTCATGGTGACCAACCTGAAGGAGA
GAAAGGAGTGTAAATGTGCCCAGTATTGGCCAGACCAAGGCTGCTGGACCTATGGGAATGTCCG
TGTGTCTGTCGAGGATGTGACTGTTCTGGTGGACTACACAGTACGGAAATTCTGCATCCAGCAG
GTGGGCGACGTCACCAACAGGAAGCCACAGCGCCTCATCACTCAGTTCCATTTCACCAGCTGGC
CAGACTTTGGGGTGCCTTTTACCCCAATTGGCATGCTCAAGTTCCTCAAGAAGGTGAAAGCCTG
TAACCCTCAGTATGCAGGGGCTATCGTGGTCCACTGCAGTGCAGGTGTAGGGCGCACTGGCACC
TTTGTTGTCATCGATGCCATGCTGGACATGATGCATTCGGAGCGCAAAGTGGATGTATATGGGT
TTGTGAGCCGGATCCGGGCCCAGCGCTGCCAGATGGTCCAGACAGACATGCAGTACGTCTTCAT
ATACCAGGCCCTTCTGGAGCATTATCTATATGGCGACACAGAGCTGGAAGTGACTTCCCTAGAC
ACCCACCTGCAAAAAATTTATAACAAGATCCCAGGAACTAGCAACAATGGACTAGAGGAGGAAT
TTAAGAAATTAACTTCAATCAAAATCCAAAATGACAAGATGCGTACGGGAAACCTTCCAGCCAA
CATGAAGAAGAACCGAGTTTTACAGATCATTCCATATGAATTTAACAGAGTGATCATTCCAGTC
AAACGGGGCGAAGAGAACACAGACTATGTGAACGCATCCTTCATTGATGGCTACCGGCAGAAAG
ATTCCTACATCGCCAGCCAGGGCCCTCTTCTCCACACAATTGAGGACTTCTGGCGAATGATCTG
GGAATGGAAGTCCTGCTCCATTGTAATGCTAACAGAACTGGAAGAAAGAGGCCAGGAGAAGTGT
GCCCAGTACTGGCCATCTGATGGCCTGGTGTCCTATGGAGACATCACAGTTGAGCTGAAGAAGG
AGGAGGAATGTGAGAGCTACACTGTCCGAGACCTCCTGGTCACCAACACCAGGGAGAACAAGAG
TCGGCAGATCCGGCAGTTCCACTTCCACGGCTGGCCTGAGGTGGGCATCCCCAGCGATGGGAAG
GGTATGATCAACATCATTGCAGCAGTGCAGAAGCAGCAGCAGCAGTCAGGGAACCATCCCATCA
CTGTGCACTGCAGTGCCGGGGCAGGACGGACAGGGACCTTTTGTGCCTTGAGCACAGTCCTGGA
GCGCGTGAAAGCAGAAGGAATTTTGGATGTCTTCCAAACTGTCAAGAGCCTGCGGCTGCAGAGG
CCACACATGGTCCAGACACTGGAACAGTATGAATTCTGCTACAAGGTGGTACAGGAGTACATCG
ATGCCTTCTCAGATTATGCCAACTTCAAGTGACAGGGGACAAGGCCCACAGACAGGAGAATTGC
CTTTAATATTTTGTAATATTCTGTTTTGTTAATATACCCAAAATTGTATATATCTTATAACTGT
TTTAGAAATGGCACATAGGCTTCTATTACCTATTAGGTGGAGATTTTGTATGTAAATGTGTTAG
CACTATAGTCCTTTTCCAGTGTTTTATTGGGGAATTAAATAGTGTGATATTTGAGTTGATTTAA
TGAAGTCCTTAGCCTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006235006 ⟹ XP_006235068

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	138,103,261 - 138,212,810 (+)	NCBI
mRatBN7.2	3	117,650,146 - 117,759,744 (+)	NCBI
Rnor_6.0	3	122,976,066 - 123,084,585 (+)	NCBI
Rnor_5.0	3	129,475,237 - 129,582,992 (+)	NCBI

Sequence:

show sequence

AGCGCCTTACAGCCCAGGCCGCGTTGGGAGTGAGGCTGCGGCGAGTGAGGCGCTGACAGGGACT
CACGGGGGCATCTTGCACAGACCCCTGGACCACGCCGCCATCGCAGCCTCCCGCCCAGTCCTCT
CTCTGCTGCTTCTCCTCGCCATGGAGGCGAGGCCGCCGCCGCCGCCGCGGGGCTTCGAGCAGCG
GACCGGGCGGCGGCCCTGAGGGGAGCGGCGGGCCGAGACGCCGCCGCGGTGCTGAGGCGGAGCT
GCCGTGCGCGTCCCCCGCGGTCCCGCCCAGCGCCGGGCTCGGTCAGCATGGATTCCTGGTTCAT
TCTTATCCTGTTTGGCAGTGGTCTAATACACATTAGTGCCAACAACACTACTACAGTTTCACCT
TCTTTAGGAACTACAAGATTAATTAAAACATCAACAACAGAATCGGCTAAGGAAGAGAATAAAA
CTTCAAATTCAACCTCTTCAGTAATTTCTCTTTCTGTGACACCAACATTCAGCCCAAATCTAAC
TCTGGAACCCACCTATGTGACTACTGTTAATTCTTCACACTCTGACAATGGGACCAAGAGAGCA
GCCAGCACGGAATCTGGAGGCACTACCATTTCACCAAACGGAACATACGGAACATGGCTTACTG
ATAACCAGTTCACGGATGCCAGAACAGAACCCTGGGAGGGGAATTCCAGCACTGCAGCAACCAC
TCCAGAAACCTTCCCCCCTGCAGGTAATTCTGACTCAAAAGACAGGAGAGATGAGACACCAATC
ATTGCGGTGATGGTGGCCCTGTCCTCTCTGCTAGTAATTGTGTTTATTATTATAGTTCTGTACA
TGTTAAGGTTTAAGAAATACAAGCAAGCTGGGAGCCATTCCAATTCTTTCCGCCTGTCAAATGG
CCGCACAGAGGATGTGGAGCCCCAAAGTGTACCACTTCTGGCCAGGTCCCCGAGCACCAACAGG
AAGTTCCCACCACTGCCTGTGGACAAGCTGGAAGAGGAGATTAACCGGAGAATGGCTGATGACA
ATAAGCTCTTCAGAGAGGAATTCAACGCCCTCCCTGCCTGTCCAATCCAGGCCACCTGTGAGGC
TGCCTCCAAGGAAGAAAACAAGGAAAAAAACCGATATGTAAACATCCTGCCTTATGACCACTCC
AGAGTGCACCTGACGCCTGTGGAAGGGGTTCCAGATTCTGATTACATCAACGCCTCATTCATTA
ATGGCTACCAGGAAAAGAACAAATTCATTGCTGCACAAGGACCAAAAGAAGAAACGGTGAATGA
TTTCTGGAGAATGATATGGGAACAGAACACAGCCACCATTGTCATGGTGACCAACCTGAAGGAG
AGAAAGGAGTGTAAATGTGCCCAGTATTGGCCAGACCAAGGCTGCTGGACCTATGGGAATGTCC
GTGTGTCTGTCGAGGATGTGACTGTTCTGGTGGACTACACAGTACGGAAATTCTGCATCCAGCA
GGTGGGCGACGTCACCAACAGGAAGCCACAGCGCCTCATCACTCAGTTCCATTTCACCAGCTGG
CCAGACTTTGGGGTGCCTTTTACCCCAATTGGCATGCTCAAGTTCCTCAAGAAGGTGAAAGCCT
GTAACCCTCAGTATGCAGGGGCTATCGTGGTCCACTGCAGTGCAGGTGTAGGGCGCACTGGCAC
CTTTGTTGTCATCGATGCCATGCTGGACATGATGCATTCGGAGCGCAAAGTGGATGTATATGGG
TTTGTGAGCCGGATCCGGGCCCAGCGCTGCCAGATGGTCCAGACAGACATGCAGTACGTCTTCA
TATACCAGGCCCTTCTGGAGCATTATCTATATGGCGACACAGAGCTGGAAGTGACTTCCCTAGA
CACCCACCTGCAAAAAATTTATAACAAGATCCCAGGAACTAGCAACAATGGACTAGAGGAGGAA
TTTAAGAAATTAACTTCAATCAAAATCCAAAATGACAAGATGCGTACGGGAAACCTTCCAGCCA
ACATGAAGAAGAACCGAGTTTTACAGATCATTCCATATGAATTTAACAGAGTGATCATTCCAGT
CAAACGGGGCGAAGAGAACACAGACTATGTGAACGCATCCTTCATTGATGGCTACCGGCAGAAA
GATTCCTACATCGCCAGCCAGGGCCCTCTTCTCCACACAATTGAGGACTTCTGGCGAATGATCT
GGGAATGGAAGTCCTGCTCCATTGTAATGCTAACAGAACTGGAAGAAAGAGGCCAGGAGAAGTG
TGCCCAGTACTGGCCATCTGATGGCCTGGTGTCCTATGGAGACATCACAGTTGAGCTGAAGAAG
GAGGAGGAATGTGAGAGCTACACTGTCCGAGACCTCCTGGTCACCAACACCAGGGAGAACAAGA
GTCGGCAGATCCGGCAGTTCCACTTCCACGGCTGGCCTGAGGTGGGCATCCCCAGCGATGGGAA
GGGTATGATCAACATCATTGCAGCAGTGCAGAAGCAGCAGCAGCAGTCAGGGAACCATCCCATC
ACTGTGCACTGCAGTGCCGGGGCAGGACGGACAGGGACCTTTTGTGCCTTGAGCACAGTCCTGG
AGCGCGTGAAAGCAGAAGGAATTTTGGATGTCTTCCAAACTGTCAAGAGCCTGCGGCTGCAGAG
GCCACACATGGTCCAGACACTGGAACAGTATGAATTCTGCTACAAGGTGGTACAGGAGTACATC
GATGCCTTCTCAGATTATGCCAACTTCAAGTGACAGGGGACAAGGCCCACAGACAGGAGAATTG
CCTTTAATATTTTGTAATATTCTGTTTTGTTAATATACCCAAAATTGTATATATCTTATAACTG
TTTTAGAAATGGCACATAGGCTTCTATTACCTATTAGGTGGAGATTTTGTATGTAAATGTGTTA
GCACTATAGTCCTTTTCCAGTGTTTTATTGGGGAATTAAATAGTGTGATATTTGAGTTGATTTA
ATGAAGTCCTTAGCCTGGAAATTGGGCCAGATTA

hide sequence

RefSeq Acc Id:

XM_039104340 ⟹ XP_038960268

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	138,103,314 - 138,212,810 (+)	NCBI
mRatBN7.2	3	117,650,203 - 117,759,744 (+)	NCBI

RefSeq Acc Id:

XM_063283139 ⟹ XP_063139209

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	138,177,357 - 138,212,810 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_036895	(Get FASTA)	NCBI Sequence Viewer
	XP_006235068	(Get FASTA)	NCBI Sequence Viewer
	XP_038960268	(Get FASTA)	NCBI Sequence Viewer
	XP_063139209	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41983	(Get FASTA)	NCBI Sequence Viewer
	AAB02230	(Get FASTA)	NCBI Sequence Viewer
	AAH81828	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000052657.4
	ENSRNOP00000069583.2
GenBank Protein	Q03348	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036895 ⟸ NM_012763
- Peptide Label:	precursor
- UniProtKB:	Q03348 (UniProtKB/Swiss-Prot), Q66HJ7 (UniProtKB/TrEMBL), F1M833 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDSWFILILFGSGLIHISANNTTTVSPSLGTTRLIKTSTTESAKEENKTSNSTSSVISLSVTPT FSPNLTLEPTYVTTVNSSHSDNGTKRAASTESGGTTISPNGTYGTWLTDNQFTDARTEPWEGNS STAATTPETFPPADETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTE DVEPQSVPLLARSPSTNRKFPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASK EENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWR MIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNVRVSVEDVTVLVDYTVRKFCIQQVGD VTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVV IDAMLDMMHSERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLDTHL QKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRG EENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQY WPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMI NIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHM VQTLEQYEFCYKVVQEYIDAFSDYANFK hide sequence

RefSeq Acc Id:	XP_006235068 ⟸ XM_006235006
- Peptide Label:	isoform X1
- UniProtKB:	Q03348 (UniProtKB/Swiss-Prot), A0A8J8YBN3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDSWFILILFGSGLIHISANNTTTVSPSLGTTRLIKTSTTESAKEENKTSNSTSSVISLSVTPT FSPNLTLEPTYVTTVNSSHSDNGTKRAASTESGGTTISPNGTYGTWLTDNQFTDARTEPWEGNS STAATTPETFPPAGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS FRLSNGRTEDVEPQSVPLLARSPSTNRKFPPLPVDKLEEEINRRMADDNKLFREEFNALPACPI QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPK EETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNVRVSVEDVTVLVDYTVR KFCIQQVGDVTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAG VGRTGTFVVIDAMLDMMHSERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTEL EVTSLDTHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFN RVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEE RGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVG IPSDGKGMINIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVK SLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK hide sequence

Ensembl Acc Id:

ENSRNOP00000069583 ⟸ ENSRNOT00000080379

Ensembl Acc Id:

ENSRNOP00000052657 ⟸ ENSRNOT00000055801

RefSeq Acc Id:	XP_038960268 ⟸ XM_039104340
- Peptide Label:	isoform X1
- UniProtKB:	Q03348 (UniProtKB/Swiss-Prot), A0A8J8YBN3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063139209 ⟸ XM_063283139
- Peptide Label:	isoform X2

Protein Domains

Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q03348-F1-model_v2	AlphaFold	Q03348	1-796	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692434

Promoter ID:

EPDNEW_R2958

Type:

multiple initiation site

Name:

Ptpra_1

Description:

protein tyrosine phosphatase, receptor type, A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	122,976,086 - 122,976,146	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3450	AgrOrtholog
BioCyc Gene	G2FUF-47855	BioCyc
Ensembl Genes	ENSRNOG00000021223	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000055801.5	UniProtKB/TrEMBL
	ENSRNOT00000080379.2	UniProtKB/TrEMBL
Gene3D-CATH	3.90.190.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7107006	IMAGE-MGC_LOAD
InterPro	Prot-tyrosine_phosphatase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein-Tyr_Phosphatase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTPase_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_Pase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_Pase_cat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_Pase_rcpt_a/e-type	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_Pase_rcpt_alpha	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25167	UniProtKB/TrEMBL
MGC_CLONE	MGC:93561	IMAGE-MGC_LOAD
NCBI Gene	25167	ENTREZGENE
PANTHER	PTHR19134:SF433	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Y_phosphatase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ptpra	PhenoGen
PIRSF	PTPR_alpha	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTPR_alpha_epsilon	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	PRTYPHPHTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	TYR_PHOSPHATASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_PTP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000021223	RatGTEx
SMART	PTPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTPc_motif	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52799	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC229590
UniProt	A0A0G2JVR0_RAT	UniProtKB/TrEMBL
	A0A8J8YBN3	ENTREZGENE, UniProtKB/TrEMBL
	F1M833	ENTREZGENE
	PTPRA_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q66HJ7	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1M833	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Ptpra	Protein tyrosine phosphatase, receptor type, A			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	has two intracellular PTPase domains	633823
gene_regulation	expression is inhibited by treatment with Il6 or Il1	633823

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)