Cd63 (Cd63 molecule) - Rat Genome Database

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Gene: Cd63 (Cd63 molecule) Rattus norvegicus
Analyze
Symbol: Cd63
Name: Cd63 molecule
RGD ID: 62080
Description: Involved in several processes, including negative regulation of epithelial cell migration; positive regulation of cell adhesion; and positive regulation of endocytosis. Located in extracellular exosome; lysosome; and plasma membrane. Part of protein-containing complex. Orthologous to human CD63 (CD63 molecule); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD63 antigen; mast cell antigen AD1; MGC72893
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.271,325,108 - 1,340,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,325,103 - 1,399,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx74,101,932 - 4,104,722 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.075,977,592 - 5,980,382 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.076,278,877 - 6,281,670 (+)NCBIRnor_WKY
Rnor_6.073,320,250 - 3,335,583 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,320,103 - 3,335,582 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,303,449 - 3,305,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,208,659 - 2,211,323 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.172,208,658 - 2,211,327 (+)NCBI
Celera71,208,422 - 1,211,249 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
ceric oxide  (ISO)
chloropicrin  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenbuconazole  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hexachlorobenzene  (EXP)
hydralazine  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
metformin  (EXP)
methylmercury(1+)  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenformin  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
pyrene  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
Yessotoxin  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Dynamics of intracellular granules with CD63-GFP in rat basophilic leukemia cells. Amano T, etal., J Biochem (Tokyo) 2001 May;129(5):739-44.
2. The tetraspanin CD63 enhances the internalization of the H,K-ATPase beta-subunit. Duffield A, etal., Proc Natl Acad Sci U S A 2003 Dec 23;100(26):15560-5. Epub 2003 Dec 5.
3. Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type 2. Fateh-Moghadam S, etal., Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1299-303. Epub 2005 Apr 7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Y receptor-mediated induction of CD63 transcripts, a tetraspanin determined to be necessary for differentiation of the intestinal epithelial cell line, hBRIE 380i cells. Hallden G, etal., J Biol Chem. 1999 Sep 24;274(39):27914-24.
7. Peptide YY and neuropeptide Y induce villin expression, reduce adhesion, and enhance migration in small intestinal cells through the regulation of CD63, matrix metalloproteinase-3, and Cdc42 activity. Lee M, etal., J Biol Chem. 2005 Jan 7;280(1):125-36. Epub 2004 Oct 25.
8. Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels. Lin D, etal., J Biol Chem. 2008 Mar 21;283(12):7674-81. Epub 2008 Jan 22.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. The rat mast cell antigen AD1 (homologue to human CD63 or melanoma antigen ME491) is expressed in other cells in culture. Nishikata H, etal., J Immunol 1992 Aug 1;149(3):862-70.
12. Platelet activation in diabetic cardiovascular autonomic neuropathy. Rauch U, etal., Diabet Med. 1999 Oct;16(10):848-52.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Levels and value of platelet activation markers in different subtypes of acute non-cardio-embolic ischemic stroke. Tsai NW, etal., Thromb Res. 2009 Jun;124(2):213-8. Epub 2009 Feb 23.
17. The effects of LAMP1 and LAMP3 on M180 amelogenin uptake, localization and amelogenin mRNA induction by amelogenin protein. Xu L, etal., J Biochem. 2008 Oct;144(4):531-7. Epub 2008 Jul 31.
18. Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection. Yu B, etal., Int J Cardiol. 2015 Mar 1;182:349-60. doi: 10.1016/j.ijcard.2014.12.043. Epub 2014 Dec 23.
Additional References at PubMed
PMID:1302249   PMID:1703158   PMID:12477932   PMID:12519789   PMID:14668490   PMID:15229288   PMID:15489334   PMID:15647390   PMID:15908444   PMID:16917503   PMID:17897319   PMID:19056867  
PMID:21149578   PMID:21505438   PMID:21962903   PMID:22431521   PMID:22660413   PMID:23092844   PMID:23376485   PMID:23533145   PMID:23632027   PMID:24038174   PMID:25645918   PMID:26280656  
PMID:27435297   PMID:30021215   PMID:30121936   PMID:30871575  


Genomics

Comparative Map Data
Cd63
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.271,325,108 - 1,340,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,325,103 - 1,399,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx74,101,932 - 4,104,722 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.075,977,592 - 5,980,382 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.076,278,877 - 6,281,670 (+)NCBIRnor_WKY
Rnor_6.073,320,250 - 3,335,583 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,320,103 - 3,335,582 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,303,449 - 3,305,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,208,659 - 2,211,323 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.172,208,658 - 2,211,327 (+)NCBI
Celera71,208,422 - 1,211,249 (+)NCBICelera
Cytogenetic Map7q11NCBI
CD63
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,725,323 - 55,729,673 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1255,725,323 - 55,729,707 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,119,107 - 56,123,457 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,405,497 - 54,409,177 (-)NCBINCBI36Build 36hg18NCBI36
Build 341254,405,519 - 54,409,076NCBI
Celera1255,771,700 - 55,775,380 (-)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,158,042 - 53,162,273 (-)NCBIHuRef
CHM1_11256,086,015 - 56,090,245 (-)NCBICHM1_1
T2T-CHM13v2.01255,691,957 - 55,696,307 (-)NCBIT2T-CHM13v2.0
Cd63
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,731,577 - 128,748,691 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,736,858 - 128,748,691 (+)EnsemblGRCm39 Ensembl
GRCm3810128,896,231 - 128,912,822 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,900,989 - 128,912,822 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710128,345,975 - 128,349,878 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610128,312,873 - 128,315,771 (+)NCBIMGSCv36mm8
Celera10131,301,602 - 131,305,504 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.19NCBI
Cd63
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,362,511 - 3,363,981 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,362,511 - 3,363,916 (-)NCBIChiLan1.0ChiLan1.0
CD63
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11233,906,343 - 33,910,595 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,906,314 - 33,910,595 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01233,181,896 - 33,186,123 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CD63
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110126,370 - 139,301 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10126,449 - 129,742 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10188,764 - 191,664 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010133,644 - 136,544 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10133,723 - 136,510 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110111,323 - 114,223 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010354,435 - 357,335 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010478,330 - 481,230 (-)NCBIUU_Cfam_GSD_1.0
Cd63
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,671,044 - 58,674,233 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936646196,002 - 199,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD63
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,172,283 - 21,176,232 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,172,275 - 21,176,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2522,652,127 - 22,656,077 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD63
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,673,402 - 51,677,075 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1151,672,740 - 51,676,301 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037194,317,476 - 194,321,231 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd63
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480212,290,688 - 12,342,733 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480212,290,733 - 12,294,293 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd63
92 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:101
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000010180
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat

Markers in Region
RH130054  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,339,842 - 1,340,363 (+)MAPPERmRatBN7.2
Rnor_6.073,334,979 - 3,335,499NCBIRnor6.0
Rnor_5.073,305,198 - 3,305,718UniSTSRnor5.0
RGSC_v3.472,210,723 - 2,211,243UniSTSRGSC3.4
Celera71,210,649 - 1,211,169UniSTS
Cytogenetic Map7q11UniSTS
RH131837  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,340,720 - 1,340,940 (+)MAPPERmRatBN7.2
Rnor_6.073,335,857 - 3,336,076NCBIRnor6.0
Rnor_5.073,306,076 - 3,306,295UniSTSRnor5.0
RGSC_v3.472,211,601 - 2,211,820UniSTSRGSC3.4
Celera71,211,527 - 1,211,746UniSTS
Cytogenetic Map7q11UniSTS
RH137352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,340,062 - 1,340,411 (+)MAPPERmRatBN7.2
Rnor_6.073,335,199 - 3,335,547NCBIRnor6.0
Rnor_5.073,305,418 - 3,305,766UniSTSRnor5.0
RGSC_v3.472,210,943 - 2,211,291UniSTSRGSC3.4
Celera71,210,869 - 1,211,217UniSTS
Cytogenetic Map7q11UniSTS
RH139213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,339,091 - 1,339,399 (+)MAPPERmRatBN7.2
Rnor_6.073,334,228 - 3,334,535NCBIRnor6.0
Rnor_5.073,304,447 - 3,304,754UniSTSRnor5.0
RGSC_v3.472,209,972 - 2,210,279UniSTSRGSC3.4
Celera71,209,898 - 1,210,205UniSTS
Cytogenetic Map7q11UniSTS
RH125938  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,339,822 - 1,340,414 (+)MAPPERmRatBN7.2
Rnor_6.073,334,959 - 3,335,550NCBIRnor6.0
Rnor_5.073,305,178 - 3,305,769UniSTSRnor5.0
RGSC_v3.472,210,703 - 2,211,294UniSTSRGSC3.4
Celera71,210,629 - 1,211,220UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010180   ⟹   ENSRNOP00000010180
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl71,337,646 - 1,399,178 (+)Ensembl
Rnor_6.0 Ensembl73,332,788 - 3,335,579 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090381   ⟹   ENSRNOP00000071571
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl71,337,616 - 1,340,436 (+)Ensembl
Rnor_6.0 Ensembl73,320,103 - 3,335,582 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093823   ⟹   ENSRNOP00000088206
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl71,325,103 - 1,340,444 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095354   ⟹   ENSRNOP00000082343
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl71,337,715 - 1,340,451 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114033   ⟹   ENSRNOP00000095573
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl71,337,637 - 1,340,445 (+)Ensembl
RefSeq Acc Id: NM_017125   ⟹   NP_058821
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.271,337,652 - 1,340,443 (+)NCBI
Rnor_6.073,332,788 - 3,335,579 (+)NCBI
Rnor_5.073,303,449 - 3,305,798 (+)NCBI
RGSC_v3.472,208,659 - 2,211,323 (+)RGD
Celera71,208,422 - 1,211,249 (+)RGD
Sequence:
RefSeq Acc Id: XM_008765024   ⟹   XP_008763246
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.271,325,108 - 1,340,447 (+)NCBI
Rnor_6.073,320,250 - 3,335,583 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765025   ⟹   XP_008763247
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.271,337,598 - 1,340,447 (+)NCBI
Rnor_6.073,332,771 - 3,335,583 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058821   ⟸   NM_017125
- UniProtKB: P28648 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008763246   ⟸   XM_008765024
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K0T2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763247   ⟸   XM_008765025
- Peptide Label: isoform X2
- UniProtKB: P28648 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071571   ⟸   ENSRNOT00000090381
RefSeq Acc Id: ENSRNOP00000010180   ⟸   ENSRNOT00000010180
RefSeq Acc Id: ENSRNOP00000095573   ⟸   ENSRNOT00000114033
RefSeq Acc Id: ENSRNOP00000088206   ⟸   ENSRNOT00000093823
RefSeq Acc Id: ENSRNOP00000082343   ⟸   ENSRNOT00000095354

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28648-F1-model_v2 AlphaFold P28648 1-238 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694957
Promoter ID:EPDNEW_R5481
Type:initiation region
Name:Cd63_1
Description:Cd63 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.073,332,784 - 3,332,844EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62080 AgrOrtholog
BioCyc Gene G2FUF-35326 BioCyc
Ensembl Genes ENSRNOG00000007650 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010180 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071571.2 UniProtKB/TrEMBL
  ENSRNOP00000082343 ENTREZGENE
  ENSRNOP00000082343.1 UniProtKB/TrEMBL
  ENSRNOP00000088206 ENTREZGENE
  ENSRNOP00000088206.1 UniProtKB/TrEMBL
  ENSRNOP00000095573.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010180 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000090381.2 UniProtKB/TrEMBL
  ENSRNOT00000093823 ENTREZGENE
  ENSRNOT00000093823.1 UniProtKB/TrEMBL
  ENSRNOT00000095354 ENTREZGENE
  ENSRNOT00000095354.1 UniProtKB/TrEMBL
  ENSRNOT00000114033.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1450.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6921594 IMAGE-MGC_LOAD
InterPro CD63_LEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tetraspanin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tetraspanin/Peripherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tetraspanin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tetraspanin_EC2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29186 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72893 IMAGE-MGC_LOAD
NCBI Gene 29186 ENTREZGENE
PANTHER PTHR19282 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tetraspanin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd63 PhenoGen
PIRSF Tetraspanin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TM4_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48652 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUS8_RAT UniProtKB/TrEMBL
  A0A8I6GFY5_RAT UniProtKB/TrEMBL
  A0A8I6GLP5_RAT UniProtKB/TrEMBL
  CD63_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-29 Cd63  Cd63 molecule  Cd63  CD63 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cd63  CD63 antigen      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains four predicted membrane-spanning helices and three potential N-glycosylation sites 61549