Olr1 (oxidized low density lipoprotein receptor 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Olr1 (oxidized low density lipoprotein receptor 1) Rattus norvegicus
Analyze
Symbol: Olr1
Name: oxidized low density lipoprotein receptor 1
RGD ID: 620515
Description: Predicted to enable identical protein binding activity and low-density lipoprotein particle receptor activity. Involved in several processes, including lipoprotein metabolic process; negative regulation of miRNA transcription; and response to hydrogen peroxide. Predicted to be located in nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of end stage renal disease and hypertension. Human ortholog(s) of this gene implicated in cerebral amyloid angiopathy; coronary artery disease; and myocardial infarction. Orthologous to human OLR1 (oxidized low density lipoprotein receptor 1); PARTICIPATES IN angiotensin II signaling pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lectin-like oxidized LDL receptor 1; lectin-like oxidized low-density lipoprotein receptor; Lectin-like oxidized low-density lipoprotein receptor-1; lectin-like oxLDL receptor 1; lectin-type oxidized LDL receptor 1; LOX-1; Oldlr1; Oldr1; ox-LDL receptor 1; oxidised low density lipoprotein (lectin-like) receptor 1; oxidized low density lipoprotein (lectin-like) receptor 1; oxidized low-density lipoprotein receptor 1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,612,460 - 164,635,082 (-)NCBIGRCr8
mRatBN7.24162,926,436 - 162,949,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4162,926,439 - 162,948,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4169,161,255 - 169,183,343 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04164,944,216 - 164,966,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,578,251 - 163,600,337 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,239,853 - 163,261,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,239,849 - 163,261,958 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04211,883,405 - 211,905,489 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44166,747,228 - 166,769,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14166,992,163 - 167,014,276 (-)NCBI
Celera4151,610,779 - 151,632,854 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
aldosterone  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
amitrole  (EXP)
amlodipine  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
apocynin  (ISO)
aristolochic acids  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
cholesterol  (EXP)
chromium atom  (EXP,ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dehydroepiandrosterone  (EXP)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
dioxygen  (EXP)
donepezil hydrochloride  (ISO)
doxorubicin  (EXP,ISO)
ergosterol  (EXP)
fluoranthene  (ISO)
furan  (EXP)
glucose  (ISO)
hydrogen peroxide  (EXP)
indometacin  (EXP)
isorhamnetin  (ISO)
L-ascorbic acid  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (EXP)
methimazole  (EXP)
methyllycaconitine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
nickel subsulfide  (EXP)
nicotinic acid  (EXP)
nifedipine  (ISO)
nitrofen  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
pentanal  (ISO)
phenethyl caffeate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
pravastatin  (ISO)
progesterone  (EXP)
propanal  (ISO)
quercetin  (EXP,ISO)
razoxane  (EXP)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
spironolactone  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
Tanshinone I  (ISO)
telmisartan  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
varenicline  (ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease. Chen Q, etal., Circulation. 2003 Jul 1;107(25):3146-51. Epub 2003 Jun 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Honjo M, etal., Proc Natl Acad Sci U S A 2003 Feb 4;100(3):1274-9.
5. LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation. Li D, etal., Am J Physiol Heart Circ Physiol 2002 Nov;283(5):H1795-801.
6. Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions. Li DY, etal., J Cardiovasc Pharmacol Ther. 2002 Jul;7(3):147-53.
7. The expression of native and oxidized LDL receptors in brain microvessels is specifically enhanced by astrocytes-derived soluble factor(s). Lucarelli M, etal., FEBS Lett 2002 Jul 3;522(1-3):19-23.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Unique repetitive sequence and unexpected regulation of expression of rat endothelial receptor for oxidized low-density lipoprotein (LOX-1). Nagase M, etal., Biochem J 1998 Mar 15;330 ( Pt 3):1417-22.
10. Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene. Nagase M, etal., J Biol Chem 1998 Dec 11;273(50):33702-7.
11. LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt. Nakagawa T, etal., Biochem Biophys Res Commun 2002 Nov 22;299(1):91-7.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. An oxidized low-density lipoprotein receptor gene variant is inversely associated with the severity of coronary artery disease. Ohmori R, etal., Clin Cardiol. 2004 Nov;27(11):641-4.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta40 load as cerebral amyloid angiopathy in Alzheimer's disease. Shi J, etal., Acta Neuropathol (Berl). 2006 Jan;111(1):15-20. Epub 2005 Nov 22.
21. Doxorubicin-induced expression of LOX-1 in H9c2 cardiac muscle cells and its role in apoptosis. Spallarossa P, etal., Biochem Biophys Res Commun. 2005 Sep 16;335(1):188-96.
22. Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction. Tatsuguchi M, etal., Biochem Biophys Res Commun. 2003 Mar 28;303(1):247-50.
23. LOX-1, an oxidized low-density lipoprotein receptor, was upregulated in the kidneys of chronic renal failure rats. Ueno T, etal., Hypertens Res. 2003 Jan;26(1):117-22.
24. Negative feedback regulation between microRNA let-7g and LOX-1 mediated hypoxia-induced PASMCs proliferation. Zhang WF, etal., Biochem Biophys Res Commun. 2017 Jul 8;488(4):655-663. doi: 10.1016/j.bbrc.2017.01.073. Epub 2017 Jan 18.
Additional References at PubMed
PMID:9588202   PMID:12477932   PMID:15489334   PMID:15939022   PMID:16214149   PMID:18322020   PMID:18661553   PMID:18796303   PMID:19664054   PMID:19705455   PMID:19997643   PMID:20216085  
PMID:21143965   PMID:21821723   PMID:21990956   PMID:22392901   PMID:22408405   PMID:22847064   PMID:22885180   PMID:23230281   PMID:23376485   PMID:23382219   PMID:24141169   PMID:24486707  
PMID:24731447   PMID:26305474   PMID:26432573   PMID:26884836   PMID:27216460   PMID:27633115   PMID:28259654   PMID:28672042   PMID:29069578   PMID:29619884   PMID:30664710   PMID:31848380  
PMID:32397936   PMID:33964218   PMID:35333694   PMID:37268943   PMID:38244081   PMID:38501247  


Genomics

Comparative Map Data
Olr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,612,460 - 164,635,082 (-)NCBIGRCr8
mRatBN7.24162,926,436 - 162,949,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4162,926,439 - 162,948,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4169,161,255 - 169,183,343 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04164,944,216 - 164,966,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,578,251 - 163,600,337 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,239,853 - 163,261,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,239,849 - 163,261,958 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04211,883,405 - 211,905,489 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44166,747,228 - 166,769,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14166,992,163 - 167,014,276 (-)NCBI
Celera4151,610,779 - 151,632,854 (-)NCBICelera
Cytogenetic Map4q42NCBI
OLR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,158,301 - 10,176,266 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,158,301 - 10,172,138 (-)EnsemblGRCh38hg38GRCh38
GRCh371210,310,900 - 10,324,731 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,202,166 - 10,216,057 (-)NCBINCBI36Build 36hg18NCBI36
Build 341210,202,168 - 10,216,004NCBI
Celera1215,471,560 - 15,485,454 (-)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1210,054,056 - 10,067,944 (-)NCBIHuRef
CHM1_11210,280,199 - 10,294,080 (-)NCBICHM1_1
T2T-CHM13v2.01210,045,018 - 10,062,993 (-)NCBIT2T-CHM13v2.0
Olr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396129,456,113 - 129,484,312 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6129,462,207 - 129,484,128 (-)EnsemblGRCm39 Ensembl
GRCm386129,479,150 - 129,507,350 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6129,485,244 - 129,507,165 (-)EnsemblGRCm38mm10GRCm38
MGSCv376129,435,265 - 129,457,183 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366129,450,945 - 129,472,847 (-)NCBIMGSCv36mm8
Celera6131,207,291 - 131,231,036 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.35NCBI
OLR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21015,639,357 - 15,653,035 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,636,115 - 15,649,789 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01210,196,712 - 10,210,432 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11210,447,353 - 10,461,071 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1210,445,202 - 10,461,071 (-)Ensemblpanpan1.1panPan2
OLR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12735,828,852 - 35,838,748 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2735,828,029 - 35,838,754 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2710,782,915 - 10,794,739 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02736,174,950 - 36,186,764 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2736,174,912 - 36,184,980 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12736,063,115 - 36,073,432 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02736,085,141 - 36,097,142 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02710,304,638 - 10,316,443 (-)NCBIUU_Cfam_GSD_1.0
Olr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494597,273,899 - 97,284,746 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936902409,704 - 416,401 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936902405,536 - 416,393 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OLR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl561,799,286 - 61,810,624 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1561,799,356 - 61,809,691 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2564,580,096 - 64,590,442 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OLR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,033,708 - 10,048,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,033,635 - 10,048,256 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660892,109,569 - 2,124,272 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Olr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475226,920,453 - 26,933,089 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475226,920,354 - 26,948,108 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Olr1
206 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1068
Count of miRNA genes:322
Interacting mature miRNAs:429
Transcripts:ENSRNOT00000011196
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
D4Wox48  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84164,635,181 - 164,635,417 (+)Marker Load Pipeline
mRatBN7.24162,949,157 - 162,949,393 (+)MAPPERmRatBN7.2
Rnor_6.04163,262,572 - 163,262,809NCBIRnor6.0
Rnor_5.04211,906,124 - 211,906,361UniSTSRnor5.0
RGSC_v3.44166,769,975 - 166,770,212UniSTSRGSC3.4
Celera4151,633,489 - 151,633,721UniSTS
Cytogenetic Map4q42UniSTS
RH131546  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24162,927,269 - 162,927,472 (+)MAPPERmRatBN7.2
Rnor_6.04163,240,684 - 163,240,886NCBIRnor6.0
Rnor_5.04211,884,236 - 211,884,438UniSTSRnor5.0
RGSC_v3.44166,748,059 - 166,748,261UniSTSRGSC3.4
Celera4151,611,610 - 151,611,812UniSTS
RH 3.4 Map41014.8UniSTS
Cytogenetic Map4q42UniSTS
BI289895  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24162,928,904 - 162,929,090 (+)MAPPERmRatBN7.2
Rnor_6.04163,242,319 - 163,242,504NCBIRnor6.0
Rnor_5.04211,885,871 - 211,886,056UniSTSRnor5.0
RGSC_v3.44166,749,694 - 166,749,879UniSTSRGSC3.4
Celera4151,613,245 - 151,613,430UniSTS
RH 3.4 Map41014.4UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 10 49 113 91 90 59 25 59 6 215 97 93 44 58 31

Sequence


Ensembl Acc Id: ENSRNOT00000086390   ⟹   ENSRNOP00000071872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4162,926,439 - 162,948,523 (-)Ensembl
Rnor_6.0 Ensembl4163,239,849 - 163,261,958 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109797   ⟹   ENSRNOP00000089079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4162,926,439 - 162,948,432 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113864   ⟹   ENSRNOP00000082938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4162,926,439 - 162,948,523 (-)Ensembl
RefSeq Acc Id: NM_133306   ⟹   NP_579840
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,612,463 - 164,634,547 (-)NCBI
mRatBN7.24162,926,439 - 162,948,523 (-)NCBI
Rnor_6.04163,239,853 - 163,261,937 (-)NCBI
Rnor_5.04211,883,405 - 211,905,489 (-)NCBI
RGSC_v3.44166,747,228 - 166,769,340 (-)RGD
Celera4151,610,779 - 151,632,854 (-)RGD
Sequence:
RefSeq Acc Id: XM_039106956   ⟹   XP_038962884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,612,460 - 164,634,520 (-)NCBI
mRatBN7.24162,926,436 - 162,948,496 (-)NCBI
RefSeq Acc Id: XM_039106957   ⟹   XP_038962885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,612,460 - 164,635,082 (-)NCBI
mRatBN7.24162,926,436 - 162,949,057 (-)NCBI
RefSeq Acc Id: NP_579840   ⟸   NM_133306
- UniProtKB: O70156 (UniProtKB/Swiss-Prot),   A0A0G2K1K0 (UniProtKB/TrEMBL),   A6IM52 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071872   ⟸   ENSRNOT00000086390
RefSeq Acc Id: XP_038962885   ⟸   XM_039106957
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038962884   ⟸   XM_039106956
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000082938   ⟸   ENSRNOT00000113864
Ensembl Acc Id: ENSRNOP00000089079   ⟸   ENSRNOT00000109797
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70156-F1-model_v2 AlphaFold O70156 1-364 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693436
Promoter ID:EPDNEW_R3961
Type:single initiation site
Name:Olr1_1
Description:oxidized low density lipoprotein receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04163,261,908 - 163,261,968EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620515 AgrOrtholog
BioCyc Gene G2FUF-42779 BioCyc
Ensembl Genes ENSRNOG00000056219 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086390 ENTREZGENE
  ENSRNOT00000086390.2 UniProtKB/TrEMBL
  ENSRNOT00000109797.1 UniProtKB/TrEMBL
  ENSRNOT00000113864.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7458637 IMAGE-MGC_LOAD
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxLDL_rcpt1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140914 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114271 IMAGE-MGC_LOAD
NCBI Gene 140914 ENTREZGENE
PANTHER OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR 1 UniProtKB/Swiss-Prot
  OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR 1 UniProtKB/Swiss-Prot
  OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR 1 UniProtKB/TrEMBL
  OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR 1 UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Olr1 PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056219 RatGTEx
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K1K0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZW63_RAT UniProtKB/TrEMBL
  A0A8I6A6G2_RAT UniProtKB/TrEMBL
  A6IM52 ENTREZGENE, UniProtKB/TrEMBL
  O70156 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-13 Olr1  oxidized low density lipoprotein receptor 1  Olr1  oxidized low density lipoprotein (lectin-like) receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Olr1  oxidized low density lipoprotein (lectin-like) receptor 1  Oldlr1  oxidized low density lipoprotein (lectin-like) receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Oldlr1  oxidized low density lipoprotein (lectin-like) receptor 1  Oldr1    Symbol updated 1299863 APPROVED
2004-11-18 Oldr1  oxidized low density lipoprotein (lectin-like) receptor 1  Olr1  oxidised low density lipoprotein (lectin-like) receptor 1  Symbol updated 1299863 APPROVED
2002-08-07 Olr1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease plays a role in endotoxin induced inflammation 629556
gene_expression mRNA expressed in retina 629556
gene_function receptor for leukocyte-endothelial interaction during LPS-induced inflammation 629556
gene_process lectin like receptor active in oxidixed low-density lipoprotein (ox-LDL) uptake 628368
gene_process plays a role in endotoxin-induced inflammation 629556
gene_process mediates ox-LDL mediated cell injury and inflammatory cell adhesion 629556
gene_process activates p38 Mapk which increases the expression of Mmp1 and adhesion molecules 629556
gene_regulation mRNA and protein expression is induced by LPS treatment 629556
gene_regulation upregulated by myocraida ischemia-reperfusion (I/R) injury 629556
gene_transcript encoded by a single copy gene spanning over 19 kilobases and consisted of eight exons 633386