Kcnk1 (potassium two pore domain channel subfamily K member 1) - Rat Genome Database

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Gene: Kcnk1 (potassium two pore domain channel subfamily K member 1) Rattus norvegicus
Analyze
Symbol: Kcnk1
Name: potassium two pore domain channel subfamily K member 1
RGD ID: 621447
Description: Enables potassium ion leak channel activity and sodium channel activity. Involved in cellular response to acidic pH; potassium ion transmembrane transport; and response to nicotine. Located in apical plasma membrane and brush border membrane. Orthologous to human KCNK1 (potassium two pore domain channel subfamily K member 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inward rectifying potassium channel protein TWIK-1; potassium channel K2P1; potassium channel subfamily K member 1; potassium channel, subfamily K, member 1; potassium channel, two pore domain subfamily K, member 1; putative potassium channel TWIK; rTWIK; Twik
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,856,985 - 70,895,053 (+)NCBIGRCr8
mRatBN7.21953,959,411 - 53,997,726 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,959,657 - 53,997,724 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1960,747,184 - 60,785,160 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01961,608,107 - 61,645,809 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01963,683,893 - 63,729,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01958,823,836 - 58,862,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,823,814 - 58,862,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01969,519,015 - 69,556,610 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41956,216,600 - 56,255,299 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11956,221,480 - 56,260,178 (+)NCBI
Celera1953,319,777 - 53,357,303 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
atrazine  (EXP)
barium(0)  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
diethyl phthalate  (EXP)
doramapimod  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
hexane  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (ISO)
nicotine  (EXP)
nitrofen  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
potassium atom  (ISO)
propiconazole  (ISO)
quinidine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
venlafaxine hydrochloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Expression of TWIK-1, a novel weakly inward rectifying potassium channel in rat kidney. Cluzeaud F, etal., Am J Physiol. 1998 Dec;275(6 Pt 1):C1602-9.
2. Deafness associated changes in two-pore domain potassium channels in the rat inferior colliculus. Cui YL, etal., Neuroscience. 2007 Oct 26;149(2):421-33. Epub 2007 Jul 17.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Region-specific transcriptional response to chronic nicotine in rat brain. Konu O, etal., Brain Res. 2001 Aug 3;909(1-2):194-203.
6. Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification. Ma L, etal., J Biol Chem. 2012 Oct 26;287(44):37145-53. doi: 10.1074/jbc.M112.398164. Epub 2012 Sep 4.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear. Nicolas MT, etal., Hear Res. 2003 Jul;181(1-2):20-6.
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Information Derived from GenBank Report RGD, Sept. 2003
15. Chronic periodontitis genome-wide association studies: gene-centric and gene set enrichment analyses. Rhodin K, etal., J Dent Res. 2014 Sep;93(9):882-90. doi: 10.1177/0022034514544506. Epub 2014 Jul 23.
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Cardiorespiratory neurons of the rat ventrolateral medulla contain TASK-1 and TASK-3 channel mRNA. Washburn CP, etal., Respir Physiol Neurobiol 2003 Oct 16;138(1):19-35.
18. TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices. Zhou M, etal., J Neurosci. 2009 Jul 1;29(26):8551-64. doi: 10.1523/JNEUROSCI.5784-08.2009.
Additional References at PubMed
PMID:9013852   PMID:15489043   PMID:15540117   PMID:18838117   PMID:20498050   PMID:21653227   PMID:22282804   PMID:35304127  


Genomics

Comparative Map Data
Kcnk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81970,856,985 - 70,895,053 (+)NCBIGRCr8
mRatBN7.21953,959,411 - 53,997,726 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1953,959,657 - 53,997,724 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1960,747,184 - 60,785,160 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01961,608,107 - 61,645,809 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01963,683,893 - 63,729,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01958,823,836 - 58,862,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,823,814 - 58,862,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01969,519,015 - 69,556,610 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41956,216,600 - 56,255,299 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11956,221,480 - 56,260,178 (+)NCBI
Celera1953,319,777 - 53,357,303 (+)NCBICelera
Cytogenetic Map19q12NCBI
KCNK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381233,614,106 - 233,672,514 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1233,614,106 - 233,672,514 (+)EnsemblGRCh38hg38GRCh38
GRCh371233,749,852 - 233,808,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361231,816,373 - 231,874,607 (+)NCBINCBI36Build 36hg18NCBI36
Build 341230,056,484 - 230,114,719NCBI
Celera1207,020,005 - 207,078,507 (+)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1204,239,702 - 204,297,905 (+)NCBIHuRef
CHM1_11235,023,248 - 235,081,757 (+)NCBICHM1_1
T2T-CHM13v2.01233,000,572 - 233,058,976 (+)NCBIT2T-CHM13v2.0
Kcnk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398126,718,692 - 126,757,424 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8126,721,909 - 126,757,424 (+)EnsemblGRCm39 Ensembl
GRCm388125,993,655 - 126,030,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8125,995,170 - 126,030,685 (+)EnsemblGRCm38mm10GRCm38
MGSCv378128,519,002 - 128,554,585 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368128,881,260 - 128,916,775 (+)NCBIMGSCv36mm8
Celera8130,307,714 - 130,343,209 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map873.67NCBI
Kcnk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554925,805,170 - 5,846,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554925,805,170 - 5,846,402 (-)NCBIChiLan1.0ChiLan1.0
KCNK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,535,821 - 15,594,268 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1115,739,512 - 15,797,993 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01209,149,558 - 209,210,873 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11214,178,637 - 214,237,175 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1214,178,631 - 214,238,379 (+)Ensemblpanpan1.1panPan2
KCNK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.146,117,406 - 6,139,390 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl46,118,373 - 6,122,093 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha46,103,320 - 6,146,391 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.046,135,667 - 6,178,755 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.146,146,186 - 6,189,176 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.046,265,595 - 6,308,878 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.046,488,606 - 6,531,685 (-)NCBIUU_Cfam_GSD_1.0
Kcnk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934442,020,958 - 42,055,745 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648418,186,144 - 18,220,938 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648418,186,184 - 18,221,304 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1457,265,780 - 57,318,989 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11457,268,064 - 57,319,338 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21461,442,843 - 61,548,774 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12570,820,089 - 70,873,654 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2570,819,706 - 70,873,961 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605572,773,743 - 72,827,587 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477516,493,949 - 16,538,025 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477516,494,054 - 16,538,089 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnk1
245 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:28
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000027058
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

Markers in Region
RH129028  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21953,997,515 - 53,997,668 (+)MAPPERmRatBN7.2
Rnor_6.01958,862,716 - 58,862,868NCBIRnor6.0
Rnor_5.01969,556,400 - 69,556,552UniSTSRnor5.0
RGSC_v3.41956,255,089 - 56,255,241UniSTSRGSC3.4
Celera1953,357,093 - 53,357,245UniSTS
RH 3.4 Map19747.5UniSTS
Cytogenetic Map19q12UniSTS
BE097296  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21953,997,389 - 53,997,582 (+)MAPPERmRatBN7.2
Rnor_6.01958,862,590 - 58,862,782NCBIRnor6.0
Rnor_5.01969,556,274 - 69,556,466UniSTSRnor5.0
RGSC_v3.41956,254,963 - 56,255,155UniSTSRGSC3.4
Celera1953,356,967 - 53,357,159UniSTS
RH 3.4 Map19739.9UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 112 84 84 53 25 53 6 211 96 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000027058   ⟹   ENSRNOP00000027058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1953,959,657 - 53,997,724 (+)Ensembl
Rnor_6.0 Ensembl1958,823,814 - 58,862,245 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088626   ⟹   ENSRNOP00000070146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1958,823,836 - 58,862,926 (+)Ensembl
RefSeq Acc Id: NM_021688   ⟹   NP_067720
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,856,985 - 70,895,053 (+)NCBI
mRatBN7.21953,959,657 - 53,997,726 (+)NCBI
Rnor_6.01958,823,836 - 58,862,926 (+)NCBI
Rnor_5.01969,519,015 - 69,556,610 (+)NCBI
RGSC_v3.41956,216,600 - 56,255,299 (+)RGD
Celera1953,319,777 - 53,357,303 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255820   ⟹   XP_006255882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,869,970 - 70,895,053 (+)NCBI
mRatBN7.21953,972,632 - 53,997,726 (+)NCBI
Rnor_6.01958,838,103 - 58,861,874 (+)NCBI
Rnor_5.01969,519,015 - 69,556,610 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097960   ⟹   XP_038953888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,863,294 - 70,895,053 (+)NCBI
mRatBN7.21953,971,794 - 53,997,726 (+)NCBI
RefSeq Acc Id: XM_063278268   ⟹   XP_063134338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81970,857,913 - 70,895,053 (+)NCBI
RefSeq Acc Id: NP_067720   ⟸   NM_021688
- UniProtKB: Q9Z2T2 (UniProtKB/Swiss-Prot),   A6KJ44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255882   ⟸   XM_006255820
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000027058   ⟸   ENSRNOT00000027058
Ensembl Acc Id: ENSRNOP00000070146   ⟸   ENSRNOT00000088626
RefSeq Acc Id: XP_038953888   ⟸   XM_039097960
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063134338   ⟸   XM_063278268
- Peptide Label: isoform X3
Protein Domains
Potassium channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2T2-F1-model_v2 AlphaFold Q9Z2T2 1-336 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701251
Promoter ID:EPDNEW_R11774
Type:initiation region
Name:Kcnk1_1
Description:potassium two pore domain channel subfamily K member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01958,823,866 - 58,823,926EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621447 AgrOrtholog
BioCyc Gene G2FUF-5181 BioCyc
Ensembl Genes ENSRNOG00000019937 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027058 ENTREZGENE
  ENSRNOT00000027058.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598415 IMAGE-MGC_LOAD
InterPro 2pore_dom_K_chnl UniProtKB/Swiss-Prot
  2pore_dom_K_chnl_TASK UniProtKB/Swiss-Prot
  2pore_dom_K_chnl_TWIK UniProtKB/Swiss-Prot
  2pore_dom_K_chnl_TWIK1 UniProtKB/Swiss-Prot
  K_chnl_dom UniProtKB/Swiss-Prot
KEGG Report rno:59324 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72470 IMAGE-MGC_LOAD
NCBI Gene 59324 ENTREZGENE
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 1 UniProtKB/Swiss-Prot
  PTHR11003 UniProtKB/Swiss-Prot
Pfam Ion_trans_2 UniProtKB/Swiss-Prot
PharmGKB KCNK1 RGD
PhenoGen Kcnk1 PhenoGen
PIRSF K_channel_subfamily_K_type UniProtKB/Swiss-Prot
PRINTS 2POREKCHANEL UniProtKB/Swiss-Prot
  TWIK1CHANNEL UniProtKB/Swiss-Prot
  TWIKCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019937 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A6KJ44 ENTREZGENE, UniProtKB/TrEMBL
  KCNK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnk1  potassium two pore domain channel subfamily K member 1  Kcnk1  potassium channel, two pore domain subfamily K, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnk1  potassium channel, two pore domain subfamily K, member 1  Kcnk1  potassium channel, subfamily K, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnk1  potassium channel, subfamily K, member 1    putative potassium channel TWIK  Name updated 1299863 APPROVED
2002-08-07 Kcnk1  putative potassium channel TWIK      Symbol and Name status set to provisional 70820 PROVISIONAL