Cybb (cytochrome b-245 beta chain) - Rat Genome Database

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Gene: Cybb (cytochrome b-245 beta chain) Rattus norvegicus
Symbol: Cybb
Name: cytochrome b-245 beta chain
RGD ID: 620574
Description: Predicted to enable several functions, including flavin adenine dinucleotide binding activity; heme binding activity; and protein heterodimerization activity. Predicted to contribute to electron transfer activity. Involved in several processes, including cellular response to L-glutamine; cellular response to ethanol; and hypoxia-inducible factor-1alpha signaling pathway. Located in dendrite; neuronal cell body; and nuclear envelope. Part of NADPH oxidase complex. Colocalizes with perinuclear endoplasmic reticulum. Biomarker of artery disease (multiple); end stage renal disease; primary hyperaldosteronism; and renal fibrosis. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain); PARTICIPATES IN thyroid hormone biosynthetic pathway; phagocytosis pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-carnitine; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytochrome b-245, beta polypeptide; endothelial type gp91-phox; endothelial type gp91-phox gene; Gp91-phox; NADPH oxidase 2; Nox2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cybbem1Mcwi   Cybbem3Mcwi  
Genetic Models: SS-Cybbem3Mcwi SS-Cybbem1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8X16,030,596 - 16,065,065 (-)NCBIGRCr8
mRatBN7.2X13,358,101 - 13,392,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX13,359,430 - 13,392,586 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX13,547,712 - 13,579,740 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X17,044,644 - 17,076,674 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X13,301,229 - 13,333,255 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X14,578,330 - 14,610,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX14,578,264 - 14,612,547 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X15,359,405 - 15,391,317 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X25,514,572 - 25,547,181 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X25,568,040 - 25,600,650 (-)NCBI
CeleraX14,033,486 - 14,065,403 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-bromopropane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-dihydroxybenzoic acid  (ISO)
2-butoxyethanol  (ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylcholine  (ISO)
adenine  (EXP)
aflatoxin B1  (ISO)
agomelatine  (EXP)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-D-galactose  (EXP)
alpha-linolenic acid  (EXP)
amitriptyline  (ISO)
amitrole  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
anagliptin  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP,ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
astaxanthin  (EXP)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
Besigomsin  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
calcium oxalate  (EXP)
calcium silicate  (ISO)
camostat  (EXP)
candesartan  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carnosic acid  (ISO)
CGP-42112A  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (EXP)
cocaine  (ISO)
corosolic acid  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (EXP,ISO)
daunorubicin  (EXP)
Deoxycorticosterone acetate  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP,ISO)
dibromine  (EXP)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
dichlorvos  (EXP)
diclofenac  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
eckol  (ISO)
edaravone  (EXP)
endosulfan  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
ferrostatin-1  (ISO)
filipin III  (ISO)
fisetin  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
galactose  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
ginkgolide B  (EXP)
glucose  (EXP,ISO)
glyburide  (ISO)
glyoxylic acid  (EXP)
GW 501516  (ISO)
hemin  (EXP)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
hydrochlorothiazide  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxylamine  (EXP)
icosanoid  (EXP)
iron dextran  (EXP)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lidocaine  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
liraglutide  (ISO)
malathion  (ISO)
malonaldehyde  (ISO)
maneb  (ISO)
manumycin A  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (EXP,ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methyl beta-cyclodextrin  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP)
microcystin-LR  (ISO)
monocrotaline  (EXP)
morphine  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-acetyl-L-cysteine  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nebivolol  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nicotinamide  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
nitroglycerin  (EXP,ISO)
ochratoxin A  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
palytoxin  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
patulin  (ISO)
PD123319  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenol  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
prodigiosin  (ISO)
quercetin  (EXP,ISO)
ramipril  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rosuvastatin calcium  (EXP,ISO)
rotenone  (EXP,ISO)
Salidroside  (ISO)
salubrinal  (ISO)
Salvianolic acid A  (EXP)
salvianolic acid B  (EXP)
saquinavir  (ISO)
SB 203580  (ISO)
sildenafil citrate  (EXP)
silibinin  (EXP)
silicon dioxide  (EXP)
simvastatin  (ISO)
sirolimus  (EXP)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium cholate  (EXP)
spironolactone  (EXP)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
superoxide  (ISO)
tamibarotene  (ISO)
tangeretin  (EXP)
taurine  (ISO)
telmisartan  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrodotoxin  (ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
titanium atom  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trans-piceid  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
tungsten  (ISO)
valsartan  (ISO)
vanadyl sulfate  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. Ambasta RK, etal., J Biol Chem. 2004 Oct 29;279(44):45935-41. Epub 2004 Aug 18.
2. Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells. Bayraktutan U, etal., Arterioscler Thromb Vasc Biol 2000 Aug;20(8):1903-11.
3. Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Chen L, etal., Free Radic Biol Med. 2011 Mar 1;50(5):624-32. doi: 10.1016/j.freeradbiomed.2010.12.032. Epub 2010 Dec 30.
4. Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat. DeMarco VG, etal., Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2659-68. Epub 2008 Apr 18.
5. Nox2 and p47(phox) modulate compensatory growth of primary collateral arteries. DiStasi MR, etal., Am J Physiol Heart Circ Physiol. 2014 May 15;306(10):H1435-43. doi: 10.1152/ajpheart.00828.2013. Epub 2014 Mar 14.
6. Nox2 is a mediator of chronic CsA nephrotoxicity. Djamali A, etal., Am J Transplant. 2012 Aug;12(8):1997-2007. doi: 10.1111/j.1600-6143.2012.04081.x. Epub 2012 May 8.
7. Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction. Fukui T, etal., Biochem Biophys Res Commun. 2001 Mar;281(5):1200-6.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Subcellular localization of nicotinamide adenine dinucleotide phosphate oxidase subunits in neurons and astroglia of the rat medial nucleus tractus solitarius: relationship with tyrosine hydroxylase immunoreactive neurons. Glass MJ, etal., Neuroscience. 2006 Dec 1;143(2):547-64. Epub 2006 Oct 4.
10. NOX2, p22phox and p47phox are targeted to the nuclear pore complex in ischemic cardiomyocytes colocalizing with local reactive oxygen species. Hahn NE, etal., Cell Physiol Biochem. 2011;27(5):471-8. doi: 10.1159/000329968. Epub 2011 Jun 15.
11. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Hink U, etal., Circ Res. 2001 Feb 2;88(2):E14-22.
12. Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke. Hong H, etal., Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2210-5. Epub 2006 Jun 9.
13. Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone. Huang BS, etal., Exp Physiol. 2011 Oct;96(10):1028-38. doi: 10.1113/expphysiol.2011.059840. Epub 2011 Aug 8.
14. Missense mutations in the gp91-phox gene encoding cytochrome b558 in patients with cytochrome b positive and negative X-linked chronic granulomatous disease. Kaneda M, etal., Blood. 1999 Mar 15;93(6):2098-104.
15. NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Kim D, etal., Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14851-6. doi: 10.1073/pnas.1009926107. Epub 2010 Aug 2.
16. Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury. Kusaka I, etal., Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2442-51.
17. Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Lassegue B, etal., Circ Res 2001 May 11;88(9):888-94.
18. The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori. Li H, etal., Dig Dis Sci. 2016 Aug;61(8):2328-2337. doi: 10.1007/s10620-016-4144-z. Epub 2016 Apr 5.
19. Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model. Li JM, etal., Gene Ther. 2010 Oct;17(10):1279-87. doi: 10.1038/gt.2010.69. Epub 2010 May 20.
20. Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia. Li X, etal., Cardiovasc Res. 2009 Jul 1;83(1):72-9. doi: 10.1093/cvr/cvp100. Epub 2009 Mar 24.
21. Iron and oxidative stress in renal insufficiency. Lim CS and Vaziri ND, Am J Nephrol. 2004 Nov-Dec;24(6):569-75. Epub 2004 Nov 17.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling. Mollnau H, etal., Circ Res. 2002 Mar 8;90(4):E58-65.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558. Newburger PE, etal., J Clin Invest. 1994 Sep;94(3):1205-11.
26. The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. Nisbet RE, etal., Am J Respir Cell Mol Biol. 2009 May;40(5):601-9. Epub 2008 Oct 23.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Neuroprotective effect of hyperbaric oxygen in a rat model of subarachnoid hemorrhage. Ostrowski RP, etal., Acta Neurochir Suppl. 2006;96:188-93.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils. Pithon-Curi TC, etal., Clin Sci (Lond). 2002 Oct;103(4):403-8.
32. Oxidative burst and neutrophil elastase contribute to clearance of Aspergillus fumigatus pneumonia in mice. Prufer S, etal., Immunobiology. 2014 Feb;219(2):87-96. doi: 10.1016/j.imbio.2013.08.010. Epub 2013 Aug 30.
33. A 40-base-pair duplication in the gp91-phox gene leading to X-linked chronic granulomatous disease. Rabbani H, etal., Eur J Haematol. 1993 Oct;51(4):218-22.
34. Nonresolving inflammation in gp91phox-/- mice, a model of human chronic granulomatous disease, has lower adenosine and cyclic adenosine 5'-monophosphate. Rajakariar R, etal., J Immunol. 2009 Mar 1;182(5):3262-9. doi: 10.4049/jimmunol.0801739.
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome. Roberts CK, etal., Metabolism. 2006 Jul;55(7):928-34.
39. Long-term high-level reconstitution of NADPH oxidase activity in murine X-linked chronic granulomatous disease using a bicistronic vector expressing gp91phox and a Delta LNGFR cell surface marker. Sadat MA, etal., Hum Gene Ther. 2003 May 1;14(7):651-66.
40. Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy. Shanmugam P, etal., J Mol Cell Cardiol. 2011 Mar 2.
41. Impairment of autoregulatory vasodilation by NAD(P)H oxidase-dependent superoxide generation during acute stage of subarachnoid hemorrhage in rat pial artery. Shin HK, etal., J Cereb Blood Flow Metab. 2002 Jul;22(7):869-77.
42. Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension. Vaziri ND, etal., Kidney Int. 2003 Jan;63(1):186-94.
43. Calcium paradox of aldosteronism and the role of the parathyroid glands. Vidal A, etal., Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H286-94.
44. Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells. Wang X, etal., Toxicology. 2015 Aug 6;334:104-10. doi: 10.1016/j.tox.2015.06.006. Epub 2015 Jun 12.
45. Point mutations in the promoter region of the CYBB gene leading to mild chronic granulomatous disease. Weening RS, etal., Clin Exp Immunol. 2000 Dec;122(3):410-7.
46. Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. Yuan G, etal., J Cell Physiol. 2011 Nov;226(11):2925-33. doi: 10.1002/jcp.22640.
Additional References at PubMed
PMID:3305576   PMID:9774399   PMID:12042318   PMID:12472781   PMID:12637340   PMID:12915388   PMID:14651853   PMID:15233623   PMID:15258578   PMID:15499027   PMID:15746442   PMID:15804439  
PMID:15850784   PMID:16344068   PMID:16505175   PMID:16685209   PMID:16831440   PMID:16897752   PMID:17283869   PMID:17324585   PMID:19204183   PMID:19436757   PMID:19926889   PMID:20079746  
PMID:20097736   PMID:20185631   PMID:21151982   PMID:21419746   PMID:21859816   PMID:21903813   PMID:21958220   PMID:22198504   PMID:22244881   PMID:22326221   PMID:22476986   PMID:22493499  
PMID:22565378   PMID:22832955   PMID:22888847   PMID:22933115   PMID:23052231   PMID:23303671   PMID:23524301   PMID:23585488   PMID:23732704   PMID:23922819   PMID:24131725   PMID:24365514  
PMID:24417961   PMID:24739962   PMID:24768926   PMID:24978055   PMID:25054130   PMID:25073061   PMID:25159478   PMID:25460548   PMID:25517730   PMID:25529920   PMID:25751622   PMID:25865156  
PMID:25873309   PMID:25982880   PMID:26058943   PMID:26617806   PMID:26650043   PMID:26698582   PMID:26869350   PMID:26910819   PMID:26950726   PMID:26950727   PMID:26963898   PMID:27499697  
PMID:27847553   PMID:27901023   PMID:27913300   PMID:28330417   PMID:28351984   PMID:28447737   PMID:28478802   PMID:28700905   PMID:28821269   PMID:29349831   PMID:29571735   PMID:29723859  
PMID:30317245   PMID:30677569   PMID:31155748   PMID:31216444   PMID:31245854   PMID:32233792   PMID:32351005   PMID:33202984   PMID:33273999   PMID:33806917   PMID:34705355   PMID:36613540  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8X16,030,596 - 16,065,065 (-)NCBIGRCr8
mRatBN7.2X13,358,101 - 13,392,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX13,359,430 - 13,392,586 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX13,547,712 - 13,579,740 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X17,044,644 - 17,076,674 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X13,301,229 - 13,333,255 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X14,578,330 - 14,610,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX14,578,264 - 14,612,547 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X15,359,405 - 15,391,317 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X25,514,572 - 25,547,181 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X25,568,040 - 25,600,650 (-)NCBI
CeleraX14,033,486 - 14,065,403 (+)NCBICelera
Cytogenetic MapXq12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X37,780,059 - 37,813,461 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX37,780,018 - 37,813,461 (+)EnsemblGRCh38hg38GRCh38
GRCh37X37,639,312 - 37,672,714 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X37,524,264 - 37,557,658 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X37,395,536 - 37,428,931NCBI
CeleraX41,776,951 - 41,810,391 (+)NCBICelera
Cytogenetic MapXp21.1-p11.4NCBI
HuRefX35,383,460 - 35,418,115 (+)NCBIHuRef
CHM1_1X37,670,409 - 37,703,853 (+)NCBICHM1_1
T2T-CHM13v2.0X37,183,630 - 37,217,034 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X9,301,493 - 9,354,005 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX9,301,491 - 9,354,010 (-)EnsemblGRCm39 Ensembl
GRCm38X9,435,252 - 9,487,766 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX9,435,252 - 9,487,771 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X9,012,378 - 9,046,450 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X8,593,665 - 8,626,226 (-)NCBIMGSCv36mm8
CeleraX7,154,874 - 7,188,991 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX4.3NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955587781,388 - 819,912 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955587781,533 - 818,149 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2X39,424,548 - 39,465,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X39,432,267 - 39,469,265 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X30,230,394 - 30,267,379 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X37,939,744 - 37,976,116 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX37,939,704 - 37,973,183 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1X32,533,365 - 32,568,149 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX32,533,320 - 32,568,217 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX19,880,947 - 19,915,729 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X32,578,634 - 32,613,434 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX32,578,588 - 32,614,792 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X32,660,059 - 32,694,839 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X32,623,867 - 32,658,828 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X32,671,823 - 32,706,767 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2X24,791,011 - 24,835,926 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365024,635,149 - 4,676,904 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365024,631,750 - 4,676,686 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 EnsemblX33,643,648 - 33,680,580 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X33,654,656 - 33,678,346 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X37,355,082 - 37,392,480 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
Vero_WHO_p1.0NW_02366605638,240,025 - 38,273,771 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476217,757,404 - 17,793,467 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476217,759,625 - 17,793,434 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cybb
151 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:88
Interacting mature miRNAs:93
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

Genetic Models
This gene Cybb is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 6 42 28 19 28 13 12 11
Low 31 15 13 13 8 11 72 22 27 8
Below cutoff 6 2 2


RefSeq Acc Id: ENSRNOT00000038994   ⟹   ENSRNOP00000031063
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX13,359,430 - 13,392,586 (-)Ensembl
Rnor_6.0 EnsemblX14,578,264 - 14,612,547 (+)Ensembl
RefSeq Acc Id: NM_023965   ⟹   NP_076455
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8X16,030,596 - 16,065,065 (-)NCBI
mRatBN7.2X13,358,101 - 13,392,570 (-)NCBI
Rnor_6.0X14,578,330 - 14,610,049 (+)NCBI
Rnor_5.0X15,359,405 - 15,391,317 (+)NCBI
RGSC_v3.4X25,514,572 - 25,547,181 (-)RGD
CeleraX14,033,486 - 14,065,403 (+)RGD
Protein Sequences
Protein RefSeqs NP_076455 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG31606 (Get FASTA)   NCBI Sequence Viewer  
  CAC09433 (Get FASTA)   NCBI Sequence Viewer  
  EDL82805 (Get FASTA)   NCBI Sequence Viewer  
  EDL82806 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031063
RefSeq Acc Id: NP_076455   ⟸   NM_023965
- UniProtKB: F1LNC0 (UniProtKB/TrEMBL),   Q9ERL1 (UniProtKB/TrEMBL),   A0A9K3Y6N7 (UniProtKB/TrEMBL),   Q9ER28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031063   ⟸   ENSRNOT00000038994
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ERL1-F1-model_v2 AlphaFold Q9ERL1 1-570 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701723
Promoter ID:EPDNEW_R12247
Type:initiation region
Description:cytochrome b-245 beta chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X14,578,255 - 14,578,315EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620574 AgrOrtholog
BioCyc Gene G2FUF-2983 BioCyc
Ensembl Genes ENSRNOG00000003622 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038994 ENTREZGENE
  ENSRNOT00000038994.4 UniProtKB/TrEMBL
  Translation factors UniProtKB/TrEMBL
InterPro Cyt_b245_heavy_chain UniProtKB/TrEMBL
  FAD-bd_8 UniProtKB/TrEMBL
  Fd_Rdtase_FAD-bd UniProtKB/TrEMBL
  Fe_red_NAD-bd_6 UniProtKB/TrEMBL
  Flavoprotein_TM UniProtKB/TrEMBL
  FNR_nucleotide_bd UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/TrEMBL
KEGG Report rno:66021 UniProtKB/TrEMBL
Pfam FAD_binding_8 UniProtKB/TrEMBL
  Ferric_reduct UniProtKB/TrEMBL
  NAD_binding_6 UniProtKB/TrEMBL
PhenoGen Cybb PhenoGen
RatGTEx ENSRNOG00000003622 RatGTEx
Superfamily-SCOP Riboflavin_synthase_like_b-brl UniProtKB/TrEMBL
  SSF52343 UniProtKB/TrEMBL
UniProt Secondary F1LNC0 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Cybb  cytochrome b-245 beta chain  Cybb  cytochrome b-245, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cybb  cytochrome b-245, beta polypeptide    endothelial type gp91-phox gene  Name updated 1299863 APPROVED
2002-08-07 Cybb  endothelial type gp91-phox gene      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum 632513