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Gene: Cybb (cytochrome b-245 beta chain) Rattus norvegicus
Symbol: Cybb
Name: cytochrome b-245 beta chain
RGD ID: 620574
Description: Predicted to contribute to electron transfer activity. Involved in several processes, including cellular response to L-glutamine; hypoxia-inducible factor-1alpha signaling pathway; and positive regulation of tumor necrosis factor production. Localizes to several cellular components, including NADPH oxidase complex; neuronal cell body; and rough endoplasmic reticulum. Colocalizes with perinuclear endoplasmic reticulum. Biomarker of artery disease (multiple); end stage renal disease; primary hyperaldosteronism; and renal fibrosis. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain); PARTICIPATES IN thyroid hormone biosynthetic pathway; phagocytosis pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-carnitine; (R)-lipoic acid.
Type: protein-coding
Also known as: cytochrome b-245, beta polypeptide; endothelial type gp91-phox; endothelial type gp91-phox gene; Gp91-phox; NADPH oxidase 2; Nox2
Homo sapiens (human) : CYBB (cytochrome b-245 beta chain)  HGNC  Alliance
Mus musculus (house mouse) : Cybb (cytochrome b-245, beta polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102012042 (cytochrome b-245 heavy chain)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100982531 (cytochrome b-245 heavy chain)
Canis lupus familiaris (dog) : CYBB (cytochrome b-245 beta chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101966992 (cytochrome b-245 heavy chain)
Sus scrofa (pig) : GP91-PHOX (NADPH oxidase heavy chain subunit)
Chlorocebus sabaeus (African green monkey) : CYBB (cytochrome b-245 heavy chain)
Heterocephalus glaber (naked mole-rat) : LOC101709509 (cytochrome b-245 heavy chain)
more info ...
Allele / Splice: Cybbem1Mcwi   Cybbem3Mcwi  
Genetic Models: SS-Cybbem3Mcwi SS-Cybbem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X14,578,330 - 14,610,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX14,578,264 - 14,612,547 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X15,359,405 - 15,391,317 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X25,514,572 - 25,547,181 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X25,568,040 - 25,600,650 (-)NCBI
CeleraX14,033,486 - 14,065,403 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cybb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620574
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.