Gadd45g (growth arrest and DNA-damage-inducible, gamma) - Rat Genome Database

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Gene: Gadd45g (growth arrest and DNA-damage-inducible, gamma) Rattus norvegicus
Analyze
Symbol: Gadd45g
Name: growth arrest and DNA-damage-inducible, gamma
RGD ID: 1311796
Description: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including positive regulation of MAPK cascade; positive regulation of apoptotic process; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within negative regulation of protein kinase activity and positive regulation of MAPK cascade. Predicted to be active in cytoplasm and nucleus. Biomarker of mesangial proliferative glomerulonephritis. Orthologous to human GADD45G (growth arrest and DNA damage inducible gamma); PARTICIPATES IN interleukin-12 signaling pathway; p38 MAPK signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH (S)-colchicine; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GADD45gamma; growth arrest and DNA damage inducible; growth arrest and DNA damage-inducible protein GADD45 gamma; growth arrest and DNA-damage-inducible 45 gamma; growth arrest and DNA-damage-inducible protein GADD45 gamma; LOC291005
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81713,528,606 - 13,530,351 (-)NCBIGRCr8
mRatBN7.21713,376,842 - 13,378,587 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1713,376,839 - 13,378,610 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1713,306,579 - 13,308,325 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01714,916,605 - 14,918,351 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01713,233,590 - 13,235,336 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01713,391,474 - 13,393,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1713,391,467 - 13,393,243 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01715,469,297 - 15,471,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41719,230,896 - 19,232,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11719,230,892 - 19,312,040 (-)NCBI
Celera1713,134,806 - 13,136,551 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
2-nitropropane  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylcoumarin  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
abexinostat  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenic trichloride  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
febuxostat  (ISO)
fenpyroximate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
furan  (EXP)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glycine betaine  (ISO)
glyphosate  (EXP,ISO)
graphene oxide  (ISO)
hydrogen cyanide  (ISO)
hydrogen sulfide  (ISO)
hypochlorous acid  (ISO)
idarubicin  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
irinotecan  (EXP)
iron dichloride  (ISO)
isoprenaline  (ISO)
kainic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
miconazole  (ISO)
microcystin-LR  (ISO)
milrinone  (EXP)
myristicin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
neomycin  (ISO)
nickel dichloride  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
ochratoxin A  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
phosphoramide mustard  (EXP)
pirinixic acid  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
ritodrine  (ISO)
rotenone  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sorafenib  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
Xanthatin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GADD45¿ regulates the thermogenic capacity of brown adipose tissue. Gantner ML, etal., Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11870-5. doi: 10.1073/pnas.1406638111. Epub 2014 Jul 28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Gene expression profile and overexpression of apoptosis-related genes (NGFI-B and Gadd 45 gamma) in early phase of Thy-1 nephritis model. Xu JH, etal., Cell Tissue Res. 2006 Oct;326(1):159-68. doi: 10.1007/s00441-006-0214-4. Epub 2006 May 31.
Additional References at PubMed
PMID:9827804   PMID:10100865   PMID:12124778   PMID:12213961   PMID:12477932   PMID:18445651   PMID:19882653   PMID:27086974   PMID:32828305  


Genomics

Comparative Map Data
Gadd45g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81713,528,606 - 13,530,351 (-)NCBIGRCr8
mRatBN7.21713,376,842 - 13,378,587 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1713,376,839 - 13,378,610 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1713,306,579 - 13,308,325 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01714,916,605 - 14,918,351 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01713,233,590 - 13,235,336 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01713,391,474 - 13,393,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1713,391,467 - 13,393,243 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01715,469,297 - 15,471,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41719,230,896 - 19,232,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11719,230,892 - 19,312,040 (-)NCBI
Celera1713,134,806 - 13,136,551 (-)NCBICelera
Cytogenetic Map17p14NCBI
GADD45G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38989,605,012 - 89,606,555 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl989,605,012 - 89,606,555 (+)EnsemblGRCh38hg38GRCh38
GRCh37992,219,927 - 92,221,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36991,409,748 - 91,411,290 (+)NCBINCBI36Build 36hg18NCBI36
Build 34989,449,481 - 89,451,021NCBI
Celera962,803,226 - 62,804,769 (+)NCBICelera
Cytogenetic Map9q22.2NCBI
HuRef962,051,611 - 62,053,154 (+)NCBIHuRef
CHM1_1992,368,717 - 92,370,261 (+)NCBICHM1_1
T2T-CHM13v2.09101,768,936 - 101,770,479 (+)NCBIT2T-CHM13v2.0
Gadd45g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391352,000,711 - 52,002,511 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1352,000,714 - 52,002,504 (+)EnsemblGRCm39 Ensembl
GRCm381351,846,675 - 51,848,475 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1351,846,678 - 51,848,468 (+)EnsemblGRCm38mm10GRCm38
MGSCv371351,942,044 - 51,943,844 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361351,859,189 - 51,860,971 (+)NCBIMGSCv36mm8
Celera1352,922,160 - 52,923,960 (+)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1326.36NCBI
Gadd45g
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555152,422,998 - 2,424,851 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555152,423,137 - 2,424,851 (-)NCBIChiLan1.0ChiLan1.0
GADD45G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21149,854,190 - 49,855,744 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1949,856,577 - 49,858,126 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0960,695,307 - 60,696,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1988,740,411 - 88,741,965 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl988,740,411 - 88,741,958 (+)Ensemblpanpan1.1panPan2
GADD45G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1196,745,001 - 96,746,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl196,744,985 - 96,746,520 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha197,197,788 - 97,199,313 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0197,346,707 - 97,348,232 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl197,346,691 - 97,348,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1196,974,994 - 96,976,519 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0196,693,996 - 96,695,522 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0197,452,325 - 97,453,850 (-)NCBIUU_Cfam_GSD_1.0
Gadd45g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494411,357,046 - 11,358,722 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936780501,681 - 503,305 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936780501,452 - 503,272 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GADD45G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl141,165,982 - 1,167,529 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1141,166,000 - 1,167,538 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2141,421,152 - 1,422,690 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GADD45G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112100,097,990 - 100,099,541 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12100,097,967 - 100,099,697 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603888,422,292 - 88,423,839 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gadd45g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476522,959,373 - 22,961,491 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476522,959,751 - 22,961,371 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gadd45g
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:175
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000018252
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat

Markers in Region
C86281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21713,376,871 - 13,377,056 (+)MAPPERmRatBN7.2
Rnor_6.01713,391,504 - 13,391,688NCBIRnor6.0
Rnor_5.01715,469,327 - 15,469,511UniSTSRnor5.0
RGSC_v3.41719,230,926 - 19,231,110UniSTSRGSC3.4
Celera1713,134,836 - 13,135,020UniSTS
Cytogenetic Map17p14UniSTS
PMC86941P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21713,377,064 - 13,377,420 (+)MAPPERmRatBN7.2
Rnor_6.01713,391,697 - 13,392,052NCBIRnor6.0
Rnor_5.01715,469,520 - 15,469,875UniSTSRnor5.0
RGSC_v3.41719,231,119 - 19,231,474UniSTSRGSC3.4
Celera1713,135,029 - 13,135,384UniSTS
Cytogenetic Map17p14UniSTS
UniSTS:237015  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21713,376,929 - 13,377,128 (+)MAPPERmRatBN7.2
Rnor_6.01713,391,562 - 13,391,760NCBIRnor6.0
Rnor_5.01715,469,385 - 15,469,583UniSTSRnor5.0
RGSC_v3.41719,230,984 - 19,231,182UniSTSRGSC3.4
Celera1713,134,894 - 13,135,092UniSTS
Cytogenetic Map17p14UniSTS
UniSTS:546781  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21713,377,931 - 13,378,527 (+)MAPPERmRatBN7.2
Rnor_6.01713,392,564 - 13,393,159NCBIRnor6.0
Rnor_5.01715,470,387 - 15,470,982UniSTSRnor5.0
Celera1713,135,896 - 13,136,491UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000018252   ⟹   ENSRNOP00000018251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1713,376,839 - 13,378,610 (-)Ensembl
Rnor_6.0 Ensembl1713,391,467 - 13,393,243 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106900   ⟹   ENSRNOP00000086432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1713,376,839 - 13,378,610 (-)Ensembl
RefSeq Acc Id: NM_001077640   ⟹   NP_001071108
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81713,528,606 - 13,530,351 (-)NCBI
mRatBN7.21713,376,842 - 13,378,587 (-)NCBI
Rnor_6.01713,391,474 - 13,393,219 (-)NCBI
Rnor_5.01715,469,297 - 15,471,042 (-)NCBI
RGSC_v3.41719,230,896 - 19,232,641 (-)RGD
Celera1713,134,806 - 13,136,551 (-)RGD
Sequence:
RefSeq Acc Id: NP_001071108   ⟸   NM_001077640
- UniProtKB: Q9WTQ7 (UniProtKB/Swiss-Prot),   B5DEF0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018251   ⟸   ENSRNOT00000018252
Ensembl Acc Id: ENSRNOP00000086432   ⟸   ENSRNOT00000106900
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTQ7-F1-model_v2 AlphaFold Q9WTQ7 1-159 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700337
Promoter ID:EPDNEW_R10860
Type:single initiation site
Name:Gadd45g_1
Description:growth arrest and DNA-damage-inducible, gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01713,393,237 - 13,393,297EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311796 AgrOrtholog
BioCyc Gene G2FUF-10076 BioCyc
Ensembl Genes ENSRNOG00000013090 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055014884 UniProtKB/Swiss-Prot
  ENSRNOG00060017964 UniProtKB/Swiss-Prot
  ENSRNOG00065010285 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018252.8 UniProtKB/Swiss-Prot
  ENSRNOT00000106900.1 UniProtKB/TrEMBL
  ENSRNOT00055025481 UniProtKB/Swiss-Prot
  ENSRNOT00060030812 UniProtKB/Swiss-Prot
  ENSRNOT00065016604 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1330.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GADD45 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L30e-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:291005 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 291005 ENTREZGENE
PANTHER GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10411 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ribosomal_L7Ae UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gadd45g PhenoGen
RatGTEx ENSRNOG00000013090 RatGTEx
  ENSRNOG00055014884 RatGTEx
  ENSRNOG00060017964 RatGTEx
  ENSRNOG00065010285 RatGTEx
Superfamily-SCOP SSF55315 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A8S9_RAT UniProtKB/TrEMBL
  B5DEF0 ENTREZGENE, UniProtKB/TrEMBL
  GA45G_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-14 Gadd45g  growth arrest and DNA-damage-inducible, gamma  Gadd45g  growth arrest and DNA-damage-inducible 45 gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Gadd45g  growth arrest and DNA-damage-inducible 45 gamma  Gadd45g_predicted  growth arrest and DNA-damage-inducible 45 gamma (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Gadd45g_predicted  growth arrest and DNA-damage-inducible 45 gamma (predicted)      Symbol and Name status set to approved 70820 APPROVED