Ahr (aryl hydrocarbon receptor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ahr (aryl hydrocarbon receptor) Rattus norvegicus
Analyze
Symbol: Ahr
Name: aryl hydrocarbon receptor
RGD ID: 2074
Description: Enables several functions, including arachidonate omega-hydroxylase activity; nuclear receptor activity; and toxic substance binding activity. Involved in several processes, including cellular response to steroid hormone stimulus; negative regulation of cell population proliferation; and regulation of macromolecule biosynthetic process. Located in cytoplasm and nucleus. Used to study hypertension; hypertrophic cardiomyopathy; pulmonary hypertension; and transient cerebral ischemia. Biomarker of hypertension and traumatic brain injury. Human ortholog(s) of this gene implicated in retinitis pigmentosa 85. Orthologous to human AHR (aryl hydrocarbon receptor); PARTICIPATES IN aryl hydrocarbon receptor signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 1,10-phenanthroline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ah receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ahrem1Sage ; Ahrem1Soar ; Ahrem2Sage ; Ahrem1Iexas
Genetic Models: SD-Ahrem2Sage ; SD-Ahrem1Soar ; SD-Ahrem1Iexas-/- ; SD-Ahrem1Iexas+/- ; SD-Nr1i2em1Sage Nr1i3em1Sage Ahrem1Sage ; SD-Ahrem1Sage
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8657,961,423 - 57,998,901 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl657,961,423 - 57,998,901 (-)EnsemblGRCr8
mRatBN7.2652,234,089 - 52,271,568 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl652,234,089 - 52,271,568 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx652,513,201 - 52,550,666 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0652,828,075 - 52,865,540 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0652,285,311 - 52,322,845 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0654,963,990 - 55,001,806 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl654,963,990 - 55,001,464 (-)Ensemblrn6Rnor6.0
Rnor_5.0664,589,066 - 64,624,078 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4654,205,104 - 54,240,268 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera651,391,870 - 51,429,719 (-)NCBICelera
RGSC_v3.1654,206,846 - 54,243,423 (-)NCBI
RH 3.4 Map6350.2RGD
Cytogenetic Map6q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acanthosis nigricans  (ISO)
Adult Pancreatic Cancer  (ISO)
alcohol dependence  (ISO)
alcoholic hepatitis  (ISO)
Alcoholic Liver Diseases  (ISO)
Animal Disease Models  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Atrophy  (ISO)
autism spectrum disorder  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Behcet's disease  (ISO)
Birth Weight  (ISO)
bladder calculus  (ISO)
bone disease  (ISO)
bone resorption disease  (ISO)
Breast Neoplasms  (ISO)
Cardiac Fibrosis  (IEP)
Cardiomegaly  (IEP,ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic kidney disease  (ISO)
Chronobiology Disorders  (ISO)
colitis  (ISO)
congenital heart disease  (ISO)
congenital nystagmus  (ISO,ISS)
contact dermatitis  (ISO)
Craniofacial Abnormalities  (ISO)
disease of cellular proliferation  (ISO)
disease of metabolism  (ISO)
Dyslipidemias  (ISO)
Edema  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (IDA,ISO)
Experimental Neoplasms  (ISO)
Female Infertility  (ISO)
Foveal Hypoplasia 3  (ISO)
fundus dystrophy  (ISO)
glucose intolerance  (ISO)
Growth Disorders  (ISO)
Hepatomegaly  (ISO)
Hyperoxia  (ISO)
Hyperpigmentation  (ISO)
hypertension  (IEP,IMP,ISO)
Hypertriglyceridemia  (IEP)
hypertrophic cardiomyopathy  (IMP)
Hypertrophy  (ISO)
Hyperventilation  (ISO)
hypoglycemia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (IEP)
keratosis  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Injury  (ISO)
male infertility  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Myocardial Reperfusion Injury  (IMP)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
nephrotoxicity  (IMP)
nicotine dependence  (ISO)
obesity  (ISO)
pancreatic cancer  (ISO)
Patent Ductus Venosus  (ISO)
peanut allergy  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pneumonia  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
Prostatic Neoplasms  (ISO)
Pruritus  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary hypertension  (IMP)
Pulmonary Hypertension, Hypoxia-Induced  (IMP)
retinitis pigmentosa 85  (ISO)
rheumatoid arthritis  (ISO)
Salmonella Infections, Animal  (ISO)
silicosis  (ISO)
splenic disease  (ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
Stomach Neoplasms  (ISO)
Tachycardia  (ISO)
Teratogenesis  (ISO)
transient cerebral ischemia  (IMP)
traumatic brain injury  (IEP)
Ureteral Neoplasms  (ISO)
vascular disease  (ISO)
Ventricular Remodeling  (IEP)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (ISO)
(+)-beta-thujone  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
(Z)-ligustilide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,10-phenanthroline  (EXP,ISO)
1,2,3,4,6,7,8-Heptachlorodibenzodioxin  (EXP,ISO)
1,2,3,4,6,7,8-Heptachlorodibenzofuran  (EXP,ISO)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (EXP)
1,2,3,4,7,8-Hexachlorodibenzofuran  (EXP,ISO)
1,2,3,4-tetrahydroisoquinoline  (ISO)
1,2,3,6,7,8-Hexachlorodibenzodioxin  (EXP,ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP,ISO)
1,2,3,7,8-Pentachlorodibenzofuran  (EXP)
1,2-benzoquinone  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,2-phenylenediamine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dicyclohexylurea  (EXP)
1,4-benzoquinone  (ISO)
1,4-dihydroxy-2-naphthoic acid  (ISO)
1,4-naphthoquinone  (ISO)
1,7-phenanthroline  (EXP)
1,8-cineole  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-Aminopyrene  (ISO)
1-benzofuran  (EXP)
1-hydroxy-2-naphthoic acid  (ISO)
1-Methylfluorene  (EXP)
1-methylnaphthalene  (EXP)
1-methylphenanthrene  (EXP)
1-methyltryptophan  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-naphthylamine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-indole  (ISO)
2,2',4,4',5,5'-hexabromobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,5-tetrachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3',4,4',5,5'-Hexachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (EXP,ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-Triphenyl-1-hexene  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-acetamidofluorene  (ISO)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (ISO)
2-Amino-9H-pyrido[2,3-b]indole  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylnaphthalene  (EXP)
2-naphthol  (ISO)
2-nitrofluorene  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3',4'-dimethoxyflavone  (EXP,ISO)
3',5'-cyclic AMP  (EXP,ISO)
3',5'-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-Dichlorobenzidine  (EXP)
3,3'-diindolylmethane  (EXP,ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP,ISO)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-(indol-3-yl)pyruvic acid  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-Methylchrysene  (EXP)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-Nitroperylene  (EXP)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,7-phenanthroline  (EXP,ISO)
4-chloro-m-cresol  (ISO)
4-nitrophenol  (EXP)
4-nonylphenol  (EXP,ISO)
4-Vinylcyclohexene  (EXP)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-Nitroacenaphthene  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chrysenamine  (EXP,ISO)
6-Methylchrysene  (EXP)
6-Nitrochrysene  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-ketocholesterol  (EXP,ISO)
7-Nitrobenz[a]anthracene  (ISO)
8-Br-cAMP  (ISO)
9-Nitroanthracene  (ISO)
9H-carbazole  (EXP,ISO)
aceanthrylene  (EXP)
acenaphthene  (ISO)
Acetyleugenol  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP,ISO)
acridines  (EXP,ISO)
acrolein  (EXP)
Actein  (ISO)
acteoside  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
ADP  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-pinene  (ISO)
Alpinetin  (ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
AMP-PNP  (EXP)
Androstane-3,17-diol dipropionate  (ISO)
anethole  (ISO)
angelicin  (EXP)
anilines  (ISO)
annomontine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene  (EXP,ISO)
anthraflavic acid  (ISO)
antigen  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
ATP  (EXP)
atrazine  (EXP,ISO)
Aurin  (ISO)
baicalein  (ISO)
baicalin  (ISO)
benidipine  (ISO)
benzene  (ISO)
Benzo[a]fluorene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[b]fluoranthene  (EXP,ISO)
Benzo[b]fluorene  (EXP)
benzo[c]phenanthrene  (ISO)
benzo[e]pyrene  (EXP,ISO)
BENZO[G]CHRYSENE  (EXP)
Benzo[ghi]perylene  (EXP,ISO)
Benzo[j]fluoranthene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP,ISO)
benzoates  (ISO)
benzofurans  (EXP,ISO)
benzothiazole  (ISO)
benzylamine  (ISO)
berberine  (EXP,ISO)
bergomottin  (EXP,ISO)
beta-carboline  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-pinene  (ISO)
betalain  (ISO)
betulin  (EXP)
bifenthrin  (ISO)
bilirubin IXalpha  (ISO)
biochanin A  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bitertanol  (ISO)
Bitumens  (EXP)
bromobenzene  (EXP)
bucladesine  (ISO)
busulfan  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
camphor  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
Capoamycin  (EXP)
capsaicin  (ISO)
carbamazepine  (ISO)
carbaryl  (EXP,ISO)
carbazole  (EXP,ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
carvacrol  (ISO)
carvone  (ISO)
catechol  (ISO)
cerium  (ISO)
CGP 52608  (ISO)
chelerythrine  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlormequat chloride  (ISO)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (ISO)
chlorothalonil  (EXP)
chlorpromazine  (EXP)
chlorpropham  (ISO)
chlorpyrifos  (EXP,ISO)
chlorpyrifos-methyl  (ISO)
cholesterol  (ISO)
cholic acid  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
chrysene  (EXP,ISO)
chrysin  (EXP,ISO)
chrysophanol  (ISO)
cidofovir anhydrous  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
climbazole  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clotrimazole  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) nitrate  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
CTP  (EXP)
curcumin  (ISO)
cyanidin cation  (ISO)
cycloheximide  (ISO)
Cyclopenta[cd]pyrene  (EXP)
cyclosporin A  (EXP,ISO)
Cynaropicrin  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP,ISO)
cyprodinil  (EXP,ISO)
D-glucose  (ISO)
daidzein  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
Dibenz[a,c]anthracene  (EXP)
dibenz[a,h]anthracene  (EXP,ISO)
Dibenz[a,j]acridine  (EXP)
Dibenz[a,j]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
dibenzofuran  (EXP,ISO)
dibenzothiophene  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (EXP,ISO)
diethofencarb  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dihydroresveratrol  (ISO)
Dihydrotanshinone I  (ISO)
Diisodecyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
diosmin  (ISO)
dioxygen  (EXP,ISO)
diphosphoric acid  (EXP)
diuron  (EXP,ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
ellipticine  (ISO)
emodin  (ISO)
endosulfan  (EXP)
epoxiconazole  (EXP,ISO)
epoxomicin  (ISO)
erastin  (ISO)
estragole  (ISO)
ethanol  (EXP,ISO)
ethylenediaminetetraacetic acid  (EXP)
ethylparaben  (ISO)
etoricoxib  (ISO)
eugenol  (ISO)
Fargesin  (ISO)
felodipine  (ISO)
fenofibrate  (EXP,ISO)
fipronil  (ISO)
flavone  (ISO)
flavones  (EXP,ISO)
flavonoids  (EXP)
flavonols  (ISO)
fludioxonil  (ISO)
fluoranthene  (EXP,ISO)
fluorene  (ISO)
fluvalinate  (ISO)
folic acid  (ISO)
folpet  (ISO)
formononetin  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
Furafylline  (ISO)
galangin  (ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gamma-terpinene  (ISO)
geldanamycin  (ISO)
gemfibrozil  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
Glu-P-1  (ISO)
Glu-P-2  (ISO)
glucose  (ISO)
glutathione  (ISO)
glyburide  (ISO)
glycitein  (ISO)
glyphosate  (ISO)
GTP  (EXP)
harman  (ISO)
harmine  (ISO)
harmol  (ISO)
herbimycin  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
hyodeoxycholic acid  (ISO)
ibuprofen  (EXP)
icosanoid  (ISO)
ifosfamide  (ISO)
imidacloprid  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP,ISO)
indigo carmine  (ISO)
indirubin  (EXP,ISO)
indirubin-3'-monoxime  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (EXP,ISO)
indoles  (EXP,ISO)
indolin-2-one  (ISO)
Indoxyl acetate  (ISO)
indoxyl sulfate  (EXP,ISO)
ionomycin  (ISO)
iprodione  (EXP,ISO)
iron dextran  (ISO)
isoeugenol  (ISO)
isoflavones  (ISO)
isoliquiritigenin  (ISO)
isopimpinellin  (EXP)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
Isosafrole  (ISO)
isovitexin  (EXP)
Isradipine  (ISO)
itraconazole  (ISO)
juglone  (ISO)
kaempferol  (ISO)
ketamine  (EXP)
ketoconazole  (EXP,ISO)
KN-93  (ISO)
kynurenic acid  (ISO)
kynurenine  (ISO)
L-tryptophan  (ISO)
lactacystin  (EXP,ISO)
laquinimod  (EXP)
lawsone  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (EXP,ISO)
leptomycin B  (ISO)
leukotriene B4  (EXP)
Licochalcone A  (ISO)
limonene  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
malathion  (ISO)
MC-4379  (ISO)
MDL-28170  (ISO)
medroxyprogesterone acetate  (ISO)
MeIQx  (ISO)
melanins  (ISO)
menadione  (ISO)
mepanipyrim  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methacholine chloride  (ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (ISO)
methyl oleate  (ISO)
methylarsonic acid  (ISO)
methylseleninic acid  (ISO)
Methysticin  (ISO)
metsulfuron methyl  (EXP)
mifepristone  (EXP,ISO)
molybdate  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotophos  (ISO)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naphthalene  (ISO)
naphthalenes  (EXP)
Naphtho[1,2-b]fluoranthene  (EXP)
NCX-4040  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitrogen mustard  (ISO)
nocodazole  (EXP,ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
Octachlorostyrene  (ISO)
oleamide  (ISO)
oleic acid  (ISO)
Olivacine  (ISO)
oltipraz  (ISO)
omeprazole  (EXP,ISO)
Omeprazole sulfide  (ISO)
ortho-Aminoazotoluene  (ISO)
oxalic acid  (EXP)
oxaliplatin  (ISO)
oxybenzone  (EXP)
oxycodone  (EXP)
ozone  (ISO)
p-cymene  (ISO)
p-tolualdehyde  (ISO)
paclobutrazol  (ISO)
palmatine  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (ISO)
pelargonidin  (ISO)
pentacene  (EXP)
pentachlorobenzene  (ISO)
pentachlorophenol  (ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
perylene  (EXP)
Pf-06840003  (ISO)
phenanthren-9-amine  (ISO)
phenanthrene  (EXP,ISO)
phenanthrolines  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
phenylhydrazines  (ISO)
phenytoin  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosphatidylcholine  (ISO)
phosphatidylethanolamine  (ISO)
picene  (EXP)
pifithrin-alpha hydrobromide  (ISO)
pinocembrin  (ISO)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
potassium chloride  (EXP)
prednisolone  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
primaquine  (EXP,ISO)
prochloraz  (EXP,ISO)
progesterone  (EXP,ISO)
propanil  (ISO)
propiconazole  (ISO)
prothioconazole  (ISO)
pterostilbene  (ISO)
puromycin  (ISO)
pyocyanine  (ISO)
pyrene  (EXP,ISO)
pyrimethanil  (ISO)
quercetin  (EXP,ISO)
quinalphos  (ISO)
quinizarin  (ISO)
quinolinic acid  (ISO)
quinolone  (ISO)
rac-lactic acid  (ISO)
radicicol  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
riddelliine  (EXP)
rifampicin  (ISO)
robinetin  (ISO)
RU 58668  (ISO)
Rutecarpine  (EXP,ISO)
rutin  (ISO)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
sabinene  (ISO)
salicylamide  (ISO)
salicylates  (ISO)
sanguinarine  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
selenic acid  (EXP)
silicon dioxide  (ISO)
sirtinol  (ISO)
skatole  (ISO)
SL-327  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium molybdate (anhydrous)  (EXP,ISO)
sodium selenate  (EXP)
sorafenib  (ISO)
spathulenol  (ISO)
spironolactone  (ISO)
steviol  (ISO)
streptozocin  (ISO)
Sudan III  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulpiride  (EXP)
sunitinib  (EXP,ISO)
T-2 toxin  (ISO)
tamarixetin  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
tasquinimod  (EXP)
tauro-beta-muricholic acid  (ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (ISO)
taurodeoxycholic acid  (ISO)
taurohyodeoxycholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tebuconazole  (ISO)
telmisartan  (EXP,ISO)
terbutylazine  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetraconazole  (ISO)
tetraphene  (EXP,ISO)
tetrodotoxin  (EXP)
thapsigargin  (ISO)
theaflavin  (EXP)
Theaflavin 3,3'-digallate  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tolterodine tartrate  (ISO)
toluene  (EXP)
tranilast  (ISO)
trans-anethole  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclocarban  (EXP,ISO)
triclosan  (EXP,ISO)
trimethoxyflavone  (EXP)
trimethylarsine oxide  (ISO)
Triptycene  (EXP)
troglitazone  (EXP)
Tryptanthrine  (ISO)
ursodeoxycholic acid  (ISO)
UTP  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
wortmannin  (EXP)
xanthenes  (EXP,ISO)
xanthurenic acid  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)
Zoxazolamine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aflatoxin metabolic process  (IEP)
apoptotic process  (TAS)
B cell homeostasis  (ISO)
blood circulation  (ISO)
blood vessel development  (ISO)
blood vessel morphogenesis  (ISO)
blood vessel remodeling  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
camera-type eye development  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cell morphogenesis  (ISO)
cellular response to 2,3,7,8-tetrachlorodibenzodioxine  (IDA,IEA,ISO)
cellular response to 3-methylcholanthrene  (ISO)
cellular response to cAMP  (ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to forskolin  (ISO)
cellular response to glucocorticoid stimulus  (IEP)
cellular response to molecule of bacterial origin  (ISO)
cellular response to toxic substance  (IMP)
circadian regulation of gene expression  (ISO,ISS)
circadian rhythm  (IEP)
circumferential growth involved in left ventricle morphogenesis  (ISO)
conditioned taste aversion  (IMP)
contact inhibition  (IMP)
estrogen receptor signaling pathway  (IDA)
female pregnancy  (IEP)
gland development  (ISO)
glomerulus morphogenesis  (ISO)
immune system process  (ISO)
intestinal epithelial structure maintenance  (ISO)
intracellular receptor signaling pathway  (IEA)
kidney morphogenesis  (ISO)
liver development  (ISO)
lymphocyte homeostasis  (ISO)
mammary duct terminal end bud growth  (IDA)
negative regulation of alkaline phosphatase activity  (IDA)
negative regulation of calcium ion transmembrane transport  (IDA)
negative regulation of DNA biosynthetic process  (IDA,IMP)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of inflammatory response  (ISO)
negative regulation of osteoblast differentiation  (IDA)
negative regulation of osteoblast proliferation  (IDA)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of T cell mediated immune response to tumor cell  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vasoconstriction  (ISO)
nitric oxide metabolic process  (IEP)
omega-hydroxylase P450 pathway  (IMP)
ovarian follicle development  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of cell size  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of growth rate  (ISO)
positive regulation of mating-type specific transcription, DNA-templated  (IDA)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
post-embryonic hemopoiesis  (ISO)
prostate gland development  (ISO)
protein localization to nucleus  (IMP)
reactive oxygen species biosynthetic process  (IMP)
regulation of adaptive immune response  (ISO,ISS)
regulation of B cell proliferation  (ISO)
regulation of cell cycle  (TAS)
regulation of cytokine production  (IMP)
regulation of DNA-templated transcription  (IDA,IEA,ISO)
regulation of eating behavior  (IDA)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
reproductive structure development  (ISO)
response to arsenic-containing substance  (IEP)
response to estradiol  (IEP)
response to toxic substance  (IEP,ISO)
response to xenobiotic stimulus  (IDA,IEA,IEP,ISO)
rhythmic process  (IEA)
spleen development  (ISO)
T cell homeostasis  (ISO)
tissue remodeling  (IEP)
transcription by RNA polymerase II  (IDA,ISO)
vasculature development  (ISO)
xenobiotic metabolic process  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors. Andersson P, etal., Proc Natl Acad Sci U S A 2002 Jul 23;99(15):9990-5. Epub 2002 Jul 9.
3. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Bessede A, etal., Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.
4. Exposure to diesel exhaust particulates induces cardiac dysfunction and remodeling. Bradley JM, etal., J Appl Physiol (1985). 2013 Oct 1;115(7):1099-106. doi: 10.1152/japplphysiol.00343.2013. Epub 2013 Jul 25.
5. Aryl hydrocarbon receptor regulation of cytochrome P4501B1 in rat mammary fibroblasts: evidence for transcriptional repression by glucocorticoids. Brake PB, etal., Mol Pharmacol. 1998 Nov;54(5):825-33.
6. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
7. Aryl hydrocarbon receptor is activated by glucose and regulates the thrombospondin-1 gene promoter in endothelial cells. Dabir P, etal., Circ Res. 2008 Jun 20;102(12):1558-65. doi: 10.1161/CIRCRESAHA.108.176990. Epub 2008 May 30.
8. Activation of AhR-NQO1 Signaling Pathway Protects Against Alcohol-Induced Liver Injury by Improving Redox Balance. Dong H, etal., Cell Mol Gastroenterol Hepatol. 2021;12(3):793-811. doi: 10.1016/j.jcmgh.2021.05.013. Epub 2021 May 31.
9. Dioxin-dependent, DNA sequence-specific binding of a multiprotein complex containing the Ah receptor. Elferink CJ and Whitlock JP Jr, Receptor. 1994 Fall;4(3):157-73.
10. Maximal aryl hydrocarbon receptor activity depends on an interaction with the retinoblastoma protein. Elferink CJ, etal., Mol Pharmacol. 2001 Apr;59(4):664-73.
11. Recombinant expression of aryl hydrocarbon receptor for quantitative ligand-binding analysis. Fan MQ, etal., Anal Biochem. 2009 Jan 15;384(2):279-87. Epub 2008 Oct 7.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice. Harrill JA, etal., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13.
15. Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3. He J, etal., Mol Cell Biol. 2013 May;33(10):2047-55. doi: 10.1128/MCB.01658-12. Epub 2013 Mar 18.
16. Cross-Talk in the Female Rat Mammary Gland: Influence of Aryl Hydrocarbon Receptor on Estrogen Receptor Signaling. Helle J, etal., Environ Health Perspect. 2016 May;124(5):601-10. doi: 10.1289/ehp.1509680. Epub 2015 Sep 15.
17. DNA binding and transcriptional enhancement by purified TCDD.Ah receptor complex. Henry EC, etal., Arch Biochem Biophys. 1997 Mar 15;339(2):305-14. doi: 10.1006/abbi.1996.9873.
18. Quantitative characterization of changes in bone geometry, mineral density and biomechanical properties in two rat strains with different Ah-receptor structures after long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Herlin M, etal., Toxicology. 2010 Jun 29;273(1-3):1-11. Epub 2010 Apr 18.
19. Maternal Resveratrol Therapy Protects Male Rat Offspring against Programmed Hypertension Induced by TCDD and Dexamethasone Exposures: Is It Relevant to Aryl Hydrocarbon Receptor? Hsu CN, etal., Int J Mol Sci. 2018 Aug 20;19(8):2459. doi: 10.3390/ijms19082459.
20. Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol. Hsu CN, etal., Int J Mol Sci. 2019 Sep 6;20(18):4382. doi: 10.3390/ijms20184382.
21. Multiple mechanisms are involved in Ah receptor-mediated cell cycle arrest. Huang G and Elferink CJ, Mol Pharmacol. 2005 Jan;67(1):88-96. doi: 10.1124/mol.104.002410. Epub 2004 Oct 18.
22. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
23. Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure. Iqbal K, etal., Environ Health Perspect. 2021 Nov;129(11):117001. doi: 10.1289/EHP9256. Epub 2021 Nov 8.
24. MG132 alleviates liver injury induced by intestinal ischemia/reperfusion in rats: involvement of the AhR and NFκB pathways. Jing H, etal., J Surg Res. 2012 Jul;176(1):63-73. doi: 10.1016/j.jss.2011.09.001. Epub 2011 Sep 29.
25. The Aryl hydrocarbon receptor mediates reproductive toxicity of polychlorinated biphenyl congener 126 in rats. Klenov V, etal., Toxicol Appl Pharmacol. 2021 Sep 1;426:115639. doi: 10.1016/j.taap.2021.115639. Epub 2021 Jul 10.
26. Increased arylhydrocarbon receptor expression offers a potential therapeutic target for pancreatic cancer. Koliopanos A, etal., Oncogene. 2002 Sep 5;21(39):6059-70.
27. Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice. Kouno T, etal., Alcohol Clin Exp Res (Hoboken). 2023 May;47(5):856-867. doi: 10.1111/acer.15048. Epub 2023 Mar 19.
28. Estradiol regulates aryl hydrocarbon receptor expression in the rat uterus. Kretzschmar G, etal., Mol Cell Endocrinol. 2010 Jun 10;321(2):253-7. Epub 2010 Feb 20.
29. Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium. Kulas J, etal., Biomed Environ Sci. 2021 Mar 20;34(3):192-202. doi: 10.3967/bes2021.025.
30. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
31. Aryl hydrocarbon receptor antagonism before reperfusion attenuates cerebral ischaemia/reperfusion injury in rats. Kwon JI, etal., Sci Rep. 2020 Sep 10;10(1):14906. doi: 10.1038/s41598-020-72023-5.
32. Aryl hydrocarbon receptor agonists trigger avoidance of novel food in rats. Mahiout S and Pohjanvirta R, Physiol Behav. 2016 Dec 1;167:49-59. doi: 10.1016/j.physbeh.2016.08.033. Epub 2016 Sep 1.
33. Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension. Masaki T, etal., Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2023899118. doi: 10.1073/pnas.2023899118.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Estrogen increases messenger RNA and immunoreactivity of aryl-hydrocarbon receptor nuclear translocator 2 in the rat mediobasal hypothalamus. Mitsushima D, etal., Biochem Biophys Res Commun 2003 Jul 25;307(2):248-53.
36. The effect of aryl hydrocarbon receptor ligands on gentamicin-induced nephrotoxicity in rats. Mokhtar MM, etal., Environ Sci Pollut Res Int. 2020 May;27(14):16189-16202. doi: 10.1007/s11356-020-08073-z. Epub 2020 Feb 28.
37. 3-Methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo. Naruse M, etal., Endocrinology 2002 Sep;143(9):3575-81.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Aryl hydrocarbon receptor antagonists attenuate the deleterious effects of benzopyrene on isolated rat follicle development. Neal MS, etal., Reprod Biomed Online. 2010 Mar 30.
40. Aryl hydrocarbon receptor is indispensable for β-naphthoflavone-induced novel food avoidance and may be involved in LiCl-triggered conditioned taste aversion in rats. Pohjanvirta R and Mahiout S, Physiol Behav. 2019 May 15;204:58-64. doi: 10.1016/j.physbeh.2019.02.014. Epub 2019 Feb 12.
41. Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain. Pohjanvirta R, etal., Mol Pharmacol 1998 Jul;54(1):86-93.
42. Role of the aryl hydrocarbon receptor in cell cycle regulation. Puga A, etal., Chem Biol Interact. 2002 Sep 20;141(1-2):117-30.
43. Aryl Hydrocarbon Receptor Deficiency in Intestinal Epithelial Cells Aggravates Alcohol-Related Liver Disease. Qian M, etal., Cell Mol Gastroenterol Hepatol. 2022;13(1):233-256. doi: 10.1016/j.jcmgh.2021.08.014. Epub 2021 Aug 25.
44. Hexachlorobenzene triggers AhR translocation to the nucleus, c-Src activation and EGFR transactivation in rat liver. Randi AS, etal., Toxicol Lett. 2008 Mar 15;177(2):116-22. Epub 2008 Jan 12.
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Daily cycle of bHLH-PAS proteins, Ah receptor and Arnt, in multiple tissues of female Sprague-Dawley rats. Richardson VM, etal., Biochem Biophys Res Commun. 1998 Nov 9;252(1):225-31. doi: 10.1006/bbrc.1998.9634.
47. Responsiveness of the adult male rat reproductive tract to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: Ah receptor and ARNT expression, CYP1A1 induction, and Ah receptor down-regulation. Roman BL, etal., Toxicol Appl Pharmacol. 1998 Jun;150(2):228-39. doi: 10.1006/taap.1998.8388.
48. Acute aflatoxin B1 - Induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein metabolism in rats. Rotimi OA, etal., Toxicol Rep. 2017 Jul 24;4:408-414. doi: 10.1016/j.toxrep.2017.07.006. eCollection 2017.
49. Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells. Safe S, etal., J Mammary Gland Biol Neoplasia. 2000 Jul;5(3):295-306.
50. Expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator messenger ribonucleic acids and proteins in rat and human testis. Schultz R, etal., Endocrinology 2003 Mar;144(3):767-76.
51. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. Seymour EM, etal., J Nutr Biochem. 2013 Sep;24(9):1580-6. doi: 10.1016/j.jnutbio.2013.01.008. Epub 2013 Mar 22.
52. Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats. Shen H, etal., Environ Sci Pollut Res Int. 2014 May;21(10):6384-99. doi: 10.1007/s11356-013-1690-1. Epub 2013 May 4.
53. Benzopyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Shimizu Y, etal., Proc Natl Acad Sci U S A 2000 Jan 18;97(2):779-82.
54. Ah receptor and ARNT protein and mRNA concentrations in rat prostate: effects of stage of development and 2,3,7, 8-tetrachlorodibenzo-p-dioxin treatment. Sommer RJ, etal., Toxicol Appl Pharmacol. 1999 Mar 1;155(2):177-89. doi: 10.1006/taap.1998.8597.
55. Glucocorticoid-enhanced expression of dioxin target genes through regulation of the rat aryl hydrocarbon receptor. Sonneveld E, etal., Toxicol Sci. 2007 Oct;99(2):455-69. Epub 2007 Aug 9.
56. Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures. Stejskalova L, etal., Toxicol Sci. 2011 Sep;123(1):26-36. doi: 10.1093/toxsci/kfr150. Epub 2011 Jun 10.
57. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
58. Aryl hydrocarbon receptor null mice develop cardiac hypertrophy and increased hypoxia-inducible factor-1alpha in the absence of cardiac hypoxia. Thackaberry EA, etal., Cardiovasc Toxicol. 2002;2(4):263-74. doi: 10.1385/ct:2:4:263.
59. Norisoboldine, an isoquinoline alkaloid, acts as an aryl hydrocarbon receptor ligand to induce intestinal Treg cells and thereby attenuate arthritis. Tong B, etal., Int J Biochem Cell Biol. 2016 Jun;75:63-73. doi: 10.1016/j.biocel.2016.03.014. Epub 2016 Mar 28.
60. Blocking the Aryl Hydrocarbon Receptor Alleviates Myocardial Ischemia/Reperfusion Injury in Rats. Wang JX, etal., Curr Med Sci. 2022 Oct;42(5):966-973. doi: 10.1007/s11596-022-2601-9. Epub 2022 Jul 5.
61. Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats. Wei M, etal., Toxicol Appl Pharmacol. 2013 Nov 15;273(1):1-9. doi: 10.1016/j.taap.2013.08.022. Epub 2013 Aug 30.
62. Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner. Wei ZF, etal., Int J Biol Sci. 2015 Jul 17;11(9):1113-26. doi: 10.7150/ijbs.12152. eCollection 2015.
63. TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A. Weiss C, etal., Oncogene. 2008 Apr 3;27(15):2198-207. doi: 10.1038/sj.onc.1210859. Epub 2007 Oct 22.
64. Protective effects of salvianolic acid B on intestinal ischemia/reperfusion injury in rats by regulating the AhR/IL-22/STAT6 axis. Xu J, etal., J Recept Signal Transduct Res. 2023 Jun;43(3):73-82. doi: 10.1080/10799893.2023.2204949. Epub 2023 Jun 30.
65. Expression of aryl hydrocarbon receptor in rat brain lesions following traumatic brain injury. Xu K, etal., Diagn Pathol. 2016 Aug 9;11(1):72. doi: 10.1186/s13000-016-0522-2.
66. Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue. Yang X, etal., J Cell Biochem. 2008 May 15;104(2):402-17.
67. Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells. Yisireyili M, etal., Nagoya J Med Sci. 2017 Nov;79(4):477-486. doi: 10.18999/nagjms.79.4.477.
68. Inhibition of CYP1B1 ameliorates cardiac hypertrophy induced by uremic toxin. Zhang Y, etal., Mol Med Rep. 2020 Jan;21(1):393-404. doi: 10.3892/mmr.2019.10810. Epub 2019 Nov 11.
Additional References at PubMed
PMID:1313028   PMID:1314586   PMID:1605850   PMID:7732381   PMID:7961644   PMID:8065918   PMID:8215422   PMID:8692887   PMID:9079689   PMID:10395741   PMID:10973493   PMID:11230806  
PMID:11755109   PMID:11782478   PMID:12151645   PMID:12215427   PMID:12927582   PMID:14644620   PMID:15342792   PMID:15581363   PMID:15630227   PMID:15641800   PMID:15681594   PMID:16443691  
PMID:17182795   PMID:17329248   PMID:17569696   PMID:17576166   PMID:17880909   PMID:18078967   PMID:18174242   PMID:18223155   PMID:18360687   PMID:18708364   PMID:19056935   PMID:19336978  
PMID:19490992   PMID:20106950   PMID:20655778   PMID:21187122   PMID:21760882   PMID:22471748   PMID:22659940   PMID:23085979   PMID:23135549   PMID:23196670   PMID:23275542   PMID:23626760  
PMID:23689136   PMID:23690540   PMID:24001774   PMID:24289088   PMID:25359166   PMID:25489928   PMID:25843524   PMID:26278112   PMID:26561638   PMID:26845845   PMID:27782878   PMID:28396409  
PMID:28433708   PMID:28487374   PMID:28585088   PMID:28602820   PMID:28956952   PMID:29381299   PMID:29753751   PMID:31718930   PMID:32816128   PMID:33759307   PMID:36047110   PMID:36600181  
PMID:36879035   PMID:38735589  


Genomics

Comparative Map Data
Ahr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8657,961,423 - 57,998,901 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl657,961,423 - 57,998,901 (-)EnsemblGRCr8
mRatBN7.2652,234,089 - 52,271,568 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl652,234,089 - 52,271,568 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx652,513,201 - 52,550,666 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0652,828,075 - 52,865,540 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0652,285,311 - 52,322,845 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0654,963,990 - 55,001,806 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl654,963,990 - 55,001,464 (-)Ensemblrn6Rnor6.0
Rnor_5.0664,589,066 - 64,624,078 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4654,205,104 - 54,240,268 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera651,391,870 - 51,429,719 (-)NCBICelera
RGSC_v3.1654,206,846 - 54,243,423 (-)NCBI
RH 3.4 Map6350.2RGD
Cytogenetic Map6q16NCBI
AHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38717,298,652 - 17,346,147 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl716,916,359 - 17,346,152 (+)Ensemblhg38GRCh38
GRCh37717,338,276 - 17,385,771 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36717,304,832 - 17,352,299 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34717,111,485 - 17,158,632NCBI
Celera717,318,278 - 17,365,781 (+)NCBICelera
Cytogenetic Map7p21.1NCBI
HuRef717,224,763 - 17,272,268 (+)NCBIHuRef
CHM1_1717,339,112 - 17,386,607 (+)NCBICHM1_1
T2T-CHM13v2.0717,428,395 - 17,475,891 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2717,391,672 - 17,439,185 (+)NCBI
Ahr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391235,547,978 - 35,584,988 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1235,547,973 - 35,585,037 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381235,497,979 - 35,534,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1235,497,974 - 35,535,038 (-)Ensemblmm10GRCm38
MGSCv371236,182,651 - 36,219,661 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361236,083,094 - 36,119,976 (-)NCBIMGSCv36mm8
Celera1236,948,584 - 36,984,257 (-)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1215.78NCBI
Ahr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541020,428,546 - 20,456,836 (+)Ensembl
ChiLan1.0NW_00495541020,428,531 - 20,459,482 (+)NCBIChiLan1.0ChiLan1.0
AHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2622,129,950 - 22,179,006 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1770,455,241 - 70,502,308 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0717,949,254 - 17,998,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1717,278,637 - 17,326,171 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl717,278,637 - 17,326,171 (+)EnsemblpanPan2panpan1.1
AHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11431,743,704 - 31,793,484 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1431,686,170 - 31,791,444 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1431,264,779 - 31,314,544 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01431,661,762 - 31,711,544 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1431,661,088 - 31,711,540 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11431,766,284 - 31,816,050 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01431,476,179 - 31,525,758 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01431,792,396 - 31,842,188 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ahr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511876,062,814 - 76,108,403 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365463,737,851 - 3,783,588 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365463,737,908 - 3,783,492 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl986,511,369 - 86,555,943 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1986,511,866 - 86,555,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2995,511,269 - 95,542,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12140,778,198 - 40,826,491 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2140,778,218 - 40,826,478 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604263,692,229 - 63,740,600 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ahr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473912,942,165 - 12,987,973 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473912,939,183 - 12,987,574 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ahr
277 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:454
Count of miRNA genes:223
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000006618, ENSRNOT00000049770
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63902865963457441Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat

Markers in Region
RH140680  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2652,235,743 - 52,235,938 (+)MAPPERmRatBN7.2
Rnor_6.0654,965,645 - 54,965,839NCBIRnor6.0
Rnor_5.0664,588,178 - 64,588,372UniSTSRnor5.0
RGSC_v3.4654,204,216 - 54,204,410UniSTSRGSC3.4
Celera651,393,525 - 51,393,719UniSTS
RH 3.4 Map6362.2UniSTS
Cytogenetic Map6q16UniSTS
RH140665  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2652,235,077 - 52,235,271 (+)MAPPERmRatBN7.2
Rnor_6.0654,964,979 - 54,965,172NCBIRnor6.0
Rnor_5.0664,587,512 - 64,587,705UniSTSRnor5.0
RGSC_v3.4654,203,550 - 54,203,743UniSTSRGSC3.4
Celera651,392,859 - 51,393,052UniSTS
RH 3.4 Map6352.39UniSTS
Cytogenetic Map6q16UniSTS


Genetic Models
This gene Ahr is modified in the following models/strains:
SD-Ahrem2Sage     SD-Ahrem1Soar     SD-Ahrem1Iexas-/-     SD-Ahrem1Iexas+/-     SD-Nr1i2em1Sage Nr1i3em1Sage Ahrem1Sage     SD-Ahrem1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 91 59 6 355 191 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001308254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001308255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_131775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_131776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF082124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF082125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF082126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ821851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM902281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM902282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM902283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM902284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM902285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM902286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U09000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000006618   ⟹   ENSRNOP00000006618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl657,961,423 - 57,998,901 (-)Ensembl
mRatBN7.2 Ensembl652,234,089 - 52,271,568 (-)Ensembl
Rnor_6.0 Ensembl654,963,990 - 55,001,464 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000136687   ⟹   ENSRNOP00000111098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl657,961,423 - 57,998,901 (-)Ensembl
RefSeq Acc Id: NM_001308254   ⟹   NP_001295183
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8657,961,423 - 57,998,901 (-)NCBI
mRatBN7.2652,234,089 - 52,271,568 (-)NCBI
Rnor_6.0654,963,990 - 55,001,464 (-)NCBI
Celera651,391,870 - 51,429,719 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001308255   ⟹   NP_001295184
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8657,961,423 - 57,998,901 (-)NCBI
mRatBN7.2652,234,089 - 52,271,568 (-)NCBI
Rnor_6.0654,963,990 - 55,001,464 (-)NCBI
Celera651,391,870 - 51,429,719 (-)NCBI
Sequence:
RefSeq Acc Id: NM_013149   ⟹   NP_037281
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8657,961,423 - 57,998,901 (-)NCBI
mRatBN7.2652,234,089 - 52,271,568 (-)NCBI
Rnor_6.0654,963,990 - 55,001,464 (-)NCBI
Rnor_5.0664,589,066 - 64,624,078 (-)NCBI
RGSC_v3.4654,205,104 - 54,240,268 (-)RGD
Celera651,391,870 - 51,429,719 (-)NCBI
Sequence:
RefSeq Acc Id: NR_131775
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8657,961,423 - 57,998,901 (-)NCBI
mRatBN7.2652,234,089 - 52,271,568 (-)NCBI
Rnor_6.0654,963,990 - 55,001,464 (-)NCBI
Celera651,391,870 - 51,429,719 (-)NCBI
Sequence:
RefSeq Acc Id: NR_131776
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8657,961,423 - 57,998,901 (-)NCBI
mRatBN7.2652,234,089 - 52,271,568 (-)NCBI
Rnor_6.0654,963,990 - 55,001,464 (-)NCBI
Celera651,391,870 - 51,429,719 (-)NCBI
Sequence:
RefSeq Acc Id: NP_037281   ⟸   NM_013149
- Peptide Label: isoform 1
- UniProtKB: P41738 (UniProtKB/Swiss-Prot),   O89105 (UniProtKB/Swiss-Prot),   O88930 (UniProtKB/Swiss-Prot),   A6HB97 (UniProtKB/TrEMBL),   A8YPR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295184   ⟸   NM_001308255
- Peptide Label: isoform 3
- UniProtKB: A6HB96 (UniProtKB/TrEMBL),   A8YPQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295183   ⟸   NM_001308254
- Peptide Label: isoform 2
- UniProtKB: G3V6M2 (UniProtKB/TrEMBL),   A6HB98 (UniProtKB/TrEMBL),   A8YPR0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006618   ⟸   ENSRNOT00000006618
Ensembl Acc Id: ENSRNOP00000111098   ⟸   ENSRNOT00000136687
Protein Domains
bHLH   PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41738-F1-model_v2 AlphaFold P41738 1-853 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694556
Promoter ID:EPDNEW_R5081
Type:multiple initiation site
Name:Ahr_1
Description:aryl hydrocarbon receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0655,001,423 - 55,001,483EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2074 AgrOrtholog
BioCyc Gene G2FUF-37810 BioCyc
Ensembl Genes ENSRNOG00000004342 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000006618 ENTREZGENE
  ENSRNOT00000136687 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
  PAS domain UniProtKB/Swiss-Prot
InterPro AHR UniProtKB/Swiss-Prot
  AHR/AHRR UniProtKB/Swiss-Prot
  bHLH_dom UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  PAS_fold UniProtKB/Swiss-Prot
  PAS_fold_3 UniProtKB/Swiss-Prot
NCBI Gene 25690 ENTREZGENE
PANTHER PTHR10649 UniProtKB/Swiss-Prot
  PTHR10649:SF9 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS_3 UniProtKB/Swiss-Prot
PharmGKB AHR RGD
PhenoGen Ahr PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004342 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
  SSF55785 UniProtKB/Swiss-Prot
TIGR TC221126
UniProt A6HB96 ENTREZGENE, UniProtKB/TrEMBL
  A6HB97 ENTREZGENE, UniProtKB/TrEMBL
  A6HB98 ENTREZGENE, UniProtKB/TrEMBL
  A8YPQ9 ENTREZGENE, UniProtKB/TrEMBL
  A8YPR0 ENTREZGENE, UniProtKB/TrEMBL
  A8YPR4 ENTREZGENE, UniProtKB/TrEMBL
  AHR_RAT UniProtKB/Swiss-Prot
  G3V6M2 ENTREZGENE, UniProtKB/TrEMBL
  O88930 ENTREZGENE
  O89105 ENTREZGENE
  P41738 ENTREZGENE
  Q683N8_RAT UniProtKB/TrEMBL
UniProt Secondary O88930 UniProtKB/Swiss-Prot
  O89105 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ahr  Aryl hydrocarbon receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs binds to dioxi- and 3-Methylcholanthrene (3MC) 625678
gene_function transcription factor 625678
gene_process activated by aromatic hydorcarbons 625678
gene_process may be involved in the effects of aromatic hydrocarbon drugs like 3MC in bone formation 625678