Gene: Chrna4 (cholinergic receptor nicotinic alpha 4 subunit) Rattus norvegicus
Symbol: Chrna4
Name: cholinergic receptor nicotinic alpha 4 subunit
Description: ENCODES a protein that exhibits acetylcholine binding; acetylcholine-gated cation-selective channel activity; drug binding; INVOLVED IN positive regulation of dopamine secretion; protein heterooligomerization; regulation of acetylcholine-gated cation channel activity; PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; ASSOCIATED WITH Heart Failure; Abnormalities, Multiple (ortholog); Alzheimer Disease (ortholog); FOUND IN acetylcholine-gated channel complex; dendrite; membrane; INTERACTS WITH (S)-anabasine; (S)-nicotine; 17alpha-ethynylestradiol
Type: protein-coding
Also known as: cholinergic receptor, nicotinic, alpha 4; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha 4 subunit; cholinergic receptor, nicotinic, alpha polypeptide 4; NARAC; neuronal acetylcholine receptor subunit alpha-4; neuronal nicotinic acetylcholine receptor alpha 4 subunit
Homo sapiens (human) : CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit)  HGNC  AGR
Mus musculus (house mouse) : Chrna4 (cholinergic receptor, nicotinic, alpha polypeptide 4)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Chrna4 (cholinergic receptor nicotinic alpha 4 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit)
Canis lupus familiaris (dog) : CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrna4 (cholinergic receptor nicotinic alpha 4 subunit)
more info ...
Allele / Splice: Chrna4em4Mcwi   Chrna4em3Mcwi  
Genetic Models: LEW-Chrna4em3Mcwi LEW-Chrna4em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03176,533,182 - 176,547,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03180,243,234 - 180,258,017 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,171,214 - 170,185,998 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13170,077,249 - 170,092,033 (-)NCBI
Celera3164,428,976 - 164,443,759 (+)NCBICelera
Cytogenetic Map3q43NCBI
RH 3.4 Map31564.7RGD
RH 3.4 Map31531.39RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Chrna4
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2346
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE