(-)-lobeline multiple interactions ISO RGD:10356 6480464 [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] more ... CTD PMID:14645658 , PMID:18448488 (S)-anabasine affects binding EXP 6480464 Anabasine analog binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15615518 (S)-nicotine increases response to substance ISO RGD:10355 6480464 CHRNA4 protein mutant form results in increased susceptibility to Nicotine CTD PMID:16339034 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of CHRNA4 mRNA CTD PMID:20060465 (S)-nicotine decreases expression ISO RGD:10355 6480464 Nicotine results in decreased expression of CHRNA4 mRNA CTD PMID:17135361 (S)-nicotine multiple interactions EXP 6480464 1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]] more ... CTD PMID:10336510 more ... (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of CHRNA4 mRNA CTD PMID:24368670 more ... (S)-nicotine increases expression ISO RGD:10356 6480464 Nicotine results in increased expression of CHRNA4 protein CTD PMID:19139119 , PMID:20106947 (S)-nicotine increases expression ISO RGD:10355 6480464 Nicotine results in increased expression of CHRNA4 mRNA, Nicotine results in increased expression of CHRNA4 protein CTD PMID:14500745 more ... (S)-nicotine affects binding ISO RGD:10356 6480464 Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:9336329 (S)-nicotine multiple interactions ISO RGD:10355 6480464 [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein] more ... CTD PMID:15551346 more ... (S)-nicotine affects response to substance ISO RGD:10355 6480464 CHRNA4 gene polymorphism affects the susceptibility to Nicotine more ... CTD PMID:10734154 more ... (S)-nicotine multiple interactions ISO RGD:10356 6480464 [CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine more ... CTD PMID:14645658 more ... (S)-nicotine affects binding EXP 6480464 Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein], Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15615518 , PMID:19252481 1,1-dichloroethene decreases expression ISO RGD:10355 6480464 vinylidene chloride results in decreased expression of CHRNA4 mRNA CTD PMID:26682919 1,1-dimethyl-4-phenylpiperazinium iodide multiple interactions ISO RGD:10356 6480464 Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] more ... CTD PMID:14645658 , PMID:9454827 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:10355 6480464 Nicotine inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO RGD:10355 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 13-desmethylspirolide C multiple interactions ISO RGD:10356 6480464 13-desmethylspirolide C binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:26063663 17alpha-ethynylestradiol multiple interactions ISO RGD:10356 6480464 [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] more ... CTD PMID:11517245 , PMID:11711029 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Ethinyl Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:11517245 17beta-estradiol affects binding ISO RGD:10356 6480464 Estradiol binds to CHRNA4 protein CTD PMID:11517245 17beta-estradiol multiple interactions ISO RGD:10356 6480464 [Estradiol co-treated with Acetylcholine] results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:11517245 2,2',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:10356 6480464 2 more ... CTD PMID:20861069 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10355 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CHRNA4 promoter] CTD PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10355 6480464 Tetrachlorodibenzodioxin results in decreased expression of CHRNA4 mRNA CTD PMID:26290441 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10355 6480464 Tetrachlorodibenzodioxin affects the expression of CHRNA4 mRNA CTD PMID:24680724 , PMID:26377647 2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expression ISO RGD:10355 6480464 2 more ... CTD PMID:26254212 3,3',5,5'-tetrabromobisphenol A multiple interactions ISO RGD:10356 6480464 tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]], tetrabromobisphenol A inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22547355 , PMID:22750351 3,4-methylenedioxymethamphetamine multiple interactions ISO RGD:10356 6480464 N-Methyl-3, 4-methylenedioxyamphetamine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:20132834 4,4'-sulfonyldiphenol decreases expression ISO RGD:10355 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of CHRNA4 mRNA CTD PMID:30951980 4-nonylphenol multiple interactions ISO RGD:10356 6480464 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11711029 4-octylphenol multiple interactions ISO RGD:10356 6480464 4-octylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11711029 5-fluorouracil multiple interactions ISO RGD:10356 6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of CHRNA4 mRNA] CTD PMID:15016801 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of CHRNA4 mRNA CTD PMID:24780913 acetylcholine multiple interactions EXP 6480464 [CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine] more ... CTD PMID:11517245 more ... acetylcholine affects binding EXP 6480464 Acetylcholine analog binds to [CHRNA4 protein binds to CHRNB2 protein], Acetylcholine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:19252481 acetylcholine increases response to substance ISO RGD:10355 6480464 CHRNA4 protein mutant form results in increased susceptibility to Acetylcholine CTD PMID:16339034 acetylcholine multiple interactions ISO RGD:10356 6480464 1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] more ... CTD PMID:11517245 more ... acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of CHRNA4 mRNA CTD PMID:28959563 alcuronium multiple interactions ISO RGD:10356 6480464 Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]], Alcuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 aldicarb multiple interactions EXP 6480464 Aldicarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 aldrin increases expression ISO RGD:10355 6480464 Aldrin results in increased expression of CHRNA4 mRNA CTD PMID:18579281 all-trans-retinoic acid decreases expression ISO RGD:10355 6480464 Tretinoin results in decreased expression of CHRNA4 mRNA, Tretinoin results in decreased expression of CHRNA4 protein CTD PMID:17203487 all-trans-retinoic acid multiple interactions ISO RGD:10355 6480464 Tretinoin promotes the reaction [epibatidine binds to CHRNA4 protein] CTD PMID:17203487 aluminium hydroxide multiple interactions ISO RGD:10356 6480464 Aluminum Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 Amaranth multiple interactions EXP 6480464 [ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein CTD PMID:23429044 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CHRNA4 mRNA CTD PMID:16483693 Antimony trioxide multiple interactions ISO RGD:10356 6480464 antimony trioxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 arsane affects methylation ISO RGD:10356 6480464 Arsenic affects the methylation of CHRNA4 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:10356 6480464 Arsenic affects the methylation of CHRNA4 gene CTD PMID:25304211 atracurium multiple interactions ISO RGD:10356 6480464 Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:16931985 atropine multiple interactions ISO RGD:10356 6480464 Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 atropine multiple interactions EXP 6480464 Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]], Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]] CTD PMID:21791372 atropine affects binding ISO RGD:10356 6480464 Atropine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15733544 barium(0) multiple interactions EXP 6480464 [CHRNA4 protein co-treated with CHRNB2 protein] affects the reaction [Barium results in increased susceptibility to Acetylcholine], [CHRNA4 protein mutant form co-treated with CHRNB2 protein] inhibits the reaction [Barium results in increased susceptibility to Acetylcholine] CTD PMID:12754307 bendiocarb multiple interactions EXP 6480464 bendiocarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 bentonite multiple interactions ISO RGD:10356 6480464 Bentonite inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 benzo[a]pyrene multiple interactions EXP 6480464 [Nicotine co-treated with Benzo(a)pyrene] results in decreased expression of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:30247698 bisphenol A increases expression ISO RGD:10355 6480464 bisphenol A results in increased expression of CHRNA4 mRNA CTD PMID:21932408 bisphenol A decreases methylation ISO RGD:10355 6480464 bisphenol A results in decreased methylation of CHRNA4 promoter CTD PMID:27312807 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CHRNA4 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A multiple interactions ISO RGD:10356 6480464 bisphenol A inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11711029 bisphenol F decreases expression ISO RGD:10355 6480464 bisphenol F results in decreased expression of CHRNA4 mRNA CTD PMID:30951980 Brilliant Blue multiple interactions EXP 6480464 [ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein CTD PMID:23429044 butan-1-ol multiple interactions ISO RGD:10356 6480464 1-Butanol affects the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] more ... CTD PMID:12604691 calcium atom multiple interactions EXP 6480464 [CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine] more ... CTD PMID:12754307 calcium(0) multiple interactions EXP 6480464 [CHRNA4 protein co-treated with CHRNB2 protein mutant form] inhibits the reaction [Calcium results in increased susceptibility to Acetylcholine] more ... CTD PMID:12754307 carbachol multiple interactions ISO RGD:10356 6480464 Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] more ... CTD PMID:14645658 carbachol affects binding EXP 6480464 Carbachol binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15615518 carbamazepine affects binding ISO RGD:10356 6480464 Carbamazepine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:12110613 carbaryl multiple interactions EXP 6480464 Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein], Carbaryl results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 carbon nanotube decreases expression ISO RGD:10355 6480464 Nanotubes, Carbon analog results in decreased expression of CHRNA4 mRNA, Nanotubes, Carbon results in decreased expression of CHRNA4 mRNA CTD PMID:25620056 chloroethene increases expression ISO RGD:10355 6480464 Vinyl Chloride results in increased expression of CHRNA4 mRNA CTD PMID:18579281 choline multiple interactions ISO RGD:10356 6480464 Choline affects the activity of [CHRNA4 protein binds to CHRNB2 protein], Choline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 choline affects activity EXP 6480464 Choline affects the activity of CHRNA4 protein CTD PMID:19047205 cisatracurium multiple interactions ISO RGD:10356 6480464 cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:16931985 Citreoviridin affects expression ISO RGD:10355 6480464 citreoviridin affects the expression of CHRNA4 mRNA CTD PMID:30071239 clothianidin multiple interactions ISO RGD:10356 6480464 clothianidin promotes the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:21538459 cocaine multiple interactions EXP 6480464 Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:10336510 cytisine multiple interactions ISO RGD:10356 6480464 cytisine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] more ... CTD PMID:14645658 more ... cytisine affects expression ISO RGD:10355 6480464 cytisine affects the expression of CHRNA4 protein CTD PMID:7756618 cytisine multiple interactions ISO RGD:10355 6480464 cytisine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein] CTD PMID:7756618 cytisine affects binding ISO RGD:10356 6480464 cytisine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:9336329 decabromodiphenyl ether multiple interactions ISO RGD:10356 6480464 decabromobiphenyl ether inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 decamethonium multiple interactions ISO RGD:10356 6480464 Carbachol inhibits the reaction [decamethonium binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] more ... CTD PMID:14645658 diazinon affects expression EXP 6480464 Diazinon affects the expression of CHRNA4 mRNA CTD PMID:18812211 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of CHRNA4 mRNA CTD PMID:18636392 dichloroacetic acid increases expression ISO RGD:10355 6480464 Dichloroacetic Acid results in increased expression of CHRNA4 mRNA CTD PMID:28962523 dichlorvos multiple interactions ISO RGD:10356 6480464 Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of CHRNA4 mRNA CTD PMID:18812211 diethylstilbestrol multiple interactions ISO RGD:10356 6480464 Diethylstilbestrol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11711029 dihydro-beta-erythroidine multiple interactions ISO RGD:10355 6480464 Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein], Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:16569710 , PMID:20100906 dihydro-beta-erythroidine affects binding EXP 6480464 [CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine CTD PMID:9687574 dihydro-beta-erythroidine multiple interactions ISO RGD:10356 6480464 Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] more ... CTD PMID:12604691 , PMID:14645658 dihydro-beta-erythroidine multiple interactions EXP 6480464 [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine more ... CTD PMID:10945867 more ... dioxygen increases expression ISO RGD:10355 6480464 Oxygen deficiency results in increased expression of CHRNA4 mRNA CTD PMID:24205000 elemental selenium increases expression ISO RGD:10356 6480464 Selenium results in increased expression of CHRNA4 mRNA CTD PMID:19244175 epibatidine affects binding EXP 6480464 epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:11124396 more ... epibatidine affects binding ISO RGD:10355 6480464 epibatidine binds to CHRNA4 protein CTD PMID:17203487 epibatidine multiple interactions EXP 6480464 2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1 more ... CTD PMID:10728888 more ... epibatidine multiple interactions ISO RGD:10355 6480464 Tretinoin promotes the reaction [epibatidine binds to CHRNA4 protein] CTD PMID:17203487 epibatidine affects binding ISO RGD:10356 6480464 [CHRNB4 protein binds to CHRNA4 protein] which binds to epibatidine, epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 , PMID:9454827 epibatidine multiple interactions ISO RGD:10356 6480464 Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] more ... CTD PMID:14645658 , PMID:22060139 EPTC multiple interactions EXP 6480464 EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein], EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 ethanol affects expression ISO RGD:10355 6480464 Ethanol affects the expression of CHRNA4 mRNA CTD PMID:30319688 fenoxycarb multiple interactions EXP 6480464 fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein], fenoxycarb results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 galanthamine affects binding ISO RGD:10356 6480464 Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15733544 galanthamine multiple interactions ISO RGD:10356 6480464 Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 galanthamine Trifluoroacetic acid multiple interactions ISO RGD:10356 6480464 Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 galanthamine Trifluoroacetic acid affects binding ISO RGD:10356 6480464 Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15733544 genistein multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in decreased expression of CHRNA4 mRNA CTD PMID:21782745 hexachlorophene decreases expression ISO RGD:10355 6480464 Hexachlorophene results in decreased expression of CHRNA4 mRNA CTD PMID:25943520 Hexamethonium multiple interactions ISO RGD:10355 6480464 Hexamethonium inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein] CTD PMID:7756618 Hexamethonium multiple interactions ISO RGD:10356 6480464 Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]], Hexamethonium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 imidacloprid multiple interactions EXP 6480464 imidacloprid analog inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]], imidacloprid binds to [CHRNA4 protein co-treated with CHRNB2 protein] CTD PMID:10377228 , PMID:10728888 imidacloprid multiple interactions ISO RGD:10356 6480464 imidacloprid inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:21538459 indigo carmine multiple interactions EXP 6480464 [ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein CTD PMID:23429044 magnesium dihydroxide multiple interactions ISO RGD:10356 6480464 Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 Mecamylamine multiple interactions EXP 6480464 Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]] more ... CTD PMID:18385335 , PMID:21791372 Mecamylamine multiple interactions ISO RGD:10355 6480464 Mecamylamine inhibits the reaction [Tacrine results in increased expression of CHRNA4 protein] CTD PMID:8930989 Mecamylamine multiple interactions ISO RGD:10356 6480464 Mecamylamine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] more ... CTD PMID:12604691 , PMID:14645658 mercury dichloride multiple interactions EXP 6480464 [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB2 protein], [Mercuric Chloride co-treated with Acetylcholine] affects the activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:12130716 methoxychlor multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in decreased expression of CHRNA4 mRNA CTD PMID:21782745 methyllycaconitine multiple interactions ISO RGD:10356 6480464 Carbachol inhibits the reaction [methyllycaconitine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] more ... CTD PMID:14645658 methyllycaconitine affects activity EXP 6480464 methyllycaconitine affects the activity of CHRNA4 protein CTD PMID:19047205 Mivacurium multiple interactions ISO RGD:10356 6480464 mivacurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:16931985 N-nitrosodiethylamine increases expression ISO RGD:10355 6480464 Diethylnitrosamine results in increased expression of CHRNA4 mRNA CTD PMID:24535843 nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of CHRNA4 mRNA CTD PMID:18812211 nicotine affects response to substance ISO RGD:10355 6480464 CHRNA4 gene polymorphism affects the susceptibility to Nicotine more ... CTD PMID:10734154 more ... nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of CHRNA4 mRNA CTD PMID:20060465 nicotine increases expression EXP 6480464 Nicotine results in increased expression of CHRNA4 mRNA CTD PMID:24368670 more ... nicotine decreases expression ISO RGD:10355 6480464 Nicotine results in decreased expression of CHRNA4 mRNA CTD PMID:17135361 nicotine increases expression ISO RGD:10355 6480464 Nicotine results in increased expression of CHRNA4 mRNA, Nicotine results in increased expression of CHRNA4 protein CTD PMID:14500745 more ... nicotine multiple interactions EXP 6480464 1-(5-azido-6-chloropyridin-3-ylmethyl)-2-nitroiminoimidazolidine inhibits the reaction [Nicotine analog binds to [CHRNA4 protein co-treated with CHRNB2 protein]] more ... CTD PMID:10336510 more ... nicotine increases expression ISO RGD:10356 6480464 Nicotine results in increased expression of CHRNA4 protein CTD PMID:19139119 , PMID:20106947 nicotine multiple interactions ISO RGD:10355 6480464 [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein] more ... CTD PMID:15551346 more ... nicotine affects binding ISO RGD:10356 6480464 Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:9336329 nicotine multiple interactions ISO RGD:10356 6480464 [CHRNA4 protein binds to CHRNB2 protein] which results in increased susceptibility to Nicotine more ... CTD PMID:14645658 more ... nicotine increases response to substance ISO RGD:10355 6480464 CHRNA4 protein mutant form results in increased susceptibility to Nicotine CTD PMID:16339034 nicotine affects binding EXP 6480464 Nicotine analog binds to [CHRNA4 protein binds to CHRNB2 protein], Nicotine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15615518 , PMID:19252481 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of CHRNA4 mRNA CTD PMID:26720608 NS-398 increases expression ISO RGD:10355 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein CTD PMID:15551346 NS-398 multiple interactions ISO RGD:10355 6480464 [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide co-treated with Nicotine] inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CHRNA4 protein] CTD PMID:15551346 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of CHRNA4 mRNA CTD PMID:18636392 pancuronium multiple interactions ISO RGD:10356 6480464 Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] more ... CTD PMID:14645658 , PMID:16931985 paracetamol affects expression ISO RGD:10355 6480464 Acetaminophen affects the expression of CHRNA4 mRNA CTD PMID:17562736 paraoxon multiple interactions EXP 6480464 Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]] more ... CTD PMID:21791372 paraoxon decreases expression EXP 6480464 Paraoxon results in decreased expression of CHRNA4 mRNA, Paraoxon results in decreased expression of CHRNA4 protein CTD PMID:21791372 phenobarbital increases expression ISO RGD:10355 6480464 Phenobarbital results in increased expression of CHRNA4 mRNA CTD PMID:23091169 physostigmine affects binding ISO RGD:10356 6480464 Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15733544 physostigmine multiple interactions ISO RGD:10356 6480464 Physostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] more ... CTD PMID:14645658 , PMID:15733544 potassium dichromate decreases expression ISO RGD:10355 6480464 Potassium Dichromate results in decreased expression of CHRNA4 mRNA CTD PMID:23608068 progesterone multiple interactions ISO RGD:10356 6480464 [Progesterone co-treated with Acetylcholine] results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:11517245 propoxur multiple interactions EXP 6480464 Propoxur results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 pyrazines multiple interactions ISO RGD:10356 6480464 Pyrazines binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:21962147 pyridines multiple interactions ISO RGD:10356 6480464 Pyridines binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:21962147 resveratrol increases expression ISO RGD:10356 6480464 resveratrol results in increased expression of CHRNA4 mRNA CTD PMID:12569576 rivastigmine multiple interactions ISO RGD:10356 6480464 Rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 rivastigmine affects binding ISO RGD:10356 6480464 Rivastigmine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15733544 rocuronium multiple interactions ISO RGD:10356 6480464 rocuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:16931985 scopolamine affects binding ISO RGD:10356 6480464 Scopolamine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15733544 scopolamine multiple interactions ISO RGD:10356 6480464 Scopolamine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 selenium atom increases expression ISO RGD:10356 6480464 Selenium results in increased expression of CHRNA4 mRNA CTD PMID:19244175 sodium fluoride decreases expression EXP 6480464 Sodium Fluoride results in decreased expression of CHRNA4 protein CTD PMID:19900517 succinylcholine multiple interactions ISO RGD:10356 6480464 Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 Sunset Yellow FCF multiple interactions EXP 6480464 [ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein CTD PMID:23429044 T-2 Toxin decreases expression ISO RGD:10355 6480464 T-2 Toxin results in decreased expression of CHRNA4 mRNA CTD PMID:26314264 tacrine multiple interactions ISO RGD:10356 6480464 Tacrine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 tacrine increases expression ISO RGD:10355 6480464 Tacrine results in increased expression of CHRNA4 protein CTD PMID:8930989 tacrine multiple interactions ISO RGD:10355 6480464 Mecamylamine inhibits the reaction [Tacrine results in increased expression of CHRNA4 protein] CTD PMID:8930989 tamoxifen multiple interactions ISO RGD:10356 6480464 Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11711029 tartrazine multiple interactions EXP 6480464 [ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein CTD PMID:23429044 tetrachloroethene multiple interactions ISO RGD:10356 6480464 Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15885267 tetrachloroethene multiple interactions EXP 6480464 Tetrachloroethylene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15885267 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of CHRNA4 mRNA CTD PMID:12734012 tetraphene decreases expression ISO RGD:10355 6480464 benz(a)anthracene results in decreased expression of CHRNA4 mRNA CTD PMID:26377693 toluene multiple interactions ISO RGD:10356 6480464 Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15885267 toluene multiple interactions EXP 6480464 Toluene inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15885267 triphenyl phosphate multiple interactions ISO RGD:10356 6480464 triphenyl phosphate inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]] CTD PMID:22750351 tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate affects binding ISO RGD:10356 6480464 Atropine binds to [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:15733544 tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate multiple interactions EXP 6480464 Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]], Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]] CTD PMID:21791372 tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate multiple interactions ISO RGD:10356 6480464 Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 tubocurarine multiple interactions ISO RGD:10356 6480464 Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] more ... CTD PMID:11711029 more ... tubocurarine multiple interactions ISO RGD:10355 6480464 Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein] CTD PMID:7756618 urethane multiple interactions EXP 6480464 Urethane promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11812690 valproic acid increases methylation ISO RGD:10356 6480464 Valproic Acid results in increased methylation of CHRNA4 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:10355 6480464 Valproic Acid affects the expression of CHRNA4 mRNA CTD PMID:17292431 vancomycin increases expression ISO RGD:10355 6480464 Vancomycin results in increased expression of CHRNA4 mRNA CTD PMID:18930951 varenicline multiple interactions ISO RGD:10356 6480464 Varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:20207347 more ... varenicline multiple interactions EXP 6480464 Varenicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:16766716 varenicline multiple interactions ISO RGD:10355 6480464 Varenicline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:20100906 vecuronium bromide multiple interactions ISO RGD:10356 6480464 Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] more ... CTD PMID:14645658 , PMID:16931985
Biological Process acetylcholine receptor signaling pathway ISO RGD:10355 1624291 (MGI:MGI:5694852, PMID:26276394) RGD MGI:MGI:5694852 , PMID:26276394 acetylcholine receptor signaling pathway IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 action potential ISO RGD:10355 1624291 MGI:MGI:1926251 (MGI:MGI:1335979 , PMID:10235262) RGD MGI:MGI:1335979 , PMID:10235262 action potential IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 B cell activation ISO RGD:10355 1624291 MGI:MGI:1926251 (MGI:MGI:3610855 , PMID:15963492) RGD MGI:MGI:3610855 , PMID:15963492 B cell activation IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 behavioral response to nicotine ISO RGD:10355 1624291 MGI:MGI:3511287 (MGI:MGI:3510061 , PMID:15528443) RGD MGI:MGI:3510061 , PMID:15528443 behavioral response to nicotine IEA UniProtKB:P43681 , ensembl:ENSP000003592851600115 GO_REF:0000107 Ensembl GO_REF:0000107 behavioral response to nicotine IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 behavioral response to nicotine ISO RGD:10356 1624291 (PMID:17955458) RGD PMID:17955458 calcium ion transport ISO RGD:10355 1624291 MGI:MGI:87891 (MGI:MGI:3521544 , PMID:15569257) RGD MGI:MGI:3521544 , PMID:15569257 calcium ion transport IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 chemical synaptic transmission IBA FB:FBgn0000036 more ... 13792537 PMID:21873635 GO_Central cognition ISO RGD:10356 1624291 (PMID:14623738) RGD PMID:14623738 cognition IEA UniProtKB:P43681 , ensembl:ENSP000003592851600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA repair ISO RGD:10356 1624291 (PMID:16332175) RGD PMID:16332175 DNA repair IEA UniProtKB:P43681 , ensembl:ENSP000003592851600115 GO_REF:0000107 Ensembl GO_REF:0000107 excitatory postsynaptic potential IEA GO:0022848 1600115 GO_REF:0000108 GOC GO_REF:0000108 exploration behavior ISO RGD:10355 1624291 MGI:MGI:1888964 (MGI:MGI:1888860 , PMID:10964949) RGD MGI:MGI:1888860 , PMID:10964949 exploration behavior IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 inhibitory postsynaptic potential ISO RGD:10355 1624291 MGI:MGI:3700204 more ... RGD MGI:MGI:3699045 , PMID:17146052 inhibitory postsynaptic potential IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 ion transmembrane transport IEA InterPro:IPR006201 1600115 GO_REF:0000002 InterPro GO_REF:0000002 ion transmembrane transport IBA FB:FBgn0000036 more ... 13792537 PMID:21873635 GO_Central locomotory behavior ISO RGD:10355 1624291 MGI:MGI:2158758 (MGI:MGI:1931636 , PMID:11226318) RGD MGI:MGI:1931636 , PMID:11226318 locomotory behavior IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 membrane depolarization ISO RGD:10355 1624291 MGI:MGI:1926251 more ... RGD MGI:MGI:1931636 more ... membrane depolarization IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 nervous system process ISO RGD:10355 1624291 MGI:MGI:3700204 more ... RGD MGI:MGI:3699045 , PMID:17146052 nervous system process IBA MGI:MGI:1202403 more ... 13792537 PMID:21873635 GO_Central nervous system process ISO RGD:10356 1624291 (PMID:17613539), (PMID:7550350) RGD PMID:17613539 , PMID:7550350 neuromuscular synaptic transmission IBA MGI:MGI:87887 more ... 13792537 PMID:21873635 GO_Central positive regulation of dopamine secretion IDA 8549526 varenicline, nicotine RGD regulation of acetylcholine-gated cation channel activity IMP 704387 RGD regulation of dopamine secretion ISO RGD:10355 1624291 MGI:MGI:1926251 (MGI:MGI:2673776 , PMID:12944511) RGD MGI:MGI:2673776 , PMID:12944511 regulation of dopamine secretion IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of membrane potential ISO RGD:10355 1624291 MGI:MGI:87891 (MGI:MGI:3521544 , PMID:15569257) RGD MGI:MGI:3521544 , PMID:15569257 regulation of membrane potential IBA MGI:MGI:106213 more ... 13792537 PMID:21873635 GO_Central regulation of synaptic vesicle exocytosis IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of synaptic vesicle exocytosis ISO RGD:10355 1624291 (MGI:MGI:2673776, PMID:12944511) RGD MGI:MGI:2673776 , PMID:12944511 respiratory gaseous exchange by respiratory system ISO RGD:10355 1624291 (MGI:MGI:5013879, PMID:21606356) RGD MGI:MGI:5013879 , PMID:21606356 respiratory gaseous exchange by respiratory system IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to hypoxia ISO RGD:10356 1624291 (PMID:12189247) RGD PMID:12189247 response to hypoxia IEA UniProtKB:P43681 , ensembl:ENSP000003592851600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to nicotine ISO RGD:10355 1624291 MGI:MGI:1926251 more ... RGD MGI:MGI:1335979 more ... response to nicotine IBA MGI:MGI:87887 more ... 13792537 PMID:21873635 GO_Central response to nicotine ISO RGD:10356 1624291 (PMID:12189247) RGD PMID:12189247 response to oxidative stress ISO RGD:10356 1624291 (PMID:16332175) RGD PMID:16332175 response to oxidative stress IEA UniProtKB:P43681 , ensembl:ENSP000003592851600115 GO_REF:0000107 Ensembl GO_REF:0000107 sensory perception of pain ISO RGD:10355 1624291 MGI:MGI:1926251 (MGI:MGI:1335979 , PMID:10235262) RGD MGI:MGI:1335979 , PMID:10235262 sensory perception of pain IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 signal transduction ISO RGD:10356 1624291 (PMID:8906617) RGD PMID:8906617 signal transduction IBA PANTHER:PTN000434994 more ... 13792537 PMID:21873635 GO_Central synaptic transmission, cholinergic IMP 1358635 RGD synaptic transmission, cholinergic IBA MGI:MGI:87887 more ... 13792537 PMID:21873635 GO_Central synaptic transmission, cholinergic IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 synaptic transmission, cholinergic ISO RGD:10355 1624291 MGI:MGI:2158758 (MGI:MGI:1931636 more ... RGD MGI:MGI:1931636 more ... Cellular Component acetylcholine-gated channel complex TAS 625623 RGD acetylcholine-gated channel complex IBA MGI:MGI:106213 more ... 13792537 PMID:21873635 GO_Central acetylcholine-gated channel complex IEA UniProtKB:P43681 , ensembl:ENSP000003592851600115 GO_REF:0000107 Ensembl GO_REF:0000107 acetylcholine-gated channel complex IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 acetylcholine-gated channel complex IDA 8549534 ; 8549520 ; 2303190 ; 2303195 RGD acetylcholine-gated channel complex ISO RGD:10356 1624291 (PMID:8906617) RGD PMID:8906617 acetylcholine-gated channel complex ISO RGD:10355 1624291 UniProtKB:Q3KP94 (MGI:MGI:2673776 more ... RGD MGI:MGI:2673776 more ... cell junction IEA UniProtKB-KW:KW-0965 1600115 GO_REF:0000038 UniProt GO_REF:0000038 cell junction IEA UniProtKB-KW:KW-0965 1600115 GO_REF:0000037 UniProt GO_REF:0000037 cholinergic synapse IDA 13702273 PMID:10414976 SynGO cholinergic synapse IDA 1600975 PMID:15044058 SynGO cholinergic synapse EXP 1600975 PMID:15044058 SynGO dendrite IDA 1643016 RGD dopaminergic synapse IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 dopaminergic synapse ISO RGD:10355 1624291 (MGI:MGI:2673776 more ... RGD MGI:MGI:2673776 more ... external side of plasma membrane ISO RGD:10355 1624291 (MGI:MGI:3610855, PMID:15963492) RGD MGI:MGI:3610855 , PMID:15963492 external side of plasma membrane IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000038 UniProt GO_REF:0000038 integral component of plasma membrane IBA FB:FBgn0000036 more ... 13792537 PMID:21873635 GO_Central integral component of postsynaptic specialization membrane IDA 13702273 PMID:10414976 SynGO integral component of presynaptic membrane IDA 13702281 PMID:24607281 SynGO integral component of presynaptic membrane ISO RGD:10355 1624291 (MGI:MGI:5577205 more ... RGD MGI:MGI:5577205 more ... integral component of presynaptic membrane IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 membrane IDA 2303195 RGD membrane ISO RGD:10355 1624291 (MGI:MGI:2176631 more ... RGD MGI:MGI:2176631 more ... neuron projection IBA FB:FBgn0004244 more ... 13792537 PMID:21873635 GO_Central neuronal cell body IDA 1643016 RGD plasma membrane ISO RGD:10355 1624291 (MGI:MGI:3581093 more ... RGD MGI:MGI:3581093 more ... postsynaptic membrane IEA UniProtKB-SubCell:SL-0219 1600115 GO_REF:0000040 UniProt GO_REF:0000040 synapse IBA MGI:MGI:106212 more ... 13792537 PMID:21873635 GO_Central Molecular Function acetylcholine binding IDA 2303194 ; 2303190 RGD acetylcholine binding contributes_to IBA MGI:MGI:87893 , PANTHER:PTN001825425 13792537 PMID:21873635 GO_Central acetylcholine receptor activity ISO RGD:10356 1624291 (PMID:8906617) RGD PMID:8906617 acetylcholine receptor activity contributes_to IBA MGI:MGI:87885 more ... 13792537 PMID:21873635 GO_Central acetylcholine receptor activity IEA UniProtKB:P43681 , ensembl:ENSP000003592851600115 GO_REF:0000107 Ensembl GO_REF:0000107 acetylcholine receptor activity IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 acetylcholine receptor activity contributes_to ISO RGD:10355 1624291 (MGI:MGI:5302654, PMID:12871652) RGD MGI:MGI:5302654 , PMID:12871652 acetylcholine-gated cation-selective channel activity IDA 727641 RGD acetylcholine-gated cation-selective channel activity IEA InterPro:IPR002394 1600115 GO_REF:0000002 InterPro GO_REF:0000002 acetylcholine-gated cation-selective channel activity ISO RGD:10355 1624291 MGI:MGI:1926251 more ... RGD MGI:MGI:2386353 more ... acetylcholine-gated cation-selective channel activity IEA UniProtKB:P43681 , ensembl:ENSP000003592851600115 GO_REF:0000107 Ensembl GO_REF:0000107 acetylcholine-gated cation-selective channel activity IEA UniProtKB:O70174 , ensembl:ENSMUSP000000663381600115 GO_REF:0000107 Ensembl GO_REF:0000107 acetylcholine-gated cation-selective channel activity IMP 8549520 RGD acetylcholine-gated cation-selective channel activity ISO RGD:10356 1624291 (PMID:8906617) RGD PMID:8906617 acetylcholine-gated cation-selective channel activity IC GO:0042166 2303190 RGD drug binding IDA 2303195 ; 2303194 RGD drug binding IDA 8549526 varenicline, nicotine RGD ion channel activity ISO RGD:10355 1624291 (MGI:MGI:2176631, PMID:11906696) RGD MGI:MGI:2176631 , PMID:11906696 protein binding IPI RGD:3966 727641 RGD protein binding ISO RGD:10356 1624291 UniProtKB:P17787 more ... RGD PMID:16238698 more ... protein binding IPI UniProtKB:P12392 10047290 PMID:20566638 IntAct protein binding IPI UniProtKB:P20420 10047290 PMID:20566638 IntAct protein binding IPI UniProtKB:P12390 10047290 PMID:20566638 IntAct protein binding ISO RGD:10355 1624291 UniProtKB:Q8BLC3 more ... RGD MGI:MGI:2176631 more ... protein-containing complex binding IDA 2303195 heterooligomerization RGD protein-containing complex binding IDA 8549534 heterodimerization RGD transmembrane signaling receptor activity IEA InterPro:IPR006201 1600115 GO_REF:0000002 InterPro GO_REF:0000002 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential EXP 1600975 PMID:15044058 SynGO transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IDA 1600975 PMID:15044058 SynGO
Gene-Chemical Interaction Annotations
