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Gene: Ngf (nerve growth factor) Rattus norvegicus
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Symbol: Ngf
Name: nerve growth factor
Description: Predicted to have molecular function regulator and nerve growth factor receptor binding activity. Involved in several processes, including generation of neurons; negative regulation of apoptotic process; and positive regulation of protein phosphorylation. Localizes to the extracellular space. Used to study bladder neck obstruction; cystitis; degenerative disc disease; and neurogenic bladder. Biomarker of several diseases, including diabetic neuropathy; eye disease (multiple); hyperhomocysteinemia; myofascial pain syndrome; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; end stage renal failure; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Orthologous to human NGF (nerve growth factor); PARTICIPATES IN apoptotic cell death pathway; mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta-nerve growth factor; beta-NGF; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta (mapped); Ngfb; Ngfb_mapped; pro-nerve growth factor long
Orthologs:
Homo sapiens (human) : NGF (nerve growth factor)  HGNC  Alliance
Mus musculus (house mouse) : Ngf (nerve growth factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ngf (nerve growth factor)
Pan paniscus (bonobo/pygmy chimpanzee) : NGF (nerve growth factor)
Canis lupus familiaris (dog) : NGF (nerve growth factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ngf (nerve growth factor)
Sus scrofa (pig) : NGF (nerve growth factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02204,886,158 - 204,939,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,886,202 - 204,940,453 (+)Ensembl
Rnor_5.02224,316,210 - 224,369,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,621,726 - 197,632,960 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2182,322,945 - 182,375,918 (+)NCBICelera
Cytogenetic Map2q34NCBI
RH 3.4 Map21294.4RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ngf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1598328
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.