Ngf (nerve growth factor) - Rat Genome Database

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Gene: Ngf (nerve growth factor) Rattus norvegicus
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Symbol: Ngf
Name: nerve growth factor
RGD ID: 1598328
Description: Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; nervous system development; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of neurotrophin TRK receptor signaling pathway and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study several diseases, including bladder neck obstruction; bone disease (multiple); middle cerebral artery infarction; neurogenic bladder; and overactive bladder syndrome. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; borna disease; cryptorchidism; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and opiate dependence (multiple). Orthologous to human NGF (nerve growth factor); PARTICIPATES IN apoptotic cell death pathway; mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-nerve growth factor; beta-NGF; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta (mapped); Ngfb; Ngfb_mapped; pro-nerve growth factor long
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cia10
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82192,589,580 - 192,642,971 (+)NCBIGRCr8
mRatBN7.22189,901,058 - 189,954,452 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2189,901,058 - 189,954,452 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2197,519,156 - 197,572,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02195,377,191 - 195,431,562 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02190,206,371 - 190,261,316 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02204,886,158 - 204,939,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,886,202 - 204,940,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,316,210 - 224,369,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,621,726 - 197,632,960 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2182,322,945 - 182,375,918 (+)NCBICelera
RH 3.4 Map21294.4RGD
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
alcohol dependence  (IEP,ISO)
alcohol use disorder  (IEP,ISO)
Alcohol Withdrawal Delirium  (ISO)
alcohol withdrawal syndrome  (ISO)
Alcohol-Related Disorders  (IEP,ISO)
Alcoholic Intoxication  (ISO)
Alzheimer's disease  (IEP)
amnestic disorder  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
bacterial meningitis  (IEP)
bipolar disorder  (ISO)
bladder disease  (ISO)
bladder neck obstruction  (IDA)
borna disease  (IEP)
Bronchial Hyperreactivity  (ISO)
Burns  (IMP)
cannabis abuse  (ISO)
Charcot-Marie-Tooth disease  (ISO)
chronic asthma  (IMP)
chronic kidney disease  (ISO)
Chronic Pancreatitis  (IEP)
chronic ulcer of skin  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
Congenital Pain Insensitivity  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
cryptorchidism  (IEP)
cystitis  (IMP,ISO)
degenerative disc disease  (IMP)
depressive disorder  (IEP)
diabetic encephalopathy  (ISO)
diabetic neuropathy  (IEP)
diabetic retinopathy  (IMP,ISO)
end stage renal disease  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
genetic disease  (ISO)
glaucoma  (IEP)
glomerulonephritis  (ISO)
hereditary sensory and autonomic neuropathy type 5  (ISO)
hereditary sensory neuropathy  (ISO)
heroin dependence  (ISO)
Hyperalgesia  (IDA,IMP,ISO)
hyperhomocysteinemia  (IEP)
Hyperkinesis  (ISO)
hypertension  (IEP)
hypothyroidism  (IEP)
IgA glomerulonephritis  (ISO)
Inflammation  (IEP,ISO)
interstitial cystitis  (ISO)
interstitial lung disease  (ISO)
interstitial nephritis  (ISO)
Lewy body dementia  (ISO)
Lung Injury  (ISO)
malignant mesothelioma  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (IMP,ISO)
morphine dependence  (IEP)
myocardial infarction  (ISO)
myofascial pain syndrome  (IEP)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Neurobehavioral Manifestations  (ISO)
neurodegenerative disease  (ISO)
neurogenic bladder  (IDA,ISO)
Neurogenic Inflammation  (ISO)
nicotine dependence  (ISO)
non-alcoholic fatty liver  (ISO)
obstructive sleep apnea  (ISO)
opiate dependence  (ISO)
opiate withdrawal syndrome  (ISO)
Optic Nerve Injuries  (IEP)
osteoarthritis  (IMP)
overactive bladder syndrome  (IDA,ISO)
Pain  (IMP,ISO)
Parkinson's disease  (ISO)
Parkinsonism  (IEP,ISO)
Peripheral Nerve Injuries  (IEP,IMP,ISO)
peripheral nervous system disease  (ISO)
Postoperative Cognitive Dysfunction  (IEP,ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
RASopathy  (ISO)
respiratory syncytial virus infectious disease  (IEP)
retinal vascular disease  (ISO)
retinitis pigmentosa  (IEP)
Retrograde Degeneration  (IMP)
rhinitis  (ISO)
Rib Fractures  (IEP)
Rotator Cuff Injuries  (IEP)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
sensorineural hearing loss  (ISO)
separation anxiety disorder  (IEP)
Skeletal Muscle Injuries  (IMP)
Spinal Cord Injuries  (IEP,IMP)
status epilepticus  (ISO)
stress-related disorder  (IEP)
Stroke  (IMP)
systemic scleroderma  (ISO)
traumatic brain injury  (IMP)
withdrawal disorder  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
13,14-dihydro-Delta(12)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-methylcatechol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
agathisflavone  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
Asiaticoside  (EXP)
ATP  (EXP)
atrazine  (EXP)
azamethiphos  (EXP)
Bay-K-8644  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-D-glucosamine  (EXP)
bicuculline  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromocriptine  (ISO)
bucladesine  (ISO)
C60 fullerene  (EXP)
cabergoline  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
calmidazolium  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbon monoxide  (EXP)
carmustine  (EXP)
carrageenan  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
colistin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
cyanocob(III)alamin  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (EXP)
dieldrin  (EXP,ISO)
dihydrolipoic acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dopaminechrome (enol form)  (EXP)
doxorubicin  (ISO)
ebselen  (ISO)
echinacoside  (EXP)
edaravone  (ISO)
endosulfan  (EXP)
epalrestat  (EXP)
epinastine  (ISO)
epothilone B  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
everolimus  (EXP)
excitatory amino acid agonist  (EXP)
fenthion  (ISO)
fluphenazine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
Fusarenone X  (ISO)
Geniposide pentaacetate  (EXP)
genistein  (EXP)
gentamycin  (EXP)
ginsenoside Rd  (ISO)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glutathione disulfide  (ISO)
glycidol  (EXP)
Goe 6976  (EXP)
heptachlor  (EXP)
heroin  (ISO)
histamine  (EXP)
hydrogen peroxide  (EXP)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (EXP)
ketamine  (EXP)
ketotifen  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP,ISO)
malathion  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
masoprocol  (EXP)
mepyramine  (EXP)
mercury atom  (EXP,ISO)
mercury(0)  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
microcystin-LR  (ISO)
mithramycin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naproxen  (EXP)
nickel atom  (EXP,ISO)
nicotine  (ISO)
nifedipine  (EXP)
nimesulide  (EXP)
nitrates  (EXP)
nitric oxide  (EXP)
nocodazole  (EXP)
Nonylphenol  (EXP)
O-acetyl-L-carnitine  (EXP)
okadaic acid  (EXP)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
panaxydol  (EXP)
paracetamol  (EXP,ISO)
parathion-methyl  (EXP)
PD-166866  (EXP)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
pergolide  (ISO)
permethrin  (EXP)
peroxynitrous acid  (EXP)
phenethyl caffeate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium atom  (EXP)
procymidone  (EXP)
progesterone  (EXP)
promethazine  (EXP)
propofol  (EXP)
propranolol  (EXP)
prostaglandin E2  (EXP)
Ptaquiloside  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
ranitidine  (EXP)
reactive oxygen species  (EXP,ISO)
reserpine  (EXP)
resveratrol  (EXP)
rofecoxib  (EXP)
roflumilast  (EXP)
rotenone  (EXP)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salidroside  (EXP)
salubrinal  (ISO)
SB 203580  (EXP)
scopolamine  (EXP,ISO)
SKF 38393  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sorbinil  (EXP)
staurosporine  (EXP,ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (EXP)
taurine  (EXP)
temozolomide  (ISO)
terbutaline  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thiopental  (EXP)
thymoquinone  (EXP)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triprolidine  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
udenafil  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
vindesine  (EXP)
wortmannin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (IMP)
axon extension  (ISO)
cell population proliferation  (IMP)
cell proliferation in forebrain  (IMP)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA)
circadian rhythm  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
memory  (IMP)
modulation of chemical synaptic transmission  (IBA)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (NAS)
negative regulation of neuron apoptotic process  (IBA,IMP,ISO)
negative regulation of type B pancreatic cell apoptotic process  (IMP)
nerve development  (IBA)
nerve growth factor signaling pathway  (IBA,ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (IMP)
neuron projection development  (IDA,ISO)
neuron projection morphogenesis  (IBA,IEA,ISO)
peripheral nervous system development  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cell growth  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of collateral sprouting  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of neuron differentiation  (IDA)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of neurotrophin TRK receptor signaling pathway  (IDA)
positive regulation of peptidyl-serine phosphorylation  (IBA)
positive regulation of protein autophosphorylation  (IDA)
positive regulation of protein phosphorylation  (IDA,ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of stem cell proliferation  (IDA)
regulation of neuron differentiation  (ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
response to electrical stimulus  (IEP)
response to glucocorticoid  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to nicotine  (IEP)
response to organic cyclic compound  (IEP)
response to ozone  (IEP)
response to peptide hormone  (IEP)
response to xenobiotic stimulus  (IEP)
sensory perception of hot stimulus  (IDA)
sensory perception of pain  (ISO)
spermatogenesis  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex] Agapova TIu, etal., Mol Gen Mikrobiol Virusol. 2008;(3):28-32.
2. Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes . Al-Gayyar MM, etal., Diabetologia. 2011 Mar;54(3):669-80. Epub 2010 Dec 7.
3. Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons. Allard S, etal., Neurobiol Aging. 2018 Jul;67:10-20. doi: 10.1016/j.neurobiolaging.2018.03.002. Epub 2018 Mar 9.
4. Changes in human plasma nerve growth factor level after chronic alcohol consumption and withdrawal. Aloe L, etal., Alcohol Clin Exp Res. 1996 May;20(3):462-5. doi: 10.1111/j.1530-0277.1996.tb01076.x.
5. Reduced serum concentrations of nerve growth factor, but not brain-derived neurotrophic factor, in chronic cannabis abusers. Angelucci F, etal., Eur Neuropsychopharmacol. 2008 Dec;18(12):882-7. doi: 10.1016/j.euroneuro.2008.07.008. Epub 2008 Sep 6.
6. Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. Angelucci F, etal., J Psychopharmacol. 2007 Nov;21(8):820-5. doi: 10.1177/0269881107078491. Epub 2007 Aug 22.
7. Prenatal ethanol effects on NGF level, NPY and ChAT immunoreactivity in mouse entorhinal cortex: a preliminary study. Angelucci F, etal., Neurotoxicol Teratol. 1999 Jul-Aug;21(4):415-25. doi: 10.1016/s0892-0362(99)00005-7.
8. Nerve growth factor and its monocyte receptors are affected in kidney disease. Antonucci MT, etal., Nephron Clin Pract. 2009;111(1):c21-8. doi: 10.1159/000178819. Epub 2008 Dec 9.
9. Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement. Araújo-Filho HG, etal., Int Immunopharmacol. 2020 Sep;86:106766. doi: 10.1016/j.intimp.2020.106766. Epub 2020 Jul 8.
10. Evaluation of the brain-derived neurotrophic factor, nerve growth factor and memory in adult rats survivors of the neonatal meningitis by Streptococcus agalactiae. Barichello T, etal., Brain Res Bull. 2013 Mar;92:56-9. doi: 10.1016/j.brainresbull.2012.05.014. Epub 2012 Jun 7.
11. Endothelin ETA receptor antagonist reverses naloxone-precipitated opioid withdrawal in mice. Bhalla S, etal., Can J Physiol Pharmacol. 2015 Nov;93(11):935-44. doi: 10.1139/cjpp-2015-0022. Epub 2015 Apr 28.
12. Upregulation of nerve growth factor in central amygdala increases sensitivity to opioid reward. Bie B, etal., Neuropsychopharmacology. 2012 Dec;37(13):2780-8. doi: 10.1038/npp.2012.144. Epub 2012 Aug 8.
13. Intravesical Escherichia coli lipopolysaccharide stimulates an increase in bladder nerve growth factor. Bjorling DE, etal., BJU Int. 2001 May;87(7):697-702.
14. Functional characterization of a chronic cyclophosphamide-induced overactive bladder model in mice. Boudes M, etal., Neurourol Urodyn. 2011 Nov;30(8):1659-65. doi: 10.1002/nau.21180. Epub 2011 Jun 29.
15. Expression of nerve growth factor carried by pseudotyped lentivirus improves neuron survival and cognitive functional recovery of post-ischemia in rats. Cao JY, etal., CNS Neurosci Ther. 2018 Jun;24(6):508-518. doi: 10.1111/cns.12818. Epub 2018 Feb 6.
16. NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Chaldakov GN, etal., Arch Physiol Biochem. 2001 Oct;109(4):357-60.
17. Nerve growth factor levels and mast cell distribution in human coronary atherosclerosis. Chaldakov GN, etal., Atherosclerosis. 2001 Nov;159(1):57-66.
18. Combination therapy with intranasal NGF and electroacupuncture enhanced cell proliferation and survival in rats after stroke. Cheng S, etal., Neurol Res. 2008 Dec 5.
19. Effect of angiotensin II receptor antagonist telmisartan on detrusor overactivity in rats with bladder outlet obstruction. Cho ST, etal., Urology. 2012 Nov;80(5):1163.e1-7. doi: 10.1016/j.urology.2012.05.002. Epub 2012 Jul 13.
20. Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis. Chung CW, etal., J Biol Chem. 2010 Feb 5;285(6):4206-12. doi: 10.1074/jbc.M109.040444. Epub 2009 Dec 7.
21. Increased neurotrophin production in a Penicillium chrysogenum-induced allergic asthma model in mice. Chung YJ, etal., J Toxicol Environ Health A. 2007 Jun;70(12):1020-6.
22. Stretch-activated signaling of nerve growth factor secretion in bladder and vascular smooth muscle cells from hypertensive and hyperactive rats. Clemow DB, etal., J Cell Physiol. 2000 Jun;183(3):289-300.
23. Mucosal expression of nerve growth factor and brain-derived neurotrophic factor in chronic rhinosinusitis. Coffey CS, etal., Am J Rhinol Allergy. 2009 Nov-Dec;23(6):571-4.
24. Variation in NGFB is associated with primary affective disorders in women. Cui D, etal., Am J Med Genet B Neuropsychiatr Genet. 2011 Jun;156B(4):401-12. doi: 10.1002/ajmg.b.31175. Epub 2011 Feb 3.
25. Neurotrophins and neurotrophin receptors in pulmonary sarcoidosis - granulomas as a source of expression. Dagnell C, etal., Respir Res. 2010 Nov 8;11:156.
26. mRNA for NGF and p75 in the central nervous system of rats affected by experimental allergic encephalomyelitis. De Simone R, etal., Neuropathol Appl Neurobiol. 1996 Feb;22(1):54-9.
27. Methamphetamine reversed maternal separation-induced decrease in nerve growth factor in the ventral hippocampus. Dimatelis JJ, etal., Metab Brain Dis. 2014 Jun;29(2):433-9. doi: 10.1007/s11011-014-9481-z. Epub 2014 Jan 11.
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PMID:11877426   PMID:11927634   PMID:12376548   PMID:12388545   PMID:12473665   PMID:12857442   PMID:14623868   PMID:14736860   PMID:14985763   PMID:15033464   PMID:15262992   PMID:15572370  
PMID:15739121   PMID:16079148   PMID:16153003   PMID:16298082   PMID:16516892   PMID:16854632   PMID:16956580   PMID:17013810   PMID:17045017   PMID:17663741   PMID:17724343   PMID:17764660  
PMID:17870109   PMID:17952852   PMID:17999938   PMID:18006272   PMID:18052984   PMID:18345501   PMID:18351465   PMID:18496748   PMID:18561899   PMID:18601856   PMID:18628984   PMID:18635195  
PMID:18660503   PMID:18690044   PMID:18709849   PMID:18728191   PMID:18817846   PMID:19013137   PMID:19019738   PMID:19036963   PMID:19100726   PMID:19104181   PMID:19125373   PMID:19150448  
PMID:19229990   PMID:19265194   PMID:19286942   PMID:19286963   PMID:19288273   PMID:19291685   PMID:19368814   PMID:19372237   PMID:19473768   PMID:19505442   PMID:19524110   PMID:19581298  
PMID:19585233   PMID:19596387   PMID:19662538   PMID:19696022   PMID:19722155   PMID:19726646   PMID:19762468   PMID:19802389   PMID:20155803   PMID:20164177   PMID:20170723   PMID:20220009  
PMID:20333299   PMID:20335077   PMID:20388358   PMID:20473744   PMID:20490673   PMID:20495008   PMID:20644345   PMID:20683769   PMID:20965859   PMID:21111819   PMID:21137370   PMID:21207218  
PMID:21270900   PMID:21295348   PMID:21312342   PMID:21408608   PMID:21473865   PMID:21549807   PMID:21561603   PMID:21640078   PMID:21642505   PMID:21677785   PMID:21889978   PMID:21938476  
PMID:21961236   PMID:22038828   PMID:22065583   PMID:22073361   PMID:22141271   PMID:22147490   PMID:22233577   PMID:22238106   PMID:22280975   PMID:22323714   PMID:22384148   PMID:22384237  
PMID:22411744   PMID:22479579   PMID:22496904   PMID:22500463   PMID:22532231   PMID:22580175   PMID:22742729   PMID:22744968   PMID:22834730   PMID:23015435   PMID:23157347   PMID:23158009  
PMID:23190308   PMID:23234417   PMID:23255148   PMID:23460346   PMID:23468336   PMID:23559405   PMID:23743199   PMID:23785138   PMID:23872662   PMID:23874817   PMID:23959444   PMID:24006456  
PMID:24154957   PMID:24265601   PMID:24270184   PMID:24303055   PMID:24327613   PMID:24380503   PMID:24508054   PMID:24620979   PMID:24713110   PMID:24733831   PMID:24760869   PMID:24771956  
PMID:24913185   PMID:24921856   PMID:24978930   PMID:25049196   PMID:25231981   PMID:25297375   PMID:25394845   PMID:25397406   PMID:25401376   PMID:25542970   PMID:25644424   PMID:25691569  
PMID:25801841   PMID:25897972   PMID:26121254   PMID:26347141   PMID:26521746   PMID:26588713   PMID:26608656   PMID:26681653   PMID:26709397   PMID:26724365   PMID:26966186   PMID:27569259  
PMID:27655914   PMID:27762470   PMID:27789288   PMID:27830679   PMID:27978417   PMID:28549966   PMID:28685530   PMID:28843696   PMID:28865749   PMID:29052293   PMID:29202822   PMID:29420916  
PMID:29483280   PMID:29523370   PMID:29895019   PMID:29901090   PMID:30553789   PMID:30592331   PMID:30911955   PMID:31298358   PMID:31575913   PMID:31638328   PMID:31875259   PMID:31980031  
PMID:32083755   PMID:32169062   PMID:32246947   PMID:32279149   PMID:32685448   PMID:33191703   PMID:33476055   PMID:33529756   PMID:33716987   PMID:34209299   PMID:34943971   PMID:34969767  
PMID:36232740   PMID:36766714   PMID:37699453   PMID:38312021   PMID:38637413   PMID:38725127  


Genomics

Comparative Map Data
Ngf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82192,589,580 - 192,642,971 (+)NCBIGRCr8
mRatBN7.22189,901,058 - 189,954,452 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2189,901,058 - 189,954,452 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2197,519,156 - 197,572,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02195,377,191 - 195,431,562 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02190,206,371 - 190,261,316 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02204,886,158 - 204,939,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,886,202 - 204,940,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,316,210 - 224,369,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,621,726 - 197,632,960 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2182,322,945 - 182,375,918 (+)NCBICelera
RH 3.4 Map21294.4RGD
Cytogenetic Map2q34NCBI
NGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381115,285,917 - 115,338,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1115,285,904 - 115,338,770 (-)EnsemblGRCh38hg38GRCh38
GRCh371115,828,538 - 115,880,870 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,630,060 - 115,682,380 (-)NCBINCBI36Build 36hg18NCBI36
Build 341115,540,580 - 115,592,899NCBI
Celera1114,057,456 - 114,109,776 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1113,686,915 - 113,739,240 (-)NCBIHuRef
CHM1_11115,943,440 - 115,995,752 (-)NCBICHM1_1
T2T-CHM13v2.01115,297,082 - 115,349,408 (-)NCBIT2T-CHM13v2.0
Ngf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393102,377,235 - 102,428,329 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3102,377,235 - 102,428,329 (+)EnsemblGRCm39 Ensembl
GRCm383102,469,919 - 102,521,013 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3102,469,919 - 102,521,013 (+)EnsemblGRCm38mm10GRCm38
MGSCv373102,273,851 - 102,324,936 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363102,598,989 - 102,650,066 (+)NCBIMGSCv36mm8
Celera3104,674,123 - 104,724,621 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.25NCBI
Ngf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,581,808 - 18,601,059 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,581,889 - 18,633,330 (-)NCBIChiLan1.0ChiLan1.0
NGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21107,940,198 - 107,992,897 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11107,539,320 - 107,592,441 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0187,223,597 - 87,276,759 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11122,272,750 - 122,325,909 (+)NCBIpanpan1.1PanPan1.1panPan2
NGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11752,900,647 - 52,901,607 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1752,900,647 - 52,901,607 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1752,550,068 - 52,550,845 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01753,781,750 - 53,834,593 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1753,781,750 - 53,782,527 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11752,820,833 - 52,821,610 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01752,855,816 - 52,856,593 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01753,428,944 - 53,429,721 (-)NCBIUU_Cfam_GSD_1.0
Ngf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505813,803,009 - 13,853,189 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936627635,788 - 645,364 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936627635,784 - 641,290 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4105,256,749 - 105,307,837 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14105,256,691 - 105,307,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24115,436,784 - 115,446,393 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12018,361,795 - 18,413,987 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2018,413,108 - 18,413,833 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603821,083,578 - 21,157,325 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ngf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477211,010,845 - 11,070,017 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477211,009,765 - 11,070,050 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ngf
224 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:37
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000022200
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2184974550193094998Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat

Markers in Region
RH142206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,954,674 - 189,954,867 (+)MAPPERmRatBN7.2
Rnor_6.02204,939,746 - 204,939,938NCBIRnor6.0
Rnor_5.02224,369,886 - 224,370,078UniSTSRnor5.0
RGSC_v3.42197,633,183 - 197,633,375UniSTSRGSC3.4
Celera2182,376,141 - 182,376,333UniSTS
RH 3.4 Map21294.4UniSTS
Cytogenetic Map2q34UniSTS
NGFB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,953,767 - 189,953,914 (+)MAPPERmRatBN7.2
Rnor_6.02204,938,839 - 204,938,985NCBIRnor6.0
Rnor_5.02224,368,979 - 224,369,125UniSTSRnor5.0
RGSC_v3.42197,632,276 - 197,632,422UniSTSRGSC3.4
Celera2182,375,234 - 182,375,380UniSTS
Cytogenetic Map2q34UniSTS
PMC20267P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,953,922 - 189,954,216 (+)MAPPERmRatBN7.2
Rnor_6.02204,938,994 - 204,939,287NCBIRnor6.0
Rnor_5.02224,369,134 - 224,369,427UniSTSRnor5.0
RGSC_v3.42197,632,431 - 197,632,724UniSTSRGSC3.4
Celera2182,375,389 - 182,375,682UniSTS
Cytogenetic Map2q34UniSTS
NGFB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22189,953,678 - 189,953,782 (+)MAPPERmRatBN7.2
Rnor_6.02204,938,750 - 204,938,853NCBIRnor6.0
Rnor_5.02224,368,890 - 224,368,993UniSTSRnor5.0
RGSC_v3.42197,632,187 - 197,632,290UniSTSRGSC3.4
Celera2182,375,145 - 182,375,248UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 31 32 17 18 17 6 6 35 35 34 8 6
Below cutoff 2 10 19 18 1 18 2 5 37 7 3 2

Sequence


RefSeq Acc Id: ENSRNOT00000022200   ⟹   ENSRNOP00000022200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2189,901,058 - 189,954,452 (+)Ensembl
Rnor_6.0 Ensembl2204,886,202 - 204,939,523 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078376   ⟹   ENSRNOP00000072445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2204,932,159 - 204,940,453 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094599   ⟹   ENSRNOP00000088176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2189,921,396 - 189,954,452 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097020   ⟹   ENSRNOP00000089587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2189,901,152 - 189,954,279 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115339   ⟹   ENSRNOP00000082212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2189,943,274 - 189,954,452 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116899   ⟹   ENSRNOP00000097792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2189,901,499 - 189,954,446 (+)Ensembl
RefSeq Acc Id: NM_001277055   ⟹   NP_001263984
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82192,589,580 - 192,642,971 (+)NCBI
mRatBN7.22189,901,058 - 189,954,452 (+)NCBI
Rnor_6.02204,886,202 - 204,939,523 (+)NCBI
Rnor_5.02224,316,210 - 224,369,663 (+)NCBI
Celera2182,322,945 - 182,375,918 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102402   ⟹   XP_038958330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82192,636,116 - 192,642,969 (+)NCBI
mRatBN7.22189,947,597 - 189,954,452 (+)NCBI
RefSeq Acc Id: XM_063281907   ⟹   XP_063137977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82192,589,586 - 192,642,969 (+)NCBI
RefSeq Acc Id: NP_001263984   ⟸   NM_001277055
- Peptide Label: precursor
- UniProtKB: P25427 (UniProtKB/Swiss-Prot),   A6K3I9 (UniProtKB/TrEMBL),   A0A8I6A8J2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072445   ⟸   ENSRNOT00000078376
RefSeq Acc Id: ENSRNOP00000022200   ⟸   ENSRNOT00000022200
RefSeq Acc Id: XP_038958330   ⟸   XM_039102402
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2Z7 (UniProtKB/TrEMBL),   A0A8I6AA86 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089587   ⟸   ENSRNOT00000097020
RefSeq Acc Id: ENSRNOP00000097792   ⟸   ENSRNOT00000116899
RefSeq Acc Id: ENSRNOP00000082212   ⟸   ENSRNOT00000115339
RefSeq Acc Id: ENSRNOP00000088176   ⟸   ENSRNOT00000094599
RefSeq Acc Id: XP_063137977   ⟸   XM_063281907
- Peptide Label: isoform X2
- UniProtKB: P25427 (UniProtKB/Swiss-Prot),   A0A8I6A8J2 (UniProtKB/TrEMBL),   A6K3I9 (UniProtKB/TrEMBL)
Protein Domains
Nerve growth factor-related

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25427-F1-model_v2 AlphaFold P25427 1-241 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691620
Promoter ID:EPDNEW_R2145
Type:single initiation site
Name:Ngf_1
Description:nerve growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02204,886,202 - 204,886,262EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598328 AgrOrtholog
BioCyc Gene G2FUF-51836 BioCyc
Ensembl Genes ENSRNOG00000016571 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055019867 UniProtKB/Swiss-Prot
  ENSRNOG00060030051 UniProtKB/Swiss-Prot
  ENSRNOG00065030707 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022200 ENTREZGENE
  ENSRNOT00000022200.7 UniProtKB/Swiss-Prot
  ENSRNOT00000094599.1 UniProtKB/TrEMBL
  ENSRNOT00000097020.1 UniProtKB/TrEMBL
  ENSRNOT00000115339.1 UniProtKB/TrEMBL
  ENSRNOT00000116899.1 UniProtKB/Swiss-Prot
  ENSRNOT00055033970 UniProtKB/Swiss-Prot
  ENSRNOT00055033983 UniProtKB/Swiss-Prot
  ENSRNOT00060052234 UniProtKB/Swiss-Prot
  ENSRNOT00060052266 UniProtKB/Swiss-Prot
  ENSRNOT00065052921 UniProtKB/Swiss-Prot
  ENSRNOT00065052933 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor_bsu_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310738 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 310738 ENTREZGENE
PANTHER BETA-NERVE GROWTH FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11589 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NGF RGD
PhenoGen Ngf PhenoGen
PIRSF NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MAMLNGFBETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NGFBETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016571 RatGTEx
  ENSRNOG00055019867 RatGTEx
  ENSRNOG00060030051 RatGTEx
  ENSRNOG00065030707 RatGTEx
SMART NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K2Z7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWC1_RAT UniProtKB/TrEMBL
  A0A8I6A8J2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AA86 ENTREZGENE, UniProtKB/TrEMBL
  A6K3I9 ENTREZGENE, UniProtKB/TrEMBL
  NGF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-17 Ngf  nerve growth factor  Ngf  nerve growth factor (beta polypeptide)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ngf  nerve growth factor (beta polypeptide)  Ngf  nerve growth factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Ngf  nerve growth factor  Ngfb  nerve growth factor, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   nerve growth factor, beta  Ngfb  nerve growth factor, beta (mapped)  Name updated 737654 APPROVED
2007-04-11 Ngfb  nerve growth factor, beta (mapped)  Ngfb_mapped  nerve growth factor, beta (mapped)  Data merged from RGD:3174 737654 APPROVED
2006-11-20 Ngfb  nerve growth factor, beta (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Ngfb_mapped  nerve growth factor, beta (mapped)  Ngfb  nerve growth factor, beta  Symbol and Name updated 1556543 APPROVED
2002-06-10 Ngfb  Nerve growth factor, beta polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the CNS 1302255
gene_expression expression is not altered by 60 Hz magnetic fields (EMFs) during gestation and lactation 1302255
gene_function functions in brain development 1302255
gene_homology mouse Ngfb exhibits growth factor, receptor signaling and brain developmental functions 704405
gene_regulation developmentally regulated in the central nervous system 1302255