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Gene: Ngf (nerve growth factor) Rattus norvegicus
Symbol: Ngf
Name: nerve growth factor
RGD ID: 1598328
Description: Predicted to have molecular function regulator and nerve growth factor receptor binding activity. Involved in several processes, including generation of neurons; negative regulation of apoptotic process; and positive regulation of protein phosphorylation. Localizes to extracellular space. Used to study bladder neck obstruction; cystitis; degenerative disc disease; and neurogenic bladder. Biomarker of several diseases, including diabetic neuropathy; hyperhomocysteinemia; mental depression; myofascial pain syndrome; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Orthologous to human NGF (nerve growth factor); PARTICIPATES IN apoptotic cell death pathway; mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta-nerve growth factor; beta-NGF; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta (mapped); Ngfb; Ngfb_mapped; pro-nerve growth factor long
Homo sapiens (human) : NGF (nerve growth factor)  HGNC  Alliance
Mus musculus (house mouse) : Ngf (nerve growth factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ngf (nerve growth factor)
Pan paniscus (bonobo/pygmy chimpanzee) : NGF (nerve growth factor)
Canis lupus familiaris (dog) : NGF (nerve growth factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ngf (nerve growth factor)
Sus scrofa (pig) : NGF (nerve growth factor)
Chlorocebus sabaeus (African green monkey) : NGF (nerve growth factor)
Heterocephalus glaber (naked mole-rat) : Ngf (nerve growth factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02204,886,158 - 204,939,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,886,202 - 204,940,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,316,210 - 224,369,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,621,726 - 197,632,960 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2182,322,945 - 182,375,918 (+)NCBICelera
Cytogenetic Map2q34NCBI
RH 3.4 Map21294.4RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ngf
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1598328
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-11-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.