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Gene: Ntrk2 (neurotrophic receptor tyrosine kinase 2) Rattus norvegicus
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Symbol: Ntrk2
Name: neurotrophic receptor tyrosine kinase 2
RGD ID: 3213
Description: Exhibits several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor-activated receptor activity; and protein homodimerization activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; positive regulation of cell communication; and regulation of neuron projection development. Localizes to several cellular components, including distal axon; perikaryon; and postsynaptic density. Used to study glaucoma. Biomarker of several diseases, including attention deficit hyperactivity disorder; colitis; mental depression; post-traumatic stress disorder; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; early infantile epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BDNF/NT-3 growth factors receptor; GP145-TrkB/GP95-TrkB; Neural receptor protein-tyrosine kinase (trkB); neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; RATTRKB1; Tkrb; trk-B; trkB; trkB tyrosine kinase; TRKB1
Orthologs:
Homo sapiens (human) : NTRK2 (neurotrophic receptor tyrosine kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ntrk2 (neurotrophic receptor tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Canis lupus familiaris (dog) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ntrk2 (neurotrophic receptor tyrosine kinase 2)
Sus scrofa (pig) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Chlorocebus sabaeus (African green monkey) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Heterocephalus glaber (naked mole-rat) : Ntrk2 (neurotrophic receptor tyrosine kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0175,934,651 - 6,245,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,933,729 - 6,244,676 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0178,156,432 - 8,464,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41711,494,463 - 11,811,654 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11711,494,462 - 11,811,645 (-)NCBI
Celera175,673,895 - 6,828,108 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ntrk2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3213
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.