Ntrk2 (neurotrophic receptor tyrosine kinase 2) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ntrk2 (neurotrophic receptor tyrosine kinase 2) Rattus norvegicus
Symbol: Ntrk2
Name: neurotrophic receptor tyrosine kinase 2
RGD ID: 3213
Description: Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway. Located in several cellular components, including dendritic spine; distal axon; and perikaryon. Is active in glutamatergic synapse and postsynaptic membrane. Used to study glaucoma. Biomarker of several diseases, including attention deficit hyperactivity disorder; colitis; depressive disorder; post-traumatic stress disorder; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BDNF/NT-3 growth factors receptor; GP145-TrkB/GP95-TrkB; Neural receptor protein-tyrosine kinase (trkB); neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; RATTRKB1; Tkrb; trk-B; trkB; trkB tyrosine kinase; TRKB1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2175,558,992 - 5,870,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl175,559,043 - 5,869,136 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx175,584,315 - 5,894,662 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0177,120,448 - 7,429,363 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0175,580,732 - 5,891,094 (-)NCBIRnor_WKY
Rnor_6.0175,934,651 - 6,245,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,933,729 - 6,244,676 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0178,156,432 - 8,464,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41711,494,463 - 11,811,654 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11711,494,462 - 11,811,645 (-)NCBI
Celera175,673,895 - 6,828,108 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-syringaresinol beta-D-glucoside  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Solamarine  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP)
arsanilic acid  (EXP)
arsenic atom  (EXP)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buprenorphine  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
citalopram  (ISO)
Citreoviridin  (ISO)
clomipramine  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
cyproconazole  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP,ISO)
dioxygen  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
echinacoside  (EXP,ISO)
endrin  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
graphite  (EXP)
heroin  (ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
indometacin  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
kainic acid  (EXP)
ketamine  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
linuron  (EXP)
lipopolysaccharide  (ISO)
lycopene  (EXP)
malathion  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylglyoxal  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
mifepristone  (EXP)
morin  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
nickel atom  (EXP)
nicotine  (ISO)
nicotinic acid  (EXP)
Nonylphenol  (EXP,ISO)
papaverine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
Phenelzine  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
physostigmine  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
Ptaquiloside  (ISO)
reboxetine  (ISO)
reserpine  (ISO)
rolipram  (EXP,ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
SB 431542  (ISO)
scopolamine  (EXP,ISO)
sevoflurane  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tacrine  (ISO)
tamibarotene  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
Tetrachlorobisphenol A  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
tranylcypromine  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
WIN 55212-2  (ISO)
zalcitabine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain-derived neurotrophic factor receptor signaling pathway  (IDA,IEA,IMP,ISO)
calcium-mediated signaling using intracellular calcium source  (ISO)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to brain-derived neurotrophic factor stimulus  (IBA,IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to tumor necrosis factor  (IEP)
central nervous system neuron development  (IEA,ISO,ISS)
cerebral cortex development  (IEA,ISO,ISS)
circadian rhythm  (IEA,ISO)
feeding behavior  (IEA,ISO)
glutamate secretion  (IEA,ISO)
learning  (IEA,ISO,ISS)
long-term memory  (IDA)
long-term synaptic potentiation  (IEA,ISO)
mechanoreceptor differentiation  (IEA,ISO)
myelination in peripheral nervous system  (IEA,ISO)
negative regulation of amyloid-beta formation  (IEA,ISO)
negative regulation of anoikis  (IEA,ISO)
negative regulation of neuron apoptotic process  (IMP)
neuromuscular junction development  (ISO)
neuron differentiation  (ISO,ISS)
neuron migration  (IEA,ISO,ISS)
neuronal action potential propagation  (IEA,ISO)
neurotrophin signaling pathway  (IEA)
oligodendrocyte differentiation  (IEA,ISO)
peptidyl-serine phosphorylation  (IEA,ISO)
peripheral nervous system neuron development  (IEA,ISO)
positive regulation of axonogenesis  (IMP)
positive regulation of cell population proliferation  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IBA)
positive regulation of gene expression  (IEA,ISO,ISS)
positive regulation of glucocorticoid receptor signaling pathway  (IGI)
positive regulation of kinase activity  (IBA)
positive regulation of MAPK cascade  (IMP)
positive regulation of neuron projection development  (IBA,IEA,ISO,ISS)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IBA,IMP)
positive regulation of synapse assembly  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (IMP)
protein autophosphorylation  (IDA,IMP)
protein phosphorylation  (IEA)
regulation of dendrite development  (IMP)
regulation of GTPase activity  (IEA,ISO,ISS)
regulation of MAPK cascade  (IDA)
regulation of metabolic process  (ISO)
regulation of neurotransmitter secretion  (IDA)
regulation of protein kinase B signaling  (IBA,IEA,ISO)
response to auditory stimulus  (IEP)
response to light stimulus  (IEP)
retina development in camera-type eye  (ISO)
retinal rod cell development  (IEA,ISO)
trans-synaptic signaling by BDNF, modulating synaptic transmission  (IEA,ISO)
trans-synaptic signaling by neuropeptide, modulating synaptic transmission  (IBA,IEA,ISO)
transmembrane receptor protein serine/threonine kinase signaling pathway  (IEA)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,IEA)
vasculogenesis  (IEA,ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Co-localization of caldesmon and calponin with cortical afferents, metabotropic glutamate and neurotrophic receptors in the lateral and central nuclei of the amygdala. Agassandian K and Cassell MD, Brain Res. 2008 Aug 21;1226:39-55. Epub 2008 Jun 11.
2. 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. Andero R, etal., Hippocampus. 2010 Dec 6.
3. Localization of brain-derived neurotrophic factor and TrkB receptors to postsynaptic densities of adult rat cerebral cortex. Aoki C, etal., J Neurosci Res. 2000 Feb 1;59(3):454-63. doi: 10.1002/(SICI)1097-4547(20000201)59:3<454::AID-JNR21>3.0.CO;2-H.
4. Temporal and spatial differences in expression of TrkB isoforms in rat retina during constant light exposure. Asai N, etal., Exp Eye Res. 2007 Sep;85(3):346-55. Epub 2007 Jun 15.
5. The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase. Atwal JK, etal., Neuron. 2000 Aug;27(2):265-77.
6. Neurotrophic tyrosine kinase receptor B/neurotrophin 4 signaling axis is perturbed in clinical and experimental pulmonary fibrosis. Avcuoglu S, etal., Am J Respir Cell Mol Biol. 2011 Oct;45(4):768-80. Epub 2011 Feb 17.
7. Patterns of expression of brain-derived neurotrophic factor and tyrosine kinase B mRNAs and distribution and ultrastructural localization of their proteins in the visual pathway of the adult rat. Avwenagha O, etal., Neuroscience. 2006 Jul 7;140(3):913-28. Epub 2006 Apr 19.
8. An agonistic TrkB mAb causes sustained TrkB activation, delays RGC death, and protects the retinal structure in optic nerve axotomy and in glaucoma. Bai Y, etal., Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4722-31. Epub 2010 Mar 31.
9. Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. Cao XH, etal., J Neurochem. 2010 Sep 1;114(5):1460-75. Epub 2010 Jun 24.
10. Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons. Cheung ZH, etal., PLoS Biol. 2007 Apr;5(4):e63.
11. Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism. Correia CT, etal., Genes Brain Behav. 2010 Oct;9(7):841-8. doi: 10.1111/j.1601-183X.2010.00627.x. Epub 2010 Aug 19.
12. Aging and a peripheral immune challenge interact to reduce mature brain-derived neurotrophic factor and activation of TrkB, PLCgamma1, and ERK in hippocampal synaptoneurosomes. Cortese GP, etal., J Neurosci. 2011 Mar 16;31(11):4274-9.
13. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. Cozza A, etal., J Alzheimers Dis. 2008 Sep;15(1):61-70.
14. [Effects of chaihu shugan powder on the behavior and expressions of BDNF and TrkB in the hippocampus, amygdala, and the frontal lobe in rat model of depression]. Deng Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Oct;31(10):1373-8.
15. 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease. Devi L and Ohno M, Neuropsychopharmacology. 2012 Jan;37(2):434-44. doi: 10.1038/npp.2011.191. Epub 2011 Sep 7.
16. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. Dong C, etal., Mol Psychiatry. 2009 Dec;14(12):1105-18. Epub 2009 Oct 20.
17. Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. Eide FF, etal., J Neurosci. 1996 May 15;16(10):3123-9.
18. A TrkB antibody agonist promotes plasticity following cervical spinal cord injury in adult rats. Fouad K, etal., J Neurotrauma. 2010 Jul 2.
19. Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. Fujita Y, etal., EMBO J. 2011 Apr 6;30(7):1389-401. doi: 10.1038/emboj.2011.55. Epub 2011 Mar 1.
20. Intermittent noxious stimulation following spinal cord contusion injury impairs locomotor recovery and reduces spinal brain-derived neurotrophic factor-tropomyosin-receptor kinase signaling in adult rats. Garraway SM, etal., Neuroscience. 2011 Dec 29;199:86-102. Epub 2011 Oct 18.
21. Sequential activation of p75 and TrkB is involved in dendritic development of subventricular zone-derived neuronal progenitors in vitro. Gascon E, etal., Eur J Neurosci. 2005 Jan;21(1):69-80.
22. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
23. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
24. The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons. Gomes RA, etal., J Neurosci. 2006 Nov 1;26(44):11487-500.
25. Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity. Gray J, etal., Int J Obes (Lond). 2007 Feb;31(2):359-64. Epub 2006 May 16.
26. TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders. Gupta VK, etal., Int J Mol Sci. 2013 May 13;14(5):10122-42. doi: 10.3390/ijms140510122.
27. Rapid Activation of the Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Signaling Pathway by Electroconvulsive Shock in the Rat Prefrontal Cortex Is Not Associated with TrkB Neurotrophin Receptor Activation. Hansen HH, etal., Cell Mol Neurobiol. 2007 Apr 20;.
28. Preservation of tropomyosin-related kinase B (TrkB) signaling by sodium orthovanadate attenuates early brain injury after subarachnoid hemorrhage in rats. Hasegawa Y, etal., Stroke. 2011 Feb;42(2):477-83. Epub 2010 Dec 30.
29. Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis. He XP, etal., J Neurosci. 2010 May 5;30(18):6188-96.
30. JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1. Huang SH, etal., J Neurosci. 2011 Jul 20;31(29):10602-14. doi: 10.1523/JNEUROSCI.0436-11.2011.
31. Treadmill exercise improves spatial learning ability by enhancing brain-derived neurotrophic factor expression in the attention-deficit/hyperactivity disorder rats. Jeong HI, etal., J Exerc Rehabil. 2014 Jun 30;10(3):162-7. doi: 10.12965/jer.140111. eCollection 2014 Jun.
32. Synectin in the nervous system: expression pattern and potential as a binding partner of neurotrophin receptors. Kato H, etal., FEBS Lett. 2004 Aug 13;572(1-3):123-8.
33. Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons. Kim YI, etal., J Neurosci Res. 2006 Nov 15;84(7):1512-20.
34. Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients. Kohli MA, etal., Arch Gen Psychiatry. 2010 Apr;67(4):348-59. Epub 2010 Feb 1.
35. Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Lambert WM, etal., Mol Cell Biol. 2013 Sep;33(18):3700-14. doi: 10.1128/MCB.00150-13. Epub 2013 Jul 22.
36. Dynamic changes of TrkB gene expression in Streptococcus pneumoniae meningitis after treatment with antibiotics and dexamethasone. Li L, etal., World J Pediatr. 2011 Aug;7(3):250-6. Epub 2011 May 20.
37. Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study. Lin YT, etal., J Neuroinflammation. 2011 Sep 30;8:126. doi: 10.1186/1742-2094-8-126.
38. Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction. McCarty JH and Feinstein SC, Oncogene. 1998 Apr 2;16(13):1691-700.
39. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
40. The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain. Miller R, etal., Brain Res 2002 Sep 20;950(1-2):137-47.
41. TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Miyamoto Y, etal., Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10444-9. Epub 2006 Jun 26.
42. Differential regulation of the expression of neurotrophin receptors in rat extraocular motoneurons after lesion. Morcuende S, etal., J Comp Neurol. 2011 Aug 15;519(12):2335-52. doi: 10.1002/cne.22630.
43. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
44. Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter. Numakawa T, etal., Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):647-52. doi: 10.1073/pnas.0800888106. Epub 2009 Jan 6.
45. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
46. Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Pease ME, etal., Invest Ophthalmol Vis Sci. 2000 Mar;41(3):764-74.
47. Trkb receptors modulation of glutamate release is limited to a subset of nerve terminals in the adult rat hippocampus. Pereira DB, etal., J Neurosci Res. 2006 Apr;83(5):832-44.
48. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
49. Colitis elicits differential changes in the expression levels of receptor tyrosine kinase TrkA and TrkB in colonic afferent neurons: a possible involvement of axonal transport. Qiao LY and Grider JR, Pain. 2010 Oct;151(1):117-27. Epub 2010 Jul 16.
50. Gangliosides activate Trk receptors by inducing the release of neurotrophins. Rabin SJ, etal., J Biol Chem 2002 Dec 20;277(51):49466-72.
51. GOA pipeline RGD automated data pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. Robinson KN, etal., J Biol Chem. 2005 Jan 7;280(1):225-35. Epub 2004 Oct 28.
55. TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice. Sahenk Z, etal., Exp Neurol. 2010 Aug;224(2):495-506. Epub 2010 May 27.
56. The effect of age and tongue exercise on BDNF and TrkB in the hypoglossal nucleus of rats. Schaser AJ, etal., Behav Brain Res. 2012 Jan 1;226(1):235-41. Epub 2011 Sep 21.
57. Treadmill exercise alleviates impairment of spatial learning ability through enhancing cell proliferation in the streptozotocin-induced Alzheimer's disease rats. Sim YJ J Exerc Rehabil. 2014 Apr 30;10(2):81-8. doi: 10.12965/jer.140102. eCollection 2014 Apr.
58. Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder. Soontornniyomkij B, etal., J Affect Disord. 2011 Oct;133(3):646-54. Epub 2011 May 25.
59. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Soppet D, etal., Cell. 1991 May 31;65(5):895-903.
60. Myosin Va mediates BDNF-induced postendocytic recycling of full-length TrkB and its translocation into dendritic spines. Sui WH, etal., J Cell Sci. 2015 Mar 15;128(6):1108-22. doi: 10.1242/jcs.160259. Epub 2015 Jan 27.
61. Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder. Takei S, etal., J Psychiatr Res. 2011 Apr;45(4):460-8. Epub 2010 Sep 21.
62. Increased expression of BDNF and proliferation of dentate granule cells after bacterial meningitis. Tauber SC, etal., J Neuropathol Exp Neurol. 2005 Sep;64(9):806-15.
63. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
64. Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. Thompson Ray M, etal., J Psychiatry Neurosci. 2011 May;36(3):195-203.
65. Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent. Tucker K and Fadool DA, J Physiol 2002 Jul 15;542(Pt 2):413-29.
66. Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure. Wang H, etal., Neuroscience. 2011 Jan 13;172:453-9. Epub 2010 Oct 27.
67. Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
68. Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain. Xu HW, etal., Acta Pharmacol Sin. 2000 Jul;21(7):600-4.
69. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Xu X, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19126-31. Epub 2010 Oct 18.
70. Involvement of a spinal brain-derived neurotrophic factor/full-length TrkB pathway in the development of nerve injury-induced thermal hyperalgesia in mice. Yajima Y, etal., Brain Res. 2002 Dec 27;958(2):338-46.
71. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Yeo GS, etal., Nat Neurosci. 2004 Nov;7(11):1187-9. Epub 2004 Oct 24.
72. TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis. Zhou XP, etal., Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17181-6. Epub 2008 Oct 28.
Additional References at PubMed
PMID:1846020   PMID:8106527   PMID:8402890   PMID:9856458   PMID:10196222   PMID:10486198   PMID:10516311   PMID:10571233   PMID:10595510   PMID:10908605   PMID:11083466   PMID:11248116  
PMID:11251075   PMID:11389170   PMID:11738045   PMID:11860191   PMID:12049326   PMID:12367511   PMID:12373512   PMID:12471037   PMID:12605901   PMID:12646573   PMID:12796784   PMID:12798291  
PMID:12858046   PMID:14603320   PMID:14642449   PMID:15014113   PMID:15231696   PMID:15282267   PMID:15329723   PMID:15372074   PMID:15376326   PMID:15384067   PMID:15507485   PMID:15518646  
PMID:15601948   PMID:15665879   PMID:15703388   PMID:15721221   PMID:16173113   PMID:16175575   PMID:16264195   PMID:16357196   PMID:16399679   PMID:16500620   PMID:16612579   PMID:16769156  
PMID:16781670   PMID:16819522   PMID:16877354   PMID:16996037   PMID:17072373   PMID:17168119   PMID:17394529   PMID:17445239   PMID:17463054   PMID:17492691   PMID:17584746   PMID:17647101  
PMID:17828750   PMID:17959796   PMID:17967490   PMID:18063479   PMID:18063676   PMID:18338800   PMID:18353779   PMID:18381284   PMID:18420184   PMID:18432062   PMID:18446825   PMID:18474605  
PMID:18511210   PMID:18515408   PMID:18550280   PMID:18559670   PMID:18957307   PMID:19036963   PMID:19141250   PMID:19159346   PMID:19179431   PMID:19222991   PMID:19224567   PMID:19332029  
PMID:19351881   PMID:19424097   PMID:19460344   PMID:19546592   PMID:19549834   PMID:19551874   PMID:19583705   PMID:19585233   PMID:19671665   PMID:19686240   PMID:19726361   PMID:20047714  
PMID:20064930   PMID:20146080   PMID:20333308   PMID:20407211   PMID:20610389   PMID:20615547   PMID:20635439   PMID:21044076   PMID:21187387   PMID:21210848   PMID:21279681   PMID:21474450  
PMID:21756980   PMID:21849472   PMID:21945647   PMID:21946312   PMID:22022509   PMID:22128160   PMID:22345308   PMID:22374757   PMID:22563458   PMID:22649026   PMID:22678720   PMID:22710915  
PMID:22806574   PMID:22841916   PMID:22878065   PMID:22961271   PMID:23017014   PMID:23058367   PMID:23086941   PMID:23382219   PMID:23392678   PMID:23526925   PMID:23550026   PMID:23785138  
PMID:23844255   PMID:23867621   PMID:23975404   PMID:24021607   PMID:24035762   PMID:24045895   PMID:24069373   PMID:24103847   PMID:24198040   PMID:24271058   PMID:24316227   PMID:24361450  
PMID:24372023   PMID:24465591   PMID:24484474   PMID:24599793   PMID:24613359   PMID:24714156   PMID:24830751   PMID:24934279   PMID:24991961   PMID:25072185   PMID:25143381   PMID:25226925  
PMID:25453757   PMID:25542970   PMID:25661191   PMID:25665281   PMID:25761522   PMID:25886766   PMID:26019338   PMID:26088421   PMID:26094765   PMID:26222433   PMID:26339375   PMID:26574547  
PMID:26712630   PMID:26899129   PMID:27151332   PMID:27334657   PMID:27438618   PMID:27735948   PMID:27771283   PMID:27830679   PMID:27926876   PMID:27984178   PMID:28004953   PMID:28500221  
PMID:28607168   PMID:28705440   PMID:28757509   PMID:28821448   PMID:28821608   PMID:28890399   PMID:29075579   PMID:29098710   PMID:29420916   PMID:29425916   PMID:29468822   PMID:29611441  
PMID:29680698   PMID:29694277   PMID:29704115   PMID:30076998   PMID:30266684   PMID:30373907   PMID:30472367   PMID:30477252   PMID:30489133   PMID:30710509   PMID:30741614   PMID:31014242  
PMID:31114979   PMID:31219215   PMID:31329835   PMID:32043504   PMID:32193501   PMID:32194188   PMID:32507324   PMID:33043964   PMID:33130041   PMID:33206632   PMID:33359781   PMID:33571451  
PMID:33616872   PMID:33874962   PMID:33954182   PMID:34695541   PMID:34728386   PMID:36233065   PMID:36375307   PMID:36499323   PMID:36565982  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2175,558,992 - 5,870,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl175,559,043 - 5,869,136 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx175,584,315 - 5,894,662 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0177,120,448 - 7,429,363 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0175,580,732 - 5,891,094 (-)NCBIRnor_WKY
Rnor_6.0175,934,651 - 6,245,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,933,729 - 6,244,676 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0178,156,432 - 8,464,522 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41711,494,463 - 11,811,654 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11711,494,462 - 11,811,645 (-)NCBI
Celera175,673,895 - 6,828,108 (-)NCBICelera
Cytogenetic Map17p14NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38984,668,522 - 85,027,054 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl984,668,375 - 85,095,751 (+)EnsemblGRCh38hg38GRCh38
GRCh37987,283,437 - 87,641,969 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36986,473,286 - 86,828,325 (+)NCBINCBI36Build 36hg18NCBI36
Build 34984,514,246 - 84,866,963NCBI
Celera957,854,390 - 58,209,019 (+)NCBICelera
Cytogenetic Map9q21.33NCBI
HuRef957,108,647 - 57,463,914 (+)NCBIHuRef
CHM1_1987,429,973 - 87,785,074 (+)NCBICHM1_1
T2T-CHM13v2.0996,818,888 - 97,177,857 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391358,954,286 - 59,281,784 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1358,954,383 - 59,281,784 (+)EnsemblGRCm39 Ensembl
GRCm381358,806,472 - 59,133,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1358,806,569 - 59,133,970 (+)EnsemblGRCm38mm10GRCm38
MGSCv371358,907,957 - 59,231,337 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361358,816,219 - 59,139,599 (+)NCBIMGSCv36mm8
Celera1359,869,829 - 60,184,466 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1331.2NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554322,288,898 - 2,630,878 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554322,284,283 - 2,629,631 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1983,835,183 - 84,380,018 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0939,663,986 - 40,208,770 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1984,022,677 - 84,378,307 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl984,021,837 - 84,372,678 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1174,447,927 - 74,777,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl174,449,060 - 74,777,032 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha175,211,260 - 75,538,451 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0174,754,263 - 75,081,259 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl174,755,372 - 75,083,341 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1174,562,918 - 74,890,457 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0174,331,860 - 74,658,907 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0175,035,216 - 75,362,564 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947121,116,646 - 121,472,444 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936680267,596 - 615,928 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936680267,850 - 621,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1030,033,405 - 30,429,882 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11030,030,050 - 30,429,938 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21034,211,939 - 34,350,822 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11295,477,612 - 95,836,734 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1295,479,447 - 95,620,364 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603883,830,767 - 84,200,895 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248098,276,951 - 8,616,765 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248098,274,736 - 8,622,287 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ntrk2
1515 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:545
Count of miRNA genes:254
Interacting mature miRNAs:310
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0178,464,362 - 8,464,522NCBIRnor5.0
RGSC_v3.41711,811,510 - 11,811,669RGDRGSC3.4
RGSC_v3.11711,811,510 - 11,811,669RGD
RH 3.4 Map1753.5RGD
RH 3.4 Map1753.5UniSTS
RH 2.0 Map1743.9RGD
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,705,480 - 5,705,653 (+)MAPPERmRatBN7.2
Rnor_6.0176,081,441 - 6,081,613NCBIRnor6.0
Rnor_5.0178,303,029 - 8,303,201UniSTSRnor5.0
RGSC_v3.41711,642,374 - 11,642,546UniSTSRGSC3.4
RGSC_v3.41711,642,373 - 11,642,546RGDRGSC3.4
RGSC_v3.11711,642,374 - 11,642,546RGD
Celera175,819,628 - 5,819,800UniSTS
RH 3.4 Map1753.6RGD
RH 3.4 Map1753.6UniSTS
RH 2.0 Map1741.7RGD
SHRSP x BN Map175.9601RGD
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,846,851 - 5,846,967 (+)MAPPERmRatBN7.2
Rnor_6.0176,222,036 - 6,222,149NCBIRnor6.0
Rnor_5.0178,441,931 - 8,442,044UniSTSRnor5.0
RGSC_v3.41711,789,390 - 11,789,504RGDRGSC3.4
RGSC_v3.41711,789,391 - 11,789,504UniSTSRGSC3.4
RGSC_v3.11711,789,391 - 11,789,504RGD
Celera175,959,620 - 5,959,733UniSTS
RH 3.4 Map1773.7UniSTS
RH 3.4 Map1773.7RGD
RH 2.0 Map1738.2RGD
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,868,983 - 5,869,137 (+)MAPPERmRatBN7.2
Rnor_6.0176,244,475 - 6,244,628NCBIRnor6.0
Rnor_5.0178,464,370 - 8,464,523UniSTSRnor5.0
RGSC_v3.41711,811,516 - 11,811,669RGDRGSC3.4
RGSC_v3.41711,811,517 - 11,811,670UniSTSRGSC3.4
RGSC_v3.11711,811,516 - 11,811,669RGD
Celera175,981,709 - 5,981,850UniSTS
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,683,917 - 5,684,106 (+)MAPPERmRatBN7.2
Rnor_6.0176,060,589 - 6,060,777NCBIRnor6.0
Rnor_5.0178,282,177 - 8,282,365UniSTSRnor5.0
RGSC_v3.41711,620,134 - 11,620,322UniSTSRGSC3.4
Celera175,798,149 - 5,798,337UniSTS
RH 3.4 Map1773.7UniSTS
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,835,067 - 5,835,260 (+)MAPPERmRatBN7.2
Rnor_6.0176,210,245 - 6,210,437NCBIRnor6.0
Rnor_5.0178,430,140 - 8,430,332UniSTSRnor5.0
RGSC_v3.41711,777,573 - 11,777,765UniSTSRGSC3.4
Celera175,947,917 - 5,948,109UniSTS
RH 3.4 Map1753.5UniSTS
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,559,068 - 5,559,315 (+)MAPPERmRatBN7.2
Rnor_6.0175,934,716 - 5,934,962NCBIRnor6.0
Rnor_5.0178,156,458 - 8,156,704UniSTSRnor5.0
RGSC_v3.41711,494,489 - 11,494,735UniSTSRGSC3.4
Celera175,673,921 - 5,674,167UniSTS
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,739,292 - 5,739,485 (+)MAPPERmRatBN7.2
Rnor_6.0176,114,720 - 6,114,912NCBIRnor6.0
Rnor_5.0178,335,513 - 8,335,705UniSTSRnor5.0
RGSC_v3.41711,676,780 - 11,676,972UniSTSRGSC3.4
Celera175,852,552 - 5,852,744UniSTS
RH 3.4 Map1754.5UniSTS
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,743,832 - 5,744,018 (+)MAPPERmRatBN7.2
Rnor_6.0176,119,115 - 6,119,300NCBIRnor6.0
Rnor_5.0178,339,908 - 8,340,093UniSTSRnor5.0
RGSC_v3.41711,681,320 - 11,681,505UniSTSRGSC3.4
Celera175,857,092 - 5,857,277UniSTS
RH 3.4 Map1773.3UniSTS
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,715,697 - 5,715,860 (+)MAPPERmRatBN7.2
Rnor_6.0176,091,659 - 6,091,821NCBIRnor6.0
Rnor_5.0178,312,470 - 8,312,632UniSTSRnor5.0
RGSC_v3.41711,652,039 - 11,652,201UniSTSRGSC3.4
Celera175,828,923 - 5,829,085UniSTS
RH 3.4 Map1773.4UniSTS
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,703,161 - 5,703,376 (+)MAPPERmRatBN7.2
Rnor_6.0176,079,122 - 6,079,336NCBIRnor6.0
Rnor_5.0178,300,710 - 8,300,924UniSTSRnor5.0
RGSC_v3.41711,640,055 - 11,640,269UniSTSRGSC3.4
Celera175,817,362 - 5,817,576UniSTS
RH 3.4 Map1772.8UniSTS
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,667,249 - 5,667,431 (+)MAPPERmRatBN7.2
Rnor_6.0176,043,939 - 6,044,120NCBIRnor6.0
Rnor_5.0178,265,619 - 8,265,800UniSTSRnor5.0
RGSC_v3.41711,603,648 - 11,603,829UniSTSRGSC3.4
Celera175,781,473 - 5,781,654UniSTS
RH 3.4 Map1753.4UniSTS
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,701,329 - 5,701,568 (+)MAPPERmRatBN7.2
Rnor_6.0176,077,290 - 6,077,528NCBIRnor6.0
Rnor_5.0178,298,878 - 8,299,116UniSTSRnor5.0
RGSC_v3.41711,638,223 - 11,638,461UniSTSRGSC3.4
Celera175,815,530 - 5,815,768UniSTS
RH 3.4 Map1752.5UniSTS
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,559,212 - 5,559,432 (+)MAPPERmRatBN7.2
Rnor_6.0175,934,860 - 5,935,079NCBIRnor6.0
Rnor_5.0178,156,602 - 8,156,821UniSTSRnor5.0
RGSC_v3.41711,494,633 - 11,494,852UniSTSRGSC3.4
Celera175,674,065 - 5,674,284UniSTS
RH 3.4 Map1755.0UniSTS
Cytogenetic Map17p14UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2175,748,331 - 5,748,504 (+)MAPPERmRatBN7.2
Rnor_6.0176,123,562 - 6,123,734NCBIRnor6.0
Rnor_5.0178,344,193 - 8,344,365UniSTSRnor5.0
RGSC_v3.41711,686,081 - 11,686,253UniSTSRGSC3.4
Celera175,861,597 - 5,861,769UniSTS
RH 3.4 Map1773.7UniSTS
Cytogenetic Map17p14UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 11 74 12 24
Low 2 39 21 6 8 6 8 11 20 16 11 8
Below cutoff 1 4 22 22 22 3 1


Nucleotide Sequences
RefSeq Transcripts NM_001163168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY265419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY266346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC855568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000042145   ⟹   ENSRNOP00000045635
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl175,559,043 - 5,869,121 (-)Ensembl
Rnor_6.0 Ensembl175,934,690 - 6,244,612 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082611   ⟹   ENSRNOP00000073595
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl175,559,043 - 5,869,121 (-)Ensembl
Rnor_6.0 Ensembl175,933,729 - 6,244,676 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090914   ⟹   ENSRNOP00000070128
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl175,739,171 - 5,869,136 (-)Ensembl
Rnor_6.0 Ensembl176,114,598 - 6,244,627 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100565   ⟹   ENSRNOP00000082641
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl175,784,667 - 5,869,136 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101783   ⟹   ENSRNOP00000078799
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl175,784,517 - 5,869,136 (-)Ensembl
RefSeq Acc Id: NM_001163168   ⟹   NP_001156640
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,739,171 - 5,869,136 (-)NCBI
Rnor_6.0176,114,598 - 6,244,627 (-)NCBI
Rnor_5.0178,156,432 - 8,464,522 (-)NCBI
RGSC_v3.41711,494,463 - 11,811,654 (-)RGD
Celera175,852,430 - 6,828,108 (-)NCBI
RefSeq Acc Id: NM_012731   ⟹   NP_036863
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,559,043 - 5,869,121 (-)NCBI
Rnor_6.0175,934,690 - 6,244,612 (-)NCBI
Rnor_5.0178,156,432 - 8,464,522 (-)NCBI
RGSC_v3.41711,494,463 - 11,811,654 (-)RGD
Celera175,673,895 - 6,828,108 (-)NCBI
RefSeq Acc Id: XM_006253507   ⟹   XP_006253569
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,683,893 - 5,868,087 (-)NCBI
Rnor_6.0176,060,564 - 6,244,716 (-)NCBI
Rnor_5.0178,156,432 - 8,464,522 (-)NCBI
RefSeq Acc Id: XM_008771425   ⟹   XP_008769647
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,560,666 - 5,869,126 (-)NCBI
Rnor_6.0175,934,651 - 6,244,725 (-)NCBI
RefSeq Acc Id: XM_008771426   ⟹   XP_008769648
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,560,666 - 5,870,171 (-)NCBI
Rnor_6.0175,934,651 - 6,245,662 (-)NCBI
RefSeq Acc Id: XM_008771427   ⟹   XP_008769649
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,689,623 - 5,868,087 (-)NCBI
Rnor_6.0176,060,564 - 6,244,715 (-)NCBI
RefSeq Acc Id: XM_017600456   ⟹   XP_017455945
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,560,666 - 5,870,299 (-)NCBI
Rnor_6.0175,934,651 - 6,245,778 (-)NCBI
RefSeq Acc Id: XM_039095370   ⟹   XP_038951298
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,560,666 - 5,869,466 (-)NCBI
RefSeq Acc Id: XM_039095371   ⟹   XP_038951299
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,558,992 - 5,868,087 (-)NCBI
RefSeq Acc Id: XM_039095372   ⟹   XP_038951300
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2175,739,171 - 5,869,136 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036863   ⟸   NM_012731
- Peptide Label: isoform 1 precursor
- UniProtKB: Q63606 (UniProtKB/Swiss-Prot),   Q63604 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001156640   ⟸   NM_001163168
- Peptide Label: isoform 2 precursor
- UniProtKB: Q63604 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253569   ⟸   XM_006253507
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008769648   ⟸   XM_008771426
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769647   ⟸   XM_008771425
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769649   ⟸   XM_008771427
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017455945   ⟸   XM_017600456
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073595   ⟸   ENSRNOT00000082611
RefSeq Acc Id: ENSRNOP00000070128   ⟸   ENSRNOT00000090914
RefSeq Acc Id: ENSRNOP00000045635   ⟸   ENSRNOT00000042145
RefSeq Acc Id: XP_038951299   ⟸   XM_039095371
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951298   ⟸   XM_039095370
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951300   ⟸   XM_039095372
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000082641   ⟸   ENSRNOT00000100565
RefSeq Acc Id: ENSRNOP00000078799   ⟸   ENSRNOT00000101783
Protein Domains
Ig-like   Ig-like C2-type   LRRCT   LRRNT   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63604-F1-model_v2 AlphaFold Q63604 1-821 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3213 AgrOrtholog
BioCyc Gene G2FUF-10400 BioCyc
Ensembl Genes ENSRNOG00000018839 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000045635 ENTREZGENE
  ENSRNOP00000045635.1 UniProtKB/Swiss-Prot
  ENSRNOP00000070128.1 UniProtKB/Swiss-Prot
  ENSRNOP00000073595.1 UniProtKB/TrEMBL
  ENSRNOP00000078799.1 UniProtKB/TrEMBL
  ENSRNOP00000082641.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042145 ENTREZGENE
  ENSRNOT00000042145.3 UniProtKB/Swiss-Prot
  ENSRNOT00000082611.2 UniProtKB/TrEMBL
  ENSRNOT00000090914.2 UniProtKB/Swiss-Prot
  ENSRNOT00000100565.1 UniProtKB/TrEMBL
  ENSRNOT00000101783.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTRK_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kin_neurotrophic_rcpt_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_NGF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25054 UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPKR_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ntrk2 PhenoGen
  NTKRECEPTOR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC207397
UniProt Secondary Q63605 UniProtKB/Swiss-Prot
  Q63606 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Ntrk2  neurotrophic receptor tyrosine kinase 2  Ntrk2  neurotrophic tyrosine kinase, receptor, type 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Ntrk2  neurotrophic tyrosine kinase, receptor, type 2    Neural receptor protein-tyrosine kinase (trkB)  Name updated 625702 APPROVED
2002-06-10 Ntrk2  Neural receptor protein-tyrosine kinase (trkB)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function responsible for tyrosine phosphorylation of voltage-gated potassium channel Kv1.3 633084
gene_regulation activated by GM1 ganglioside 727459