Ticam1 (TIR domain containing adaptor molecule 1)

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Gene: Ticam1 (TIR domain containing adaptor molecule 1) Rattus norvegicus

Analyze

Symbol:

Ticam1 (Ensembl: AABR07066529.1)

Name:

TIR domain containing adaptor molecule 1 (Ensembl:toll-like receptor adaptor molecule 1)

RGD ID:

1590868

Description:

Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including TRIF-dependent toll-like receptor signaling pathway; cellular response to oxidised low-density lipoprotein particle stimulus; and positive regulation of cytokine production. Predicted to act upstream of or within several processes, including positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of nitrogen compound metabolic process. Predicted to be located in cytosol and mitochondrion. Predicted to be part of ripoptosome. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (TIR domain containing adaptor molecule 1); PARTICIPATES IN Toll-like receptor signaling pathway; INTERACTS WITH alpha-D-galactose; bisphenol A; ethanol.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC363328; similar to TICAM-1; TIR domain-containing adapter molecule 1; toll-like receptor adaptor molecule 1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	1,102,559 - 1,115,573 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	1,102,366 - 1,123,147 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	9	10,780,185 - 10,790,280 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	9	9,774,816 - 9,781,948 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,397,373 - 7,407,468 (+)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Herpes Simplex Encephalitis (ISO)

Herpes Simplex Encephalitis 4 (ISO)

pneumoconiosis (ISO)

Reperfusion Injury (ISO)

respiratory syncytial virus infectious disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

alpha-D-galactose (EXP,ISO)

aripiprazole (ISO)

aristolochic acid A (ISO)

auranofin (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cudratricusxanthone A (ISO)

curcumin (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

dioxygen (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

ethanol (EXP,ISO)

folic acid (ISO)

galactose (EXP,ISO)

genistein (ISO)

hydroquinone (ISO)

indometacin (ISO)

lipopolysaccharide (ISO)

menadione (ISO)

methamphetamine (ISO)

methotrexate (ISO)

monocrotaline (ISO)

N-ethyl-N-nitrosourea (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel atom (ISO)

ochratoxin A (ISO)

ozone (ISO)

phenobarbital (ISO)

poly(I:C) (ISO)

progesterone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

scoparone (ISO)

scopoletin (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

thymoquinone (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic signaling pathway (ISO)

B cell activation (ISO)

B cell proliferation (ISO)

cellular response to lipopolysaccharide (ISO)

cellular response to oxidised low-density lipoprotein particle stimulus (ISO)

defense response to virus (ISO)

I-kappaB kinase/NF-kappaB signaling (ISO)

inflammatory response (IEA)

innate immune response (IEA)

lipid storage (IBA)

lipopolysaccharide-mediated signaling pathway (ISO)

macrophage activation involved in immune response (ISO)

MyD88-independent toll-like receptor signaling pathway (ISO)

nitric oxide biosynthetic process (ISO)

positive regulation of autophagy (ISO)

positive regulation of B cell activation (ISO)

positive regulation of B cell proliferation (ISO)

positive regulation of chemokine production (ISO)

positive regulation of cytokine production involved in inflammatory response (ISO)

positive regulation of gene expression (ISO)

positive regulation of I-kappaB kinase/NF-kappaB signaling (ISO)

positive regulation of interferon-beta production (ISO)

positive regulation of interleukin-6 production (ISO)

positive regulation of macrophage cytokine production (ISO)

positive regulation of myeloid dendritic cell cytokine production (ISO)

positive regulation of natural killer cell activation (ISO)

positive regulation of NF-kappaB transcription factor activity (ISO)

positive regulation of nitric oxide biosynthetic process (ISO)

positive regulation of protein binding (ISO)

positive regulation of protein ubiquitination (ISO)

positive regulation of sequestering of triglyceride (IBA)

positive regulation of tumor necrosis factor production (ISO)

positive regulation of type I interferon production (ISO)

regulation of protein-containing complex assembly (ISO)

response to exogenous dsRNA (ISO)

response to lipopolysaccharide (ISO)

toll-like receptor signaling pathway (ISO)

TRIF-dependent toll-like receptor signaling pathway (ISO)

Cellular Component

autophagosome (IEA)

cytosol (IBA,ISO)

early endosome (ISO)

endosome (ISO)

lipid droplet (IBA,TAS)

mitochondrion (ISO)

ripoptosome (ISO)

Molecular Function

molecular adaptor activity (ISO)

protein binding (ISO)

protein kinase binding (ISO)

ubiquitin-protein transferase activator activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Toll-like receptor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12761501	PMID:12855817	PMID:12872135	PMID:14530355	PMID:14982987	PMID:17658277	PMID:19734906	PMID:20037584	PMID:21059856	PMID:21266579	PMID:21703541	PMID:21737330
PMID:25636800

Genomics

Comparative Map Data

Ticam1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	9	1,102,559 - 1,115,573 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	1,102,366 - 1,123,147 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	9	10,780,185 - 10,790,280 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	9	9,774,816 - 9,781,948 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,397,373 - 7,407,468 (+)	NCBI		Celera
Cytogenetic Map	9	q12	NCBI

TICAM1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	4,815,932 - 4,831,712 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	19	4,815,932 - 4,831,712 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	4,815,944 - 4,831,724 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	4,766,992 - 4,769,451 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	4,753,860 - 4,769,659 (-)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	4,577,650 - 4,593,372 (-)	NCBI		HuRef
CHM1_1	19	4,815,534 - 4,831,367 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	4,801,397 - 4,817,189 (-)	NCBI		T2T-CHM13v2.0

Ticam1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	56,576,462 - 56,583,767 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	56,576,319 - 56,583,786 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	56,269,462 - 56,276,767 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	56,269,319 - 56,276,786 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	56,408,885 - 56,416,190 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	55,903,171 - 55,910,412 (-)	NCBI		MGSCv36	mm8
MGSCv36	17	55,328,736 - 55,335,977 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	17	D	NCBI

Ticam1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	4,202,372 - 4,204,513 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	4,197,083 - 4,204,999 (+)	NCBI	ChiLan1.0	ChiLan1.0

TICAM1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	4,787,244 - 4,803,727 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	4,787,557 - 4,790,206 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	3,836,100 - 3,852,017 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

TICAM1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	54,948,237 - 54,961,996 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	54,959,525 - 54,961,780 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	54,672,888 - 54,686,637 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	55,602,634 - 55,616,374 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	20	54,664,010 - 54,677,669 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	55,144,587 - 55,158,319 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	55,342,534 - 55,356,281 (+)	NCBI		UU_Cfam_GSD_1.0

Ticam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	215,005,381 - 215,015,878 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936588	2,818,909 - 2,827,797 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TICAM1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	74,004,308 - 74,021,873 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	74,004,566 - 74,021,100 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TICAM1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	4,526,719 - 4,543,251 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	4,527,033 - 4,529,168 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	3,618,262 - 3,633,550 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ticam1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	4,971,093 - 4,973,198 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	4,964,199 - 4,973,465 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ticam1
30 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054141	Gmadr4	Adrenal mass QTL 4	2.45	0.0074	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	9	1	14209783	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	25661317	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	37999212	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	37999212	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	37999212	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	40594091	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat

Markers in Region

RH134483

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	1,111,285 - 1,111,482 (-)	MAPPER	mRatBN7.2
mRatBN7.2	20	22,132,543 - 22,132,740 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	23,566,923 - 23,567,119	NCBI	Rnor6.0
Rnor_6.0	9	10,781,357 - 10,781,553	NCBI	Rnor6.0
Rnor_5.0	9	9,773,025 - 9,773,221	UniSTS	Rnor5.0
Rnor_5.0	20	25,646,916 - 25,647,112	UniSTS	Rnor5.0
RGSC_v3.4	20	23,019,069 - 23,019,265	UniSTS	RGSC3.4
Celera	20	23,484,940 - 23,485,136	UniSTS
Celera	9	7,398,545 - 7,398,741	UniSTS
Cytogenetic Map	20	p11	UniSTS
Cytogenetic Map	9	q11	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008757917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008766802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000070978 ⟹ ENSRNOP00000066344

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	1,102,941 - 1,123,147 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000072501 ⟹ ENSRNOP00000076995

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	1,102,366 - 1,109,331 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111500 ⟹ ENSRNOP00000085855

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	1,110,592 - 1,118,597 (-)	Ensembl

RefSeq Acc Id:

XM_008766802 ⟹ XP_008765024

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	1,102,559 - 1,115,573 (-)	NCBI
Rnor_6.0	9	10,780,185 - 10,790,280 (+)	NCBI

Sequence:

show sequence

AGGAGAAGCTGCACCAGATGTGGCTCACCTGGAATCAGAAGACCCCACAGGATGCCGAAAAGGA
CCCATCTAAGCCAGAGGTCTGCACTGTCACCCTCCAGGATCCTTGTGGCAGGGGACAAGGCTGT
GCATAAGACAATTGGTTCGGAACATGTCTCCATCCACCCCACTCTCTGTGGCTCCAGGCTTCAT
CCTCCCCCATCCATGACCAACCCAGCCCCGTCACTCCATAGTGTCTTTGGCATTCTAAGTGCCT
TGGAAAGGGACAGGCTGACCTGTCTGAAACACAAGCTGGGGAGTCTGCATCCAGGCAGCCTGGA
GTCAAAACTTCTCCACGCCATGGTACTCCTGGCTCTGGGCCAGGACACGGAGGCCAGGGTCTCT
CTGGAGTCCTTGAAGGTAAATACAGCAGCGCAGCTGGTAGCTGGCCAGTGGGCAGACATGGAGA
ACACAGAGGACCCTGAGGAGCCTCCAGACTTGTCCTGGACGGTGGCTCGCCTGTACCACCTGCT
GGCTGAGGAGAACCTGTGCCCGGCCTCCACAAGGGATGTGGCTTACCAGGTGGCCCTTCGTGAC
CTCACCTCCCAGGGTGACCACCAGCTGGGCCAACTCCAGAAGGAGGCCTGGGATCGGTGTAGTT
CTCATCAGGGTTCCCTGCAGCCACCATCAGCTGCCCCTGCAATGACTAGAAGTCAGCCTCGCCC
CATTGACACATCAGACTGGAGTTGGGGACATACGTTACACTCCACCGGCAGCACTGCCACACTG
GCCAGTCACCTAGAGATCAGCCAGTCGCCCACTCTGGCCTTTTTCTCTTCACACCATGGAGCCC
ATGGGCCCAGCAAGCTATGCGACAAACCACTGGGCACTCAGGAGCCTCAGCTTGTCCCTGAAGG
CTGCGAAGAACCTGACAGGAGCCAGCCTCCACCAGTGCAGACCAGTATCTCTTTGGGGTTACCA
CACGAAATTAGGGTCCCAGAGGTGGCTTTGCCCATCCTCCCTGACTCTCTGGCTGCTCCAAACA
CAAGTGTCCACTGTCCCATTGAATGCACAGAGGTGTCTGCAGACTCTAGGTCTCCCCTGACATC
CATCACAGAAAGTGTTGGAAAGCAGTGGCCTATCACAAGTCAGAGGTCACCTCAGTTTCCAGTA
GGAGACGATGTTCTGCCGAACTCCATGTCATCCAGCCCTCCTGCCCAGCCACCGTCTTCCCAAG
CCTCCTCTGTGCAGCCCCCTCTGTCCTCTGCTTCCTCCCAGAGCAGCTGCCCTGCTCCCCCAGC
CTCCACACCCCCTGTTTCGGAACACTTGGAAACATCTGATCAGAAATTCTATAACTTTGTGGTC
ATCCATGCCAGGGCTGATGAACATGTGGCCCTACGTATTCGGGAGAAGCTAGAGACCCTTGGGG
TACCTGATGGGGCCACCTTCTGTGAGGAATTTCAGGTGCCTGGGCGTGGTGAGCTGCACTGTCT
CCAAGATGCCATCGATCACTCAGGGTTCATGATCCTGCTCCTGACTGCCAGCTTTGATTGTCCC
CTAAGCCTGCATCAAGTCAACCATGCTCTCATGAACAGCCTCACCCAGTCTGGGAGGCAGGACT
GTGTGATCCCCCTCCTCCCACTTGAGTGCTCCCAGGCTCAGCTCAGCCCAGACACAACCAGACT
GCTCCATAGTATTGTGTGGCTGGATGAGCACTCCCCAATCTTTGCCAGAAAGGTGGCAAACACC
TTCAAAGCACAGAAGCTCCAGGCACAGCGCGAGCGCTGGAAGAAAGAGCAGGAAGCCAGAACCC
TCAAGGAGCAGAGCACACAGCTGGAGGCTGAGCGGCAAAGGGTGGCTGCCATATCTGCAGCCTA
CTCAGCCTATGTCCATGGCTACACAGCCTGGCAAACAGAAATGAACAGACTTGGGGTGGCCTTT
GGGAAGGACTTGTCACTGGGGCCCCCAACACCTTTCCCCAGCTGGCCAGGGTTTCCGAAGCCAA
TGCCTTCCCATCCTCAGGGTTGTACTCCAGTTTCCCCCTATTCTCCGAGGCAGCCTCCGTCCTC
TTCCCTATCCCAATCCTTTTCACCAGCCTCCTCCCCAGCCCCCCAGACTCCAGGACCTCAGCCT
CTAATTATTCATCATGCCCAGATGGTACAGTTGGGAGTTAACAACCACATGTGGGGCCACACAG
GGGCCCAGTCATCTGATGACAAGACTGAGTTTGGAGAAACCTTGGATGGGCCCTCTGACCGAGG
GGAACCCCTTTCTTGAAACTCCAGAGTGACCAGGTTGGACCCCACCTAGATTGCGAGAGTGGCA
AGACTGAACTTCACTTGGGTTCTTAAAGTTATATTAGAGGAAGGGAACCTTGCCTGGGCCCCCA
CAGTGGCCATTAGTTGGTCCCAGTTTGAGACCCCAGAGGCAGGGAAGACCACACCTGTAAATCA
GGGCTTGGGAAACGTGCAGAACCCCCATTTGAACAGACTCTGTGGGACCCCAACCTGCATCATC
TCTGTGAATAGAGGATGATGGGGCCATAGGCTCCTGTGAGGGGTCCTCAGTGTGGCCATGTAAC
CTTCATATGGTCTCTCTGGGGGGGGGATGCGGTGCTGGGGCACATAGGGAAGGTCCTGTTTATA
ATAAAGTTATTGACAGCTGAGTCACAAGCCAACGCCCCCACACTCCATCACCCTCAGGAAACAA
GCAGGTCACGCCAACTTCGCCATGACTAGAATAGAAAAGGGGGTGTACCAGCCCAGTCCTTGAG
TGGCAGGAACCGGAAATTATGTAGATATACTCATCCCATTGGTCAGTTCAGGCTACGTAGCCTT
CTGTTGCAAGGAATTCTAGGAAATGTAGTCTGGTGGGGGGGGTGCTGCAGCCATTCATCAGGAA
GTCTTATAACTTCAAGAAAGGAGGAGAAAAAAAACTGGGAGTTGCTGCCAGTTTTGATTGTTTT
GTCACTGCGGATCATCTTCCTTCATGCTGATTCCCCTCCCCAAGACATGTCAGACTCTTATACA
TTAAACAAACAAACAAAAACAA

hide sequence

RefSeq Acc Id:

XM_017596709 ⟹ XP_017452198

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	9	1,102,559 - 1,111,023 (-)	NCBI
Rnor_6.0	9	10,783,149 - 10,790,280 (+)	NCBI

Sequence:

show sequence

TTCCTTAGTTTTAAAACATGCCTGTAATTTCACCACCTAGCTGAGAAATACTCACAACTAAACA
GTTGTATAAGATCTTTTGGCCTCCAGCACTTCTGTTCACTTATCTTGTATTAATTTATTTTTGA
GATGGAGCTCTCTCTGTGTTGGTCAGGCTTTCTTCGAACTTGGGGCAATCCACCTGCCTCAGTT
TCCTGTGTGCTGCTGGACTGATAAGAGTGAGTCACCAGGCTCCCTGTGAACTTAGCCACGTGGT
ACTTTGCGAAACCCCAGAGTATGTCACTAGCTGAGCTCTGTGGCTGCCAGCTTAACATTCTCTA
GGGGTGGAGGGTTCCTTCCTTCTTCCGCAGCTCTGGCCCCACAGAGTGCAAGCCCTGCCTAGTT
CCACGTGGCGCCAGGGCACTGGGCCGGAGGGCAGGGCCTGGCTCAGCTAGATGATGTGATTACA
GGCGAGACTGCTGACTTCATCCTCTCCTCCCCACAAGACCCGGAAGGGAGGAAGGGGTGGAACC
GAACTCTCCCTCCTCCTCCAGCAGCTACCAGGGACCTCGAAATCTACCAGCTCAGGACCCCCAC
AGCCAGGTCTGCACTGTCACCCTCCAGGATCCTTGTGGCAGGGGACAAGGCTGTGCATAAGACA
ATTGGTTCGGAACATGTCTCCATCCACCCCACTCTCTGTGGCTCCAGGCTTCATCCTCCCCCAT
CCATGACCAACCCAGCCCCGTCACTCCATAGTGTCTTTGGCATTCTAAGTGCCTTGGAAAGGGA
CAGGCTGACCTGTCTGAAACACAAGCTGGGGAGTCTGCATCCAGGCAGCCTGGAGTCAAAACTT
CTCCACGCCATGGTACTCCTGGCTCTGGGCCAGGACACGGAGGCCAGGGTCTCTCTGGAGTCCT
TGAAGGTAAATACAGCAGCGCAGCTGGTAGCTGGCCAGTGGGCAGACATGGAGAACACAGAGGA
CCCTGAGGAGCCTCCAGACTTGTCCTGGACGGTGGCTCGCCTGTACCACCTGCTGGCTGAGGAG
AACCTGTGCCCGGCCTCCACAAGGGATGTGGCTTACCAGGTGGCCCTTCGTGACCTCACCTCCC
AGGGTGACCACCAGCTGGGCCAACTCCAGAAGGAGGCCTGGGATCGGTGTAGTTCTCATCAGGG
TTCCCTGCAGCCACCATCAGCTGCCCCTGCAATGACTAGAAGTCAGCCTCGCCCCATTGACACA
TCAGACTGGAGTTGGGGACATACGTTACACTCCACCGGCAGCACTGCCACACTGGCCAGTCACC
TAGAGATCAGCCAGTCGCCCACTCTGGCCTTTTTCTCTTCACACCATGGAGCCCATGGGCCCAG
CAAGCTATGCGACAAACCACTGGGCACTCAGGAGCCTCAGCTTGTCCCTGAAGGCTGCGAAGAA
CCTGACAGGAGCCAGCCTCCACCAGTGCAGACCAGTATCTCTTTGGGGTTACCACACGAAATTA
GGGTCCCAGAGGTGGCTTTGCCCATCCTCCCTGACTCTCTGGCTGCTCCAAACACAAGTGTCCA
CTGTCCCATTGAATGCACAGAGGTGTCTGCAGACTCTAGGTCTCCCCTGACATCCATCACAGAA
AGTGTTGGAAAGCAGTGGCCTATCACAAGTCAGAGGTCACCTCAGTTTCCAGTAGGAGACGATG
TTCTGCCGAACTCCATGTCATCCAGCCCTCCTGCCCAGCCACCGTCTTCCCAAGCCTCCTCTGT
GCAGCCCCCTCTGTCCTCTGCTTCCTCCCAGAGCAGCTGCCCTGCTCCCCCAGCCTCCACACCC
CCTGTTTCGGAACACTTGGAAACATCTGATCAGAAATTCTATAACTTTGTGGTCATCCATGCCA
GGGCTGATGAACATGTGGCCCTACGTATTCGGGAGAAGCTAGAGACCCTTGGGGTACCTGATGG
GGCCACCTTCTGTGAGGAATTTCAGGTGCCTGGGCGTGGTGAGCTGCACTGTCTCCAAGATGCC
ATCGATCACTCAGGGTTCATGATCCTGCTCCTGACTGCCAGCTTTGATTGTCCCCTAAGCCTGC
ATCAAGTCAACCATGCTCTCATGAACAGCCTCACCCAGTCTGGGAGGCAGGACTGTGTGATCCC
CCTCCTCCCACTTGAGTGCTCCCAGGCTCAGCTCAGCCCAGACACAACCAGACTGCTCCATAGT
ATTGTGTGGCTGGATGAGCACTCCCCAATCTTTGCCAGAAAGGTGGCAAACACCTTCAAAGCAC
AGAAGCTCCAGGCACAGCGCGAGCGCTGGAAGAAAGAGCAGGAAGCCAGAACCCTCAAGGAGCA
GAGCACACAGCTGGAGGCTGAGCGGCAAAGGGTGGCTGCCATATCTGCAGCCTACTCAGCCTAT
GTCCATGGCTACACAGCCTGGCAAACAGAAATGAACAGACTTGGGGTGGCCTTTGGGAAGGACT
TGTCACTGGGGCCCCCAACACCTTTCCCCAGCTGGCCAGGGTTTCCGAAGCCAATGCCTTCCCA
TCCTCAGGGTTGTACTCCAGTTTCCCCCTATTCTCCGAGGCAGCCTCCGTCCTCTTCCCTATCC
CAATCCTTTTCACCAGCCTCCTCCCCAGCCCCCCAGACTCCAGGACCTCAGCCTCTAATTATTC
ATCATGCCCAGATGGTACAGTTGGGAGTTAACAACCACATGTGGGGCCACACAGGGGCCCAGTC
ATCTGATGACAAGACTGAGTTTGGAGAAACCTTGGATGGGCCCTCTGACCGAGGGGAACCCCTT
TCTTGAAACTCCAGAGTGACCAGGTTGGACCCCACCTAGATTGCGAGAGTGGCAAGACTGAACT
TCACTTGGGTTCTTAAAGTTATATTAGAGGAAGGGAACCTTGCCTGGGCCCCCACAGTGGCCAT
TAGTTGGTCCCAGTTTGAGACCCCAGAGGCAGGGAAGACCACACCTGTAAATCAGGGCTTGGGA
AACGTGCAGAACCCCCATTTGAACAGACTCTGTGGGACCCCAACCTGCATCATCTCTGTGAATA
GAGGATGATGGGGCCATAGGCTCCTGTGAGGGGTCCTCAGTGTGGCCATGTAACCTTCATATGG
TCTCTCTGGGGGGGGGATGCGGTGCTGGGGCACATAGGGAAGGTCCTGTTTATAATAAAGTTAT
TGACAGCTGAGTCACAAGCCAACGCCCCCACACTCCATCACCCTCAGGAAACAAGCAGGTCACG
CCAACTTCGCCATGACTAGAATAGAAAAGGGGGTGTACCAGCCCAGTCCTTGAGTGGCAGGAAC
CGGAAATTATGTAGATATACTCATCCCATTGGTCAGTTCAGGCTACGTAGCCTTCTGTTGCAAG
GAATTCTAGGAAATGTAGTCTGGTGGGGGGGGTGCTGCAGCCATTCATCAGGAAGTCTTATAAC
TTCAAGAAAGGAGGAGAAAAAAAACTGGGAGTTGCTGCCAGTTTTGATTGTTTTGTCACTGCGG
ATCATCTTCCTTCATGCTGATTCCCCTCCCCAAGACATGTCAGACTCTTATACATTAAACAAAC
AAACAAAAACAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008765024	(Get FASTA)	NCBI Sequence Viewer
	XP_017452198	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_008765024 ⟸ XM_008766802
- Peptide Label:	isoform X1
- UniProtKB:	M0RA08 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPKRTHLSQRSALSPSRILVAGDKAVHKTIGSEHVSIHPTLCGSRLHPPPSMTNPAPSLHSVFG ILSALERDRLTCLKHKLGSLHPGSLESKLLHAMVLLALGQDTEARVSLESLKVNTAAQLVAGQW ADMENTEDPEEPPDLSWTVARLYHLLAEENLCPASTRDVAYQVALRDLTSQGDHQLGQLQKEAW DRCSSHQGSLQPPSAAPAMTRSQPRPIDTSDWSWGHTLHSTGSTATLASHLEISQSPTLAFFSS HHGAHGPSKLCDKPLGTQEPQLVPEGCEEPDRSQPPPVQTSISLGLPHEIRVPEVALPILPDSL AAPNTSVHCPIECTEVSADSRSPLTSITESVGKQWPITSQRSPQFPVGDDVLPNSMSSSPPAQP PSSQASSVQPPLSSASSQSSCPAPPASTPPVSEHLETSDQKFYNFVVIHARADEHVALRIREKL ETLGVPDGATFCEEFQVPGRGELHCLQDAIDHSGFMILLLTASFDCPLSLHQVNHALMNSLTQS GRQDCVIPLLPLECSQAQLSPDTTRLLHSIVWLDEHSPIFARKVANTFKAQKLQAQRERWKKEQ EARTLKEQSTQLEAERQRVAAISAAYSAYVHGYTAWQTEMNRLGVAFGKDLSLGPPTPFPSWPG FPKPMPSHPQGCTPVSPYSPRQPPSSSLSQSFSPASSPAPQTPGPQPLIIHHAQMVQLGVNNHM WGHTGAQSSDDKTEFGETLDGPSDRGEPLS hide sequence

RefSeq Acc Id:	XP_017452198 ⟸ XM_017596709
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I5Y6Z3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTNPAPSLHSVFGILSALERDRLTCLKHKLGSLHPGSLESKLLHAMVLLALGQDTEARVSLESL KVNTAAQLVAGQWADMENTEDPEEPPDLSWTVARLYHLLAEENLCPASTRDVAYQVALRDLTSQ GDHQLGQLQKEAWDRCSSHQGSLQPPSAAPAMTRSQPRPIDTSDWSWGHTLHSTGSTATLASHL EISQSPTLAFFSSHHGAHGPSKLCDKPLGTQEPQLVPEGCEEPDRSQPPPVQTSISLGLPHEIR VPEVALPILPDSLAAPNTSVHCPIECTEVSADSRSPLTSITESVGKQWPITSQRSPQFPVGDDV LPNSMSSSPPAQPPSSQASSVQPPLSSASSQSSCPAPPASTPPVSEHLETSDQKFYNFVVIHAR ADEHVALRIREKLETLGVPDGATFCEEFQVPGRGELHCLQDAIDHSGFMILLLTASFDCPLSLH QVNHALMNSLTQSGRQDCVIPLLPLECSQAQLSPDTTRLLHSIVWLDEHSPIFARKVANTFKAQ KLQAQRERWKKEQEARTLKEQSTQLEAERQRVAAISAAYSAYVHGYTAWQTEMNRLGVAFGKDL SLGPPTPFPSWPGFPKPMPSHPQGCTPVSPYSPRQPPSSSLSQSFSPASSPAPQTPGPQPLIIH HAQMVQLGVNNHMWGHTGAQSSDDKTEFGETLDGPSDRGEPLS hide sequence

RefSeq Acc Id:

ENSRNOP00000076995 ⟸ ENSRNOT00000072501

RefSeq Acc Id:

ENSRNOP00000085855 ⟸ ENSRNOT00000111500

RefSeq Acc Id:

ENSRNOP00000066344 ⟸ ENSRNOT00000070978

Protein Domains

TIR

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1590868	AgrOrtholog
BioCyc Gene	G2FUF-28538	BioCyc
Ensembl Genes	ENSRNOG00000048462	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000066344	ENTREZGENE
	ENSRNOP00000066344.2	UniProtKB/TrEMBL
	ENSRNOP00000076995	ENTREZGENE
	ENSRNOP00000076995.1	UniProtKB/TrEMBL
	ENSRNOP00000085855.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000070978	ENTREZGENE
	ENSRNOT00000070978.3	UniProtKB/TrEMBL
	ENSRNOT00000072501	ENTREZGENE
	ENSRNOT00000072501.2	UniProtKB/TrEMBL
	ENSRNOT00000111500.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.780	UniProtKB/TrEMBL
	3.40.50.10140	UniProtKB/TrEMBL
	Flagellar protein FliS	UniProtKB/TrEMBL
	Perilipin, alpha-beta domain	UniProtKB/TrEMBL
InterPro	Perilipin	UniProtKB/TrEMBL
	RHIM_dom	UniProtKB/TrEMBL
	TCAM1/2	UniProtKB/TrEMBL
	TIR_dom	UniProtKB/TrEMBL
	Toll_tir_struct_dom_sf	UniProtKB/TrEMBL
	TRIF_N	UniProtKB/TrEMBL
KEGG Report	rno:316130	UniProtKB/TrEMBL
NCBI Gene	363328	ENTREZGENE
PANTHER	PERILIPIN	UniProtKB/TrEMBL
	PERILIPIN-3	UniProtKB/TrEMBL
	PTHR47230	UniProtKB/TrEMBL
	TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1	UniProtKB/TrEMBL
Pfam	Perilipin	UniProtKB/TrEMBL
	RHIM	UniProtKB/TrEMBL
	TRIF-NTD	UniProtKB/TrEMBL
PhenoGen	Ticam1	PhenoGen
PIRSF	PAT	UniProtKB/TrEMBL
PROSITE	TIR	UniProtKB/TrEMBL
Superfamily-SCOP	Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain	UniProtKB/TrEMBL
	SSF52200	UniProtKB/TrEMBL
UniProt	A0A8I5Y6Z3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A147_RAT	UniProtKB/TrEMBL
	M0RA08	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-17	Ticam1	TIR domain containing adaptor molecule 1	Ticam1	toll-like receptor adaptor molecule 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-09	Ticam1	toll-like receptor adaptor molecule 1	LOC363328	similar to TICAM-1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC363328	similar to TICAM-1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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