Ticam1 (TIR domain containing adaptor molecule 1) - Rat Genome Database

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Gene: Ticam1 (TIR domain containing adaptor molecule 1) Rattus norvegicus
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Symbol: Ticam1 (Ensembl: Plin3)
Name: TIR domain containing adaptor molecule 1 (Ensembl:perilipin 3)
RGD ID: 1590868
Description: Predicted to enable protein kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; pattern recognition receptor signaling pathway; and positive regulation of cytokine production. Predicted to act upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of lymphocyte activation. Predicted to be located in cytosol and mitochondrion. Predicted to be part of ripoptosome. Predicted to be active in early endosome and endosome membrane. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (TIR domain containing adaptor molecule 1); PARTICIPATES IN Toll-like receptor signaling pathway; INTERACTS WITH alpha-D-galactose; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363328; similar to TICAM-1; TIR domain-containing adapter molecule 1; toll-like receptor adaptor molecule 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,189,717 - 1,197,730 (-)NCBIGRCr8
mRatBN7.291,102,559 - 1,111,023 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,102,366 - 1,123,147 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0910,780,185 - 10,790,280 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.099,774,816 - 9,781,948 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,397,373 - 7,407,468 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic signaling pathway  (ISO)
B cell activation  (ISO)
B cell proliferation  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
defense response to virus  (ISO)
inflammatory response  (IEA)
innate immune response  (IEA)
lipid storage  (IBA)
lipopolysaccharide-mediated signaling pathway  (ISO)
macrophage activation involved in immune response  (ISO)
MyD88-independent toll-like receptor signaling pathway  (ISO)
nitric oxide biosynthetic process  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of myeloid dendritic cell cytokine production  (ISO)
positive regulation of natural killer cell activation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of sequestering of triglyceride  (IBA)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (ISO)
regulation of protein-containing complex assembly  (ISO)
response to exogenous dsRNA  (ISO)
response to lipopolysaccharide  (ISO)
toll-like receptor 3 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (ISO)
toll-like receptor signaling pathway  (ISO)
TRIF-dependent toll-like receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12761501   PMID:12855817   PMID:12872135   PMID:14530355   PMID:14982987   PMID:17658277   PMID:19734906   PMID:20037584   PMID:21059856   PMID:21266579   PMID:21703541   PMID:21737330  
PMID:25636800  


Genomics

Comparative Map Data
Ticam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,189,717 - 1,197,730 (-)NCBIGRCr8
mRatBN7.291,102,559 - 1,111,023 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,102,366 - 1,123,147 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0910,780,185 - 10,790,280 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.099,774,816 - 9,781,948 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,397,373 - 7,407,468 (+)NCBICelera
Cytogenetic Map9q11NCBI
TICAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,815,932 - 4,831,712 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,815,932 - 4,831,712 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,815,944 - 4,831,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,766,992 - 4,769,451 (-)NCBINCBI36Build 36hg18NCBI36
Celera194,753,860 - 4,769,659 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,577,650 - 4,593,372 (-)NCBIHuRef
CHM1_1194,815,534 - 4,831,367 (-)NCBICHM1_1
T2T-CHM13v2.0194,801,397 - 4,817,189 (-)NCBIT2T-CHM13v2.0
Ticam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,576,462 - 56,583,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,576,319 - 56,583,786 (-)EnsemblGRCm39 Ensembl
GRCm381756,269,462 - 56,276,767 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,269,319 - 56,276,786 (-)EnsemblGRCm38mm10GRCm38
MGSCv371756,408,885 - 56,416,190 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361755,328,736 - 55,335,977 (-)NCBIMGSCv36mm8
MGSCv361755,903,171 - 55,910,412 (-)NCBIMGSCv36mm8
Cytogenetic Map17DNCBI
cM Map1729.24NCBI
Ticam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,202,372 - 4,204,513 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,197,083 - 4,204,999 (+)NCBIChiLan1.0ChiLan1.0
TICAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2209,211,162 - 9,227,692 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,440,455 - 8,456,977 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,836,100 - 3,852,017 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,787,244 - 4,803,727 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,787,557 - 4,790,206 (-)Ensemblpanpan1.1panPan2
TICAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,948,237 - 54,961,996 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,959,525 - 54,961,780 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2054,672,888 - 54,686,637 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02055,602,634 - 55,616,374 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12054,664,010 - 54,677,669 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,144,587 - 55,158,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,342,534 - 55,356,281 (+)NCBIUU_Cfam_GSD_1.0
Ticam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,005,381 - 215,015,878 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365882,818,909 - 2,827,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TICAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,004,308 - 74,021,873 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,004,566 - 74,021,100 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TICAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,526,719 - 4,543,251 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,527,033 - 4,529,168 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660813,618,262 - 3,633,550 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ticam1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,971,093 - 4,973,198 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248284,964,199 - 4,973,465 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ticam1
15 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat

Markers in Region
RH134483  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,111,285 - 1,111,482 (-)MAPPERmRatBN7.2
mRatBN7.22022,132,543 - 22,132,740 (+)MAPPERmRatBN7.2
Rnor_6.02023,566,923 - 23,567,119NCBIRnor6.0
Rnor_6.0910,781,357 - 10,781,553NCBIRnor6.0
Rnor_5.099,773,025 - 9,773,221UniSTSRnor5.0
Rnor_5.02025,646,916 - 25,647,112UniSTSRnor5.0
RGSC_v3.42023,019,069 - 23,019,265UniSTSRGSC3.4
Celera2023,484,940 - 23,485,136UniSTS
Celera97,398,545 - 7,398,741UniSTS
Cytogenetic Map20p11UniSTS
Cytogenetic Map9q11UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000070978   ⟹   ENSRNOP00000066344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,102,941 - 1,123,147 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000072501   ⟹   ENSRNOP00000076995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,102,366 - 1,109,331 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111500   ⟹   ENSRNOP00000085855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,110,592 - 1,118,597 (-)Ensembl
RefSeq Acc Id: XM_017596709   ⟹   XP_017452198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,189,717 - 1,197,730 (-)NCBI
mRatBN7.291,102,559 - 1,111,023 (-)NCBI
Rnor_6.0910,783,149 - 10,790,280 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001418256 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452198 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066344.2
  ENSRNOP00000076995.1
  ENSRNOP00000085855.1
RefSeq Acc Id: XP_017452198   ⟸   XM_017596709
- Sequence:
Ensembl Acc Id: ENSRNOP00000076995   ⟸   ENSRNOT00000072501
Ensembl Acc Id: ENSRNOP00000085855   ⟸   ENSRNOT00000111500
Ensembl Acc Id: ENSRNOP00000066344   ⟸   ENSRNOT00000070978
Protein Domains
TIR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590868 AgrOrtholog
BioCyc Gene G2FUF-28538 BioCyc
Ensembl Genes ENSRNOG00000048462 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070978.3 UniProtKB/TrEMBL
  ENSRNOT00000072501.2 UniProtKB/TrEMBL
  ENSRNOT00000111500.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.780 UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/TrEMBL
  Flagellar protein FliS UniProtKB/TrEMBL
  Perilipin, alpha-beta domain UniProtKB/TrEMBL
InterPro Perilipin UniProtKB/TrEMBL
  RHIM_dom UniProtKB/TrEMBL
  TCAM1/2 UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
  TRIF_N UniProtKB/TrEMBL
KEGG Report rno:363328 UniProtKB/TrEMBL
NCBI Gene 363328 ENTREZGENE
PANTHER PERILIPIN UniProtKB/TrEMBL
  PERILIPIN-3 UniProtKB/TrEMBL
  PTHR47230 UniProtKB/TrEMBL
  TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1 UniProtKB/TrEMBL
Pfam Perilipin UniProtKB/TrEMBL
  RHIM UniProtKB/TrEMBL
  TRIF-NTD UniProtKB/TrEMBL
PhenoGen Ticam1 PhenoGen
PIRSF PAT UniProtKB/TrEMBL
PROSITE TIR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048462 RatGTEx
Superfamily-SCOP Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain UniProtKB/TrEMBL
  SSF52200 UniProtKB/TrEMBL
UniProt A0A8I5Y6Z3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A147_RAT UniProtKB/TrEMBL
  M0RA08_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-17 Ticam1  TIR domain containing adaptor molecule 1  Ticam1  toll-like receptor adaptor molecule 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-09 Ticam1  toll-like receptor adaptor molecule 1  LOC363328  similar to TICAM-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC363328  similar to TICAM-1      Symbol and Name status set to provisional 70820 PROVISIONAL