TICAM1 (TIR domain containing adaptor molecule 1) - Rat Genome Database

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Pathways
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Gene: TICAM1 (TIR domain containing adaptor molecule 1) Canis lupus familiaris
Analyze
Symbol: TICAM1
Name: TIR domain containing adaptor molecule 1 (Ensembl:toll like receptor adaptor molecule 1)
RGD ID: 12287748
Description: ENCODES a protein that exhibits molecular adaptor activity (ortholog); signaling adaptor activity (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); B cell activation (ortholog); B cell proliferation (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH genetic disease (ortholog); Herpes Simplex Encephalitis (ortholog); Herpes Simplex Encephalitis 4 (ortholog); FOUND IN early endosome (ortholog); endosome (ortholog); endosome membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TIR domain-containing adapter molecule 1; toll like receptor adaptor molecule 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,948,237 - 54,961,996 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,959,525 - 54,961,780 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2054,672,888 - 54,686,637 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02055,602,634 - 55,616,374 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12054,664,010 - 54,677,669 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,144,587 - 55,158,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,342,534 - 55,356,281 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
apoptotic signaling pathway  (ISO)
B cell activation  (ISO)
B cell proliferation  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
defense response to virus  (IEA,ISO)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
macrophage activation involved in immune response  (ISO)
MyD88-independent toll-like receptor signaling pathway  (ISO)
nitric oxide biosynthetic process  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of B cell activation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of chemokine production  (ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of myeloid dendritic cell cytokine production  (IEA)
positive regulation of natural killer cell activation  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (ISO)
regulation of protein-containing complex assembly  (ISO)
response to exogenous dsRNA  (IEA,ISO)
response to lipopolysaccharide  (ISO)
signal transduction  (IEA)
toll-like receptor 3 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (ISO)
toll-like receptor signaling pathway  (ISO)
TRIF-dependent toll-like receptor signaling pathway  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TICAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,948,237 - 54,961,996 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,959,525 - 54,961,780 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2054,672,888 - 54,686,637 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02055,602,634 - 55,616,374 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12054,664,010 - 54,677,669 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,144,587 - 55,158,319 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,342,534 - 55,356,281 (+)NCBIUU_Cfam_GSD_1.0
TICAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,815,932 - 4,831,712 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,815,932 - 4,831,712 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,815,944 - 4,831,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,766,992 - 4,769,451 (-)NCBINCBI36Build 36hg18NCBI36
Celera194,753,860 - 4,769,659 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef194,577,650 - 4,593,372 (-)NCBIHuRef
CHM1_1194,815,534 - 4,831,367 (-)NCBICHM1_1
T2T-CHM13v2.0194,801,397 - 4,817,189 (-)NCBIT2T-CHM13v2.0
Ticam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391756,576,462 - 56,583,767 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1756,576,319 - 56,583,786 (-)EnsemblGRCm39 Ensembl
GRCm381756,269,462 - 56,276,767 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,269,319 - 56,276,786 (-)EnsemblGRCm38mm10GRCm38
MGSCv371756,408,885 - 56,416,190 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361755,328,736 - 55,335,977 (-)NCBIMGSCv36mm8
MGSCv361755,903,171 - 55,910,412 (-)NCBIMGSCv36mm8
Cytogenetic Map17DNCBI
cM Map1729.24NCBI
Ticam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,189,717 - 1,197,730 (-)NCBIGRCr8
mRatBN7.291,102,559 - 1,111,023 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,102,366 - 1,123,147 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0910,780,185 - 10,790,280 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.099,774,816 - 9,781,948 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera97,397,373 - 7,407,468 (+)NCBICelera
Cytogenetic Map9q11NCBI
Ticam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,202,372 - 4,204,513 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,197,083 - 4,204,999 (+)NCBIChiLan1.0ChiLan1.0
TICAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2209,211,162 - 9,227,692 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,440,455 - 8,456,977 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,836,100 - 3,852,017 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,787,244 - 4,803,727 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,787,557 - 4,790,206 (-)Ensemblpanpan1.1panPan2
Ticam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,005,381 - 215,015,878 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365882,818,909 - 2,827,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TICAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,004,308 - 74,021,873 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,004,566 - 74,021,100 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TICAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.164,526,719 - 4,543,251 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl64,527,033 - 4,529,168 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660813,618,262 - 3,633,550 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ticam1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,971,093 - 4,973,198 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248284,964,199 - 4,973,465 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TICAM1
195 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 6 6 1 6 2 1
Low 4 5 16 5 6 6 12 8 5
Below cutoff 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000030093   ⟹   ENSCAFP00000033738
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2054,959,525 - 54,961,780 (+)Ensembl
RefSeq Acc Id: XM_005633023   ⟹   XP_005633080
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12054,948,237 - 54,961,996 (+)NCBI
Dog10K_Boxer_Tasha2054,672,888 - 54,686,637 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038429024   ⟹   XP_038284952
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02055,602,634 - 55,616,374 (+)NCBI
RefSeq Acc Id: XM_038504633   ⟹   XP_038360561
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12054,664,010 - 54,677,669 (+)NCBI
RefSeq Acc Id: XM_038567705   ⟹   XP_038423633
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02055,342,534 - 55,356,281 (+)NCBI
RefSeq Acc Id: XM_038631842   ⟹   XP_038487770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02055,144,587 - 55,158,319 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005633080   ⟸   XM_005633023
- Peptide Label: isoform X5
- UniProtKB: A0A8P0SQ68 (UniProtKB/TrEMBL),   A0A8C0PJI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000033738   ⟸   ENSCAFT00000030093
RefSeq Acc Id: XP_038360561   ⟸   XM_038504633
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038487770   ⟸   XM_038631842
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038284952   ⟸   XM_038429024
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PJI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038423633   ⟸   XM_038567705
- Peptide Label: isoform X4
- UniProtKB: A0A8C0PJI2 (UniProtKB/TrEMBL)
Protein Domains
TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018946 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024378 UniProtKB/TrEMBL
  ENSCAFG00845014291 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000030093.5 UniProtKB/TrEMBL
  ENSCAFT00030044841.1 UniProtKB/TrEMBL
  ENSCAFT00845025561.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.780 UniProtKB/TrEMBL
  3.40.50.10140 UniProtKB/TrEMBL
InterPro RHIM_dom UniProtKB/TrEMBL
  TCAM1/2 UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
  TRIF_N UniProtKB/TrEMBL
NCBI Gene TICAM1 ENTREZGENE
PANTHER PTHR47230 UniProtKB/TrEMBL
  TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1 UniProtKB/TrEMBL
Pfam RHIM UniProtKB/TrEMBL
  TRIF-NTD UniProtKB/TrEMBL
PROSITE TIR UniProtKB/TrEMBL
Superfamily-SCOP SSF52200 UniProtKB/TrEMBL
UniProt A0A8C0PJI2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P245_CANLF UniProtKB/TrEMBL
  A0A8P0SQ68 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:55000 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-01-16 TICAM1  TIR domain containing adaptor molecule 1  TICAM1  toll like receptor adaptor molecule 1  Symbol and/or name change 19259463 PROVISIONAL