Nes (nestin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Nes (nestin) Rattus norvegicus
Analyze
Symbol: Nes
Name: nestin
RGD ID: 3162
Description: Enables CCR5 chemokine receptor binding activity. Involved in several processes, including positive regulation of intermediate filament depolymerization; positive regulation of neural precursor cell proliferation; and response to ionizing radiation. Located in intermediate filament. Biomarker of acute kidney failure; brain infarction; brain ischemia; and nephrosis. Orthologous to human NES (nestin); INTERACTS WITH 1,3-dinitrobenzene; 15-deoxy-Delta(12,14)-prostaglandin J2; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100910255; nestin-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,735,715 - 175,745,631 (+)NCBIGRCr8
mRatBN7.22173,437,867 - 173,447,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,438,734 - 173,447,777 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,583,526 - 180,592,569 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,605,885 - 178,614,928 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,205,949 - 173,214,992 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,343,109 - 187,352,972 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,344,056 - 187,352,969 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,746,885 - 206,755,989 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,051,907 - 180,060,947 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,002,012 - 180,011,053 (+)NCBI
Celera2167,386,159 - 167,395,202 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-dinitrobenzene  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethyl-4-tridecylmorpholine  (ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (EXP)
Anatoxin a  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (EXP,ISO)
beta-amyrin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carmustine  (EXP)
CHIR 99021  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
desipramine  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
eckol  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethosuximide  (EXP)
fenamidone  (ISO)
fenpropidin  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gefitinib  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
glycerol  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lupeol  (ISO)
LY294002  (ISO)
melatonin  (EXP,ISO)
methylmercury chloride  (EXP,ISO)
monocrotophos  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenytoin  (ISO)
progesterone  (EXP,ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
saccharin  (ISO)
SB 431542  (ISO)
sildenafil citrate  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2. Altered pancreatic morphology in the offspring of pregnant rats given reduced dietary protein is time and gender specific. Chamson-Reig A, etal., J Endocrinol. 2006 Oct;191(1):83-92.
3. Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments during mitosis. Chou YH, etal., Mol Biol Cell 2003 Apr;14(4):1468-78.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. [EphB2-Fc promotes activation of endogenous neural stem cells after cerebral cortex infarction: experimental with hypertensive rats] He YD, etal., Zhonghua Yi Xue Za Zhi. 2005 Sep 7;85(34):2395-9.
7. Desipramine activated Bcl-2 expression and inhibited lipopolysaccharide-induced apoptosis in hippocampus-derived adult neural stem cells. Huang YY, etal., J Pharmacol Sci. 2007 May;104(1):61-72.
8. Nestin immunoreactivity in local neurons of the adult rat striatum after remote cortical injury. Kuroda T, etal., J Chem Neuroanat 2002 Jul;24(2):137-46.
9. CNS stem cells express a new class of intermediate filament protein. Lendahl U, etal., Cell 1990 Feb 23;60(4):585-95.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Chemokines released from astrocytes promote chemokine receptor 5-mediated neuronal cell differentiation. Park MH, etal., Exp Cell Res. 2009 Oct 1;315(16):2715-26. Epub 2009 Jun 24.
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Cdk5 regulates the organization of Nestin and its association with p35. Sahlgren CM, etal., Mol Cell Biol 2003 Jul;23(14):5090-106.
17. Nestin expression persists in astrocytes of organotypic slice cultures from rat cortex. Schmidt-Kastner R and Humpel C, Int J Dev Neurosci 2002 Feb;20(1):29-38.
18. Enhancement of nestin protein-immunoreactivity induced by ionizing radiation in the forebrain ependymal regions of rats. Shi M, etal., Neurosci Res. 2002 Dec;44(4):475-81.
19. [Neuroprotective effects of exogenous basic fibroblast growth factor on the hypoxic-ischemic brain damage of neonatal rats] Sun JQ, etal., Zhonghua Er Ke Za Zhi. 2007 May;45(5):354-9.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Nestin is essential for mitogen-stimulated proliferation of neural progenitor cells. Xue XJ and Yuan XB, Mol Cell Neurosci. 2010 Sep;45(1):26-36. doi: 10.1016/j.mcn.2010.05.006. Epub 2010 May 25.
22. Identification of nestin as a urinary biomarker for acute kidney injury. Zhang W, etal., Am J Nephrol. 2014;39(2):110-21. doi: 10.1159/000358260. Epub 2014 Feb 6.
23. [Effect of electroacupuncture on expression of nestin protein after focal ischemia/reperfusion in rats] Zhao ZQ and Luo Y, Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jun;26 Suppl:20-4.
24. Time course of expression of intermediate filament protein vimentin, nestin and desmin in rat renal glomerular injury. Zou J, etal., Chin Med J (Engl). 2007 Jul 5;120(13):1203-5.
Additional References at PubMed
PMID:9364068   PMID:9917366   PMID:12107504   PMID:12687705   PMID:12819359   PMID:14706696   PMID:15145750   PMID:15206826   PMID:15293228   PMID:15526158   PMID:15677762   PMID:15966898  
PMID:16230517   PMID:16571784   PMID:16612832   PMID:16856331   PMID:16949759   PMID:16997483   PMID:17429339   PMID:17671844   PMID:17784648   PMID:17901127   PMID:17916630   PMID:18377259  
PMID:18439098   PMID:18614158   PMID:18805450   PMID:18851944   PMID:18941770   PMID:19013217   PMID:19036983   PMID:19241870   PMID:19245830   PMID:19306852   PMID:19384922   PMID:19409199  
PMID:19451150   PMID:19468198   PMID:19562035   PMID:19679743   PMID:19704967   PMID:19723548   PMID:20153393   PMID:20617137   PMID:20945344   PMID:20963821   PMID:21139996   PMID:21185309  
PMID:21679183   PMID:21906524   PMID:21993267   PMID:22038821   PMID:22185478   PMID:23000950   PMID:23236886   PMID:23250576   PMID:23319587   PMID:23447615   PMID:23611784   PMID:23855824  
PMID:23938193   PMID:23979707   PMID:24657285   PMID:24915827   PMID:25139503   PMID:26574905   PMID:26699726   PMID:27439108   PMID:28358926   PMID:28448522   PMID:29359828   PMID:30883593  
PMID:31841640   PMID:32654195   PMID:32714078   PMID:32910393   PMID:32950539   PMID:36690826   PMID:37934159  


Genomics

Comparative Map Data
Nes
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82175,735,715 - 175,745,631 (+)NCBIGRCr8
mRatBN7.22173,437,867 - 173,447,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,438,734 - 173,447,777 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,583,526 - 180,592,569 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,605,885 - 178,614,928 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,205,949 - 173,214,992 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,343,109 - 187,352,972 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,344,056 - 187,352,969 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,746,885 - 206,755,989 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,051,907 - 180,060,947 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,002,012 - 180,011,053 (+)NCBI
Celera2167,386,159 - 167,395,202 (+)NCBICelera
Cytogenetic Map2q34NCBI
NES
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,668,763 - 156,677,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,668,763 - 156,677,407 (-)EnsemblGRCh38hg38GRCh38
GRCh371156,638,555 - 156,647,199 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,905,179 - 154,913,813 (-)NCBINCBI36Build 36hg18NCBI36
Build 341153,451,630 - 153,460,262NCBI
Celera1129,709,369 - 129,718,003 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1127,996,154 - 128,004,788 (-)NCBIHuRef
CHM1_11158,034,765 - 158,043,399 (-)NCBICHM1_1
T2T-CHM13v2.01155,805,165 - 155,813,809 (-)NCBIT2T-CHM13v2.0
Nes
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39387,878,400 - 87,887,758 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl387,878,385 - 87,887,758 (+)EnsemblGRCm39 Ensembl
GRCm38387,971,093 - 87,980,451 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl387,971,078 - 87,980,451 (+)EnsemblGRCm38mm10GRCm38
MGSCv37387,775,015 - 87,784,373 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,057,020 - 88,066,378 (+)NCBIMGSCv36mm8
Celera388,008,485 - 88,017,845 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.78NCBI
Nes
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,748,078 - 2,756,301 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,748,132 - 2,756,595 (-)NCBIChiLan1.0ChiLan1.0
NES
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,167,229 - 93,175,869 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1192,901,730 - 92,910,368 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01132,012,273 - 132,020,907 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,835,456 - 135,844,094 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,835,456 - 135,844,094 (-)Ensemblpanpan1.1panPan2
NES
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,296,395 - 41,305,641 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,295,989 - 41,303,736 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha740,783,666 - 40,792,924 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,159,499 - 41,168,749 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,160,198 - 41,168,746 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1740,941,448 - 40,950,698 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0740,994,447 - 41,003,699 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,278,086 - 41,287,336 (+)NCBIUU_Cfam_GSD_1.0
Nes
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,807,567 - 26,817,174 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,837,936 - 5,847,020 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,837,949 - 5,847,499 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NES
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,412,247 - 93,421,893 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,412,660 - 93,421,899 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24101,984,527 - 101,993,772 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NES
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,185,208 - 7,193,964 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,185,390 - 7,193,983 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,480,916 - 6,489,509 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nes
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,837,926 - 1,844,895 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,837,614 - 1,845,029 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nes
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:99
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000025314, ENSRNOT00000025384
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
AA166324  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,446,921 - 173,447,055 (+)MAPPERmRatBN7.2
Rnor_6.02184,908,098 - 184,908,231NCBIRnor6.0
Rnor_6.02187,352,117 - 187,352,250NCBIRnor6.0
Rnor_5.02204,299,171 - 204,299,304UniSTSRnor5.0
Rnor_5.02206,755,134 - 206,755,267UniSTSRnor5.0
RGSC_v3.42180,060,095 - 180,060,228UniSTSRGSC3.4
Celera2167,394,347 - 167,394,480UniSTS
Cytogenetic Map2q34UniSTS
RH131466  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,447,453 - 173,447,672 (+)MAPPERmRatBN7.2
Rnor_6.02187,352,649 - 187,352,867NCBIRnor6.0
Rnor_5.02206,755,666 - 206,755,884UniSTSRnor5.0
RGSC_v3.42180,060,627 - 180,060,845UniSTSRGSC3.4
Celera2167,394,879 - 167,395,097UniSTS
RH 3.4 Map21130.7UniSTS
Cytogenetic Map2q34UniSTS
UniSTS:497298  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,442,457 - 173,443,090 (+)MAPPERmRatBN7.2
Rnor_6.02187,347,653 - 187,348,285NCBIRnor6.0
Rnor_6.02184,903,634 - 184,904,266NCBIRnor6.0
Rnor_5.02204,294,707 - 204,295,339UniSTSRnor5.0
Rnor_5.02206,750,670 - 206,751,302UniSTSRnor5.0
RGSC_v3.42180,055,631 - 180,056,263UniSTSRGSC3.4
Celera2167,389,883 - 167,390,515UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 87 86 55 25 55 6 214 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000025314   ⟹   ENSRNOP00000025314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,438,734 - 173,447,777 (+)Ensembl
Rnor_6.0 Ensembl2187,344,056 - 187,352,568 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000025384   ⟹   ENSRNOP00000025384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,442,222 - 173,447,373 (+)Ensembl
Rnor_6.0 Ensembl2187,347,602 - 187,352,969 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100350   ⟹   ENSRNOP00000089157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,438,734 - 173,447,373 (+)Ensembl
RefSeq Acc Id: NM_001308239   ⟹   NP_001295168
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,736,588 - 175,745,631 (+)NCBI
mRatBN7.22173,438,734 - 173,447,777 (+)NCBI
Rnor_6.02187,343,929 - 187,352,972 (+)NCBI
Celera2167,386,159 - 167,395,202 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012987   ⟹   NP_037119
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,736,588 - 175,745,631 (+)NCBI
mRatBN7.22173,438,734 - 173,447,777 (+)NCBI
Rnor_6.02187,343,929 - 187,352,972 (+)NCBI
Rnor_5.02206,746,885 - 206,755,989 (+)NCBI
RGSC_v3.42180,051,907 - 180,060,947 (+)RGD
Celera2167,386,159 - 167,395,202 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590648   ⟹   XP_017446137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82175,735,715 - 175,745,631 (+)NCBI
mRatBN7.22173,437,867 - 173,447,777 (+)NCBI
Rnor_6.02187,343,109 - 187,352,972 (+)NCBI
Sequence:
RefSeq Acc Id: NP_037119   ⟸   NM_012987
- Peptide Label: isoform 2
- UniProtKB: A0A8I6ABC1 (UniProtKB/TrEMBL),   A6J640 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295168   ⟸   NM_001308239
- Peptide Label: isoform 1
- UniProtKB: Q8CJ14 (UniProtKB/Swiss-Prot),   P21263 (UniProtKB/Swiss-Prot),   A6J639 (UniProtKB/TrEMBL),   G3V8F8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446137   ⟸   XM_017590648
- Peptide Label: isoform X1
- UniProtKB: Q8CJ14 (UniProtKB/Swiss-Prot),   P21263 (UniProtKB/Swiss-Prot),   A6J639 (UniProtKB/TrEMBL),   G3V8F8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025384   ⟸   ENSRNOT00000025384
Ensembl Acc Id: ENSRNOP00000025314   ⟸   ENSRNOT00000025314
Ensembl Acc Id: ENSRNOP00000089157   ⟸   ENSRNOT00000100350
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21263-F1-model_v2 AlphaFold P21263 1-1893 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3162 AgrOrtholog
BioCyc Gene G2FUF-52524 BioCyc
Ensembl Genes ENSRNOG00000018681 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025314.4 UniProtKB/TrEMBL
  ENSRNOT00000025384.7 UniProtKB/TrEMBL
  ENSRNOT00000100350.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nestin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25491 UniProtKB/TrEMBL
NCBI Gene 25491 ENTREZGENE
PANTHER NESTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47051 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nes PhenoGen
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018681 RatGTEx
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205473
UniProt A0A8I6ABC1 ENTREZGENE, UniProtKB/TrEMBL
  A6J639 ENTREZGENE, UniProtKB/TrEMBL
  A6J640 ENTREZGENE, UniProtKB/TrEMBL
  A6J641_RAT UniProtKB/TrEMBL
  D3ZWJ2_RAT UniProtKB/TrEMBL
  G3V8F8 ENTREZGENE, UniProtKB/TrEMBL
  NEST_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CJ14 ENTREZGENE
UniProt Secondary Q8CJ14 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Nes  nestin  LOC100910255  nestin-like  Data merged from RGD:6499605 737654 PROVISIONAL
2012-07-05 LOC100910255  nestin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Nes  Nestin      Symbol and Name status set to approved 70586 APPROVED