Gprasp3 (G protein-coupled receptor associated sorting protein family member 3) - Rat Genome Database

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Gene: Gprasp3 (G protein-coupled receptor associated sorting protein family member 3) Rattus norvegicus
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Symbol: Gprasp3
Name: G protein-coupled receptor associated sorting protein family member 3
RGD ID: 1303224
Description: Predicted to enable protein homodimerization activity. Predicted to be involved in learning or memory; negative regulation of neuron apoptotic process; and positive regulation of nervous system development. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including GPRASP3 (G protein-coupled receptor associated sorting protein family member 3); INTERACTS WITH 1,2-dimethylhydrazine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: basic helix-loop-helix domain containing, class B, 9; basic helix-loop-helix family member B9; Bhlhb9; G protein-coupled receptor associated sorting protein 3; KKPROT; LOC317407; p60TRP; transcription regulator of 60 kDa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,639,366 - 103,644,561 (+)NCBIGRCr8
mRatBN7.2X98,847,591 - 98,854,949 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,817,593 - 98,854,545 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX100,985,493 - 100,988,191 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,496,103 - 104,498,801 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,047,888 - 102,050,587 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,359,981 - 106,393,457 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,390,759 - 106,393,459 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X106,726,766 - 106,739,896 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X123,149,086 - 123,151,846 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X123,222,518 - 123,225,279 (+)NCBI
CeleraX100,291,299 - 100,293,998 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Characterizing the new transcription regulator protein p60TRP. Heese K, etal., J Cell Biochem 2004 Apr 1;91(5):1030-42.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19056867   PMID:21199326  


Genomics

Comparative Map Data
Gprasp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,639,366 - 103,644,561 (+)NCBIGRCr8
mRatBN7.2X98,847,591 - 98,854,949 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,817,593 - 98,854,545 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX100,985,493 - 100,988,191 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,496,103 - 104,498,801 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,047,888 - 102,050,587 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,359,981 - 106,393,457 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,390,759 - 106,393,459 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X106,726,766 - 106,739,896 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X123,149,086 - 123,151,846 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X123,222,518 - 123,225,279 (+)NCBI
CeleraX100,291,299 - 100,293,998 (-)NCBICelera
Cytogenetic MapXq32NCBI
GPRASP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X102,720,743 - 102,753,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX102,720,688 - 102,753,540 (+)EnsemblGRCh38hg38GRCh38
GRCh37X101,975,671 - 102,008,468 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X101,862,310 - 101,894,024 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X101,781,798 - 101,813,513NCBI
CeleraX102,414,680 - 102,446,406 (+)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX91,641,229 - 91,672,865 (+)NCBIHuRef
CHM1_1X101,868,307 - 101,900,034 (+)NCBICHM1_1
T2T-CHM13v2.0X101,165,692 - 101,198,489 (+)NCBIT2T-CHM13v2.0
Bhlhb9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X134,742,388 - 134,791,828 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX134,698,343 - 134,791,830 (+)EnsemblGRCm39 Ensembl
GRCm38X135,841,639 - 135,891,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX135,797,594 - 135,891,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X132,420,390 - 132,425,620 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X131,235,266 - 131,237,439 (+)NCBIMGSCv36mm8
CeleraX119,202,603 - 119,207,835 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX57.31NCBI
Gprasp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955548230,525 - 236,043 (+)NCBIChiLan1.0ChiLan1.0
GPRASP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X102,327,152 - 102,360,738 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X102,330,757 - 102,363,242 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X91,944,691 - 91,978,289 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X102,324,471 - 102,358,183 (+)NCBIpanpan1.1PanPan1.1panPan2
GPRASP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X76,635,887 - 76,651,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX76,636,667 - 76,638,319 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X77,830,292 - 77,845,859 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX77,695,389 - 77,846,736 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X75,380,346 - 75,395,910 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X77,043,280 - 77,058,840 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X76,753,328 - 76,768,896 (+)NCBIUU_Cfam_GSD_1.0
Gprasp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,370,715 - 62,375,944 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049368131,099,164 - 1,137,974 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPRASP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X83,895,554 - 83,911,573 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X97,835,521 - 97,851,537 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPRASP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X90,695,125 - 90,735,910 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606515,532,543 - 15,573,372 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gprasp3
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:26
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000049375
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat

Markers in Region
RH133247  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X98,849,160 - 98,850,651 (+)MAPPERmRatBN7.2
Rnor_6.0X106,389,107 - 106,390,597NCBIRnor6.0
Rnor_5.0X106,729,626 - 106,731,116UniSTSRnor5.0
RGSC_v3.4X123,147,434 - 123,148,924UniSTSRGSC3.4
CeleraX100,294,160 - 100,295,650UniSTS
Cytogenetic MapXq35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 30 17 8 17 1 1 74 29 34 11 1
Low 3 15 27 24 11 24 7 10 6 7 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000049375   ⟹   ENSRNOP00000042638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,847,713 - 98,854,545 (+)Ensembl
Rnor_6.0 EnsemblX106,390,759 - 106,393,459 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103691   ⟹   ENSRNOP00000089209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,848,164 - 98,854,545 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108351   ⟹   ENSRNOP00000080161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,817,593 - 98,854,545 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110806   ⟹   ENSRNOP00000089980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,848,023 - 98,854,545 (+)Ensembl
RefSeq Acc Id: NM_207611   ⟹   NP_997494
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X103,639,366 - 103,644,561 (+)NCBI
mRatBN7.2X98,847,732 - 98,852,927 (+)NCBI
Rnor_6.0X106,390,759 - 106,393,457 (+)NCBI
Rnor_5.0X106,726,766 - 106,739,896 (-)NCBI
RGSC_v3.4X123,149,086 - 123,151,846 (+)RGD
CeleraX100,291,299 - 100,293,998 (-)RGD
Sequence:
RefSeq Acc Id: NP_997494   ⟸   NM_207611
- UniProtKB: Q71HP2 (UniProtKB/Swiss-Prot),   A6KT33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042638   ⟸   ENSRNOT00000049375
RefSeq Acc Id: ENSRNOP00000089980   ⟸   ENSRNOT00000110806
RefSeq Acc Id: ENSRNOP00000080161   ⟸   ENSRNOT00000108351
RefSeq Acc Id: ENSRNOP00000089209   ⟸   ENSRNOT00000103691
Protein Domains
Armadillo repeat-containing

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q71HP2-F1-model_v2 AlphaFold Q71HP2 1-539 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303224 AgrOrtholog
BioCyc Gene G2FUF-1644 BioCyc
Ensembl Genes ENSRNOG00000003191 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055024672 UniProtKB/Swiss-Prot
  ENSRNOG00060022521 UniProtKB/Swiss-Prot
  ENSRNOG00065006090 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000049375.6 UniProtKB/Swiss-Prot
  ENSRNOT00000103691.1 UniProtKB/Swiss-Prot
  ENSRNOT00000108351.1 UniProtKB/Swiss-Prot
  ENSRNOT00000110806.1 UniProtKB/Swiss-Prot
  ENSRNOT00055042483 UniProtKB/Swiss-Prot
  ENSRNOT00055042490 UniProtKB/Swiss-Prot
  ENSRNOT00055042513 UniProtKB/Swiss-Prot
  ENSRNOT00055042529 UniProtKB/Swiss-Prot
  ENSRNOT00060039047 UniProtKB/Swiss-Prot
  ENSRNOT00060039092 UniProtKB/Swiss-Prot
  ENSRNOT00060039153 UniProtKB/Swiss-Prot
  ENSRNOT00060039189 UniProtKB/Swiss-Prot
  ENSRNOT00065009259 UniProtKB/Swiss-Prot
  ENSRNOT00065009262 UniProtKB/Swiss-Prot
  ENSRNOT00065009264 UniProtKB/Swiss-Prot
  ENSRNOT00065009265 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-rpt_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BHLHb9/GASP-1/GASP-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:317407 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 317407 ENTREZGENE
PANTHER PROTEIN BHLHB9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN BHLHB9-RELATED UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Arm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gprasp3 PhenoGen
RatGTEx ENSRNOG00000003191 RatGTEx
  ENSRNOG00055024672 RatGTEx
  ENSRNOG00060022521 RatGTEx
  ENSRNOG00065006090 RatGTEx
Superfamily-SCOP ARM repeat UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KT33 ENTREZGENE, UniProtKB/TrEMBL
  BHLH9_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-29 Gprasp3  G protein-coupled receptor associated sorting protein family member 3  Bhlhb9  basic helix-loop-helix family member B9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-09 Bhlhb9  basic helix-loop-helix family member B9  Bhlhb9  basic helix-loop-helix domain containing, class B, 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-21 Bhlhb9  basic helix-loop-helix domain containing, class B, 9  LOC317407  KKPROT  Symbol and Name updated 1299863 APPROVED