Scnn1a (sodium channel epithelial 1 subunit alpha) - Rat Genome Database

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Gene: Scnn1a (sodium channel epithelial 1 subunit alpha) Rattus norvegicus
Analyze
Symbol: Scnn1a
Name: sodium channel epithelial 1 subunit alpha
RGD ID: 3639
Description: Enables WW domain binding activity; actin binding activity; and ligand-gated sodium channel activity. Contributes to sodium ion transmembrane transporter activity. Involved in intracellular sodium ion homeostasis; regulation of body fluid levels; and sodium ion import across plasma membrane. Located in several cellular components, including acrosomal vesicle; apical plasma membrane; and sperm principal piece. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 2; and pseudohypoaldosteronism. Orthologous to human SCNN1A (sodium channel epithelial 1 subunit alpha); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-ENaC; alpha-NaCH; amiloride-sensitive epithelial sodium channel alpha subunit; amiloride-sensitive sodium channel subunit alpha; ENaCA; epithelial Na(+) channel subunit alpha; epithelial sodium channel alpha subunit; epithelial sodium channel subunit alpha; nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; sodium channel epithelial 1 alpha subunit; Sodium channel nonvoltage-gated 1 alpha (epithelial); sodium channel, non-voltage-gated 1 alpha subunit; sodium channel, nonvoltage-gated 1 alpha; sodium channel, nonvoltage-gated, type 1, alpha subunit; sodium channel, nonvoltage-gated, type I, alpha; sodium channel, nonvoltage-gated, type I, alpha polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,809,187 - 159,832,409 (+)NCBIGRCr8
mRatBN7.24158,122,962 - 158,146,184 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,122,962 - 158,146,181 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4164,352,580 - 164,375,779 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04160,135,500 - 160,158,705 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,774,454 - 158,797,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,834,339 - 157,860,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,836,912 - 157,860,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,853,710 - 224,877,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,445,936 - 161,469,267 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,690,871 - 161,714,200 (+)NCBI
Celera4146,859,208 - 146,882,414 (+)NCBICelera
RH 3.4 Map41000.7RGD
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
8-(4-chlorophenylthio)-cAMP  (EXP)
8-(4-chlorophenylthio)-cGMP  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amiloride  (EXP,ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenzofurans  (ISO)
dicrotophos  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
farglitazar  (EXP)
fenthion  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
hexachlorobenzene  (EXP)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
iodide salt  (EXP)
isotretinoin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methoxychlor  (EXP)
methylmercury(1+)  (EXP)
nitrates  (EXP)
nitrofen  (EXP)
orphenadrine  (EXP)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
progesterone  (EXP,ISO)
propranolol  (EXP)
prothioconazole  (ISO)
pyrethrins  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium chloride  (EXP)
sodium fluoride  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
terbutaline  (EXP)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thallium atom  (EXP)
thallium sulfate  (EXP)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiourea  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
acrosomal vesicle  (IDA,IEA)
apical plasma membrane  (IDA,IEA,ISO)
cell projection  (IEA)
ciliary membrane  (IEA,ISO,ISS)
cilium  (IEA)
cortical actin cytoskeleton  (IDA)
cytoplasm  (IDA,IEA,ISO)
cytoplasmic vesicle  (IEA)
cytosol  (IEA,ISO)
external side of plasma membrane  (IEA,ISO)
extracellular exosome  (IEA,ISO)
membrane  (IEA,ISO)
motile cilium  (IEA,ISO,ISS)
plasma membrane  (IBA,IEA,ISO,ISS,NAS)
sodium channel complex  (IBA,IEA,IPI,ISO,ISS)
sperm principal piece  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Determination of epithelial Na+ channel subunit stoichiometry from single-channel conductances. Anantharam A and Palmer LG, J Gen Physiol. 2007 Jul;130(1):55-70. doi: 10.1085/jgp.200609716. Epub 2007 Jun 11.
2. Na transport proteins are expressed by rat alveolar epithelial type I cells. Borok Z, etal., Am J Physiol Lung Cell Mol Physiol 2002 Apr;282(4):L599-608.
3. Epithelial sodium channel related to proteins involved in neurodegeneration. Canessa CM, etal., Nature 1993 Feb 4;361(6411):467-70.
4. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Canessa CM, etal., Nature 1994 Feb 3;367(6462):463-7.
5. Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma. Caren H, etal., BMC Cancer. 2011 Feb 11;11:66.
6. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Chang SS, etal., Nat Genet. 1996 Mar;12(3):248-53.
7. A novel pathway of epithelial sodium channel activation involves a serum- and glucocorticoid-inducible kinase consensus motif in the C terminus of the channel's alpha-subunit. Diakov A and Korbmacher C, J Biol Chem. 2004 Sep 10;279(37):38134-42. Epub 2004 Jul 1.
8. The epithelial sodium channel (ENaC) is intracellularly located as a tetramer. Dijkink L, etal., Pflugers Arch. 2002 Jul;444(4):549-55. doi: 10.1007/s00424-002-0855-4. Epub 2002 May 29.
9. Regulation of maturation and processing of ENaC subunits in the rat kidney. Ergonul Z, etal., Am J Physiol Renal Physiol. 2006 Sep;291(3):F683-93. Epub 2006 Mar 22.
10. The heterotetrameric architecture of the epithelial sodium channel (ENaC). Firsov D, etal., EMBO J. 1998 Jan 15;17(2):344-52. doi: 10.1093/emboj/17.2.344.
11. The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC. Friedrich B, etal., Pflugers Arch 2003 Mar;445(6):693-6. Epub 2003 Jan 21.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel. Gründer S, etal., EMBO J. 1997 Mar 3;16(5):899-907. doi: 10.1093/emboj/16.5.899.
15. Trafficking and cell surface stability of the epithelial Na+ channel expressed in epithelial Madin-Darby canine kidney cells. Hanwell D, etal., J Biol Chem 2002 Mar 22;277(12):9772-9.
16. Impact of alphaENaC polymorphisms on the risk of ischemic cerebrovascular events: a multicenter case-control study. Hsieh K, etal., Clin Chem. 2005 Jun;51(6):952-6. Epub 2005 Feb 25.
17. δ ENaC: a novel divergent amiloride-inhibitable sodium channel. Ji HL, etal., Am J Physiol Lung Cell Mol Physiol. 2012 Dec 15;303(12):L1013-26. doi: 10.1152/ajplung.00206.2012. Epub 2012 Sep 14.
18. Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats. Kim SW, etal., Am J Physiol Renal Physiol. 2004 May;286(5):F922-35. Epub 2004 Jan 6.
19. Role of the alpha-, beta-, and gamma-subunits of epithelial sodium channel in a model of polygenic hypertension. Kreutz R, etal., Hypertension 1997 Jan;29(1 Pt 1):131-6.
20. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
21. RNA interference for alpha-ENaC inhibits rat lung fluid absorption in vivo. Li T and Folkesson HG, Am J Physiol Lung Cell Mol Physiol. 2006 Apr;290(4):L649-L660. Epub 2005 Oct 28.
22. The carboxyl terminus of the alpha-subunit of the amiloride-sensitive epithelial sodium channel binds to F-actin. Mazzochi C, etal., J Biol Chem. 2006 Mar 10;281(10):6528-38. Epub 2005 Dec 14.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Mineralocorticoid effects in the kidney: correlation between alphaENaC, GILZ, and Sgk-1 mRNA expression and urinary excretion of Na+ and K+. Muller OG, etal., J Am Soc Nephrol 2003 May;14(5):1107-15.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Structure and hormone responsiveness of the gene encoding the alpha-subunit of the rat amiloride-sensitive epithelial sodium channel. Otulakowski G, etal., Am J Respir Cell Mol Biol 1999 May;20(5):1028-40.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
30. Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. Planes C, etal., J Biol Chem 2002 Dec 6;277(49):47318-24.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa. Sharma S, etal., J Mol Histol. 2018 Apr;49(2):195-208. doi: 10.1007/s10735-018-9759-2. Epub 2018 Feb 16.
35. WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. Staub O, etal., EMBO J 1996 May 15;15(10):2371-80.
36. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
37. Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells. Warnock DG, etal., Nat Rev Nephrol. 2014 Mar;10(3):146-57. doi: 10.1038/nrneph.2013.275. Epub 2014 Jan 14.
Additional References at PubMed
PMID:7744818   PMID:7929098   PMID:8175716   PMID:8382172   PMID:9351815   PMID:10212229   PMID:10409305   PMID:10642508   PMID:11323714   PMID:12381825   PMID:12548398   PMID:12631124  
PMID:12876281   PMID:12928313   PMID:12967915   PMID:14514522   PMID:14556380   PMID:14567502   PMID:14576089   PMID:14672917   PMID:14969999   PMID:15161604   PMID:15219314   PMID:15326289  
PMID:15755725   PMID:15956070   PMID:16020936   PMID:16099816   PMID:16172119   PMID:16449357   PMID:16877633   PMID:16941024   PMID:17693485   PMID:17715136   PMID:17926064   PMID:18024548  
PMID:18298571   PMID:18504317   PMID:18586672   PMID:18615584   PMID:18806814   PMID:18990692   PMID:19202345   PMID:19218112   PMID:19224431   PMID:19460695   PMID:19732740   PMID:20664544  
PMID:20686170   PMID:21413931   PMID:21423289   PMID:21953222   PMID:22045317   PMID:22126768   PMID:22207244   PMID:22485214   PMID:24097558   PMID:24124190   PMID:25873260   PMID:28130590  
PMID:28218740   PMID:30977984   PMID:31113930  


Genomics

Comparative Map Data
Scnn1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,809,187 - 159,832,409 (+)NCBIGRCr8
mRatBN7.24158,122,962 - 158,146,184 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,122,962 - 158,146,181 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4164,352,580 - 164,375,779 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04160,135,500 - 160,158,705 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,774,454 - 158,797,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,834,339 - 157,860,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,836,912 - 157,860,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,853,710 - 224,877,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,445,936 - 161,469,267 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14161,690,871 - 161,714,200 (+)NCBI
Celera4146,859,208 - 146,882,414 (+)NCBICelera
RH 3.4 Map41000.7RGD
Cytogenetic Map4q42NCBI
SCNN1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,346,847 - 6,377,359 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,346,843 - 6,377,730 (-)EnsemblGRCh38hg38GRCh38
GRCh37126,456,013 - 6,486,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,326,274 - 6,354,976 (-)NCBINCBI36Build 36hg18NCBI36
Build 34126,326,275 - 6,354,976NCBI
Celera128,072,686 - 8,103,776 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,309,328 - 6,340,388 (-)NCBIHuRef
CHM1_1126,455,271 - 6,485,705 (-)NCBICHM1_1
T2T-CHM13v2.0126,356,269 - 6,387,417 (-)NCBIT2T-CHM13v2.0
Scnn1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396125,286,657 - 125,321,906 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6125,297,622 - 125,321,906 (+)EnsemblGRCm39 Ensembl
GRCm386125,314,271 - 125,344,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6125,320,659 - 125,344,943 (+)EnsemblGRCm38mm10GRCm38
MGSCv376125,271,358 - 125,294,961 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366125,287,472 - 125,310,562 (+)NCBIMGSCv36mm8
Celera6126,992,384 - 127,015,966 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map659.32NCBI
Scnn1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554133,999,613 - 4,023,596 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,000,083 - 4,023,596 (-)NCBIChiLan1.0ChiLan1.0
SCNN1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21011,906,576 - 11,936,618 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11211,903,334 - 11,934,030 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,475,723 - 6,506,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,392,354 - 6,423,118 (-)NCBIpanpan1.1PanPan1.1panPan2
SCNN1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,612,206 - 38,638,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,612,194 - 38,638,980 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,976,259 - 8,002,278 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,968,240 - 38,994,329 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,969,121 - 38,994,321 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,840,880 - 38,866,869 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,882,321 - 38,908,328 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,455,013 - 7,481,038 (-)NCBIUU_Cfam_GSD_1.0
Scnn1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,703,982 - 102,735,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367091,377,831 - 1,403,833 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367091,377,852 - 1,403,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCNN1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl564,285,015 - 64,313,612 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1564,287,529 - 64,312,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,749,072 - 66,773,949 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCNN1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,384,073 - 6,418,620 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,383,956 - 6,416,337 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,817,244 - 1,851,507 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scnn1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,126,379 - 3,145,043 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,123,676 - 3,152,217 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scnn1a
129 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:84
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000067271
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4157680158158841762Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
D4Hmgc2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24158,133,085 - 158,133,293 (+)MAPPERmRatBN7.2
Rnor_6.04157,846,956 - 157,847,163NCBIRnor6.0
Rnor_5.04224,864,059 - 224,864,266UniSTSRnor5.0
RGSC_v3.44161,456,171 - 161,456,378UniSTSRGSC3.4
Celera4146,869,318 - 146,869,525UniSTS
RH 3.4 Map41003.1UniSTS
RH 3.4 Map41003.1RGD
Cytogenetic Map4q42UniSTS
RH94629  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24158,145,273 - 158,145,342 (+)MAPPERmRatBN7.2
Rnor_6.04157,859,142 - 157,859,210NCBIRnor6.0
Rnor_5.04224,876,245 - 224,876,313UniSTSRnor5.0
RGSC_v3.44161,468,357 - 161,468,425UniSTSRGSC3.4
Celera4146,881,504 - 146,881,572UniSTS
RH 3.4 Map41000.7UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 46 113 91 90 59 25 59 6 214 94 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000067271   ⟹   ENSRNOP00000061813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4158,122,962 - 158,146,181 (+)Ensembl
Rnor_6.0 Ensembl4157,836,912 - 157,860,049 (+)Ensembl
RefSeq Acc Id: NM_031548   ⟹   NP_113736
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,809,187 - 159,832,409 (+)NCBI
mRatBN7.24158,122,962 - 158,146,184 (+)NCBI
Rnor_6.04157,836,912 - 157,860,052 (+)NCBI
Rnor_5.04224,853,710 - 224,877,459 (+)NCBI
RGSC_v3.44161,445,936 - 161,469,267 (+)RGD
Celera4146,859,208 - 146,882,414 (+)RGD
Sequence:
RefSeq Acc Id: NP_113736   ⟸   NM_031548
- UniProtKB: Q9QUI4 (UniProtKB/Swiss-Prot),   Q64593 (UniProtKB/Swiss-Prot),   P37089 (UniProtKB/Swiss-Prot),   Q6IRJ1 (UniProtKB/TrEMBL),   B8QP47 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061813   ⟸   ENSRNOT00000067271

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P37089-F1-model_v2 AlphaFold P37089 1-698 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3639 AgrOrtholog
BioCyc Gene G2FUF-42993 BioCyc
Ensembl Genes ENSRNOG00000019368 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000067271 ENTREZGENE
Gene3D-CATH Acid-sensing ion channels like domains UniProtKB/Swiss-Prot
  YojJ-like UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100777 IMAGE-MGC_LOAD
InterPro ENaC UniProtKB/Swiss-Prot
  ENaC_chordates UniProtKB/Swiss-Prot
  ENaC_CS UniProtKB/Swiss-Prot
KEGG Report rno:25122 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91636 IMAGE-MGC_LOAD
NCBI Gene 25122 ENTREZGENE
PANTHER AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT ALPHA UniProtKB/Swiss-Prot
  PTHR11690 UniProtKB/Swiss-Prot
Pfam ASC UniProtKB/Swiss-Prot
PharmGKB SCNN1A RGD
PhenoGen Scnn1a PhenoGen
PRINTS AMINACHANNEL UniProtKB/Swiss-Prot
PROSITE ASC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019368 RatGTEx
UniProt B8QP47 ENTREZGENE, UniProtKB/TrEMBL
  P37089 ENTREZGENE
  Q64593 ENTREZGENE
  Q6IRJ1 ENTREZGENE, UniProtKB/TrEMBL
  Q9QUI4 ENTREZGENE
  Q9Z2W4_RAT UniProtKB/TrEMBL
  SCNNA_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q64593 UniProtKB/Swiss-Prot
  Q9QUI4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Scnn1a  sodium channel epithelial 1 subunit alpha  Scnn1a  sodium channel epithelial 1 alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Scnn1a  sodium channel epithelial 1 alpha subunit  Scnn1a  sodium channel, non-voltage-gated 1 alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-13 Scnn1a  sodium channel, non-voltage-gated 1 alpha subunit  Scnn1a  sodium channel, nonvoltage-gated 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-02-23 Scnn1a  sodium channel, nonvoltage-gated 1 alpha  Scnn1a  sodium channel, nonvoltage-gated, type I, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Scnn1a  sodium channel, nonvoltage-gated, type I, alpha  Scnn1a  sodium channel, nonvoltage-gated, type 1, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-20 Scnn1a  sodium channel, nonvoltage-gated, type 1, alpha subunit  Scnn1a  sodium channel, nonvoltage-gated 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Scnn1a  sodium channel, nonvoltage-gated 1 alpha    sodium channel, nonvoltage-gated, type I, alpha polypeptide  Name updated 1299863 APPROVED
2002-06-10 Scnn1a  Sodium channel, nonvoltage-gated 1, alpha (epithelial)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function alpha subunit with beta and gamma subunits forms the amiloride-sensitive sodium channel 729911