Gene: Scnn1a (sodium channel epithelial 1 alpha subunit) Rattus norvegicus
Symbol: Scnn1a
Name: sodium channel epithelial 1 alpha subunit
Description: ENCODES a protein that exhibits actin binding; ligand-gated sodium channel activity; WW domain binding; INVOLVED IN regulation of body fluid levels; sodium ion transport; multicellular organismal water homeostasis (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH Nephrotic Syndrome; autosomal recessive pseudohypoaldosteronism type 1 (ortholog); Bronchiectasis with or without Elevated Sweat Chloride 1 (ortholog); FOUND IN apical plasma membrane; cortical actin cytoskeleton; ciliary membrane (ortholog); INTERACTS WITH 2,4,6-trinitrotoluene; 2,4-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine
Type: protein-coding
Also known as: alpha-ENaC; alpha-NaCH; amiloride-sensitive epithelial sodium channel alpha subunit; amiloride-sensitive sodium channel subunit alpha; ENaCA; epithelial Na(+) channel subunit alpha; epithelial sodium channel alpha subunit; nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; Sodium channel nonvoltage-gated 1 alpha (epithelial); sodium channel, non-voltage-gated 1 alpha subunit; sodium channel, nonvoltage-gated 1 alpha; sodium channel, nonvoltage-gated, type 1, alpha subunit; sodium channel, nonvoltage-gated, type I, alpha; sodium channel, nonvoltage-gated, type I, alpha polypeptide
Homo sapiens (human) : SCNN1A (sodium channel epithelial 1 alpha subunit)  HGNC  Alliance
Mus musculus (house mouse) : Scnn1a (sodium channel, nonvoltage-gated 1 alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scnn1a (sodium channel epithelial 1 alpha subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : SCNN1A (sodium channel epithelial 1 alpha subunit)
Canis lupus familiaris (dog) : SCNN1A (sodium channel epithelial 1 alpha subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scnn1a (sodium channel epithelial 1 alpha subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04157,834,339 - 157,860,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,853,710 - 224,877,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,445,936 - 161,469,267 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14161,690,871 - 161,714,200 (+)NCBI
Celera4146,859,208 - 146,882,414 (+)NCBICelera
Cytogenetic Map4q42NCBI
RH 3.4 Map41000.7RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Scnn1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3639
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-02-06
Status: ACTIVE