Gabra5 (gamma-aminobutyric acid type A receptor subunit alpha 5) - Rat Genome Database

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Gene: Gabra5 (gamma-aminobutyric acid type A receptor subunit alpha 5) Rattus norvegicus
Analyze
Symbol: Gabra5
Name: gamma-aminobutyric acid type A receptor subunit alpha 5
RGD ID: 61859
Description: Enables GABA receptor binding activity; GABA-A receptor activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in chemical synaptic transmission. Located in dendrite and neuronal cell body membrane. Part of receptor complex. Is active in GABA-ergic synapse; postsynaptic specialization membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in bipolar disorder; depressive disorder; and developmental and epileptic encephalopathy 79. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5); INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GABA(A) receptor subunit alpha-5; GABA-A receptor alpha-5 subunit; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid (GABA-A) receptor subunit alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; gamma-aminobutyric acid A receptor, alpha 5; gamma-aminobutyric acid receptor subunit alpha-5; gamma-aminobutyric acid type A receptor alpha 5 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21108,268,728 - 108,381,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1108,268,776 - 108,380,917 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1113,646,984 - 113,751,778 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01122,119,493 - 122,224,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01115,367,807 - 115,472,601 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01112,833,941 - 112,947,482 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1112,833,944 - 112,947,451 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01113,844,235 - 113,955,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41108,843,086 - 108,955,130 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11108,921,428 - 109,033,473 (-)NCBI
Celera1102,441,576 - 102,547,389 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Synaptic alpha 5 subunit-containing GABAA receptors mediate IPSPs elicited by dendrite-preferring cells in rat neocortex. Ali AB and Thomson AM, Cereb Cortex. 2008 Jun;18(6):1260-71. doi: 10.1093/cercor/bhm160. Epub 2007 Oct 19.
2. mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism. Fatemi SH, etal., J Autism Dev Disord. 2010 Jun;40(6):743-50.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Functional expression and sites of gene transcription of a novel alpha subunit of the GABAA receptor in rat brain. Malherbe P, etal., FEBS Lett 1990 Jan 29;260(2):261-5.
6. Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study. Massat I, etal., Mol Psychiatry 2002;7(2):201-7.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Positive association between the GABRA5 gene and unipolar recurrent major depression. Oruc L, etal., Neuropsychobiology 1997;36(2):62-4.
10. Association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) and bipolar affective disorder. Papadimitriou GN, etal., Am J Med Genet 1998 Feb 7;81(1):73-80.
11. Expression of alpha 5 GABAA receptor subunit in developing rat hippocampus. Ramos B, etal., Brain Res Dev Brain Res 2004 Jul 19;151(1-2):87-98.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Identification, coassembly, and activity of gamma-aminobutyric acid receptor subunits in renal proximal tubular cells. Sarang SS, etal., J Pharmacol Exp Ther. 2008 Jan;324(1):376-82. Epub 2007 Oct 24.
16. Synaptic and nonsynaptic localization of GABAA receptors containing the alpha5 subunit in the rat brain. Serwanski DR, etal., J Comp Neurol. 2006 Nov 20;499(3):458-70. doi: 10.1002/cne.21115.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1312131   PMID:1312132   PMID:1379501   PMID:1966765   PMID:2157817   PMID:2561977   PMID:9682826   PMID:12084936   PMID:16934248   PMID:17021187   PMID:17317750   PMID:19265570  
PMID:21549811   PMID:22869088   PMID:22944187   PMID:23962649   PMID:24823837   PMID:25663431   PMID:26169564   PMID:26545088   PMID:26930443   PMID:27038517   PMID:29758348   PMID:30637435  
PMID:31249307   PMID:32240868   PMID:32750173   PMID:34937496   PMID:35732272  


Genomics

Comparative Map Data
Gabra5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21108,268,728 - 108,381,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1108,268,776 - 108,380,917 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1113,646,984 - 113,751,778 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01122,119,493 - 122,224,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01115,367,807 - 115,472,601 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01112,833,941 - 112,947,482 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1112,833,944 - 112,947,451 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01113,844,235 - 113,955,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41108,843,086 - 108,955,130 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11108,921,428 - 109,033,473 (-)NCBI
Celera1102,441,576 - 102,547,389 (-)NCBICelera
Cytogenetic Map1q22NCBI
GABRA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381526,866,719 - 26,949,208 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1526,866,911 - 26,949,208 (+)EnsemblGRCh38hg38GRCh38
GRCh371527,111,866 - 27,194,355 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361524,663,151 - 24,679,797 (+)NCBINCBI36Build 36hg18NCBI36
Build 361524,742,696 - 24,776,749 (+)NCBINCBI36Build 36hg18NCBI36
Build 341524,742,694 - 24,776,749NCBI
Celera155,273,203 - 5,355,540 (+)NCBICelera
Cytogenetic Map15q12NCBI
HuRef155,241,009 - 5,262,207 (+)NCBIHuRef
HuRef155,288,011 - 5,322,374 (+)NCBIHuRef
CHM1_11527,061,401 - 27,143,890 (+)NCBICHM1_1
T2T-CHM13v2.01524,607,751 - 24,690,792 (+)NCBIT2T-CHM13v2.0
Gabra5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39757,057,417 - 57,240,808 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl757,057,420 - 57,159,807 (-)EnsemblGRCm39 Ensembl
GRCm38757,407,669 - 57,591,016 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl757,407,672 - 57,510,059 (-)EnsemblGRCm38mm10GRCm38
MGSCv37764,663,039 - 64,765,379 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36757,275,688 - 57,377,873 (-)NCBIMGSCv36mm8
Celera754,720,522 - 54,830,242 (-)NCBICelera
Cytogenetic Map7B5NCBI
cM Map733.52NCBI
Gabra5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555332,563,319 - 2,631,289 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555332,563,499 - 2,631,086 (-)NCBIChiLan1.0ChiLan1.0
GABRA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11511,969,290 - 12,052,259 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0152,953,857 - 3,036,722 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11524,300,300 - 24,382,535 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1524,300,300 - 24,382,730 (+)Ensemblpanpan1.1panPan2
GABRA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1333,663,414 - 33,746,120 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl333,664,169 - 33,744,328 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha336,353,800 - 36,436,241 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0333,999,325 - 34,081,790 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl333,999,318 - 34,081,948 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1333,539,876 - 33,622,259 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0333,802,491 - 33,884,937 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0333,949,742 - 34,032,243 (-)NCBIUU_Cfam_GSD_1.0
Gabra5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640121,933,396 - 122,009,905 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647139,781,451 - 39,975,518 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647139,781,451 - 39,856,766 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1140,486,104 - 140,567,894 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11140,486,107 - 140,568,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21156,791,330 - 156,874,272 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABRA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12655,147,512 - 55,227,801 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2655,147,511 - 55,227,297 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605437,978,006 - 38,060,544 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabra5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248961,267,077 - 1,337,038 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabra5
1049 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:67
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000014573
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847121834139Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 50
Low 24 26
Below cutoff 12 12 9 3 9 2 2 10 14 6 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014573   ⟹   ENSRNOP00000014573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1112,833,989 - 112,947,162 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083894   ⟹   ENSRNOP00000072389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1108,268,776 - 108,380,917 (-)Ensembl
Rnor_6.0 Ensembl1112,833,975 - 112,947,173 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093259   ⟹   ENSRNOP00000076137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1112,834,190 - 112,947,451 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093306   ⟹   ENSRNOP00000076124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1112,833,944 - 112,947,399 (-)Ensembl
RefSeq Acc Id: NM_017295   ⟹   NP_058991
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21108,268,776 - 108,380,888 (-)NCBI
Rnor_6.01112,833,989 - 112,946,731 (-)NCBI
Rnor_5.01113,844,235 - 113,955,760 (-)NCBI
RGSC_v3.41108,843,086 - 108,955,130 (-)RGD
Celera1102,441,576 - 102,547,389 (-)RGD
Sequence:
RefSeq Acc Id: XM_017589073   ⟹   XP_017444562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21108,268,728 - 108,381,424 (-)NCBI
Rnor_6.01112,833,941 - 112,947,385 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589074   ⟹   XP_017444563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21108,268,728 - 108,381,620 (-)NCBI
Rnor_6.01112,833,941 - 112,947,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589075   ⟹   XP_017444564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21108,268,728 - 108,381,670 (-)NCBI
Rnor_6.01112,833,941 - 112,947,446 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589076   ⟹   XP_017444565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21108,268,728 - 108,381,422 (-)NCBI
Rnor_6.01112,833,941 - 112,947,385 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109837   ⟹   XP_038965765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21108,268,728 - 108,380,956 (-)NCBI
RefSeq Acc Id: XM_039109851   ⟹   XP_038965779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21108,268,728 - 108,381,424 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_058991   ⟸   NM_017295
- Peptide Label: precursor
- UniProtKB: P19969 (UniProtKB/Swiss-Prot),   A6KD38 (UniProtKB/TrEMBL),   A6KD37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444563   ⟸   XM_017589074
- Peptide Label: isoform X1
- UniProtKB: P19969 (UniProtKB/Swiss-Prot),   A6KD38 (UniProtKB/TrEMBL),   A6KD37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444564   ⟸   XM_017589075
- Peptide Label: isoform X1
- UniProtKB: P19969 (UniProtKB/Swiss-Prot),   A6KD38 (UniProtKB/TrEMBL),   A6KD37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444565   ⟸   XM_017589076
- Peptide Label: isoform X1
- UniProtKB: P19969 (UniProtKB/Swiss-Prot),   A6KD38 (UniProtKB/TrEMBL),   A6KD37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444562   ⟸   XM_017589073
- Peptide Label: isoform X1
- UniProtKB: P19969 (UniProtKB/Swiss-Prot),   A6KD38 (UniProtKB/TrEMBL),   A6KD37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014573   ⟸   ENSRNOT00000014573
RefSeq Acc Id: ENSRNOP00000076124   ⟸   ENSRNOT00000093306
RefSeq Acc Id: ENSRNOP00000076137   ⟸   ENSRNOT00000093259
RefSeq Acc Id: ENSRNOP00000072389   ⟸   ENSRNOT00000083894
RefSeq Acc Id: XP_038965779   ⟸   XM_039109851
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965765   ⟸   XM_039109837
- Peptide Label: isoform X1
- UniProtKB: P19969 (UniProtKB/Swiss-Prot),   A6KD38 (UniProtKB/TrEMBL),   A6KD37 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19969-F1-model_v2 AlphaFold P19969 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61859 AgrOrtholog
BioCyc Gene G2FUF-59443 BioCyc
Ensembl Genes ENSRNOG00000010803 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000072389 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083894 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter-gated ion-channel transmembrane domain UniProtKB/TrEMBL
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAAa_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABBAa5_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gabra-1-6_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29707 UniProtKB/Swiss-Prot
NCBI Gene 29707 ENTREZGENE
PANTHER GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-2 UniProtKB/TrEMBL
  GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROTRANSMITTER GATED ION CHANNEL UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gabra5 PhenoGen
PRINTS GABAARALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARALPHA5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Neurotransmitter-gated ion-channel transmembrane pore UniProtKB/TrEMBL
  Nicotinic receptor ligand binding domain-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
TIGR TC233322
UniProt A6KD37 ENTREZGENE, UniProtKB/TrEMBL
  A6KD38 ENTREZGENE, UniProtKB/TrEMBL
  GBRA5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Gabra5  gamma-aminobutyric acid type A receptor subunit alpha 5  Gabra5  gamma-aminobutyric acid type A receptor alpha 5 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Gabra5  gamma-aminobutyric acid type A receptor alpha 5 subunit  Gabra5  gamma-aminobutyric acid (GABA) A receptor, alpha 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-04 Gabra5  gamma-aminobutyric acid (GABA) A receptor, alpha 5  Gabra5  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gabra5  gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5    gamma-aminobutyric acid A receptor, alpha 5  Name updated 1299863 APPROVED
2002-06-10 Gabra5  gamma-aminobutyric acid A receptor, alpha 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in cerebral cortex, hippocampal formation, and olfactory bulb granular layer 61593