Gnmt (glycine N-methyltransferase) - Rat Genome Database

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Gene: Gnmt (glycine N-methyltransferase) Rattus norvegicus
Symbol: Gnmt
Name: glycine N-methyltransferase
RGD ID: 2719
Description: Enables glycine N-methyltransferase activity; identical protein binding activity; and ion binding activity. Involved in several processes, including S-adenosylmethionine metabolic process; alpha-amino acid metabolic process; and protein homotetramerization. Located in cytosol. Part of methyltransferase complex. Human ortholog(s) of this gene implicated in glycine N-methyltransferase deficiency. Orthologous to human GNMT (glycine N-methyltransferase); PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
Previously known as: folate-binding protein; glycine methyltransferase; glycine N-methyltransferase-like; LOC100911564
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2914,254,675 - 14,258,028 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,254,675 - 14,258,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx922,837,543 - 22,840,774 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,901,607 - 27,904,956 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,200,917 - 26,204,148 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,565,274 - 16,568,626 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,565,225 - 16,568,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0915,471,889 - 15,475,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4910,127,092 - 10,130,444 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1910,124,413 - 10,127,766 (+)NCBI
Celera912,003,123 - 12,006,473 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-methyltetrahydrofolic acid  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
aflatoxin Q1  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (EXP)
dicrotophos  (ISO)
diquat  (ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
glafenine  (EXP)
gliotoxin  (EXP)
GW 4064  (ISO)
indometacin  (EXP)
Lasiocarpine  (ISO)
leflunomide  (ISO)
MeIQx  (ISO)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
quercetin  (ISO)
rotenone  (EXP)
selenium atom  (EXP)
senecionine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulindac  (EXP)
tebuconazole  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triazines  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IDA,IEA,ISO,TAS)
methyltransferase complex  (IMP)

Molecular Function


References - curated
# Reference Title Reference Citation
1. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cavuoto P and Fenech MF, Cancer Treat Rev. 2012 Oct;38(6):726-36. doi: 10.1016/j.ctrv.2012.01.004. Epub 2012 Feb 17.
2. Glycine N-methyltransferase is a folate binding protein of rat liver cytosol. Cook RJ and Wagner C, Proc Natl Acad Sci U S A. 1984 Jun;81(12):3631-4. doi: 10.1073/pnas.81.12.3631.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes. Huang Y, etal., J Mol Biol. 2000 Apr 21;298(1):149-62.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats. Kharbanda KK, etal., Biochem Biophys Res Commun. 2009 Apr 17;381(4):523-7. doi: 10.1016/j.bbrc.2009.02.082. Epub 2009 Feb 23.
8. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
9. Acetylation of N-terminal valine of glycine N-methyltransferase affects enzyme inhibition by folate. Luka Z, etal., Biochim Biophys Acta. 2008 Sep;1784(9):1342-6. doi: 10.1016/j.bbapap.2008.04.016. Epub 2008 May 2.
10. Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate. Luka Z, etal., Biochim Biophys Acta. 2012 Feb;1824(2):286-91. doi: 10.1016/j.bbapap.2011.10.008. Epub 2011 Oct 20.
11. 5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase. Luka Z, etal., J Biol Chem. 2007 Feb 9;282(6):4069-75. Epub 2006 Dec 7.
12. Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific. McMullen MH, etal., Arch Biochem Biophys 2002 May 1;401(1):73-80.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. Nieman KM, etal., J Biol Chem 2004 Oct 29;279(44):45708-12. Epub 2004 Aug 30.
16. Rat glycine methyltransferase. Complete amino acid sequence deduced from a cDNA clone and characterization of the genomic DNA. Ogawa H, etal., Eur J Biochem 1987 Oct 1;168(1):141-51.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes. Pakhomova S, etal., Proteins. 2004 Nov 1;57(2):331-7.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Vitamin A and its derivatives induce hepatic glycine N-methyltransferase and hypomethylation of DNA in rats. Rowling MJ, etal., J Nutr 2002 Mar;132(3):365-9.
25. Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver. Yeo EJ and Wagner C, Proc Natl Acad Sci U S A 1994 Jan 4;91(1):210-4.
Additional References at PubMed
PMID:8810903   PMID:9655336   PMID:14608049   PMID:16189514   PMID:17937387   PMID:21445860   PMID:25336395   PMID:25502805   PMID:26871637   PMID:31515488  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2914,254,675 - 14,258,028 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,254,675 - 14,258,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx922,837,543 - 22,840,774 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,901,607 - 27,904,956 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,200,917 - 26,204,148 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,565,274 - 16,568,626 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,565,225 - 16,568,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0915,471,889 - 15,475,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4910,127,092 - 10,130,444 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1910,124,413 - 10,127,766 (+)NCBI
Celera912,003,123 - 12,006,473 (+)NCBICelera
Cytogenetic Map9q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38642,960,754 - 42,963,880 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl642,960,754 - 42,963,880 (+)EnsemblGRCh38hg38GRCh38
GRCh37642,928,492 - 42,931,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,036,478 - 43,039,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 34643,036,477 - 43,039,595NCBI
Celera644,480,758 - 44,483,869 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef642,645,801 - 42,648,911 (+)NCBIHuRef
CHM1_1642,930,969 - 42,934,095 (+)NCBICHM1_1
T2T-CHM13v2.0642,789,900 - 42,793,018 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391747,036,590 - 47,040,091 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,036,590 - 47,040,094 (-)EnsemblGRCm39 Ensembl
GRCm381746,725,664 - 46,729,211 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,725,664 - 46,729,168 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,862,613 - 46,866,114 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361746,188,855 - 46,192,356 (-)NCBIMGSCv36mm8
Celera1750,161,350 - 50,164,841 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554378,944,047 - 8,946,642 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554378,944,288 - 8,946,642 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1653,326,193 - 53,342,571 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0642,550,631 - 42,554,385 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1643,846,560 - 43,849,679 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl643,846,560 - 43,849,679 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11211,500,363 - 11,503,075 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,500,392 - 11,503,481 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,527,380 - 11,530,090 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01211,981,562 - 11,984,272 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1211,981,589 - 11,984,224 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,509,980 - 11,512,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01211,594,281 - 11,596,795 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01211,688,299 - 11,691,025 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494646,995,031 - 46,998,424 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,957,270 - 16,965,346 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647616,961,734 - 16,965,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl738,038,358 - 38,041,217 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,038,359 - 38,041,218 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,486,726 - 43,489,585 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11729,196,142 - 29,199,728 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1729,196,321 - 29,198,947 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604443,019,849 - 43,022,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Gnmt
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:68
Interacting mature miRNAs:70
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
Medium 16 16 16 2
Low 15 15 15 8 19 1
Below cutoff 12 10 10 1 10 19 12 17 1


RefSeq Acc Id: ENSRNOT00000022307   ⟹   ENSRNOP00000022307
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl914,254,675 - 14,258,028 (+)Ensembl
Rnor_6.0 Ensembl916,565,225 - 16,568,627 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000072812   ⟹   ENSRNOP00000067671
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl914,254,675 - 14,258,434 (+)Ensembl
Rnor_6.0 Ensembl916,314,173 - 16,317,413 (+)Ensembl
RefSeq Acc Id: NM_017084   ⟹   NP_058780
Rat AssemblyChrPosition (strand)Source
mRatBN7.2914,254,675 - 14,258,028 (+)NCBI
Rnor_6.0916,565,274 - 16,568,626 (+)NCBI
Rnor_5.0915,471,889 - 15,475,241 (+)NCBI
RGSC_v3.4910,127,092 - 10,130,444 (+)RGD
Celera912,003,123 - 12,006,473 (+)RGD
RefSeq Acc Id: NP_058780   ⟸   NM_017084
- UniProtKB: P13255 (UniProtKB/Swiss-Prot),   A6JIM7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022307   ⟸   ENSRNOT00000022307
RefSeq Acc Id: ENSRNOP00000067671   ⟸   ENSRNOT00000072812
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RDH0-F1-model_v2 AlphaFold M0RDH0 1-293 view protein structure
AF-P13255-F1-model_v2 AlphaFold P13255 1-293 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696506
Promoter ID:EPDNEW_R7030
Type:multiple initiation site
Description:glycine N-methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0916,565,260 - 16,565,320EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2719 AgrOrtholog
BioCyc Gene G2FUF-28242 BioCyc
Ensembl Genes ENSRNOG00000016349 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000048623 Ensembl
  ENSRNOG00055008666 UniProtKB/Swiss-Prot
  ENSRNOG00060023668 UniProtKB/Swiss-Prot
  ENSRNOG00065026940 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022307 ENTREZGENE
  ENSRNOT00000022307.5 UniProtKB/Swiss-Prot
  ENSRNOT00000072812.2 UniProtKB/TrEMBL
  ENSRNOT00055014634 UniProtKB/Swiss-Prot
  ENSRNOT00060041013 UniProtKB/Swiss-Prot
  ENSRNOT00065046482 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycine N-methyltransferase, chain A, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Gly/Sar_N_MeTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyltransf_25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25134 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16458 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Methyltransf_25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gnmt PhenoGen
PIRSF Gly_N-mtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016349 RatGTEx
  ENSRNOG00000048623 RatGTEx
  ENSRNOG00055008666 RatGTEx
  ENSRNOG00060023668 RatGTEx
  ENSRNOG00065026940 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GNMT_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gnmt  glycine N-methyltransferase  LOC100911564  glycine N-methyltransferase-like  Data merged from RGD:6491825 737654 PROVISIONAL
2012-07-05 LOC100911564  glycine N-methyltransferase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Gnmt  glycine N-methyltransferase    glycine methyltransferase  Name updated 1299863 APPROVED
2002-06-10 Gnmt  Glycine methyltransferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation increased enzyme levels and activity are induced by retinoid compounds specifically in liver and are not induced in other tissues 728472