Uchl1 (ubiquitin C-terminal hydrolase L1) - Rat Genome Database

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Gene: Uchl1 (ubiquitin C-terminal hydrolase L1) Rattus norvegicus
Analyze
Symbol: Uchl1
Name: ubiquitin C-terminal hydrolase L1
RGD ID: 3928
Description: Predicted to enable several functions, including alpha-2A adrenergic receptor binding activity; peptidase activity; and ubiquitin protein ligase binding activity. Involved in ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including neuron projection terminus; neuronal cell body; and nucleoplasm. Predicted to be active in cytoplasm. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; hereditary spastic paraplegia 79A; and hereditary spastic paraplegia 79B. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; ubiquitin carboxy-terminal hydrolase L1; ubiquitin carboxyl-terminal esterase L1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; UCH-L1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81441,838,859 - 41,849,743 (-)NCBIGRCr8
mRatBN7.21441,485,031 - 41,495,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1441,831,048 - 41,841,616 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01443,131,128 - 43,141,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01441,611,942 - 41,622,510 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01443,133,224 - 43,143,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1443,133,218 - 43,143,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01442,928,247 - 42,938,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41444,114,392 - 44,124,947 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11444,116,782 - 44,127,338 (-)NCBI
Celera1440,639,549 - 40,650,302 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1,3-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-methoxyethanol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-methylcatechol  (ISO)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allopurinol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt atom  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
daidzein  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
ferric oxide  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
glutathione  (ISO)
glycitein  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
L-methionine  (ISO)
Licochalcone B  (ISO)
lidocaine  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP,ISO)
methylmercury chloride  (ISO)
mevinphos  (EXP)
mitomycin C  (ISO)
mitoxantrone  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naphthalene  (ISO)
nickel dichloride  (EXP)
nicotine  (ISO)
nitrofen  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pinosylvin  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
pyrogallol  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
resiniferatoxin  (ISO)
rotenone  (ISO)
rutin  (EXP)
sarin  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
T-2 toxin  (EXP)
tebufenpyrad  (ISO)
thapsigargin  (EXP)
theophylline  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
trans-pinosylvin  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
Tungsten carbide  (ISO)
valproic acid  (EXP,ISO)
vincristine  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. Choi J, etal., J Biol Chem. 2004 Mar 26;279(13):13256-64. Epub 2004 Jan 13.
2. The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Ciechanover A and Brundin P, Neuron 2003 Oct 9;40(2):427-46.
3. Changes in ocular aquaporin-4 (AQP4) expression following retinal injury. Dibas A, etal., Mol Vis. 2008 Sep 25;14:1770-83.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Patient education: how we designed our own program. Hoffman LE Jr Group Pract 1976 Sep-Oct;25(5):21-4.
7. cDNA cloning and tissue distribution of a rat ubiquitin carboxyl-terminal hydrolase PGP9.5. Kajimoto Y, etal., J Biochem (Tokyo) 1992 Jul;112(1):28-32.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Kurihara LJ, etal., Hum Mol Genet 2001 Sep 1;10(18):1963-70.
10. The ubiquitin pathway in Parkinson's disease. Leroy E, etal., Nature 1998 Oct 1;395(6701):451-2.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. A role of the ubiquitin-proteasome system in neuropathic pain. Moss A, etal., J Neurosci 2002 Feb 15;22(4):1363-72.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. Saigoh K, etal., Nat Genet 1999 Sep;23(1):47-51.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1630580   PMID:2558488   PMID:3340629   PMID:7555927   PMID:8007658   PMID:8474599   PMID:8639624   PMID:8896700   PMID:9521656   PMID:11466438   PMID:11549719   PMID:11739622  
PMID:12074562   PMID:12107488   PMID:12408865   PMID:12477932   PMID:12638230   PMID:12866128   PMID:12913066   PMID:14695319   PMID:14973275   PMID:15489334   PMID:17011532   PMID:17599367  
PMID:17634366   PMID:17690318   PMID:18616865   PMID:19267071   PMID:19477270   PMID:19725078   PMID:20231490   PMID:20387083   PMID:20933087   PMID:21069350   PMID:21606356   PMID:22871113  
PMID:22926577   PMID:23064229   PMID:23284756   PMID:23376485   PMID:23599427   PMID:24090154   PMID:24625528   PMID:24760869   PMID:25326379   PMID:25638021   PMID:25763798   PMID:28500221  
PMID:29339092   PMID:29964011   PMID:30305579   PMID:30551363   PMID:31041655   PMID:34130526   PMID:36952018   PMID:38727276  


Genomics

Comparative Map Data
Uchl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81441,838,859 - 41,849,743 (-)NCBIGRCr8
mRatBN7.21441,485,031 - 41,495,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1441,831,048 - 41,841,616 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01443,131,128 - 43,141,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01441,611,942 - 41,622,510 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01443,133,224 - 43,143,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1443,133,218 - 43,143,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01442,928,247 - 42,938,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41444,114,392 - 44,124,947 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11444,116,782 - 44,127,338 (-)NCBI
Celera1440,639,549 - 40,650,302 (-)NCBICelera
Cytogenetic Map14p11NCBI
UCHL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38441,256,928 - 41,268,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl441,256,413 - 41,268,455 (+)EnsemblGRCh38hg38GRCh38
GRCh37441,258,945 - 41,270,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36440,953,686 - 40,965,203 (+)NCBINCBI36Build 36hg18NCBI36
Build 34441,099,856 - 41,111,373NCBI
Celera441,702,199 - 41,713,746 (+)NCBICelera
Cytogenetic Map4p13NCBI
HuRef440,580,844 - 40,592,391 (+)NCBIHuRef
CHM1_1441,259,044 - 41,270,591 (+)NCBICHM1_1
T2T-CHM13v2.0441,230,716 - 41,242,242 (+)NCBIT2T-CHM13v2.0
Uchl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39566,833,464 - 66,844,577 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl566,833,434 - 66,844,577 (+)EnsemblGRCm39 Ensembl
GRCm38566,676,121 - 66,687,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl566,676,091 - 66,687,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv37567,067,360 - 67,078,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36566,955,425 - 66,966,369 (+)NCBIMGSCv36mm8
Celera563,976,841 - 63,987,914 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map535.95NCBI
Uchl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554436,367,460 - 6,380,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554436,367,519 - 6,379,638 (-)NCBIChiLan1.0ChiLan1.0
UCHL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2341,440,064 - 41,451,601 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1441,633,489 - 41,645,029 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0435,580,755 - 35,592,314 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1441,432,367 - 41,440,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl441,428,759 - 41,440,129 (+)Ensemblpanpan1.1panPan2
UCHL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,396,694 - 71,430,395 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,370,822 - 71,411,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha373,946,978 - 73,961,370 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0372,157,557 - 72,171,966 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1371,427,585 - 71,441,983 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,589,640 - 71,604,050 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,972,745 - 71,987,146 (-)NCBIUU_Cfam_GSD_1.0
Uchl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528537,734,649 - 37,746,530 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364828,551,603 - 8,563,651 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364828,551,749 - 8,563,586 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCHL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl832,353,246 - 32,367,332 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1832,353,766 - 32,367,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2833,970,620 - 33,982,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UCHL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1279,074,961 - 9,086,606 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl279,074,923 - 9,086,517 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604755,406,774 - 55,418,174 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uchl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476125,784,257 - 25,797,549 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476125,786,028 - 25,797,641 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uchl1
70 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:57
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000003248
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142216796767167967Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat

Markers in Region
RH128109  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,485,066 - 41,485,252 (+)MAPPERmRatBN7.2
Rnor_6.01443,133,258 - 43,133,443NCBIRnor6.0
Rnor_5.01442,928,281 - 42,928,466UniSTSRnor5.0
RGSC_v3.41444,114,426 - 44,114,611UniSTSRGSC3.4
Celera1440,639,583 - 40,639,768UniSTS
Cytogenetic Map14p11UniSTS
BF399140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,492,213 - 41,492,422 (+)MAPPERmRatBN7.2
Rnor_6.01443,140,568 - 43,140,776NCBIRnor6.0
Rnor_5.01442,935,591 - 42,935,799UniSTSRnor5.0
RGSC_v3.41444,121,573 - 44,121,781UniSTSRGSC3.4
Celera1440,646,926 - 40,647,134UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 85 84 53 25 53 6 212 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000003248   ⟹   ENSRNOP00000003248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)Ensembl
Rnor_6.0 Ensembl1443,133,218 - 43,143,973 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094226   ⟹   ENSRNOP00000086461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106879   ⟹   ENSRNOP00000082700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)Ensembl
RefSeq Acc Id: NM_017237   ⟹   NP_058933
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81441,838,859 - 41,849,417 (-)NCBI
mRatBN7.21441,485,031 - 41,495,590 (-)NCBI
Rnor_6.01443,133,224 - 43,143,942 (-)NCBI
Rnor_5.01442,928,247 - 42,938,981 (-)NCBI
RGSC_v3.41444,114,392 - 44,124,947 (-)RGD
Celera1440,639,549 - 40,650,302 (-)RGD
Sequence:
RefSeq Acc Id: XM_063273003   ⟹   XP_063129073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81441,839,356 - 41,849,493 (-)NCBI
RefSeq Acc Id: XM_063273004   ⟹   XP_063129074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81441,838,859 - 41,849,743 (-)NCBI
RefSeq Acc Id: NP_058933   ⟸   NM_017237
- UniProtKB: Q6P9V8 (UniProtKB/Swiss-Prot),   Q00981 (UniProtKB/Swiss-Prot),   A6JDB6 (UniProtKB/TrEMBL),   A0A8L2Q0S4 (UniProtKB/TrEMBL),   A6JDB5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003248   ⟸   ENSRNOT00000003248
Ensembl Acc Id: ENSRNOP00000086461   ⟸   ENSRNOT00000094226
Ensembl Acc Id: ENSRNOP00000082700   ⟸   ENSRNOT00000106879
RefSeq Acc Id: XP_063129074   ⟸   XM_063273004
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q0S4 (UniProtKB/TrEMBL),   A6JDB5 (UniProtKB/TrEMBL),   A0A8I6G7R6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129073   ⟸   XM_063273003
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q0S4 (UniProtKB/TrEMBL),   A6JDB5 (UniProtKB/TrEMBL)
Protein Domains
Ubiquitin carboxyl-terminal hydrolase family   UCH catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00981-F1-model_v2 AlphaFold Q00981 1-223 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699307
Promoter ID:EPDNEW_R9832
Type:multiple initiation site
Name:Uchl1_1
Description:ubiquitin C-terminal hydrolase L1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01443,143,942 - 43,144,002EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3928 AgrOrtholog
BioCyc Gene G2FUF-15768 BioCyc
Ensembl Genes ENSRNOG00000002343 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003248 ENTREZGENE
  ENSRNOT00000094226.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.532.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6920680 IMAGE-MGC_LOAD
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Peptidase_C12_UCH UniProtKB/Swiss-Prot
  Peptidase_C12_UCH_sf UniProtKB/Swiss-Prot
KEGG Report rno:29545 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72862 IMAGE-MGC_LOAD
NCBI Gene 29545 ENTREZGENE
PANTHER PTHR10589 UniProtKB/Swiss-Prot
  PTHR10589:SF19 UniProtKB/Swiss-Prot
Pfam Peptidase_C12 UniProtKB/Swiss-Prot
PhenoGen Uchl1 PhenoGen
PRINTS UBCTHYDRLASE UniProtKB/Swiss-Prot
PROSITE UCH_1 UniProtKB/Swiss-Prot
  UCH_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002343 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
TIGR TC228392
UniProt A0A8I6G7R6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q0S4 ENTREZGENE, UniProtKB/TrEMBL
  A6JDB5 ENTREZGENE, UniProtKB/TrEMBL
  A6JDB6 ENTREZGENE, UniProtKB/TrEMBL
  A6JDB7_RAT UniProtKB/TrEMBL
  A6JDB8_RAT UniProtKB/TrEMBL
  Q00981 ENTREZGENE
  Q6P9V8 ENTREZGENE
  UCHL1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6P9V8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Uchl1  ubiquitin C-terminal hydrolase L1  Uchl1  ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Uchl1  ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)  Uchl1  ubiquitin carboxy-terminal hydrolase L1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Uchl1  ubiquitin carboxy-terminal hydrolase L1      Name updated 70584 APPROVED