Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Uchl1 (ubiquitin carboxy-terminal hydrolase L1) Mus musculus
Symbol: Uchl1
Name: ubiquitin carboxy-terminal hydrolase L1
Description: Exhibits thiol-dependent ubiquitin-specific protease activity and ubiquitin binding activity. Involved in several processes, including adult walking behavior; axon target recognition; and response to ischemia. Localizes to several cellular components, including the axon; neuron projection terminus; and neuronal cell body. Predicted to colocalize with the plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary spastic paraplegia; and late onset Parkinson's disease. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW822034; C88048; gad; gracile axonal dystrophy; neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; protein gene product 9.5; R75593; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; UCH-L1; UCHL-1
Homo sapiens (human) : UCHL1 (ubiquitin C-terminal hydrolase L1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Uchl1 (ubiquitin C-terminal hydrolase L1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Uchl1 (ubiquitin C-terminal hydrolase L1)
Pan paniscus (bonobo/pygmy chimpanzee) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Canis lupus familiaris (dog) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Uchl1 (ubiquitin C-terminal hydrolase L1)
Sus scrofa (pig) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Chlorocebus sabaeus (green monkey) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Heterocephalus glaber (naked mole-rat) : Uchl1 (ubiquitin C-terminal hydrolase L1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl566,676,091 - 66,687,234 (+)Ensembl
GRCm38566,676,121 - 66,687,234 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37567,067,360 - 67,078,473 (+)NCBIGRCm37mm9NCBIm37
MGSCv36566,955,425 - 66,966,369 (+)NCBImm8
Celera563,976,841 - 63,987,914 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map535.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Uchl1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736277
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.