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Gene: Uchl1 (ubiquitin carboxy-terminal hydrolase L1) Mus musculus
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Symbol: Uchl1
Name: ubiquitin carboxy-terminal hydrolase L1
Description: Exhibits thiol-dependent ubiquitin-specific protease activity and ubiquitin binding activity. Involved in several processes, including adult walking behavior; axon target recognition; and response to ischemia. Localizes to several cellular components, including the axon; neuron projection terminus; and neuronal cell body. Predicted to colocalize with the plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary spastic paraplegia; and late onset Parkinson's disease. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW822034; C88048; gad; gracile axonal dystrophy; neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; protein gene product 9.5; R75593; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; UCH-L1; UCHL-1
Orthologs:
Homo sapiens (human) : UCHL1 (ubiquitin C-terminal hydrolase L1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Uchl1 (ubiquitin C-terminal hydrolase L1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Uchl1 (ubiquitin C-terminal hydrolase L1)
Pan paniscus (bonobo/pygmy chimpanzee) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Canis lupus familiaris (dog) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Uchl1 (ubiquitin C-terminal hydrolase L1)
Sus scrofa (pig) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Chlorocebus sabaeus (green monkey) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Heterocephalus glaber (naked mole-rat) : Uchl1 (ubiquitin C-terminal hydrolase L1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl566,676,091 - 66,687,234 (+)Ensembl
GRCm38566,676,121 - 66,687,234 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37567,067,360 - 67,078,473 (+)NCBIGRCm37mm9NCBIm37
MGSCv36566,955,425 - 66,966,369 (+)NCBImm8
Celera563,976,841 - 63,987,914 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map535.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Uchl1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736277
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.