Uchl1 (ubiquitin C-terminal hydrolase L1) - Rat Genome Database

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Gene: Uchl1 (ubiquitin C-terminal hydrolase L1) Chinchilla lanigera
Analyze
Symbol: Uchl1
Name: ubiquitin C-terminal hydrolase L1
RGD ID: 8799930
Description: ENCODES a protein that exhibits alpha-2A adrenergic receptor binding (ortholog); cysteine-type deubiquitinase activity (ortholog); cysteine-type endopeptidase activity (ortholog); INVOLVED IN adult walking behavior (ortholog); axon target recognition (ortholog); axonal transport of mitochondrion (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Deglutition Disorders (ortholog); Diaphragmatic Hernia (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554436,367,460 - 6,380,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554436,367,519 - 6,379,638 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1Chinchillagenetic disease  ISOUCHL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:17576681 more ...
Uchl1Chinchillahereditary spastic paraplegia 79A  ISOUCHL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegia 79A more ...ClinVarPMID:25741868 more ...
Uchl1Chinchillahereditary spastic paraplegia 79B  ISOUCHL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndromeClinVarPMID:10203348 more ...
Uchl1ChinchillaHyperglycinemia, Lactic Acidosis, and Seizures  ISOUCHL1 (Homo sapiens)8554872ClinVar Annotator: match by term: HYPERGLYCINEMIA more ...ClinVarPMID:28492532
Uchl1ChinchillaParkinson's disease  ISOUCHL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parkinson Disease and DominantClinVarPMID:25741868 and PMID:28492532
Uchl1ChinchillaParkinson's Disease 5  ISOUCHL1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10203348 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1ChinchillaDiaphragmatic Hernia  ISOUCHL1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18958481
Uchl1ChinchillaEsophageal Neoplasms  ISOUCHL1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15930319
Uchl1ChinchillaGallbladder Neoplasms  ISOUCHL1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16965602
Uchl1Chinchillahepatocellular carcinoma  ISOUCHL1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18666234
Uchl1Chinchillalung non-small cell carcinoma  ISOUCHL1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17094902
Uchl1Chinchillaperipheral nervous system disease  ISOUCHL1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16797537
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1Chinchillahereditary spastic paraplegia 79A  ISOUCHL1 (Homo sapiens)7240710 OMIM 
Uchl1Chinchillahereditary spastic paraplegia 79B  ISOUCHL1 (Homo sapiens)7240710 OMIM 
Uchl1ChinchillaParkinson's Disease 5  ISOUCHL1 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1Chinchillaadult walking behavior acts_upstream_of_or_withinISOMGI:13552749068941 PMID:11555633MGIPMID:11555633
Uchl1Chinchillaadult walking behavior acts_upstream_of_or_withinISOMGI:18568829068941 PMID:11555633 and PMID:3340629MGIPMID:11555633 and PMID:3340629
Uchl1Chinchillaaxon target recognition acts_upstream_of_or_withinISOMGI:18568829068941 PMID:8474599MGIPMID:8474599
Uchl1Chinchillaaxonal transport of mitochondrion acts_upstream_of_or_withinISOMGI:18568829068941 PMID:2558488MGIPMID:2558488
Uchl1Chinchillaaxonogenesis acts_upstream_of_or_withinISOMGI:18568829068941 PMID:1630580MGIPMID:1630580
Uchl1Chinchillacellular response to xenobiotic stimulus involved_inISOUchl1 (Mus musculus)9068941 PMID:23064229MGIPMID:23064229
Uchl1Chinchillaeating behavior acts_upstream_of_or_withinISOMGI:13552749068941 PMID:11555633MGIPMID:11555633
Uchl1Chinchillamale germ cell proliferation acts_upstream_of_or_withinISOMGI:18568829068941 PMID:12638230MGIPMID:12638230
Uchl1Chinchillamuscle cell development acts_upstream_of_or_withinISOMGI:949099068941 PMID:8007658MGIPMID:8007658
Uchl1Chinchillanegative regulation of MAPK cascade involved_inISOUCHL1 (Homo sapiens)9068941 PMID:19477270BHF-UCLPMID:19477270
Uchl1Chinchillaneuromuscular process acts_upstream_of_or_withinISOMGI:18568829068941 PMID:3340629 and PMID:7555927MGIPMID:3340629 and PMID:7555927
Uchl1Chinchillapositive regulation of glycolytic process involved_inISOUCHL1 (Homo sapiens)9068941 PMID:34244144FlyBasePMID:34244144
Uchl1Chinchillaprotein deubiquitination involved_inISOUCHL1 (Homo sapiens)9068941 PMID:9521656UniProtPMID:9521656
Uchl1Chinchillaresponse to ischemia acts_upstream_of_or_withinISOMGI:18568829068941 PMID:14695319MGIPMID:14695319
Uchl1Chinchillasubstantia nigra development involved_inISOUCHL1 (Homo sapiens)9068941 PMID:22926577UniProtPMID:22926577
Uchl1Chinchillaubiquitin-dependent protein catabolic process  ISOUchl1 (Rattus norvegicus)9068941 RGDPMID:11850463 and REF_RGD_ID:70392
1 to 16 of 16 rows

Cellular Component
1 to 9 of 9 rows

  
1 to 9 of 9 rows

Molecular Function
1 to 19 of 19 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1Chinchillaalpha-2A adrenergic receptor binding enablesISOUniProtKB:P089139068941 PMID:19477270BHF-UCLPMID:19477270
Uchl1Chinchillacysteine-type deubiquitinase activity enablesISOUCHL1 (Homo sapiens)9068941 PMID:34244144FlyBasePMID:34244144
Uchl1Chinchillacysteine-type deubiquitinase activity enablesISOUchl1 (Mus musculus)9068941 PMID:12913066MGIPMID:12913066
Uchl1Chinchillacysteine-type deubiquitinase activity enablesISOUCHL1 (Homo sapiens)9068941 PMID:9521656UniProtPMID:9521656
Uchl1Chinchillacysteine-type endopeptidase activity enablesISOUCHL1 (Homo sapiens)9068941 PMID:8639624UniProtPMID:8639624
Uchl1Chinchillaomega peptidase activity enablesISOUCHL1 (Homo sapiens)9068941 PMID:9521656UniProtPMID:9521656
Uchl1Chinchillaprotein binding enablesISOUniProtKB:Q9NYB09068941 PMID:21044950IntActPMID:21044950
Uchl1Chinchillaprotein binding enablesISOUniProtKB:P11802 and UniProtKB:Q005359068941 PMID:23543736IntActPMID:23543736
Uchl1Chinchillaprotein binding enablesISOUniProtKB:P83916 and UniProtKB:Q158439068941 PMID:16169070IntActPMID:16169070
Uchl1Chinchillaprotein binding enablesISOUniProtKB:A4FUJ8 more ...9068941 PMID:32814053IntActPMID:32814053
Uchl1Chinchillaprotein binding enablesISOUniProtKB:Q9UK809068941 PMID:19615732IntActPMID:19615732
Uchl1Chinchillaprotein binding enablesISOUniProtKB:P050679068941 PMID:16049941IntActPMID:16049941
Uchl1Chinchillaprotein binding enablesISOUniProtKB:P005339068941 PMID:20029029 and PMID:31980649IntActPMID:20029029 and PMID:31980649
Uchl1Chinchillaprotein binding enablesISOUniProtKB:Q929059068941 PMID:12082530IntActPMID:12082530
Uchl1Chinchillaribosome binding enablesISOUchl1 (Mus musculus)9068941 PMID:23064229MGIPMID:23064229
Uchl1Chinchillasignaling receptor inhibitor activity enablesISOUCHL1 (Homo sapiens)9068941 PMID:19477270BHF-UCLPMID:19477270
Uchl1Chinchillaubiquitin binding enablesISOUCHL1 (Homo sapiens)9068941 PMID:9521656UniProtPMID:9521656
Uchl1Chinchillaubiquitin binding enablesISOUchl1 (Mus musculus)9068941 PMID:12913066MGIPMID:12913066
Uchl1Chinchillaubiquitin protein ligase binding enablesISOUniProtKB:O602609068941 PMID:19725078ParkinsonsUK-UCLPMID:19725078
1 to 19 of 19 rows


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



Uchl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554436,367,460 - 6,380,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554436,367,519 - 6,379,638 (-)NCBIChiLan1.0ChiLan1.0
UCHL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38441,256,928 - 41,268,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl441,256,413 - 41,268,455 (+)EnsemblGRCh38hg38GRCh38
GRCh37441,258,945 - 41,270,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36440,953,686 - 40,965,203 (+)NCBINCBI36Build 36hg18NCBI36
Build 34441,099,856 - 41,111,373NCBI
Celera441,702,199 - 41,713,746 (+)NCBICelera
Cytogenetic Map4p13NCBI
HuRef440,580,844 - 40,592,391 (+)NCBIHuRef
CHM1_1441,259,044 - 41,270,591 (+)NCBICHM1_1
T2T-CHM13v2.0441,230,716 - 41,242,242 (+)NCBIT2T-CHM13v2.0
Uchl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39566,833,464 - 66,844,577 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl566,833,434 - 66,844,577 (+)EnsemblGRCm39 Ensembl
GRCm38566,676,121 - 66,687,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl566,676,091 - 66,687,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv37567,067,360 - 67,078,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36566,955,425 - 66,966,369 (+)NCBIMGSCv36mm8
Celera563,976,841 - 63,987,914 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map535.95NCBI
Uchl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81441,838,859 - 41,849,743 (-)NCBIGRCr8
mRatBN7.21441,485,031 - 41,495,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1441,831,048 - 41,841,616 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01443,131,128 - 43,141,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01441,611,942 - 41,622,510 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01443,133,224 - 43,143,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1443,133,218 - 43,143,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01442,928,247 - 42,938,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41444,114,392 - 44,124,947 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11444,116,782 - 44,127,338 (-)NCBI
Celera1440,639,549 - 40,650,302 (-)NCBICelera
Cytogenetic Map14p11NCBI
UCHL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2341,440,064 - 41,451,601 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1441,633,489 - 41,645,029 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0435,580,755 - 35,592,314 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1441,432,367 - 41,440,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl441,428,759 - 41,440,129 (+)Ensemblpanpan1.1panPan2
UCHL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,396,694 - 71,430,395 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,370,822 - 71,411,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha373,946,978 - 73,961,370 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0372,157,557 - 72,171,966 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1371,427,585 - 71,441,983 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,589,640 - 71,604,050 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,972,745 - 71,987,146 (-)NCBIUU_Cfam_GSD_1.0
Uchl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528537,734,649 - 37,746,530 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364828,551,603 - 8,563,651 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364828,551,749 - 8,563,586 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCHL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl832,353,246 - 32,367,332 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1832,353,766 - 32,367,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2833,970,620 - 33,982,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UCHL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1279,074,961 - 9,086,606 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl279,074,923 - 9,086,517 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604755,406,774 - 55,418,174 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uchl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476125,784,257 - 25,797,549 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476125,786,028 - 25,797,641 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000001951   ⟹   ENSCLAP00000001908
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554436,367,460 - 6,380,462 (-)Ensembl
RefSeq Acc Id: XM_005391935   ⟹   XP_005391992
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554436,367,519 - 6,379,637 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013518123   ⟹   XP_013373577
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554436,367,519 - 6,379,638 (-)NCBI
Sequence:
Protein RefSeqs XP_005391992 (Get FASTA)   NCBI Sequence Viewer  
  XP_013373577 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000001908
  ENSCLAP00000001908.1
RefSeq Acc Id: XP_005391992   ⟸   XM_005391935
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UQZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013373577   ⟸   XM_013518123
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSCLAP00000001908   ⟸   ENSCLAT00000001951


1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000001405 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000001951 ENTREZGENE
  ENSCLAT00000001951.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.532.10 UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Peptidase_C12_UCH UniProtKB/TrEMBL
  Peptidase_C12_UCH_sf UniProtKB/TrEMBL
NCBI Gene Uchl1 ENTREZGENE
PANTHER PTHR10589 UniProtKB/TrEMBL
  PTHR10589:SF19 UniProtKB/TrEMBL
Pfam Peptidase_C12 UniProtKB/TrEMBL
PRINTS UBCTHYDRLASE UniProtKB/TrEMBL
PROSITE UCH_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A8C2UQZ9 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Uchl1  ubiquitin C-terminal hydrolase L1    ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)  Symbol and/or name change 5135510 APPROVED