Gm2a (ganglioside GM2 activator) - Rat Genome Database

Name: Gm2a
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: Gm2a (ganglioside GM2 activator) Rattus norvegicus

Analyze

Symbol:

Gm2a

Name:

ganglioside GM2 activator

RGD ID:

628651

Description:

Enables lipid transporter activity and phospholipase activator activity. Contributes to beta-N-acetylgalactosaminidase activity. Involved in ganglioside metabolic process; lipid transport; and positive regulation of hydrolase activity. Located in apical plasma membrane; basolateral plasma membrane; and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in GM2 gangliosidosis and GM2 gangliosidosis, AB variant. Orthologous to human GM2A (ganglioside GM2 activator); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GM2 ganglioside activator; GM2 ganglioside activator protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GM2A (ganglioside GM2 activator)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Gm2a (GM2 ganglioside activator protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gm2a (GM2 ganglioside activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GM2A (ganglioside GM2 activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GM2A (ganglioside GM2 activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gm2a (GM2 ganglioside activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GM2A (ganglioside GM2 activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GM2A (GM2 ganglioside activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gm2a (GM2 ganglioside activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GGNBP2 (gametogenetin binding protein 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GM2A (ganglioside GM2 activator)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gm2a (GM2 ganglioside activator protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gm2a (GM2 ganglioside activator)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gm2a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Candidate Gene For:

Kidm50

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	39,719,919 - 39,732,452 (+)	NCBI		GRCr8
mRatBN7.2	10	39,219,221 - 39,231,756 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	39,219,243 - 39,231,757 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	43,905,943 - 43,918,481 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	43,396,017 - 43,408,555 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	38,899,722 - 38,912,260 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	40,438,394 - 40,450,927 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	40,438,356 - 40,450,930 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	40,277,005 - 40,289,541 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	40,502,175 - 40,514,708 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	40,515,797 - 40,528,331 (+)	NCBI
Celera	10	38,556,830 - 38,569,363 (+)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial adenomatous polyposis 1 (ISO)

genetic disease (ISO)

GM2 gangliosidosis (ISO)

GM2 Gangliosidosis, AB variant (ISO,ISS)

Hereditary Neoplastic Syndromes (ISO)

neurodegenerative disease (ISO)

Stiff-Person syndrome (ISO)

Tay-Sachs disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

biochanin A (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cadmium sulfate (ISO)

camptothecin (ISO)

choline (ISO)

cisplatin (ISO)

clobetasol (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

diuron (EXP,ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

glycidyl methacrylate (ISO)

L-methionine (ISO)

lead(0) (ISO)

lead(II) chloride (ISO)

maneb (ISO)

methamphetamine (EXP)

methyl methanesulfonate (ISO)

methylparaben (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-methyl-4-phenylpyridinium (ISO)

nefazodone (EXP)

nickel sulfate (ISO)

nicotine (ISO)

nimesulide (EXP)

Nutlin-3 (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (EXP,ISO)

pirinixic acid (ISO)

piroxicam (ISO)

prednisolone (ISO)

propanal (ISO)

SB 431542 (ISO)

silicon dioxide (EXP)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

thimerosal (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Yessotoxin (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ganglioside catabolic process (IBA,ISO)

ganglioside metabolic process (IDA)

learning or memory (ISO)

lipid storage (ISO)

lipid transport (IBA,IDA)

maintenance of location in cell (ISO)

membrane fusion (IDA)

nervous system process (ISO)

neuromuscular process controlling balance (ISO)

oligosaccharide catabolic process (ISO)

positive regulation of hydrolase activity (IDA)

Cellular Component

apical plasma membrane (IDA)

basolateral plasma membrane (IDA)

cytoplasmic side of plasma membrane (IBA,IDA)

cytosol (IEA,ISO)

intracellular membrane-bounded organelle (IEA,ISO)

Molecular Function

beta-N-acetylgalactosaminidase activity (IDA)

beta-N-acetylhexosaminidase activity (ISO)

enzyme activator activity (ISO)

lipid binding (IC)

lipid transporter activity (IBA,IDA)

phospholipase activator activity (IDA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Cloning and sequence analysis of a cDNA clone coding for the mouse GM2 activator protein.	Bellachioma G, etal., Biochem J 1993 Aug 15;294 ( Pt 1):227-30.
2.	Structure of the GM2A gene: identification of an exon 2 nonsense mutation and a naturally occurring transcript with an in-frame deletion of exon 2.	Chen B, etal., Am J Hum Genet. 1999 Jul;65(1):77-87.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Identification of a lysosomal protein causing lipid transfer, using a fluorescence assay designed to monitor membrane fusion between rat liver endosomes and lysosomes.	Kuwana T, etal., Biochem J. 1995 Jun 15;308 ( Pt 3):937-46.
5.	Identification of a protein capable of causing fusion of endosome and lysosome membranes.	Kuwana T, etal., Biochem Soc Trans. 1993 May;21(2):299-300.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cells.	Mundel TM, etal., J Am Soc Nephrol. 1999 Mar;10(3):435-43.
8.	Requirement of GM2 ganglioside activator for phospholipase D activation.	Nakamura S, etal., Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12249-53.
9.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:7980537	PMID:9223328	PMID:9584189	PMID:11672434	PMID:14651853	PMID:19056867	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Gm2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	39,719,919 - 39,732,452 (+)	NCBI		GRCr8
mRatBN7.2	10	39,219,221 - 39,231,756 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	39,219,243 - 39,231,757 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	43,905,943 - 43,918,481 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	43,396,017 - 43,408,555 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	38,899,722 - 38,912,260 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	40,438,394 - 40,450,927 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	40,438,356 - 40,450,930 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	40,277,005 - 40,289,541 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	40,502,175 - 40,514,708 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	40,515,797 - 40,528,331 (+)	NCBI
Celera	10	38,556,830 - 38,569,363 (+)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

GM2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	151,253,185 - 151,270,440 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	151,212,150 - 151,270,440 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	150,632,746 - 150,650,001 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	150,612,837 - 150,629,000 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	150,612,836 - 150,629,000	NCBI
Celera	5	146,713,960 - 146,731,303 (+)	NCBI		Celera
Cytogenetic Map	5	q33.1	NCBI
HuRef	5	145,777,975 - 145,795,318 (+)	NCBI		HuRef
CHM1_1	5	150,065,374 - 150,082,713 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	151,792,130 - 151,809,386 (+)	NCBI		T2T-CHM13v2.0

Gm2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	54,988,811 - 55,003,855 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	54,988,941 - 55,003,855 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	55,097,985 - 55,113,029 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	55,098,115 - 55,113,029 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	54,911,619 - 54,924,400 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	54,941,540 - 54,954,321 (+)	NCBI		MGSCv36	mm8
Celera	11	59,688,047 - 59,700,826 (+)	NCBI		Celera
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	32.13	NCBI

Gm2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	2,442,406 - 2,449,426 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	2,442,406 - 2,449,426 (-)	NCBI	ChiLan1.0	ChiLan1.0

GM2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	146,484,984 - 146,501,347 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	144,624,529 - 144,640,892 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	146,680,277 - 146,696,505 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	152,680,745 - 152,697,018 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	152,680,696 - 152,697,018 (+)	Ensembl	panpan1.1		panPan2

GM2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	58,002,438 - 58,016,003 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	58,003,946 - 58,015,753 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	57,818,863 - 57,832,428 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	58,440,543 - 58,454,108 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	58,440,549 - 58,454,097 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	58,258,206 - 58,271,770 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	58,356,896 - 58,370,443 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	58,860,464 - 58,874,029 (-)	NCBI		UU_Cfam_GSD_1.0

Gm2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	117,123,754 - 117,138,030 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936647	4,126,577 - 4,140,786 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936647	4,126,524 - 4,140,800 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GM2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	71,742,090 - 71,754,884 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	71,742,090 - 71,767,872 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	77,974,674 - 78,000,601 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GM2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	53,808,447 - 53,831,489 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666034	23,887,594 - 23,903,943 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gm2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	41,141,552 - 41,156,188 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	41,141,507 - 41,152,957 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gm2a
55 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	184
Count of miRNA genes:	129
Interacting mature miRNAs:	146
Transcripts:	ENSRNOT00000015803
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
152025229	Scl83	Serum cholesterol level QTL 83	4.33		blood cholesterol amount (VT:0000180)		10	35710580	68663659	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
2317043	Aia7	Adjuvant induced arthritis QTL 7	3.82		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	37565079	82565079	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
2317042	Aia20	Adjuvant induced arthritis QTL 20	3.38		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	37565079	82565079	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1354614	Hpcl1	Hepatic cholesterol level QTL 1	3.3		liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	35392267	51793994	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat

Markers in Region

RH140262

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	39,231,042 - 39,231,223 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	40,450,214 - 40,450,394	NCBI	Rnor6.0
Rnor_5.0	10	40,288,825 - 40,289,005	UniSTS	Rnor5.0
RGSC_v3.4	10	40,513,995 - 40,514,175	UniSTS	RGSC3.4
Celera	10	38,568,650 - 38,568,830	UniSTS
RH 3.4 Map	10	406.6	UniSTS
Cytogenetic Map	10	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_172335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB051391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC093965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC072474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000078910 ⟹ ENSRNOP00000071876

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	39,219,243 - 39,231,755 (+)	Ensembl
Rnor_6.0 Ensembl	10	40,438,356 - 40,450,930 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115497 ⟹ ENSRNOP00000086248

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	39,223,661 - 39,231,757 (+)	Ensembl

RefSeq Acc Id:

NM_172335 ⟹ NP_758838

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	39,719,919 - 39,732,452 (+)	NCBI
mRatBN7.2	10	39,219,221 - 39,231,756 (+)	NCBI
Rnor_6.0	10	40,438,394 - 40,450,927 (+)	NCBI
Rnor_5.0	10	40,277,005 - 40,289,541 (+)	NCBI
RGSC_v3.4	10	40,502,175 - 40,514,708 (+)	RGD
Celera	10	38,556,830 - 38,569,363 (+)	RGD

Sequence:

show sequence

GGAGAGTCGCCGTGCCTAGACCGACCTCGAGGACCGTCGCCATGCGTCGTGTACCGCTGCTGCT
CGTGCTGGGCTTGCTGTTCGTGCTGGGCTTGCTGTTCGCTGGCCCTGTCGCCCCTTCGCGCCTC
ATCTCGAAGCGCCCTTCCCAACTTGGTGGCTTCTCCTGGGATAACTGTGATGAAGGAAAGGACC
CTGCAGTGATCAAAAGCCTCACGCTCCAACCTGACCCCATTGTCGTTCCTGGAGATGTGATCGT
CAGTGCTGAGGGCAAGACCAGCATTCCCCTCACTTCTCCTCAGAAGGTGGAGCTCACCGTGGAG
AAGGAAGTGGCTGGCTTCTGGGTCAAGATCCCTTGCGTAGAACAGCTAGGAAGCTGTACCTATG
AGAATGTCTGTGACCTGATAGACCAATACATCCCCCCTGGAGAGACCTGCCCAGAGCCGCTGCA
CACCTACGGGCTGCCCTGCCATTGTCCCTTCAAGGAAGGCACCTACTCACTGCCTTCGAGCAAC
TTCACAGTGCCTGATCTGGAGCTTCCAAGCTGGCTAAGCACGGGCAACTACCGCATCCAGAGCA
TCTTGAGCAGCGGTGGAAAGCGCCTGGCCTGCATCAAGATTGCCGCCTCTCTCAAGGGCAAATA
ACCAGGCAGCAGCCACCATAGAATGAAAGGGCACCAGGAAGGCATGCTTCTTCTTCTGTGTTCC
GGGGCCCAGAGCTGCCTGCCTCTAACTCCGTTCTATGGTTCTCTACCCTTTCTGCAAATCACGA
CAACCTGACCTGAGGGAGGATGGACCAGGCGGGTCTCGACATCTGTTGGGCTGTACGCCATGCT
CCTTCGCACCCCTACCAACTTTCTAAGAGTTTCTCTCATGTCCCAAACAGTCAAGGAATGGGAA
CCAACATGTTATGGAATCTTAAGTTCAAGCTGGCCCAACATGGGCCTCCTGAAGCTATGCTCAC
CCCACCTCTTCGTTTTAGCCACCAACTTAAAAACCAAGATGACAGTATTAATCTCTCATTCCAC
CCTAAACCTCTCATCCAGCAAAGAGGTCTAGGTAGCCAGTCTTAGGTCTGCCCCCCTATTAACT
TCCATGATTAACTACATTCCCTTTGCAACTTGCCTAGCCAACACTGGGGCTGACAGATCCTGAA
AGGGCAGGATGGCGTGTGACAGAAACCCTGGGAGAGTTATTGTTGGGCATGCCCCATTAACCTC
AGTAAAGCACAGGTGCCCAGGGCCAAGCAGATCGAGGGAGCCAAAGCAGTCACTCCCAGGAGCG
ATGCCCACTTTTCTTCCTTTGGTATGACGCATACAGAATGGGATGACATTCCTTATACCTGACA
AGAAACAAAACTGAAACCCCAACAGCACATGTGCTCCAGTGCCAGGAGGCCAGGGTCTGGAATG
GCATGTCTAGTCCTGGAGGTACAGTCCAGTGACCTGTAAGTGCCATGTAAGGAATGTTACCGGA
TATTTGCAACAGTTTTCTTCCTTAGGCCCCAAACCCCAGACTTTTCTATGAAGTCTTAGATTTT
TTAACTATTAGAAACAAATTGTTTTTTATATACTGTTCAGGCCAAAGGGGCCACGTGGACTTGT
CTGGGGGGTGGGGGGGGACATAGCTGGCTCACAGGTGGCTGCTTTTTTTCTCACACCTGTTCGT
CTTCTCAGTCTCAAGTTATCTGACTTCATTTCTCTCCCCCTCAAGGTCAAGTCCTTGGTACCAG
ACCTCAGAGAGGGCTCAGCCTGCACTGGAGCAGGTCTGCATGGCCTCTGAGAGCTGGGCCCTGT
GCCAGCCTCAGAGCCCCATCACCATCAGGGTATAGGGGTTCACACTGGAGTGGATCTCCCCACC
CCCACCCCCCAGCAGCCACCTTGTGGAACAGGGGTCCCATGTAGAGAGTGGATCCCACACCGGG
TTGTACCATGACAACTTCCTGAGCCTCCGTCAGCCCGGTTCTGGACTGCAAGACTAGTCTGTCA
ATAAATCTTCTTAACTTGCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_758838	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH72474	(Get FASTA)	NCBI Sequence Viewer
	BAC24018	(Get FASTA)	NCBI Sequence Viewer
	EDM04464	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000071876.2
	ENSRNOP00000086248.1

RefSeq Acc Id:	NP_758838 ⟸ NM_172335
- Peptide Label:	precursor
- UniProtKB:	Q6IN37 (UniProtKB/TrEMBL), Q8CJH4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRRVPLLLVLGLLFVLGLLFAGPVAPSRLISKRPSQLGGFSWDNCDEGKDPAVIKSLTLQPDPI VVPGDVIVSAEGKTSIPLTSPQKVELTVEKEVAGFWVKIPCVEQLGSCTYENVCDLIDQYIPPG ETCPEPLHTYGLPCHCPFKEGTYSLPSSNFTVPDLELPSWLSTGNYRIQSILSSGGKRLACIKI AASLKGK hide sequence

Ensembl Acc Id:

ENSRNOP00000071876 ⟸ ENSRNOT00000078910

Ensembl Acc Id:

ENSRNOP00000086248 ⟸ ENSRNOT00000115497

Protein Domains

MD-2-related lipid-recognition

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6IN37-F1-model_v2	AlphaFold	Q6IN37	1-199	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697198

Promoter ID:

EPDNEW_R7722

Type:

initiation region

Name:

Gm2a_1

Description:

GM2 ganglioside activator

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	40,438,360 - 40,438,420	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628651	AgrOrtholog
BioCyc Gene	G2FUF-25088	BioCyc
Ensembl Genes	ENSRNOG00000052219	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000078910.2	UniProtKB/TrEMBL
	ENSRNOT00000115497.1	UniProtKB/TrEMBL
Gene3D-CATH	2.70.220.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7100875	IMAGE-MGC_LOAD
InterPro	GM2-AP	UniProtKB/TrEMBL
	GM2-AP_sf	UniProtKB/TrEMBL
	MD-2_lipid-recog	UniProtKB/TrEMBL
KEGG Report	rno:282838	UniProtKB/TrEMBL
MGC_CLONE	MGC:91430	IMAGE-MGC_LOAD
NCBI Gene	282838	ENTREZGENE
PANTHER	GANGLIOSIDE GM2 ACTIVATOR	UniProtKB/TrEMBL
	PTHR17357	UniProtKB/TrEMBL
Pfam	E1_DerP2_DerF2	UniProtKB/TrEMBL
PhenoGen	Gm2a	PhenoGen
RatGTEx	ENSRNOG00000052219	RatGTEx
SMART	SM00737	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63707	UniProtKB/TrEMBL
UniProt	A0A0G2K1K3_RAT	UniProtKB/TrEMBL
	A0A8I6A5G9_RAT	UniProtKB/TrEMBL
	Q6IN37	ENTREZGENE, UniProtKB/TrEMBL
	Q8CJH4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-04-21	Gm2a	ganglioside GM2 activator	Gm2a	GM2 ganglioside activator	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-16	Gm2a	GM2 ganglioside activator	Gm2a	GM2 ganglioside activator protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Gm2a	GM2 ganglioside activator protein			Symbol and Name status set to approved	1299863	APPROVED
2003-02-27	Gm2a	GM2 ganglioside activator protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM