Casp14 (caspase 14) - Rat Genome Database

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Gene: Casp14 (caspase 14) Rattus norvegicus
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Symbol: Casp14
Name: caspase 14
RGD ID: 1311781
Description: Predicted to be involved in execution phase of apoptosis; positive regulation of cell death; and proteolysis. Located in keratin filament and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis. Orthologous to human CASP14 (caspase 14); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: caspase-14; LOC299587
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2710,929,759 - 10,932,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,926,725 - 10,933,405 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,750,087 - 13,752,901 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0715,627,533 - 15,630,347 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0713,505,382 - 13,508,196 (+)NCBIRnor_WKY
Rnor_6.0713,938,376 - 13,944,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,938,302 - 13,945,130 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,094,304 - 14,099,953 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,487,166 - 12,489,998 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,456,557 - 12,489,998 (+)NCBI
Celera79,047,174 - 9,050,006 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cornified envelope  (ISO)
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
keratin filament  (IDA)
mitochondrion  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Distribution of caspase-14 in epidermis and hair follicles is evolutionarily conserved among mammals. Alibardi L, etal., Anat Rec A Discov Mol Cell Evol Biol. 2005 Oct;286(2):962-73.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:23376485   PMID:23377137   PMID:23979707  


Genomics

Comparative Map Data
Casp14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2710,929,759 - 10,932,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,926,725 - 10,933,405 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx713,750,087 - 13,752,901 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0715,627,533 - 15,630,347 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0713,505,382 - 13,508,196 (+)NCBIRnor_WKY
Rnor_6.0713,938,376 - 13,944,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,938,302 - 13,945,130 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,094,304 - 14,099,953 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,487,166 - 12,489,998 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,456,557 - 12,489,998 (+)NCBI
Celera79,047,174 - 9,050,006 (+)NCBICelera
Cytogenetic Map7q11NCBI
CASP14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,049,480 - 15,058,293 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1915,049,480 - 15,058,293 (+)EnsemblGRCh38hg38GRCh38
GRCh371915,160,291 - 15,169,104 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,024,015 - 15,027,900 (+)NCBINCBI36Build 36hg18NCBI36
Build 341915,024,014 - 15,027,900NCBI
Celera1915,058,743 - 15,062,628 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,727,867 - 14,736,682 (+)NCBIHuRef
CHM1_11915,159,760 - 15,168,573 (+)NCBICHM1_1
T2T-CHM13v2.01915,174,417 - 15,183,232 (+)NCBIT2T-CHM13v2.0
Casp14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,547,829 - 78,554,181 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1078,547,825 - 78,554,128 (-)EnsemblGRCm39 Ensembl
GRCm381078,711,995 - 78,718,347 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,711,991 - 78,718,294 (-)EnsemblGRCm38mm10GRCm38
MGSCv371078,174,740 - 78,181,038 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361078,115,126 - 78,121,371 (-)NCBIMGSCv36mm8
Celera1079,733,914 - 79,740,355 (-)NCBICelera
Cytogenetic Map10C1NCBI
Casp14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554958,213,763 - 8,221,616 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554958,214,512 - 8,221,124 (-)NCBIChiLan1.0ChiLan1.0
CASP14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11915,565,543 - 15,574,402 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1915,565,543 - 15,574,402 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01914,594,810 - 14,604,109 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CASP14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12047,060,351 - 47,067,169 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2047,062,278 - 47,065,001 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,911,092 - 46,917,669 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02047,553,425 - 47,560,009 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2047,553,782 - 47,560,035 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12046,784,855 - 46,791,428 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02047,204,643 - 47,211,219 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02047,475,191 - 47,481,766 (-)NCBIUU_Cfam_GSD_1.0
Casp14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118205,846,067 - 205,852,182 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365965,396,866 - 5,399,278 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365965,396,866 - 5,399,255 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl262,524,183 - 62,531,642 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1262,522,294 - 62,531,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2262,076,316 - 62,089,874 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASP14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,649,993 - 13,654,309 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,648,598 - 13,652,821 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660745,899,601 - 5,914,400 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249012,127,743 - 2,130,496 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249012,125,575 - 2,131,656 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Casp14
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:85
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000009643
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system reproductive system respiratory system
High
Medium
Low 2 7 7 6
Below cutoff 1 6 2 1 1 1 12 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009643   ⟹   ENSRNOP00000009643
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl710,926,725 - 10,933,405 (+)Ensembl
Rnor_6.0 Ensembl713,938,302 - 13,945,130 (+)Ensembl
RefSeq Acc Id: NM_001191776   ⟹   NP_001178705
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2710,929,759 - 10,932,591 (+)NCBI
Rnor_6.0713,940,638 - 13,943,470 (+)NCBI
Rnor_5.0714,094,304 - 14,099,953 (+)NCBI
Celera79,047,174 - 9,050,006 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178705 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001178705   ⟸   NM_001191776
- UniProtKB: D3ZZ65 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009643   ⟸   ENSRNOT00000009643
Protein Domains
CASPASE_P10   CASPASE_P20

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZ65-F1-model_v2 AlphaFold D3ZZ65 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695063
Promoter ID:EPDNEW_R5588
Type:multiple initiation site
Name:Casp14_1
Description:caspase 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0713,938,395 - 13,938,455EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311781 AgrOrtholog
BioCyc Gene G2FUF-34845 BioCyc
Ensembl Genes ENSRNOG00000007352 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009643 ENTREZGENE
  ENSRNOP00000009643.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009643 ENTREZGENE
  ENSRNOT00000009643.4 UniProtKB/TrEMBL
InterPro Caspase-14 UniProtKB/TrEMBL
  Caspase-like_dom UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
  Pept_C14_ICE_p20 UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p45_core UniProtKB/TrEMBL
KEGG Report rno:299587 UniProtKB/TrEMBL
NCBI Gene 299587 ENTREZGENE
PANTHER PTHR10454 UniProtKB/TrEMBL
  PTHR10454:SF131 UniProtKB/TrEMBL
PhenoGen Casp14 PhenoGen
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
Superfamily-SCOP SSF52129 UniProtKB/TrEMBL
UniProt D3ZZ65 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Casp14  caspase 14   Casp14_predicted  caspase 14 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Casp14_predicted  caspase 14 (predicted)      Symbol and Name status set to approved 70820 APPROVED