Myog (myogenin) - Rat Genome Database

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Pathways
Gene: Myog (myogenin) Rattus norvegicus
Analyze
Symbol: Myog
Name: myogenin
RGD ID: 620432
Description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to magnetism; regulation of generation of precursor metabolites and energy; and response to stimulus involved in regulation of muscle adaptation. Located in nucleus. Part of protein-DNA complex. Biomarker of obesity. Orthologous to human MYOG (myogenin); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21345,745,455 - 45,748,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,745,436 - 45,748,039 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,353,288 - 48,355,876 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,641,358 - 49,643,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,906,096 - 46,908,691 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,126,459 - 51,129,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,126,459 - 51,129,048 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,182,747 - 56,185,336 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,243,712 - 47,246,301 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,257,754 - 47,260,344 (+)NCBI
Celera1346,073,572 - 46,076,161 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamiprid  (EXP)
alpha-naphthoflavone  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
arecoline  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (ISO)
bupivacaine  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chromium atom  (EXP)
dexamethasone  (ISO)
diacetylmonoxime  (ISO)
dimethylarsinous acid  (ISO)
fulvestrant  (ISO)
indole-3-methanol  (EXP)
indoxyl sulfate  (ISO)
lead diacetate  (ISO)
lumiracoxib  (ISO)
methylmercury chloride  (ISO)
ML-7  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
nickel subsulfide  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
Ptaquiloside  (ISO)
resveratrol  (EXP,ISO)
salubrinal  (ISO)
SB 203580  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
spermine  (ISO)
tebuconazole  (ISO)
testosterone  (EXP,ISO)
titanium dioxide  (ISO)
toluene  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to estradiol stimulus  (IEA,ISO,ISS)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to lithium ion  (IEA,ISO)
cellular response to magnetism  (IEP)
cellular response to retinoic acid  (IEP)
cellular response to tumor necrosis factor  (IEA,ISO)
muscle cell differentiation  (ISO)
muscle organ development  (ISO)
myoblast differentiation  (IEP)
myotube differentiation  (IMP,ISO)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of glycolytic process  (IDA)
ossification  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of muscle atrophy  (IEA,ISO,ISS)
positive regulation of myoblast differentiation  (IBA,IEA,ISO,ISS)
positive regulation of myotube differentiation  (IEA,ISO,ISS)
positive regulation of oxidative phosphorylation  (IDA)
positive regulation of skeletal muscle fiber development  (IBA,IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISO,ISS)
regulation of cell cycle  (IEA,ISO,ISS)
regulation of myoblast fusion  (IEA,ISO,ISS)
regulation of skeletal muscle satellite cell proliferation  (IEA,ISO,ISS)
response to denervation involved in regulation of muscle adaptation  (IEA,ISO,ISS)
response to electrical stimulus involved in regulation of muscle adaptation  (IDA,IEP)
response to gravity  (IEP)
response to muscle activity  (IEP)
response to muscle activity involved in regulation of muscle adaptation  (IDA)
skeletal muscle atrophy  (IEP)
skeletal muscle cell differentiation  (IBA)
skeletal muscle fiber development  (IEA,ISO)
skeletal muscle tissue development  (ISO)
skeletal muscle tissue regeneration  (IEP)
striated muscle atrophy  (IEA,ISO,ISS)

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IDA,ISO)
protein-DNA complex  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Retinoic acid induces myogenin synthesis and myogenic differentiation in the rat rhabdomyosarcoma cell line BA-Han-1C. Arnold HH, etal., J Cell Biol. 1992 Aug;118(4):877-87.
2. Changes in the expression of mRNAs for myogenic factors and other muscle-specific proteins in experimental autoimmune myasthenia gravis. Asher O, etal., FEBS Lett. 1992 Mar 24;299(1):15-8.
3. Fenofibrate administration to arthritic rats increases adiponectin and leptin and prevents oxidative muscle wasting. Castillero E, etal., Endocr Connect. 2012 Jun 8;1(1):1-12. doi: 10.1530/EC-12-0003. Print 2012 Jul 1.
4. Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects on other actions of IGF-T. Florini JR and Ewton DZ, J Biol Chem. 1990 Aug 15;265(23):13435-7.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Myogenin induces a shift of enzyme activity from glycolytic to oxidative metabolism in muscles of transgenic mice. Hughes SM, etal., J Cell Biol. 1999 May 3;145(3):633-42.
8. Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei. Hyatt JP, etal., Am J Physiol Cell Physiol 2003 Nov;285(5):C1161-73. Epub 2003 Jul 2.
9. Repetitive stretch induces c-fos and myogenin mRNA within several hours in skeletal muscle removed from rats. Ikeda S, etal., Arch Phys Med Rehabil 2003 Mar;84(3):419-23.
10. Effects of microgravity on myogenic factor expressions during postnatal development of rat skeletal muscle. Inobe M, etal., J Appl Physiol 2002 May;92(5):1936-42.
11. Localization of MyoD, myogenin and cell cycle regulatory factors in hypertrophying rat skeletal muscles. Ishido M, etal., Acta Physiol Scand. 2004 Mar;180(3):281-9.
12. Expression of MyoD and myogenin in dystrophic mice, mdx and dy, during regeneration. Jin Y, etal., Acta Neuropathol. 2000 Jun;99(6):619-27.
13. Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle. Macpherson PC, etal., J Cell Biochem. 2011 Aug;112(8):2149-59. doi: 10.1002/jcb.23136.
14. Time-based gene expression programme following diaphragm injury in a rat model. Mehiri SN, etal., Eur Respir J. 2005 Mar;25(3):422-30.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading. Peterson JM, etal., Am J Physiol Cell Physiol. 2008 Aug;295(2):C521-8. Epub 2008 May 28.
18. Satellite cell proliferation in low frequency-stimulated fast muscle of hypothyroid rat. Putman CT, etal., Am J Physiol Cell Physiol. 2000 Sep;279(3):C682-90.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. Simultaneous myogenin expression and overall DNA hypomethylation promote in vitro myoblast differentiation. Scarpa S, etal., Cell Growth Differ. 1996 Aug;7(8):1051-8.
24. Myogenin and oxidative enzyme gene expression levels are elevated in rat soleus muscles after endurance training. Siu PM, etal., J Appl Physiol (1985). 2004 Jul;97(1):277-85. Epub 2004 Mar 19.
25. CaM kinase II-dependent phosphorylation of myogenin contributes to activity-dependent suppression of nAChR gene expression in developing rat myotubes. Tang H, etal., Cell Signal. 2004 May;16(5):551-63.
26. Differentiation of myoblasts is accelerated in culture in a magnetic field. Yuge L and Kataoka K, In Vitro Cell Dev Biol Anim. 2000 Jun;36(6):383-6.
27. Antisense inhibition of myoD expression in regenerating rat soleus muscle is followed by an increase in the mRNA levels of myoD, myf-5 and myogenin and by a retarded regeneration. Zador E, etal., Biochim Biophys Acta 2002 Jun 12;1590(1-3):52-63.
Additional References at PubMed
PMID:2537150   PMID:8393145   PMID:8587605   PMID:8760303   PMID:10835421   PMID:11076940   PMID:12133506   PMID:12486129   PMID:14762206   PMID:15322112   PMID:15489316   PMID:15673614  
PMID:15706034   PMID:16140986   PMID:16554364   PMID:17531403   PMID:17904117   PMID:18849500   PMID:19319192   PMID:19783823   PMID:20384792   PMID:20399744   PMID:21177767   PMID:21858842  
PMID:22106411   PMID:22464481   PMID:22638570   PMID:22847234   PMID:23085379   PMID:24349514   PMID:24361185   PMID:24532688   PMID:25056796   PMID:25085416   PMID:26452256   PMID:26914683  
PMID:35124612  


Genomics

Comparative Map Data
Myog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21345,745,455 - 45,748,044 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,745,436 - 45,748,039 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,353,288 - 48,355,876 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,641,358 - 49,643,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,906,096 - 46,908,691 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,126,459 - 51,129,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,126,459 - 51,129,048 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,182,747 - 56,185,336 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,243,712 - 47,246,301 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,257,754 - 47,260,344 (+)NCBI
Celera1346,073,572 - 46,076,161 (+)NCBICelera
Cytogenetic Map13q13NCBI
MYOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381203,083,129 - 203,086,012 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,083,129 - 203,086,012 (-)EnsemblGRCh38hg38GRCh38
GRCh371203,052,257 - 203,055,140 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,318,880 - 201,322,000 (-)NCBINCBI36Build 36hg18NCBI36
Build 341199,783,916 - 199,786,823NCBI
Celera1176,181,515 - 176,184,632 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,217,862 - 174,220,769 (-)NCBIHuRef
CHM1_11204,474,600 - 204,477,509 (-)NCBICHM1_1
T2T-CHM13v2.01202,345,882 - 202,348,764 (-)NCBIT2T-CHM13v2.0
Myog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,217,742 - 134,220,286 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,217,727 - 134,220,286 (+)EnsemblGRCm39 Ensembl
GRCm381134,290,004 - 134,292,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,289,989 - 134,292,548 (+)EnsemblGRCm38mm10GRCm38
MGSCv371136,186,581 - 136,189,125 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361136,106,424 - 136,108,961 (+)NCBIMGSCv36mm8
Celera1136,900,556 - 136,903,100 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.18NCBI
Myog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,099,716 - 39,102,501 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,099,044 - 39,102,479 (-)NCBIChiLan1.0ChiLan1.0
MYOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1146,258,868 - 46,263,290 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01178,684,933 - 178,687,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11182,979,700 - 182,982,607 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1182,979,700 - 182,982,611 (-)Ensemblpanpan1.1panPan2
MYOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17112,116 - 114,604 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7112,034 - 113,892 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha7167,989 - 170,338 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07122,772 - 125,124 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7122,763 - 125,152 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17111,008 - 113,379 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07220,521 - 222,887 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.07243,050 - 245,421 (+)NCBIUU_Cfam_GSD_1.0
Myog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934472,272,365 - 72,275,138 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365671,507,042 - 1,509,815 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365671,507,042 - 1,509,814 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9113,782,284 - 113,787,340 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19113,783,233 - 113,785,312 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,243,803 - 125,245,882 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9q2.1-q2.6NCBI
MYOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12526,264,872 - 26,269,652 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2526,266,717 - 26,268,867 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605527,042,619 - 27,045,566 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248077,749,852 - 7,753,336 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248077,742,926 - 7,753,149 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myog
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:355
Count of miRNA genes:216
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000042046
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134343790447841255Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134522835847841255Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat

Markers in Region
PMC207566P7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,745,282 - 45,745,492 (+)MAPPERmRatBN7.2
Rnor_6.01351,126,287 - 51,126,496NCBIRnor6.0
Rnor_5.01356,182,575 - 56,182,784UniSTSRnor5.0
RGSC_v3.41347,243,540 - 47,243,749UniSTSRGSC3.4
Celera1346,073,400 - 46,073,609UniSTS
Cytogenetic Map13q13UniSTS
Myog  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41347,244,008 - 47,245,508UniSTSRGSC3.4
Celera1346,073,868 - 46,075,368UniSTS
Cytogenetic Map13q13UniSTS
UniSTS:205458  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,745,649 - 45,745,922 (+)MAPPERmRatBN7.2
Rnor_6.01351,126,654 - 51,126,926NCBIRnor6.0
Rnor_5.01356,182,942 - 56,183,214UniSTSRnor5.0
RGSC_v3.41347,243,907 - 47,244,179UniSTSRGSC3.4
Celera1346,073,767 - 46,074,039UniSTS
Cytogenetic Map13q13UniSTS
UniSTS:234220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,745,523 - 45,745,850 (+)MAPPERmRatBN7.2
Rnor_6.01351,126,528 - 51,126,854NCBIRnor6.0
Rnor_5.01356,182,816 - 56,183,142UniSTSRnor5.0
RGSC_v3.41347,243,781 - 47,244,107UniSTSRGSC3.4
Celera1346,073,641 - 46,073,967UniSTS
Cytogenetic Map13q13UniSTS
PMC133893P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,745,628 - 45,746,580 (+)MAPPERmRatBN7.2
Rnor_6.01351,126,633 - 51,127,584NCBIRnor6.0
Rnor_5.01356,182,921 - 56,183,872UniSTSRnor5.0
RGSC_v3.41347,243,886 - 47,244,837UniSTSRGSC3.4
Celera1346,073,746 - 46,074,697UniSTS
Cytogenetic Map13q13UniSTS
UniSTS:463953  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,745,903 - 45,746,577 (+)MAPPERmRatBN7.2
Rnor_6.01351,126,908 - 51,127,581NCBIRnor6.0
Rnor_5.01356,183,196 - 56,183,869UniSTSRnor5.0
RGSC_v3.41347,244,161 - 47,244,834UniSTSRGSC3.4
Celera1346,074,021 - 46,074,694UniSTS
Cytogenetic Map13q13UniSTS
Myog  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,747,899 - 45,748,013 (+)MAPPERmRatBN7.2
Rnor_6.01351,128,904 - 51,129,017NCBIRnor6.0
Rnor_5.01356,185,192 - 56,185,305UniSTSRnor5.0
RGSC_v3.41347,246,157 - 47,246,270UniSTSRGSC3.4
Celera1346,076,017 - 46,076,130UniSTS
Cytogenetic Map13q13UniSTS
Myog  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41347,244,171 - 47,245,692UniSTSRGSC3.4
Celera1346,074,031 - 46,075,552UniSTS
Cytogenetic Map13q13UniSTS
Myog  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,745,488 - 45,745,673 (+)MAPPERmRatBN7.2
Rnor_6.01351,126,493 - 51,126,677NCBIRnor6.0
Rnor_5.01356,182,781 - 56,182,965UniSTSRnor5.0
RGSC_v3.41347,243,746 - 47,243,930UniSTSRGSC3.4
Celera1346,073,606 - 46,073,790UniSTS
Cytogenetic Map13q13UniSTS
Myog  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01356,183,043 - 56,184,543UniSTSRnor5.0
RGSC_v3.41347,244,008 - 47,245,508UniSTSRGSC3.4
Celera1346,073,868 - 46,075,368UniSTS
Cytogenetic Map13q13UniSTS
Myog  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01356,183,206 - 56,184,727UniSTSRnor5.0
RGSC_v3.41347,244,171 - 47,245,692UniSTSRGSC3.4
Celera1346,074,031 - 46,075,552UniSTS
Cytogenetic Map13q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 8 7 7
Low 16 12 6 7 6 1 3 6 17 7 1
Below cutoff 2 14 17 14 12 14 31 10 6 2

Sequence


RefSeq Acc Id: ENSRNOT00000042046   ⟹   ENSRNOP00000039817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1345,745,436 - 45,748,039 (+)Ensembl
Rnor_6.0 Ensembl1351,126,459 - 51,129,048 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087240   ⟹   ENSRNOP00000073308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1351,126,459 - 51,129,048 (+)Ensembl
RefSeq Acc Id: NM_017115   ⟹   NP_058811
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21345,745,455 - 45,748,044 (+)NCBI
Rnor_6.01351,126,459 - 51,129,048 (+)NCBI
Rnor_5.01356,182,747 - 56,185,336 (+)NCBI
RGSC_v3.41347,243,712 - 47,246,301 (+)RGD
Celera1346,073,572 - 46,076,161 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058811 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41662 (Get FASTA)   NCBI Sequence Viewer  
  AAC12644 (Get FASTA)   NCBI Sequence Viewer  
  EDM09735 (Get FASTA)   NCBI Sequence Viewer  
  P20428 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058811   ⟸   NM_017115
- UniProtKB: P20428 (UniProtKB/Swiss-Prot),   O70425 (UniProtKB/TrEMBL),   F7EW09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073308   ⟸   ENSRNOT00000087240
RefSeq Acc Id: ENSRNOP00000039817   ⟸   ENSRNOT00000042046
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20428-F1-model_v2 AlphaFold P20428 1-287 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620432 AgrOrtholog
BioCyc Gene G2FUF-18246 BioCyc
Ensembl Genes ENSRNOG00000030743 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000039817 ENTREZGENE
  ENSRNOP00000039817.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042046 ENTREZGENE
  ENSRNOT00000042046.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Basic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myogenic_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29148 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29148 ENTREZGENE
PANTHER MYOGENIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11534 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Basic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Myog PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7EW09 ENTREZGENE, UniProtKB/TrEMBL
  MYOG_RAT UniProtKB/Swiss-Prot
  O70425 ENTREZGENE, UniProtKB/TrEMBL
  P20428 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Myog  myogenin      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Myog        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is increased with repetitive stretching of soleus muscles 727517