Igf1 (insulin-like growth factor 1) - Rat Genome Database

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Gene: Igf1 (insulin-like growth factor 1) Rattus norvegicus
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Symbol: Igf1
Name: insulin-like growth factor 1
RGD ID: 2868
Description: Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to steroid hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); borna disease; congenital diaphragmatic hernia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1); PARTICIPATES IN altered insulin-like growth factor signaling pathway; cardiovascular system disease pathway; insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IGF; IGF-I; insulin-like growth factor I; somatomedin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Bp102  
Candidate Gene For: Bw19 Lnnr1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8724,169,608 - 24,249,446 (+)NCBIGRCr8
mRatBN7.2722,282,895 - 22,361,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl722,282,930 - 22,359,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx724,277,579 - 24,351,455 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,440,272 - 26,514,144 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0726,217,310 - 26,291,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,412,123 - 28,491,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,412,198 - 28,486,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,528,165 - 28,607,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,531,669 - 24,605,742 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,553,367 - 24,625,089 (+)NCBI
Celera719,453,213 - 19,527,075 (+)NCBICelera
RH 3.4 Map7116.9RGD
RH 3.4 Map7118.8RGD
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acoustic neuroma  (ISO)
acromegaly  (ISO)
acute kidney failure  (ISO)
adenoma  (ISO)
Albuminuria  (ISO)
alcoholic neuropathy  (IEP)
alopecia  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
borna disease  (IEP)
Brain Hypoxia-Ischemia  (IDA,IEP,ISO)
Brain Injuries  (ISO)
brain ischemia  (IDA,ISO)
breast cancer  (IEP)
Breast Neoplasms  (ISO)
Burns  (IEP)
Cachexia  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (IEP,ISO)
Closed Head Injuries  (ISO)
Cockayne syndrome  (ISO)
colitis  (ISO)
congenital diaphragmatic hernia  (IEP)
congenital disorder of glycosylation Ia  (ISO)
congenital hypothyroidism  (IEP)
congestive heart failure  (IEP)
corneal disease  (ISO)
Coronary Disease  (ISO)
coronary stenosis  (IEP)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
Deafness  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (IEP,ISO)
diabetic neuropathy  (IMP,ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dwarfism  (IEP,ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (IEP)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP,IMP,ISO)
Experimental Mammary Neoplasms  (ISO)
familial Mediterranean fever  (ISO)
Female Urogenital Diseases  (ISO)
fetal alcohol spectrum disorder  (IEP)
Fetal Growth Retardation  (IEP,ISO)
Fetal Macrosomia  (ISO)
folic acid deficiency anemia  (IEP)
genetic disease  (ISO)
glycogen storage disease III  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (IDA)
hypertension  (IAGP,IEP,ISO)
hypertrophic cardiomyopathy  (ISO)
hypothyroidism  (IEP)
Insulin-Like Growth Factor I Deficiency  (ISO)
intellectual disability  (ISO)
Intervertebral Disc Displacement  (IMP)
kidney disease  (ISO)
Knee Osteoarthritis  (IEP,ISO)
Kuhnt-Junius degeneration  (ISO)
Laron syndrome  (ISO)
learning disability  (ISO)
lung disease  (ISO)
Malocclusion  (IEP)
Memory Disorders  (ISO)
Metabolic Bone Diseases  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
movement disease  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (IDA,ISO)
myopia  (ISO)
Nasal Polyps  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
Neurodevelopmental Disorders  (ISO)
Noonan syndrome  (ISO)
osteoarthritis  (ISO)
Osteophytes  (IEP)
osteoporosis  (IEP,ISO)
Osteoporotic Fractures  (IDA,ISO)
Oxygen-Induced Retinopathy  (IEP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
PEHO syndrome  (ISO)
peripheral nervous system disease  (ISO)
Pituitary Neoplasms  (ISO)
Plaque, Atherosclerotic  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
Precocious Puberty  (ISO)
progeria  (ISO)
prostate carcinoma in situ  (IEP)
Prostatic Neoplasms  (IEP,ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pycnodysostosis  (ISO)
Reperfusion Injury  (ISO)
retinopathy of prematurity  (IEP,ISO)
rheumatic heart disease  (ISO)
Rhinosinusitis  (ISO)
Right Ventricular Hypertrophy  (IEP)
Sarcopenia  (ISO)
severe acute respiratory syndrome  (ISO)
Skin Neoplasms  (ISO)
Skull Fractures  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (IEP,ISO)
Sudden Hearing Loss  (ISO)
Thinness  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (IEP)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
vascular dementia  (IEP,ISO)
Wounds and Injuries  (IEP,ISO)
Zinc Deficiency  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-noradrenaline  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylphenanthrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-tert-Octylphenol  (EXP)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)