Igf1 (insulin-like growth factor 1) - Rat Genome Database

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Gene: Igf1 (insulin-like growth factor 1) Rattus norvegicus
Analyze
Symbol: Igf1
Name: insulin-like growth factor 1
RGD ID: 2868
Description: Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of cell death; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); congenital diaphragmatic hernia; folic acid deficiency anemia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1); PARTICIPATES IN altered insulin-like growth factor signaling pathway; cardiovascular system disease pathway; insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IGF; IGF-I; insulin-like growth factor I; somatomedin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp102  
Candidate Gene For: Bw19 Lnnr1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2722,282,895 - 22,361,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl722,282,930 - 22,359,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx724,277,579 - 24,351,455 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0726,440,272 - 26,514,144 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0726,217,310 - 26,291,178 (+)NCBIRnor_WKY
Rnor_6.0728,412,123 - 28,491,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,412,198 - 28,486,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,528,165 - 28,607,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,531,669 - 24,605,742 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,553,367 - 24,625,089 (+)NCBI
Celera719,453,213 - 19,527,075 (+)NCBICelera
RH 3.4 Map7118.8RGD
RH 3.4 Map7116.9RGD
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acoustic neuroma  (ISO)
acromegaly  (ISO)
acute kidney failure  (ISO)
adenoma  (ISO)
Albuminuria  (ISO)
alcoholic neuropathy  (IEP)
alopecia  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
Brain Hypoxia-Ischemia  (IDA,IEP,ISO)
Brain Injuries  (ISO)
brain ischemia  (IDA,ISO)
breast cancer  (IEP)
Breast Neoplasms  (ISO)
Burns  (IEP)
Cachexia  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (IEP,ISO)
Closed Head Injuries  (ISO)
Cockayne syndrome  (ISO)
colitis  (ISO)
congenital diaphragmatic hernia  (IEP)
congenital disorder of glycosylation Ia  (ISO)
congenital hypothyroidism  (IEP)
congestive heart failure  (IEP)
corneal disease  (ISO)
Coronary Disease  (ISO)
coronary stenosis  (IEP)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
Deafness  (ISO)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (IEP,ISO)
diabetic neuropathy  (IMP,ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dwarfism  (IEP,ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (IEP)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP,IMP,ISO)
Experimental Mammary Neoplasms  (ISO)
familial Mediterranean fever  (ISO)
Female Urogenital Diseases  (ISO)
fetal alcohol spectrum disorder  (IEP)
Fetal Growth Retardation  (IEP,ISO)
Fetal Macrosomia  (ISO)
folic acid deficiency anemia  (IEP)
granulomatosis with polyangiitis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (IDA)
hypertension  (IAGP,IEP,ISO)
hypertrophic cardiomyopathy  (ISO)
hypothyroidism  (IEP)
Insulin-Like Growth Factor I Deficiency  (ISO)
intellectual disability  (ISO)
Intervertebral Disc Displacement  (IMP)
kidney disease  (ISO)
Knee Osteoarthritis  (IEP,ISO)
Kuhnt-Junius degeneration  (ISO)
Laron syndrome  (ISO)
Malocclusion  (IEP)
Metabolic Bone Diseases  (IEP,ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (IDA,ISO)
myopia  (ISO)
Nasal Polyps  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
non-alcoholic fatty liver disease  (IEP)
Noonan syndrome  (ISO)
osteoarthritis  (ISO)
Osteophytes  (IEP)
osteoporosis  (IEP,ISO)
Osteoporotic Fractures  (IDA,ISO)
Oxygen-Induced Retinopathy  (IEP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
PEHO syndrome  (ISO)
peripheral nervous system disease  (ISO)
Pituitary Neoplasms  (ISO)
Plaque, Atherosclerotic  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
Precocious Puberty  (ISO)
progeria  (ISO)
prostate carcinoma in situ  (IEP)
Prostatic Neoplasms  (IEP,ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pycnodysostosis  (ISO)
Reperfusion Injury  (ISO)
retinopathy of prematurity  (IEP,ISO)
rheumatic heart disease  (ISO)
Rhinosinusitis  (ISO)
Right Ventricular Hypertrophy  (IEP)
Sarcopenia  (ISO)
severe acute respiratory syndrome  (ISO)
Skin Neoplasms  (ISO)
Skull Fractures  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (IEP,ISO)
Sudden Hearing Loss  (ISO)
Thinness  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (IEP)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
vascular dementia  (IEP,ISO)
Wounds and Injuries  (IEP,ISO)
Zinc Deficiency  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylphenanthrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-tert-Octylphenol  (EXP)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-(methylamino)isobutyric acid  (EXP)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (ISO)
amino acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
astemizole  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzoyl peroxide  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bezafibrate  (ISO)
bicalutamide  (ISO)
biochanin A  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bosentan  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP)
bucladesine  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcidiol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium silicate  (ISO)
calcium(0)  (EXP,ISO)
Candesartan cilexetil  (EXP)
cannabidiolic acid  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
capsiate  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chelerythrine  (EXP)
chlormequat chloride  (EXP)
chloroacetic acid  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
chromium atom  (EXP)
chromium(3+) trichloride  (EXP,ISO)
chrysin  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
cyproconazole  (ISO)
cyproterone acetate  (ISO)
D-glucose  (ISO)
D-mannitol  (ISO)
D-penicillamine  (ISO)
dantrolene  (ISO)
DDE  (ISO)
DDT  (EXP,ISO)
deguelin  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dicoumarol  (ISO)
dieldrin  (EXP)
dienogest  (ISO)
diethyl malate  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
dihydrocapsaicin  (ISO)
Dimethyl phthalate  (EXP)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
dobutamine  (EXP)
doxorubicin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP)
enzalutamide  (ISO)
epoxiconazole  (ISO)
estriol  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
felbamate  (EXP)
fenarimol  (EXP)
fenvalerate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flavonol  (ISO)
fluoranthene  (ISO)
flutamide  (EXP,ISO)
fluvastatin  (ISO)
folpet  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
furazolidone  (ISO)
furosemide  (EXP)
gabapentin  (EXP)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
ginsenoside Rb1  (EXP)
Ginsenoside Rh4  (ISO)
glucose  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (ISO)
heptachlor  (EXP)
herbicide  (EXP)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (EXP)
icariin  (EXP)
indometacin  (EXP,ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoflavones  (EXP,ISO)
isoflurane  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
leuprolide  (ISO)
levonorgestrel  (ISO)
lidocaine  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lornoxicam  (EXP)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
maleic acid  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
masoprocol  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methimazole  (ISO)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP,ISO)
MK-2206  (EXP)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
naringin  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP)
nifedipine  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
nitroprusside  (EXP,ISO)
nonivamide  (ISO)
Nordihydrocapsaicin  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
octreotide  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
Osajin  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (EXP)
para-Cresidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
pendimethalin  (EXP)
pentane-2,3-dione  (EXP)
pentetic acid  (EXP)
pentetrazol  (EXP)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (EXP)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (EXP)
phenylephrine  (EXP)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
picolinic acid  (EXP)
picropodophyllotoxin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
polaprezinc  (ISO)
poly(I:C)  (ISO)
Pomiferin  (ISO)
potassium atom  (EXP)
potassium chloride  (EXP)
potassium dichromate  (EXP)
prazosin  (EXP)
prednisolone  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
Ptaquiloside  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
quinidine  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rivastigmine  (EXP)
Rosavin  (ISO)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
rutin  (EXP)
SB 203580  (ISO)
serpentine asbestos  (ISO)
shikimic acid  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (EXP)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Sodium salicylate  (ISO)
sophoraflavanone B  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
staurosporine  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
tetramethrin  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thymidine  (ISO)
thyroxine  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
topotecan  (EXP)
tremolite asbestos  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (EXP)
trilostane  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
wortmannin  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (IEA,ISO)
aging  (IEP)
androgen receptor signaling pathway  (ISO)
blood vessel remodeling  (ISO)
bone development  (IEP)
bone mineralization involved in bone maturation  (IEA,ISO)
branching morphogenesis of an epithelial tube  (ISO)
cardiac atrium development  (IEP)
cell activation  (IEA,ISO)
cell development  (ISO)
cell population proliferation  (IBA,ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to electrical stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to glucose stimulus  (ISO)
cellular response to insulin stimulus  (IEP)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to nicotine  (IEP)
cellular response to progesterone stimulus  (IEP)
cellular response to Thyroglobulin triiodothyronine  (IEP)
cellular response to zinc ion starvation  (IEP)
cerebellar granule cell precursor proliferation  (ISO)
chondroitin sulfate proteoglycan biosynthetic process  (ISO)
circadian rhythm  (ISO)
cranial suture morphogenesis  (IEP)
detection of mechanical stimulus involved in sensory perception  (IMP)
ERK1 and ERK2 cascade  (IEA,ISO)
exocrine pancreas development  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
female pregnancy  (IEP)
glial cell differentiation  (ISO)
inner ear development  (ISO)
insulin-like growth factor receptor signaling pathway  (IBA,IDA,IEA,ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lung lobe morphogenesis  (ISO)
lung vasculature development  (ISO)
mammary gland development  (ISO)
memory  (IMP)
multicellular organism growth  (ISO)
muscle hypertrophy  (IEA,ISO)
myoblast differentiation  (IEA,ISO)
myoblast proliferation  (IEA,ISO)
myotube cell development  (IEA,ISO)
negative regulation of amyloid-beta formation  (IEA,ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (IBA,IDA,ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cholangiocyte apoptotic process  (IMP)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IDA,IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of immune system process  (IMP)
negative regulation of interleukin-1 beta production  (IEA,ISO)
negative regulation of muscle cell apoptotic process  (IMP)
negative regulation of neuroinflammatory response  (IEA,ISO)
negative regulation of neuron death  (IDA)
negative regulation of oligodendrocyte apoptotic process  (IDA)
negative regulation of oocyte development  (IEA,ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO,ISS)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (IEA,ISO)
nervous system development  (ISO)
osteoblast differentiation  (ISO)
phosphatidylinositol 3-kinase signaling  (IEA,ISO)
phosphatidylinositol-mediated signaling  (ISO)
positive regulation of activated T cell proliferation  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (IGI)
positive regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell growth  (IDA,IMP)
positive regulation of cell growth involved in cardiac muscle cell development  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IBA,ISO,ISS)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of fat cell differentiation  (IDA)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glial cell proliferation  (IDA)
positive regulation of glucose import  (IEA,ISO,ISS)
positive regulation of glycogen biosynthetic process  (IEA,ISO,ISS)
positive regulation of glycolytic process  (IEA,ISO)
positive regulation of glycoprotein biosynthetic process  (IEA,ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of myelination  (ISO)
positive regulation of myoblast proliferation  (ISO)
positive regulation of osteoblast differentiation  (IDA,IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA,ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IBA,IDA,IEA,ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein secretion  (IEA,ISO)
positive regulation of protein serine/threonine kinase activity  (IDA)
positive regulation of Ras protein signal transduction  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of steroid hormone biosynthetic process  (IDA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription regulatory region DNA binding  (IEA,ISO)
positive regulation of trophectodermal cell proliferation  (IEA,ISO)
positive regulation of type B pancreatic cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
positive regulation of vascular endothelial cell proliferation  (IGI)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (ISO)
prostate gland epithelium morphogenesis  (ISO)
prostate gland growth  (ISO)
prostate gland stromal morphogenesis  (ISO)
protein kinase B signaling  (IEA,ISO)
protein stabilization  (IEA,ISO)
proteoglycan biosynthetic process  (IEA,ISO)
regulation of calcium ion transport  (IDA)
regulation of cell population proliferation  (IDA)
regulation of establishment or maintenance of cell polarity  (ISO)
regulation of gene expression  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of protein metabolic process  (ISO)
regulation of protein phosphorylation  (IBA,ISO)
regulation of translation  (IMP)
response to activity  (IEP)
response to caffeine  (IEP)
response to epidermal growth factor  (IEP)
response to estradiol  (IEP)
response to ethanol  (IDA,IEP)
response to glucocorticoid  (IEP)
response to growth hormone  (IEP)
response to heat  (IEA,ISO)
response to hypoxia  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to nicotine  (IEP)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to starvation  (IEP)
response to steroid hormone  (IEP)
response to thyroid hormone  (IEP)
signal transduction  (IEA)
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  (IEA,ISO)
type B pancreatic cell proliferation  (ISO)
type I pneumocyte differentiation  (ISO)
type II pneumocyte differentiation  (ISO)
water homeostasis  (ISO)
wound healing  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Vascular endothelial growth factor and insulin-like growth factor-1 in polycystic ovary syndrome and their relation to ovarian blood flow. Abd El Aal DE, etal., Eur J Obstet Gynecol Reprod Biol. 2005 Feb 1;118(2):219-24.
2. Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I. Adams MM, etal., Growth Factors. 2009 Apr 2:1.
3. Elevated serum insulin-like growth factor-1 (IGF-1) levels in women with postadolescent acne. Aizawa H and Niimura M, J Dermatol. 1995 Apr;22(4):249-52.
4. Growth hormone action on proliferation and differentiation of cerebral cortical cells from fetal rat. Ajo R, etal., Endocrinology 2003 Mar;144(3):1086-97.
5. Identification of IGF-I in the calvarial suture of young rats: histochemical analysis of the cranial sagittal sutures in a hyperthyroid rat model. Akita S, etal., Plast Reconstr Surg. 1996 Jan;97(1):1-12.
6. The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis. Alvaro D, etal., J Hepatol. 2005 Nov;43(5):875-83. Epub 2005 May 31.
7. Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study. Asthana S, etal., Psychoneuroendocrinology. 1999 Aug;24(6):657-77.
8. Circulating levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. Beeton CA, etal., J Bone Joint Surg Br. 2002 Apr;84(3):434-9.
9. Different effects of insulin and insulin-like growth factors I and II on osteoprogenitors and adipocyte progenitors in fetal rat bone cell populations. Bellows CG, etal., Calcif Tissue Int. 2006 Jul;79(1):57-65. Epub 2006 Jul 31.
10. Effect of insulin-like growth factor-1 deficiency or administration on the occurrence of acne. Ben-Amitai D and Laron Z, J Eur Acad Dermatol Venereol. 2011 Aug;25(8):950-4. doi: 10.1111/j.1468-3083.2010.03896.x. Epub 2010 Nov 4.
11. Changes in the expression of insulin-like growth factor 1 variants in the postnatal brain development and in neonatal hypoxia-ischaemia. Beresewicz M, etal., Int J Dev Neurosci. 2010 Feb;28(1):91-7. doi: 10.1016/j.ijdevneu.2009.09.002. Epub 2009 Sep 18.
12. Growth hormone treatment prevents osteoporosis in uremic rats. Berger I, etal., Histol Histopathol. 2007 Nov;22(11):1231-9.
13. Circulating markers and growth factors as prognosticators in men with advanced tongue cancer. Bhatavdekar JM, etal., Tumour Biol. 1993;14(1):55-8.
14. Long-term hyperglycaemia impairs vascular smooth muscle cell function in women with type 1 diabetes mellitus. Bjarnegard N, etal., Diab Vasc Dis Res. 2009 Jan;6(1):25-31.
15. No evidence for involvement of the growth hormone/insulin-like growth factor-1 axis in psoriasis. Bjorntorp E, etal., J Invest Dermatol. 1997 Nov;109(5):661-5.
16. Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. Blakytny R, etal., J Pathol. 2000 Apr;190(5):589-94.
17. Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice. Bol DK, etal., Oncogene. 1997 Apr 10;14(14):1725-34.
18. Predictive value of circulating insulin-like growth factor I levels in ischemic stroke outcome. Bondanelli M, etal., J Clin Endocrinol Metab. 2006 Oct;91(10):3928-34. Epub 2006 Aug 1.
19. Diabetic bone disease. Low turnover osteoporosis related to decreased IGF-I production. Bouillon R Verh K Acad Geneeskd Belg. 1992;54(4):365-91; discussion 391-2.
20. Increased IGF-I and IGF-II mRNA and IGF-I peptide in fusing rat cranial sutures suggest evidence for a paracrine role of insulin-like growth factors in suture fusion. Bradley JP, etal., Plast Reconstr Surg. 1999 Jul;104(1):129-38.
21. Effect of high-fat diet on body composition and hormone responses to glucose tolerance tests. Brown JL, etal., Endocrine 2002 Dec;19(3):327-32.
22. Phospholipase D is a target for inhibition of astroglial proliferation by ethanol. Burkhardt U, etal., Neuropharmacology. 2014 Apr;79:1-9. doi: 10.1016/j.neuropharm.2013.11.002. Epub 2013 Nov 19.
23. Inverse correlation between serum free IGF-I and IGFBP-3 levels and blood pressure in patients affected with type 1 diabetes. Capoluongo E, etal., Cytokine. 2006 Jun;34(5-6):303-11. Epub 2006 Aug 2.
24. Association between serum free IGF-I and IGFBP-3 levels in type-I diabetes patients affected with associated autoimmune diseases or diabetic complications. Capoluongo E, etal., Eur Cytokine Netw. 2006 Sep;17(3):167-74.
25. Isolation of rat testis cDNAs encoding an insulin-like growth factor I precursor. Casella SJ, etal., DNA 1987 Aug;6(4):325-30.
26. Differentially expressed angiogenic genes in diabetic erectile tissue - results from a microarray screening. Castela A, etal., Mol Genet Metab. 2012 Feb;105(2):255-62. doi: 10.1016/j.ymgme.2011.11.002. Epub 2011 Nov 10.
27. Comparison of serum insulin-like growth factor-1 and growth hormone levels in osteoporotic and non-osteoporotic postmenopausal women. Celiker R and Arslan S, Rheumatol Int. 2000;19(6):205-8.
28. Comparative analysis of aqueous humor cytokine levels between patients with exudative age-related macular degeneration and normal controls. Cha DM, etal., Invest Ophthalmol Vis Sci. 2013 Oct 25;54(10):7038-44. doi: 10.1167/iovs.13-12730.
29. Double-stranded ribonucleic acid decreases c6 rat glioma cell proliferation in part by activating protein kinase R and decreasing insulin-like growth factor I levels. Chacko MS, etal., Endocrinology 2002 Jun;143(6):2144-54.
30. Chondrocyte cytokine and growth factor expression in murine osteoarthritis. Chambers MG, etal., Osteoarthritis Cartilage. 1997 Sep;5(5):301-8.
31. Megakaryocytes endocytose insulin-like growth factor (IGF) I and IGF-binding protein-3: a novel mechanism directing them into alpha granules of platelets. Chan K and Spencer EM, Endocrinology. 1998 Feb;139(2):559-65.
32. Intracellular insulin-like growth factor-1 induces Bcl-2 expression in airway epithelial cells. Chand HS, etal., J Immunol. 2012 May 1;188(9):4581-9. doi: 10.4049/jimmunol.1102673. Epub 2012 Mar 28.
33. Effects of maternal undernutrition on lung growth and insulin-like growth factor system expression in rat offspring. Chen CM, etal., Acta Paediatr Taiwan. 2007 Mar-Apr;48(2):62-7.
34. Elevated serum heme oxygenase-1 and insulin-like growth factor-1 levels in patients with Henoch-Schonlein purpura. Chen T, etal., Rheumatol Int. 2011 Mar;31(3):321-6. doi: 10.1007/s00296-009-1254-3. Epub 2009 Dec 16.
35. Suppression of insulin-like growth factor I during epidermal growth factor-induced growth retardation. Chernausek SD, etal., Am J Physiol. 1991 Mar;260(3 Pt 1):E416-21.
36. Progesterone and dexamethasone differentially regulate the IGF-system in glial cells. Chesik D and De Keyser J, Neurosci Lett. 2010 Jan 14;468(3):178-82. doi: 10.1016/j.neulet.2009.10.051. Epub 2009 Oct 22.
37. Systemic Insulin-like growth factor-1 reverses hypoalgesia and improves mobility in a mouse model of diabetic peripheral neuropathy. Chu Q, etal., Mol Ther. 2008 Aug;16(8):1400-8. doi: 10.1038/mt.2008.115. Epub 2008 Jun 10.
38. Rh/IGF-I/rhIGFBP-3 administration to patients with type 2 diabetes mellitus reduces insulin requirements while also lowering fasting glucose. Clemmons DR, etal., Growth Horm IGF Res. 2005 Aug;15(4):265-74.
39. Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat Part 1: Effects on somatic growth, growth hormone-axis activity and bone mass in the offspring. Cocchi D, etal., Toxicol Appl Pharmacol. 2009 Mar 24.
40. Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model. Cohen AC, etal., Alcohol Clin Exp Res. 2007 Sep;31(9):1558-73. Epub 2007 Jul 11.
41. Effects of brief, clustered versus dispersed hypoxic episodes on systemic and ocular growth factors in a rat model of oxygen-induced retinopathy. Coleman RJ, etal., Pediatr Res. 2008 Jul;64(1):50-5. doi: 10.1203/PDR.0b013e31817307ac.
42. Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development. Colon E, etal., Endocrinology. 2007 Jan;148(1):128-39. Epub 2006 Oct 5.
43. Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice. Corrochano S, etal., PLoS One. 2014 Aug 20;9(8):e105595. doi: 10.1371/journal.pone.0105595. eCollection 2014.
44. Preconditioning and post-treatment with cobalt chloride in rat model of perinatal hypoxic-ischemic encephalopathy. Dai Y, etal., Brain Dev. 2014 Mar;36(3):228-40. doi: 10.1016/j.braindev.2013.04.007. Epub 2013 May 18.
45. Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Davis ME, etal., Proc Natl Acad Sci U S A. 2006 May 23;103(21):8155-60. Epub 2006 May 12.
46. Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature. De Rocca Serra-Nedelec A, etal., Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4257-62. doi: 10.1073/pnas.1119803109. Epub 2012 Feb 27.
47. Radiometrical, hormonal and biological correlates of skeletal growth in the female rat from birth to senescence. del Pozo E, etal., Growth Horm IGF Res. 2014 Apr-Jun;24(2-3):83-8. doi: 10.1016/j.ghir.2014.03.003. Epub 2014 Mar 26.
48. Nicotine-induced retardation of chondrogenesis through down-regulation of IGF-1 signaling pathway to inhibit matrix synthesis of growth plate chondrocytes in fetal rats. Deng Y, etal., Toxicol Appl Pharmacol. 2013 May 15;269(1):25-33. doi: 10.1016/j.taap.2013.02.008. Epub 2013 Feb 27.
49. Growth promoting peptides in osteoarthritis: insulin, insulin-like growth factor-1, growth hormone. Denko CW, etal., J Rheumatol. 1990 Sep;17(9):1217-21.
50. Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function. Ding Q, etal., Neuroscience. 2006 Jul 7;140(3):823-33. Epub 2006 May 2.
51. Bile salts regulate proliferation and apoptosis of liver cells by modulating the IGF1 system. Drudi Metalli V, etal., Dig Liver Dis. 2007 Jul;39(7):654-62. Epub 2007 May 24.
52. Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions. Duan C and Xu Q, Gen Comp Endocrinol. 2005 May 15;142(1-2):44-52. Epub 2005 Feb 5.
53. Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints. Ekenstedt KJ, etal., Arthritis Rheum. 2006 Dec;54(12):3850-8.
54. Insulin-like growth factor-1 in psoriatic plaques treated with PUVA and methotrexate. El-Komy M, etal., J Eur Acad Dermatol Venereol. 2011 Nov;25(11):1288-94. doi: 10.1111/j.1468-3083.2010.03966.x. Epub 2011 Jan 17.
55. Insulin growth factor-1 protects against excitotoxicity in the rat striatum. Escartin C, etal., Neuroreport. 2004 Oct 5;15(14):2251-4.
56. Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy. Fanzani A, etal., FEBS J. 2006 Aug;273(16):3709-21. Epub 2006 Jul 26.
57. Abdominal coarctation increases insulin-like growth factor I mRNA levels in rat aorta. Fath KA, etal., Circ Res. 1993 Feb;72(2):271-7.
58. Inhibition of muscle insulin-like growth factor I expression by tumor necrosis factor-alpha. Fernandez-Celemin L, etal., Am J Physiol Endocrinol Metab 2002 Dec;283(6):E1279-90.
59. Associations of insulin-like growth factors, insulin-like growth factor binding proteins and acid-labile subunit with coronary heart disease. Fischer F, etal., Clin Endocrinol (Oxf). 2004 Nov;61(5):595-602.
60. Insulin-like growth factor-1 as a predictive biomarker for metastatic uveal melanoma in humans. Frenkel S, etal., Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):490-3. doi: 10.1167/iovs.12-10228.
61. Developmental changes in serum levels of free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 and -3, and the acid-labile subunit in rats. Frystyk J, etal., Endocrinology. 1998 Oct;139(10):4286-92.
62. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat Galli J, etal., Nat Genet 1996 Jan;12(1):31-7
63. Insulin-like growth factor-1 modulation of CaV1.3 calcium channels depends on Ca2+ release from IP3-sensitive stores and calcium/calmodulin kinase II phosphorylation of the alpha1 subunit EF hand. Gao L, etal., J Neurosci. 2006 Jun 7;26(23):6259-68.
64. Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women. Garnero P, etal., Lancet. 2000 Mar 11;355(9207):898-9.
65. Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury. Gatto M, etal., Lab Invest. 2008 Sep;88(9):986-94. doi: 10.1038/labinvest.2008.63. Epub 2008 Jul 7.
66. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
67. Estradiol and triiodothyronine increase production of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) by GH4C1 rat pituitary tumor cells. Gilchrist CA, etal., Mol Cell Endocrinol 1995 Oct 30;114(1-2):147-56.
68. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
69. Growth factors and glucose homeostasis in diabetic rats: effects of exercise training. Gomes RJ, etal., Cell Biochem Funct. 2009 Apr 20.
70. Down-regulation of IGF-1/IGF-1R in hippocampus of rats with vascular dementia. Gong X, etal., Neurosci Lett. 2012 Mar 28;513(1):20-4. doi: 10.1016/j.neulet.2012.01.077. Epub 2012 Feb 10.
71. Inverse correlation between insulin-like growth factor (IGF)-binding protein-5 and IGF-I and II during postnatal development of the anterior pituitary gland. Gonzalez-Parra S, etal., Horm Res 2002;57(1-2):10-4.
72. Reduced free IGF-I and increased IGFBP-3 proteolysis in Turner syndrome: modulation by female sex steroids. Gravholt CH, etal., Am J Physiol Endocrinol Metab. 2001 Feb;280(2):E308-14.
73. The GH-IGF-IGFBP axis is changed in Turner syndrome: partial normalization by HRT. Gravholt CH, etal., Growth Horm IGF Res. 2006 Oct-Dec;16(5-6):332-9. Epub 2006 Oct 25.
74. Insulin-like growth factor-1 improves somatosensory function and reduces the extent of cortical infarction and ongoing neuronal loss after hypoxia-ischemia in rats. Guan J, etal., Neuroscience. 2001;105(2):299-306.
75. Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta. Gårdebjer EM, etal., Placenta. 2014 Jan;35(1):50-7. doi: 10.1016/j.placenta.2013.10.008. Epub 2013 Nov 5.
76. Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy. Haddad F and Adams GR, J Appl Physiol. 2006 Apr;100(4):1188-203. Epub 2005 Dec 22.
77. A graded model of dietary zinc deficiency: effects on growth, insulin-like growth factor-I, and the glucose/insulin axis in weanling rats. Hall AG, etal., J Pediatr Gastroenterol Nutr. 2005 Jul;41(1):72-80.
78. The influence of gestational zinc deficiency on the fetal insulin-like growth factor axis in the rat. Hanna LA, etal., Exp Biol Med (Maywood). 2010 Feb;235(2):206-14. doi: 10.1258/ebm.2009.009018.
79. Immunohistochemical demonstration of insulin-like growth factor I in inflammatory lesions in Wegener's granulomatosis and idiopathic midline destructive disease. Hansson HA, etal., Scand J Rheumatol. 1989;18(3):133-41.
80. Effects of recombinant human growth hormone (r-hGH) on experimental osteoporotic fracture healing. Hao Y, etal., Chin J Traumatol. 2001 May;4(2):102-5.
81. Characterization of SV-40 Tag rats as a model to study prostate cancer. Harper CE, etal., BMC Cancer. 2009 Jan 26;9:30.
82. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
83. Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation. Hie M, etal., Int J Mol Med. 2011 Sep;28(3):455-62. doi: 10.3892/ijmm.2011.697. Epub 2011 May 11.
84. Production and autocrine/paracrine effects of endogenous insulin-like growth factor-1 in rat cardiac fibroblasts. Horio T, etal., Regul Pept. 2005 Jan 15;124(1-3):65-72.
85. MicroRNA-98 induces an Alzheimer's disease-like disturbance by targeting insulin-like growth factor 1. Hu YK, etal., Neurosci Bull. 2013 Dec;29(6):745-51. doi: 10.1007/s12264-013-1348-5. Epub 2013 Jun 5.
86. A potential inverse association between insulin-like growth factor I and hypertension in a cross-sectional study. Hunt KJ, etal., Ann Epidemiol. 2006 Jul;16(7):563-71. Epub 2006 Jan 23.
87. Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate. Huynh H, etal., J Endocrinol 2001 Oct;171(1):109-18.
88. Cochlear protection by local insulin-like growth factor-1 application using biodegradable hydrogel. Iwai K, etal., Laryngoscope. 2006 Apr;116(4):529-33.
89. Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart. Jiang Y and Steinle JJ, Can J Physiol Pharmacol. 2010 May;88(5):553-61.
90. [Effects of recombinant human insulin-like growth factor-1 on the expression of Clara cell secretory protein in lung of hyperoxia-exposed newborn rats]. Jin ZA, etal., Zhonghua Er Ke Za Zhi. 2007 May;45(5):369-73.
91. Pattern of retinopathy of prematurity and its correlation with insulin-like growth factor-1 (IGF-1). Kant S, etal., Ann Ophthalmol (Skokie). 2009 Fall-Winter;41(3-4):157-61.
92. Changes of human menisci in osteoarthritic knee joints. Katsuragawa Y, etal., Osteoarthritis Cartilage. 2010 Sep;18(9):1133-43. doi: 10.1016/j.joca.2010.05.017. Epub 2010 Jul 13.
93. Circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 are associated with early carotid atherosclerosis. Kawachi S, etal., Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):617-21. Epub 2004 Dec 29.
94. Physiological concentrations of insulin promote binding of nuclear proteins to the insulin-like growth factor I gene. Kaytor EN, etal., Endocrinology 2001 Mar;142(3):1041-9.
95. Serum insulin-like growth factor-I (IGF-I) IGF binding protein-3 (IGFBP-3) and leptin levels are related to abdominal aortic intima-media thickness in macrosomic newborns. Koklu E, etal., Growth Horm IGF Res. 2007 Feb;17(1):26-32. Epub 2006 Nov 20.
96. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
97. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
98. Cardiomyoblast apoptosis induced by insulin-like growth factor (IGF)-I resistance is IGF-II dependent and synergistically enhanced by angiotensin II. Kuo WW, etal., Apoptosis. 2006 Jul;11(7):1075-89.
99. Impaired IGF-I signalling of hypertrophic hearts in the developmental phase of hypertension in genetically hypertensive rats. Kuo WW, etal., Cell Biochem Funct. 2005 Sep-Oct;23(5):325-31.
100. Spontaneous dwarf rat: a novel model for aging research. Kuramoto K, etal., Geriatr Gerontol Int. 2010 Jan;10(1):94-101. doi: 10.1111/j.1447-0594.2009.00559.x.
101. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
102. Insulin-like growth factor-I and its receptor in neovascular age-related macular degeneration. Lambooij AC, etal., Invest Ophthalmol Vis Sci. 2003 May;44(5):2192-8.
103. Acute response of IGF-I and IGF binding proteins induced by thermal injury. Lang CH, etal., Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1087-96.
104. Disruption of growth hormone secretion alters Ca2+ current density and expression of Ca2+ channel and insulin-like growth factor genes in rat atria. Larsen JK, etal., Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H829-38. Epub 2004 Oct 14.
105. Pro-inflammatory states and IGF-I level in ischemic heart disease with low or high serum iron. Lee SD, etal., Clin Chim Acta. 2006 Aug;370(1-2):50-6. Epub 2006 Jun 21.
106. Serum insulin-like growth factor-axis and matrix metalloproteinases in patients with rheumatic arthritis or rheumatic heart disease. Lee SD, etal., Clin Chim Acta. 2006 May;367(1-2):62-8. Epub 2006 Jan 9.
107. The relationship of retinal VEGF and retinal IGF-1 mRNA with neovascularization in an acidosis-induced model of retinopathy of prematurity. Leske DA, etal., Curr Eye Res. 2006 Feb;31(2):163-9.
108. Arterial injury in mice with severe insulin-like growth factor-1 (IGF-1) deficiency. Li H, etal., J Cardiovasc Pharmacol Ther. 2002 Oct;7(4):227-33.
109. MicroRNA-29 regulates myocardial microvascular endothelial cells proliferation and migration in association with IGF1 in type 2 diabetes. Li Z, etal., Biochem Biophys Res Commun. 2017 May 20;487(1):15-21. doi: 10.1016/j.bbrc.2017.03.055. Epub 2017 Mar 15.
110. [Study on the mechanism of insulin resistance in rats born with intrauterine growth retardation]. Liao Y, etal., Beijing Da Xue Xue Bao. 2008 Dec 18;40(6):590-4.
111. Noonan syndrome: relationships between genotype, growth, and growth factors. Limal JM, etal., J Clin Endocrinol Metab. 2006 Jan;91(1):300-6. Epub 2005 Nov 1.
112. Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats. Lin S, etal., Exp Neurol. 2009 Mar 28.
113. Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic beta-cell death. Liu W, etal., Endocrinology 2002 Oct;143(10):3802-12.
114. Insulin-like growth factor I improves intestinal barrier function in cirrhotic rats. Lorenzo-Zuniga V, etal., Gut. 2006 Sep;55(9):1306-12. Epub 2006 Jan 24.
115. Insulin-like growth factor-1 and insulin-like growth factor receptor in thyroid tissues of patients with Graves' disease. Maiorano E, etal., Int J Mol Med. 1998 Oct;2(4):483-6.
116. Association of IGF1 gene haplotypes with high myopia in Chinese adults. Mak JY, etal., Arch Ophthalmol. 2012 Feb;130(2):209-16. doi: 10.1001/archophthalmol.2011.365.
117. Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. Marino G, etal., Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16268-73. doi: 10.1073/pnas.1002696107. Epub 2010 Aug 30.
118. Cyclooxygenase-2 activation by endotoxin mediates the decrease in IGF1, but not in IGFBP3, [corrected] gene expression in the liver. Martin AI, etal., J Endocrinol. 2008 Aug;198(2):385-94. doi: 10.1677/JOE-08-0205. Epub 2008 May 20.
119. Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort. Metlapally R, etal., Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4476-9. doi: 10.1167/iovs.09-4912. Epub 2010 Apr 30.
120. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
121. IGF system in children with congenital disorders of glycosylation. Miller BS, etal., Clin Endocrinol (Oxf). 2009 Jun;70(6):892-7. doi: 10.1111/j.1365-2265.2009.03531.x. Epub 2009 Jan 22.
122. Peripheral sensitization caused by insulin-like growth factor 1 contributes to pain hypersensitivity after tissue injury. Miura M, etal., Pain. 2011 Apr;152(4):888-95. doi: 10.1016/j.pain.2011.01.004. Epub 2011 Feb 5.
123. Postnatal catch-up growth induced by growth hormone and insulin-like growth factor-I in rats with intrauterine growth retardation caused by maternal protein malnutrition. Muaku SM, etal., Pediatr Res. 1997 Sep;42(3):370-7.
124. Identification, characterization, and regulation of a rat complementary deoxyribonucleic acid which encodes insulin-like growth factor-I. Murphy LJ, etal., Endocrinology 1987 Aug;121(2):684-91.
125. Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial. Nakagawa T, etal., BMC Med. 2010 Nov 25;8:76. doi: 10.1186/1741-7015-8-76.
126. Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. Nakamura K, etal., PLoS One. 2010 Jan 21;5(1):e8824.
127. The effects of recombinant human insulin-like growth factor (rhIGF)-1 and rhIGF-1/IGF binding protein-3 administration on rat osteopenia induced by ovariectomy with concomitant bilateral sciatic neurectomy. Narusawa K, etal., J Bone Miner Res. 1995 Dec;10(12):1853-64.
128. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
129. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
130. Experimental alcohol-related peripheral neuropathy: role of insulin/IGF resistance. Nguyen VA, etal., Nutrients. 2012 Aug;4(8):1042-57. Epub 2012 Aug 17.
131. IGF-I and IGF-binding protein gene expressions in spontaneous dwarf rat. Nogami H, etal., Am J Physiol. 1994 Sep;267(3 Pt 1):E396-401.
132. Dose-dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin-like growth factor-1. Nogueira LM, etal., Cancer Med. 2012 Oct;1(2):275-88. doi: 10.1002/cam4.23. Epub 2012 Aug 6.
133. Insulin-like growth factor binding protein expression in the hypothyroid rat is age dependent. Näntö-Salonen K and Rosenfeld RG, Endocrinology. 1992 Sep;131(3):1489-96.
134. The effects of thyroid hormone on insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) expression in the neonatal rat: prolonged high expression of IGFBP-2 in methimazole-induced congenital hypothyroidism. Näntö-Salonen K, etal., Endocrinology. 1991 Nov;129(5):2563-70.
135. Expression of insulin-like growth factor I messenger ribonucleic acid in developing osteophytes in murine experimental osteoarthritis and in rats inoculated with growth hormone-secreting tumor. Okazaki K, etal., Endocrinology. 1999 Oct;140(10):4821-30.
136. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
137. Differential expression of TNF-alpha, IL-6, and IGF-1 by graded mechanical stress in normal rat myocardium. Palmieri EA, etal., Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H926-34.
138. Insulin-like growth factor-1: roles in androgenetic alopecia. Panchaprateep R and Asawanonda P, Exp Dermatol. 2014 Mar;23(3):216-8. doi: 10.1111/exd.12339.
139. IGF-1 protects oligodendrocyte progenitors against TNFalpha-induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathway. Pang Y, etal., Glia. 2007 Aug 15;55(11):1099-107.
140. Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study. Payette H, etal., J Am Geriatr Soc. 2003 Sep;51(9):1237-43.
141. Chromium improves protein deposition through regulating the mRNA levels of IGF-1, IGF-1R, and Ub in rat skeletal muscle cells. Peng Z, etal., Biol Trace Elem Res. 2010 Nov;137(2):226-34. doi: 10.1007/s12011-009-8579-3. Epub 2009 Dec 15.
142. Etiopathogenesis of hepatic osteodystrophy in Wistar rats with cholestatic liver disease. Pereira FA, etal., Calcif Tissue Int. 2009 Jul;85(1):75-83. doi: 10.1007/s00223-009-9249-3. Epub 2009 May 8.
143. Serum levels of IGF1 are a useful predictor of retinopathy of prematurity. Perez-Munuzuri A, etal., Acta Paediatr. 2010 Apr;99(4):519-25. doi: 10.1111/j.1651-2227.2009.01677.x. Epub 2010 Jan 18.
144. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
145. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
146. Independent alterations in the central and peripheral somatosensory pathways in rat diabetic neuropathy. Piriz J, etal., Neuroscience. 2009 May 5;160(2):402-11. Epub 2009 Mar 3.
147. Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3. Platz EA, etal., J Am Acad Dermatol. 2000 Jun;42(6):1003-7.
148. Nutritional status, insulin-like growth factor-1 and quality of life in elderly women with hip fractures. Ponzer S, etal., Clin Nutr. 1999 Aug;18(4):241-6.
149. Experimental arthritis: Effect on growth parameters and total skeletal calcium. Pozo ED, etal., Growth Horm IGF Res. 2009 Feb 24.
150. Insulin-like growth factor I is a comitogen for hepatocyte growth factor in a rat model of hepatocellular carcinoma. Price JA, etal., Hepatology 2002 Nov;36(5):1089-97.
151. Effects of early nutrition intervention on IGF1, IGFBP3, intestinal development, and catch-up growth of intrauterine growth retardation rats. Qiu XS, etal., Chin Med Sci J. 2004 Sep;19(3):189-92.
152. Impaired basal and running-induced hippocampal neurogenesis coincides with reduced Akt signaling in adult R6/1 HD mice. Ransome MI and Hannan AJ, Mol Cell Neurosci. 2013 May;54:93-107. doi: 10.1016/j.mcn.2013.01.005. Epub 2013 Feb 4.
153. Impairment of myocyte contractility following coronary artery narrowing is associated with activation of the myocyte IGF1 autocrine system, enhanced expression of late growth related genes, DNA synthesis, and myocyte nuclear mitotic division in rats. Reiss K, etal., Exp Cell Res. 1993 Aug;207(2):348-60.
154. Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells. Resnicoff M, etal., Lab Invest. 1994 Nov;71(5):657-62.
155. GOA pipeline RGD automated data pipeline
156. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
157. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
158. An igf-I gene polymorphism modifies the risk of diabetic retinopathy. Rietveld I, etal., Diabetes. 2006 Aug;55(8):2387-91.
159. An insulin-like growth factor-I gene polymorphism modifies the risk of microalbuminuria in subjects with an abnormal glucose tolerance. Rietveld I, etal., Eur J Endocrinol. 2006 May;154(5):715-21.
160. The PEHO syndrome. Riikonen R, Brain Dev. 2001 Nov;23(7):765-9.
161. A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice. Riquelme R, etal., Front Neuroanat. 2010 Jun 23;4:27. doi: 10.3389/fnana.2010.00027. eCollection 2010.
162. Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women. Rivadeneira F, etal., J Bone Miner Res. 2006 Sep;21(9):1443-56.
163. Rat IGF-I cDNA's contain multiple 5'-untranslated regions. Roberts CT Jr, etal., Biochem Biophys Res Commun 1987 Aug 14;146(3):1154-9.
164. Molecular cloning of rat insulin-like growth factor I complementary deoxyribonucleic acids: differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues. Roberts CT Jr, etal., Mol Endocrinol 1987 Mar;1(3):243-8.
165. Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition. Rohrmann S, etal., Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2174-82. doi: 10.1158/1055-9965.EPI-11-0179. Epub 2011 Jul 25.
166. Daily rat tibial growth in vivo following hypothalamic sex reversal with neonatal and pubertal treatments with gonadal steroids. Rol De Lama MA, etal., Ann Hum Biol. 2001 Jan-Feb;28(1):38-50.
167. IGF-1 gene polymorphisms in Polish families with high-grade myopia. Rydzanicz M, etal., Mol Vis. 2011;17:2428-39. Epub 2011 Sep 21.
168. Insulin-like growth factor-1 (IGF-1) improves both neurological motor and cognitive outcome following experimental brain injury. Saatman KE, etal., Exp Neurol. 1997 Oct;147(2):418-27.
169. Circulating levels of insulin-like growth factor-1 and its binding proteins in patients with hypertrophic cardiomyopathy. Saeki H, etal., Circ J. 2002 Jul;66(7):639-44.
170. Changes in the mRNA expressions of insulin-like growth factors, their receptors, and binding proteins during the postnatal development of rat masseter muscle. Saito T, etal., Zoolog Sci 2003 Apr;20(4):441-7.
171. Decreased TGF-beta1 and IGF-1 protein expression in rat embryo skull bone in folic acid-restricted diet. Santoso MI and Rohman MS, J Nutr Biochem. 2006 Jan;17(1):51-6. Epub 2005 Jun 14.
172. Effect of electrical stimulation on IGF-1 transcription by L-type calcium channels in cultured retinal Muller cells. Sato T, etal., Jpn J Ophthalmol. 2008 May-Jun;52(3):217-23. doi: 10.1007/s10384-008-0533-y. Epub 2008 Jul 27.
173. Dose-dependent effects of recombinant human insulin-like growth factor (IGF)-I/IGF binding protein-3 complex on overnight growth hormone secretion and insulin sensitivity in type 1 diabetes. Saukkonen T, etal., J Clin Endocrinol Metab. 2004 Sep;89(9):4634-41.
174. Insulin-like growth factor-1: a prognostic factor of knee osteoarthritis. Schouten JS, etal., Br J Rheumatol. 1993 Apr;32(4):274-80.
175. Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulinlike growth factor-I in chronic heart failure. Schulze PC, etal., Basic Res Cardiol. 2003 Jul;98(4):267-74.
176. Evidence for suppression of immune function by insulin-like growth factor-1 in dwarf rats in vivo. Schurmann A, etal., Experientia. 1996 Jan 16;52(1):55-9.
177. Polymorphism in the promoter region of the insulin-like growth factor I gene is related to carotid intima-media thickness and aortic pulse wave velocity in subjects with hypertension. Schut AF, etal., Stroke. 2003 Jul;34(7):1623-7. Epub 2003 Jun 5.
178. Effects of estradiol-17beta, testosterone and a black cohosh preparation on bone and prostate in orchidectomized rats. Seidlova-Wuttke D, etal., Maturitas. 2005 Jun 16;51(2):177-86.
179. Inhibition of neuroretinal cell death by insulin-like growth factor-1 and its analogs. Seigel GM, etal., Mol Vis. 2000 Aug 31;6:157-63.
180. The Effect of Insulin-like Growth Factor-I on Hepatocyte Apoptosis After Bile Duct Ligation in Rat. Sheen-Chen SM, etal., Dig Dis Sci. 2006 Nov 11;.
181. Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. Shen L, etal., Toxicol Appl Pharmacol. 2014 Jan 15;274(2):263-73. doi: 10.1016/j.taap.2013.11.009. Epub 2013 Nov 22.
182. Advanced rat mammary cancers are growth hormone dependent. Shen Q, etal., Endocrinology. 2007 Oct;148(10):4536-44. Epub 2007 Jun 21.
183. Identification of liver metastasis-related genes in a novel human pancreatic carcinoma cell model by microarray analysis. Shi WD, etal., Cancer Lett. 2009 Sep 28;283(1):84-91. Epub 2009 Apr 17.
184. Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade. Shi Y, etal., Mol Cancer Ther. 2005 Oct;4(10):1533-40.
185. Chronic exposure to perfluorododecanoic acid disrupts testicular steroidogenesis and the expression of related genes in male rats. Shi Z, etal., Toxicol Lett. 2009 Apr 24.
186. Mosaic evolution of the insulin-like growth factors. Organization, sequence, and expression of the rat insulin-like growth factor I gene. Shimatsu A and Rotwein P, J Biol Chem 1987 Jun 5;262(16):7894-900.
187. Sequence of two rat insulin-like growth factor I mRNAs differing within the 5' untranslated region. Shimatsu A and Rotwein P, Nucleic Acids Res 1987 Sep 11;15(17):7196.
188. Insulin-Like Growth Factors and Their Binding Proteins Define Specific Phases of Myometrial Differentiation During Pregnancy. Shynlova O, etal., Biol Reprod. 2006 Nov 22;.
189. Insulin-like growth factor I gene transfer to cirrhotic liver induces fibrolysis and reduces fibrogenesis leading to cirrhosis reversion in rats. Sobrevals L, etal., Hepatology. 2010 Mar;51(3):912-21. doi: 10.1002/hep.23412.
190. Pycnodysostosis: clinical, radiologic, and endocrine evaluation and linear growth after growth hormone therapy. Soliman AT, etal., Metabolism. 2001 Aug;50(8):905-11.
191. Locally produced insulin-like growth factor-1 by orbital fibroblasts as implicative pathogenic factor rather than systemically circulated IGF-1 for patients with thyroid-associated ophthalmopathy. Song D, etal., Graefes Arch Clin Exp Ophthalmol. 2012 Mar;250(3):433-40. doi: 10.1007/s00417-011-1876-5. Epub 2011 Dec 9.
192. Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain. Soscia SJ, etal., Cell Mol Life Sci. 2006 Sep;63(17):2039-56.
193. IGF-1 Expression in Infarcted Myocardium and MGF E Peptide Actions on Rat Cardiomyocytes, In Vitro. Stavropoulou A, etal., Mol Med. 2009 Mar 19.
194. IGF-1 reduces inflammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-deficient mice. Sukhanov S, etal., Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2684-90. Epub 2007 Oct 4.
195. Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer. Suzuki H, etal., Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3467-73.
196. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
197. Effect of dietary proteins on the plasma immunoreactive insulin-like growth factor-1/somatomedin C concentration in the rat. Takahashi S, etal., Br J Nutr. 1990 May;63(3):521-34.
198. Localization and function of insulin-like growth factor 1 in dorsal root ganglia in a rat disc herniation model. Takayama B, etal., Spine (Phila Pa 1976). 2011 Jan 15;36(2):E75-9. doi: 10.1097/BRS.0b013e3181d56208.
199. Ghrelin improves renal function in mice with ischemic acute renal failure. Takeda R, etal., J Am Soc Nephrol. 2006 Jan;17(1):113-21. Epub 2005 Nov 23.
200. Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation. Tan Y, etal., Toxicol Lett. 2012 Nov 15;214(3):279-87. doi: 10.1016/j.toxlet.2012.09.007. Epub 2012 Sep 17.
201. Development of an animal model for wound healing in chronic rhinosinusitis. Tansavatdi KP, etal., Arch Otolaryngol Head Neck Surg. 2010 Aug;136(8):807-12. doi: 10.1001/archoto.2010.136.
202. Gene expression of insulin-like growth factor-1 and epidermal growth factor is downregulated in the heart of rats with nitrofen-induced diaphragmatic hernia. Teramoto H and Puri P, Pediatr Surg Int. 2001 May;17(4):284-7.
203. Effects of lipopolysaccharide endotoxin on the insulin-like growth factor I system in rats with cirrhosis. Thomsen KL, etal., In Vivo. 2008 Nov-Dec;22(6):655-61.
204. Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats. Todd BJ, etal., Biol Reprod. 2007 Sep;77(3):492-503. Epub 2007 Jun 13.
205. Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. Tong M, etal., J Alzheimers Dis. 2009;16(3):585-99.
206. Neuroendocrine immune system in familial Mediterranean fever. Topaloglu R, etal., Turk J Pediatr. 2010 Nov-Dec;52(6):588-93.
207. Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice. Trueba-Saiz A, etal., Transl Psychiatry. 2013 Dec 3;3:e330. doi: 10.1038/tp.2013.102.
208. Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. van der Pluijm I, etal., PLoS Biol. 2007 Jan;5(1):e2.
209. Short stature associated with a novel heterozygous mutation in the insulin-like growth factor 1 gene. van Duyvenvoorde HA, etal., J Clin Endocrinol Metab. 2010 Nov;95(11):E363-7. doi: 10.1210/jc.2010-0511. Epub 2010 Jul 28.
210. Insulin-like growth factor-1 and risk of late-onset Alzheimer's disease: findings from a family study. van Exel E, etal., Neurobiol Aging. 2014 Mar;35(3):725.e7-10. doi: 10.1016/j.neurobiolaging.2013.08.014. Epub 2013 Sep 20.
211. Insulin-like growth factor I increases rat peptide YY promoter activity through Sp1 binding sites. Wang G, etal., Endocrinology 2004 Feb;145(2):659-66. Epub 2003 Oct 30.
212. Glomerular ultrafiltration of IGF-I may contribute to increased renal sodium retention in diabetic nephropathy. Wang SN, etal., J Lab Clin Med. 1999 Aug;134(2):154-60.
213. Insulin-like growth factor 1 (IGF1) polymorphism is associated with Alzheimer's disease in Han Chinese. Wang W, etal., Neurosci Lett. 2012 Nov 30;531(1):20-3. doi: 10.1016/j.neulet.2012.10.015. Epub 2012 Oct 23.
214. MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Wang XH, etal., Clin Exp Pharmacol Physiol. 2009 Feb;36(2):181-8. Epub 2008 Sep 26.
215. Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor and its intervention by interleukin-10 in experimental hepatic fibrosis. Wang XZ, etal., World J Gastroenterol. 2003 Jun;9(6):1287-91.
216. Relationship between serum insulin-like growth factor-1 levels and Alzheimer's disease and vascular dementia. Watanabe T, etal., J Am Geriatr Soc. 2005 Oct;53(10):1748-53.
217. Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice. Welch S, etal., Circ Res. 2002 Apr 5;90(6):641-8.
218. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. Woods KA, etal., N Engl J Med. 1996 Oct 31;335(18):1363-7.
219. Interaction between the renin-angiotensin system and insulin-like growth factor I in aorto-caval fistula-induced cardiac hypertrophy in rats. Wåhlander H, etal., Acta Physiol Scand. 1999 Feb;165(2):143-54.
220. The levels of Pdx1/insulin, Cacna1c and Cacna1d, and β-cell mass in a rat model of intrauterine undernutrition. Xu YP, etal., J Matern Fetal Neonatal Med. 2011 Mar;24(3):437-43. doi: 10.3109/14767058.2010.497571. Epub 2010 Sep 27.
221. Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence. Yan H, etal., J Endocrinol. 2011 Oct;211(1):27-37. doi: 10.1530/JOE-11-0200. Epub 2011 Jul 12.
222. Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat. Yan H, etal., J Gerontol A Biol Sci Med Sci. 2014 Nov;69(11):1353-62. doi: 10.1093/gerona/glu118. Epub 2014 Aug 6.
223. Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation. Yan YP, etal., Eur J Neurosci. 2006 Jul;24(1):45-54.
224. Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis. Yao DL, etal., Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6190-4.
225. An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population. Yazdanpanah M, etal., Am J Cardiol. 2006 May 1;97(9):1274-6. Epub 2006 Mar 10.
226. Regulation of signaling pathways downstream of IGF-I/insulin by androgen in skeletal muscle of glucocorticoid-treated rats. Yin HN, etal., J Trauma. 2009 Apr;66(4):1083-90.
227. Differential expression of IGF1, IGFR1 and IGFBP3 in mandibular condylar cartilage between male and female rats applied with malocclusion. Yu S, etal., J Oral Rehabil. 2012 Oct;39(10):727-36. doi: 10.1111/j.1365-2842.2012.02332.x. Epub 2012 Jul 3.
228. Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period. Zakaria R, etal., Acta Histochem. 2009;111(1):52-60. Epub 2008 Aug 3.
229. Expression analysis of VEGFA, FGF2, TGFbeta1, EGF and IGF1 in human nasal polyposis. Zaravinos A, etal., Oncol Rep. 2008 Feb;19(2):385-91.
230. Expression of insulin-like growth factor 1 and receptor in ischemic rats treated with human marrow stromal cells. Zhang J, etal., Brain Res. 2004 Dec 24;1030(1):19-27.
231. Immunohistochemical localisation of growth hormone (GH), GH receptor (GHR), insulin-like growth factor I (IGF-I) and type I IGF-I receptor, and gene expression of GH and GHR in rat pre-antral follicles. Zhao J, etal., Zygote 2002 Feb;10(1):85-94.
232. Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells. Zheng WH and Quirion R, BMC Neurosci. 2006 Jun 22;7:51.
233. Association of insulin-like growth factor-1 polymorphisms with high myopia in the Chinese population. Zhuang W, etal., Mol Vis. 2012;18:634-44. Epub 2012 Mar 13.
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