Igf1 (insulin-like growth factor 1) - Rat Genome Database

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Gene: Igf1 (insulin-like growth factor 1) Rattus norvegicus
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Symbol: Igf1
Name: insulin-like growth factor 1
RGD ID: 2868
Description: Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); borna disease; congenital diaphragmatic hernia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1); PARTICIPATES IN altered insulin-like growth factor signaling pathway; cardiovascular system disease pathway; insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IGF; IGF-I; insulin-like growth factor I; somatomedin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Bp102  
Candidate Gene For: Bw19 Lnnr1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8724,169,608 - 24,249,446 (+)NCBIGRCr8
mRatBN7.2722,282,895 - 22,361,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl722,282,930 - 22,359,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx724,277,579 - 24,351,455 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,440,272 - 26,514,144 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0726,217,310 - 26,291,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,412,123 - 28,491,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,412,198 - 28,486,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,528,165 - 28,607,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,531,669 - 24,605,742 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,553,367 - 24,625,089 (+)NCBI
Celera719,453,213 - 19,527,075 (+)NCBICelera
RH 3.4 Map7116.9RGD
RH 3.4 Map7118.8RGD
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acoustic neuroma  (ISO)
acromegaly  (ISO)
acute kidney failure  (ISO)
adenoma  (ISO)
Albuminuria  (ISO)
alcoholic neuropathy  (IEP)
alopecia  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
borna disease  (IEP)
Brain Hypoxia-Ischemia  (IDA,IEP,ISO)
Brain Injuries  (ISO)
brain ischemia  (IDA,ISO)
breast cancer  (IEP)
Breast Neoplasms  (ISO)
Burns  (IEP)
Cachexia  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (IEP,ISO)
Closed Head Injuries  (ISO)
Cockayne syndrome  (ISO)
colitis  (ISO)
congenital diaphragmatic hernia  (IEP)
congenital disorder of glycosylation Ia  (ISO)
congenital hypothyroidism  (IEP)
congestive heart failure  (IEP)
corneal disease  (ISO)
Coronary Disease  (ISO)
coronary stenosis  (IEP)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
Deafness  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (IEP,ISO)
diabetic neuropathy  (IMP,ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dwarfism  (IEP,ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (IEP)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP,IMP,ISO)
Experimental Mammary Neoplasms  (ISO)
familial mediterranean fever  (ISO)
Female Urogenital Diseases  (ISO)
fetal alcohol spectrum disorder  (IEP)
Fetal Growth Retardation  (IEP,ISO)
Fetal Macrosomia  (ISO)
folic acid deficiency anemia  (IEP)
genetic disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (IDA)
hypertension  (IAGP,IEP,ISO)
hypertrophic cardiomyopathy  (ISO)
hypothyroidism  (IEP)
Insulin-Like Growth Factor I Deficiency  (ISO)
intellectual disability  (ISO)
Intervertebral Disc Displacement  (IMP)
kidney disease  (ISO)
Knee Osteoarthritis  (IEP,ISO)
Kuhnt-Junius degeneration  (ISO)
Laron syndrome  (ISO)
lung disease  (ISO)
Malocclusion  (IEP)
Metabolic Bone Diseases  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (IDA,ISO)
myopia  (ISO)
Nasal Polyps  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
Noonan syndrome  (ISO)
osteoarthritis  (ISO)
Osteophytes  (IEP)
osteoporosis  (IEP,ISO)
Osteoporotic Fractures  (IDA,ISO)
Oxygen-Induced Retinopathy  (IEP)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
PEHO syndrome  (ISO)
peripheral nervous system disease  (ISO)
Pituitary Neoplasms  (ISO)
Plaque, Atherosclerotic  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
Precocious Puberty  (ISO)
progeria  (ISO)
prostate carcinoma in situ  (IEP)
Prostatic Neoplasms  (IEP,ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pycnodysostosis  (ISO)
Reperfusion Injury  (ISO)
retinopathy of prematurity  (IEP,ISO)
rheumatic heart disease  (ISO)
Rhinosinusitis  (ISO)
Right Ventricular Hypertrophy  (IEP)
Sarcopenia  (ISO)
severe acute respiratory syndrome  (ISO)
Skin Neoplasms  (ISO)
Skull Fractures  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (IEP,ISO)
Sudden Hearing Loss  (ISO)
Thinness  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (IEP)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
vascular dementia  (IEP,ISO)
Wounds and Injuries  (IEP,ISO)
Zinc Deficiency  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-noradrenaline  (EXP)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylphenanthrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-nitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-tert-Octylphenol  (EXP)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-(methylamino)isobutyric acid  (EXP)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (ISO)
amino acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
astemizole  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzoyl peroxide  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bezafibrate  (ISO)
bicalutamide  (ISO)
biochanin A  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bosentan  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP)
bucladesine  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcidiol  (EXP)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium silicate  (ISO)
calcium(0)  (EXP,ISO)
Candesartan cilexetil  (EXP)
cannabidiolic acid  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (EXP)
capsiate  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
cetrorelix  (ISO)
CGP 52608  (ISO)
chelerythrine  (EXP)
chlormequat chloride  (EXP)
chloroacetic acid  (ISO)
chloroethene  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
chromium atom  (EXP)
chromium(3+) trichloride  (EXP,ISO)
chrysin  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP)
cyproconazole  (ISO)
cyproterone acetate  (ISO)
D-glucose  (ISO)
D-mannitol  (ISO)
D-penicillamine  (ISO)
dantrolene  (ISO)
DDE  (ISO)
DDT  (EXP,ISO)
deguelin  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicoumarol  (ISO)
dieldrin  (EXP)
dienogest  (ISO)
diethyl malate  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
dihydrocapsaicin  (ISO)
dimethyl fumarate  (EXP)
Dimethyl phthalate  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dobutamine  (EXP)
doxorubicin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP)
enzalutamide  (ISO)
epoxiconazole  (ISO)
estriol  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
felbamate  (EXP)
fenarimol  (EXP)
fenvalerate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
flavonol  (ISO)
fluoranthene  (ISO)
flutamide  (EXP,ISO)
fluvastatin  (ISO)
folpet  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
furazolidone  (ISO)
furosemide  (EXP)
gabapentin  (EXP)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
ginsenoside Rb1  (EXP)
Ginsenoside Rh4  (ISO)
glucose  (ISO)
glutathione  (ISO)
glyburide  (EXP)
glycidol  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (ISO)
heptachlor  (EXP)
herbicide  (EXP)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (EXP)
icariin  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoflavones  (EXP,ISO)
isoflurane  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
leuprolide  (ISO)
levonorgestrel  (ISO)
lidocaine  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
loliolide  (ISO)
lornoxicam  (EXP)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
maleic acid  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
masoprocol  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methimazole  (ISO)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP,ISO)
MK-2206  (EXP)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
naringin  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP)
nifedipine  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
nitroprusside  (EXP,ISO)
nonivamide  (ISO)
Nordihydrocapsaicin  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
octreotide  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
Osajin  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (EXP)
para-Cresidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
pendimethalin  (EXP)
pentane-2,3-dione  (EXP)
pentetic acid  (EXP)
pentetrazol  (EXP)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (EXP)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (EXP)
phenylephrine  (EXP)
phenytoin  (EXP)
phloretin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
picolinic acid  (EXP)
picropodophyllotoxin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
polaprezinc  (ISO)
poly(I:C)  (ISO)
Pomiferin  (ISO)
potassium atom  (EXP)
potassium chloride  (EXP)
potassium dichromate  (EXP)
prazosin  (EXP)
prednisolone  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propofol  (ISO)
Ptaquiloside  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
quinidine  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rivastigmine  (EXP)
Rosavin  (ISO)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
rutin  (EXP)
SB 203580  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
shikimic acid  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (EXP)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Sodium salicylate  (ISO)
sophoraflavanone B  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
staurosporine  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
tetramethrin  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thymidine  (ISO)
thyroxine  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
topotecan  (EXP)
tremolite asbestos  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (EXP)
trilostane  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
wortmannin  (EXP,ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen receptor signaling pathway  (ISO)
blood vessel remodeling  (ISO)
bone development  (IEP)
bone mineralization involved in bone maturation  (IEA,ISO)
branching morphogenesis of an epithelial tube  (ISO)
cardiac atrium development  (IEP)
cell activation  (IEA,ISO)
cell development  (ISO)
cell population proliferation  (IBA,IEA,ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to electrical stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to glucose stimulus  (ISO)
cellular response to insulin stimulus  (IEP)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to nicotine  (IEP)
cellular response to progesterone stimulus  (IEP)
cellular response to Thyroglobulin triiodothyronine  (IEP)
cellular response to zinc ion starvation  (IEP)
cerebellar granule cell precursor proliferation  (ISO)
chondroitin sulfate proteoglycan biosynthetic process  (ISO)
circadian rhythm  (ISO)
cranial suture morphogenesis  (IEP)
detection of mechanical stimulus involved in sensory perception  (IMP)
exocrine pancreas development  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
female pregnancy  (IEP)
glial cell differentiation  (ISO)
inner ear development  (ISO)
insulin-like growth factor receptor signaling pathway  (IBA,IDA,IEA,ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lung lobe morphogenesis  (ISO)
lung vasculature development  (ISO)
mammary gland development  (ISO)
memory  (IMP)
multicellular organism growth  (ISO)
muscle hypertrophy  (IEA,ISO)
myoblast differentiation  (IEA,ISO)
myoblast proliferation  (IEA,ISO)
myotube cell development  (IEA,ISO)
myotube differentiation  (ISO)
negative regulation of amyloid-beta formation  (IEA,ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (IBA,IDA,IEA,ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cholangiocyte apoptotic process  (IMP)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IDA,IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of immune system process  (IMP)
negative regulation of interleukin-1 beta production  (IEA,ISO)
negative regulation of muscle cell apoptotic process  (IMP)
negative regulation of neuroinflammatory response  (IEA,ISO)
negative regulation of oligodendrocyte apoptotic process  (IDA)
negative regulation of oocyte development  (IEA,ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO,ISS)
negative regulation of smooth muscle cell apoptotic process  (IMP,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (IEA,ISO)
nervous system development  (ISO)
osteoblast differentiation  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of activated T cell proliferation  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (IGI)
positive regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell growth  (IDA,IMP)
positive regulation of cell growth involved in cardiac muscle cell development  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IBA,IEA,ISO,ISS)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of fat cell differentiation  (IDA)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glial cell proliferation  (IDA)
positive regulation of glucose import  (IEA,ISO,ISS)
positive regulation of glycogen biosynthetic process  (IEA,ISO,ISS)
positive regulation of glycolytic process  (IEA,ISO)
positive regulation of glycoprotein biosynthetic process  (IEA,ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of MAPK cascade  (IMP,ISO)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of myelination  (ISO)
positive regulation of myoblast proliferation  (ISO)
positive regulation of osteoblast differentiation  (IDA,IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA,IDA,IEA,ISO)
positive regulation of protein secretion  (IEA,ISO)
positive regulation of Ras protein signal transduction  (IEA,ISO)
positive regulation of smooth muscle cell migration  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of steroid hormone biosynthetic process  (IDA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of trophectodermal cell proliferation  (IEA,ISO)
positive regulation of type B pancreatic cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
positive regulation of vascular endothelial cell proliferation  (IGI)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (ISO)
prostate gland epithelium morphogenesis  (ISO)
prostate gland growth  (ISO)
prostate gland stromal morphogenesis  (ISO)
protein stabilization  (IEA,ISO)
proteoglycan biosynthetic process  (IEA,ISO)
regulation of calcium ion transport  (IDA)
regulation of cell population proliferation  (IDA)
regulation of establishment or maintenance of cell polarity  (ISO)
regulation of gene expression  (ISO)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of protein metabolic process  (ISO)
regulation of protein phosphorylation  (IBA,IEA,ISO)
regulation of translation  (IMP)
response to activity  (IEP)
response to caffeine  (IEP)
response to epidermal growth factor  (IEP)
response to estradiol  (IEP)
response to ethanol  (IDA,IEP)
response to glucocorticoid  (IEP)
response to growth hormone  (IEP)
response to heat  (IEA,ISO)
response to hypoxia  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to nicotine  (IEP)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to starvation  (IEP)
response to steroid hormone  (IEP)
response to thyroid hormone  (IEP)
retinal cell apoptotic process  (IDA)
signal transduction  (IEA)
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  (IEA,ISO)
type B pancreatic cell proliferation  (ISO)
type I pneumocyte differentiation  (ISO)
type II pneumocyte differentiation  (ISO)
wound healing  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
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2. Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I. Adams MM, etal., Growth Factors. 2009 Apr 2:1.
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8. Circulating levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in patients with severe head injury. Beeton CA, etal., J Bone Joint Surg Br. 2002 Apr;84(3):434-9.
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10. Effect of insulin-like growth factor-1 deficiency or administration on the occurrence of acne. Ben-Amitai D and Laron Z, J Eur Acad Dermatol Venereol. 2011 Aug;25(8):950-4. doi: 10.1111/j.1468-3083.2010.03896.x. Epub 2010 Nov 4.
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14. Long-term hyperglycaemia impairs vascular smooth muscle cell function in women with type 1 diabetes mellitus. Bjarnegard N, etal., Diab Vasc Dis Res. 2009 Jan;6(1):25-31.
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17. Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice. Bol DK, etal., Oncogene. 1997 Apr 10;14(14):1725-34.
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20. Increased IGF-I and IGF-II mRNA and IGF-I peptide in fusing rat cranial sutures suggest evidence for a paracrine role of insulin-like growth factors in suture fusion. Bradley JP, etal., Plast Reconstr Surg. 1999 Jul;104(1):129-38.
21. Effect of high-fat diet on body composition and hormone responses to glucose tolerance tests. Brown JL, etal., Endocrine 2002 Dec;19(3):327-32.
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24. Association between serum free IGF-I and IGFBP-3 levels in type-I diabetes patients affected with associated autoimmune diseases or diabetic complications. Capoluongo E, etal., Eur Cytokine Netw. 2006 Sep;17(3):167-74.
25. Isolation of rat testis cDNAs encoding an insulin-like growth factor I precursor. Casella SJ, etal., DNA 1987 Aug;6(4):325-30.
26. Differentially expressed angiogenic genes in diabetic erectile tissue - results from a microarray screening. Castela A, etal., Mol Genet Metab. 2012 Feb;105(2):255-62. doi: 10.1016/j.ymgme.2011.11.002. Epub 2011 Nov 10.
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30. Chondrocyte cytokine and growth factor expression in murine osteoarthritis. Chambers MG, etal., Osteoarthritis Cartilage. 1997 Sep;5(5):301-8.
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36. Progesterone and dexamethasone differentially regulate the IGF-system in glial cells. Chesik D and De Keyser J, Neurosci Lett. 2010 Jan 14;468(3):178-82. doi: 10.1016/j.neulet.2009.10.051. Epub 2009 Oct 22.
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38. Rh/IGF-I/rhIGFBP-3 administration to patients with type 2 diabetes mellitus reduces insulin requirements while also lowering fasting glucose. Clemmons DR, etal., Growth Horm IGF Res. 2005 Aug;15(4):265-74.
39. Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat Part 1: Effects on somatic growth, growth hormone-axis activity and bone mass in the offspring. Cocchi D, etal., Toxicol Appl Pharmacol. 2009 Mar 24.
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50. Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function. Ding Q, etal., Neuroscience. 2006 Jul 7;140(3):823-33. Epub 2006 May 2.
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62. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat Galli J, etal., Nat Genet 1996 Jan;12(1):31-7
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65. Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury. Gatto M, etal., Lab Invest. 2008 Sep;88(9):986-94. doi: 10.1038/labinvest.2008.63. Epub 2008 Jul 7.
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67. Estradiol and triiodothyronine increase production of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) by GH4C1 rat pituitary tumor cells. Gilchrist CA, etal., Mol Cell Endocrinol 1995 Oct 30;114(1-2):147-56.
68. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
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72. Reduced free IGF-I and increased IGFBP-3 proteolysis in Turner syndrome: modulation by female sex steroids. Gravholt CH, etal., Am J Physiol Endocrinol Metab. 2001 Feb;280(2):E308-14.
73. The GH-IGF-IGFBP axis is changed in Turner syndrome: partial normalization by HRT. Gravholt CH, etal., Growth Horm IGF Res. 2006 Oct-Dec;16(5-6):332-9. Epub 2006 Oct 25.
74. Insulin-like growth factor-1 improves somatosensory function and reduces the extent of cortical infarction and ongoing neuronal loss after hypoxia-ischemia in rats. Guan J, etal., Neuroscience. 2001;105(2):299-306.
75. Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta. GÃ¥rdebjer EM, etal., Placenta. 2014 Jan;35(1):50-7. doi: 10.1016/j.placenta.2013.10.008. Epub 2013 Nov 5.
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77. A graded model of dietary zinc deficiency: effects on growth, insulin-like growth factor-I, and the glucose/insulin axis in weanling rats. Hall AG, etal., J Pediatr Gastroenterol Nutr. 2005 Jul;41(1):72-80.
78. Serum Levels of Growth Factors in Alcohol-dependent Patients according to Comorbid Depressive Symptoms. Han C, etal., Clin Psychopharmacol Neurosci. 2016 Feb 29;14(1):43-8. doi: 10.9758/cpn.2016.14.1.43.
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80. Immunohistochemical demonstration of insulin-like growth factor I in inflammatory lesions in Wegener's granulomatosis and idiopathic midline destructive disease. Hansson HA, etal., Scand J Rheumatol. 1989;18(3):133-41.
81. Effects of recombinant human growth hormone (r-hGH) on experimental osteoporotic fracture healing. Hao Y, etal., Chin J Traumatol. 2001 May;4(2):102-5.
82. Characterization of SV-40 Tag rats as a model to study prostate cancer. Harper CE, etal., BMC Cancer. 2009 Jan 26;9:30.
83. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
84. Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation. Hie M, etal., Int J Mol Med. 2011 Sep;28(3):455-62. doi: 10.3892/ijmm.2011.697. Epub 2011 May 11.
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86. MicroRNA-98 induces an Alzheimer's disease-like disturbance by targeting insulin-like growth factor 1. Hu YK, etal., Neurosci Bull. 2013 Dec;29(6):745-51. doi: 10.1007/s12264-013-1348-5. Epub 2013 Jun 5.
87. A potential inverse association between insulin-like growth factor I and hypertension in a cross-sectional study. Hunt KJ, etal., Ann Epidemiol. 2006 Jul;16(7):563-71. Epub 2006 Jan 23.
88. Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate. Huynh H, etal., J Endocrinol 2001 Oct;171(1):109-18.
89. Cochlear protection by local insulin-like growth factor-1 application using biodegradable hydrogel. Iwai K, etal., Laryngoscope. 2006 Apr;116(4):529-33.
90. Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart. Jiang Y and Steinle JJ, Can J Physiol Pharmacol. 2010 May;88(5):553-61.
91. [Effects of recombinant human insulin-like growth factor-1 on the expression of Clara cell secretory protein in lung of hyperoxia-exposed newborn rats]. Jin ZA, etal., Zhonghua Er Ke Za Zhi. 2007 May;45(5):369-73.
92. Pattern of retinopathy of prematurity and its correlation with insulin-like growth factor-1 (IGF-1). Kant S, etal., Ann Ophthalmol (Skokie). 2009 Fall-Winter;41(3-4):157-61.
93. Changes of human menisci in osteoarthritic knee joints. Katsuragawa Y, etal., Osteoarthritis Cartilage. 2010 Sep;18(9):1133-43. doi: 10.1016/j.joca.2010.05.017. Epub 2010 Jul 13.
94. Circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 are associated with early carotid atherosclerosis. Kawachi S, etal., Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):617-21. Epub 2004 Dec 29.
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Additional References at PubMed
PMID:1368571   PMID:1605853   PMID:1847964   PMID:2538424   PMID:2967174   PMID:7188854   PMID:7510770   PMID:7513704   PMID:7688386   PMID:7692086   PMID:7782332   PMID:7848824  
PMID:8421089   PMID:8452530   PMID:8889548   PMID:9497324   PMID:9564845   PMID:9630227   PMID:9714146   PMID:9722506   PMID:10027293   PMID:10191278   PMID:10218945   PMID:10465256  
PMID:10644978   PMID:10766744   PMID:11404306   PMID:11675876   PMID:11796174   PMID:11849991   PMID:11914039   PMID:11949853   PMID:11999215   PMID:12057928   PMID:12101187   PMID:12115579  
PMID:12130673   PMID:12139923   PMID:12223347   PMID:12352620   PMID:12415260   PMID:12431371   PMID:12477932   PMID:12485837   PMID:12574418   PMID:12588046   PMID:12593720   PMID:12612011  
PMID:12624094   PMID:12626499   PMID:12637793   PMID:12682066   PMID:12692175   PMID:12700634   PMID:12704096   PMID:12706025   PMID:12746903   PMID:12764579   PMID:12773315   PMID:12805218  
PMID:12819007   PMID:12837295   PMID:12865332   PMID:12876289   PMID:12902319   PMID:12904469   PMID:12957504   PMID:12960075   PMID:13129855   PMID:14506616   PMID:14512843   PMID:14532269  
PMID:14566968   PMID:14624474   PMID:14711902   PMID:14716834   PMID:14997011   PMID:15042585   PMID:15050532   PMID:15059951   PMID:15059953   PMID:15070850   PMID:15272025   PMID:15284206  
PMID:15322112   PMID:15476580   PMID:15489316   PMID:15530650   PMID:15609625   PMID:15611844   PMID:15632127   PMID:15668985   PMID:15694994   PMID:15701575   PMID:15790724   PMID:15793718  
PMID:15800930   PMID:15831712   PMID:15833775   PMID:15845077   PMID:16010989   PMID:16046480   PMID:16077083   PMID:16139950   PMID:16150839   PMID:16168389   PMID:16169204   PMID:16169763  
PMID:16204335   PMID:16204415   PMID:16288470   PMID:16311053   PMID:16339156   PMID:16339387   PMID:16340176   PMID:16408277   PMID:16433617   PMID:16448778   PMID:16464236   PMID:16614058  
PMID:16691571   PMID:16782835   PMID:16838042   PMID:16867182   PMID:16871256   PMID:16941139   PMID:16942485   PMID:16949134   PMID:16999977   PMID:17003344   PMID:17033095   PMID:17038487  
PMID:17119061   PMID:17138659   PMID:17241280   PMID:17289286   PMID:17299765   PMID:17328060   PMID:17350303   PMID:17363111   PMID:17382293   PMID:17400715   PMID:17412794   PMID:17531227  
PMID:17574386   PMID:17636024   PMID:17644814   PMID:17693256   PMID:17804753   PMID:17852404   PMID:17915215   PMID:17959844   PMID:17982240   PMID:18021255   PMID:18255192   PMID:18256135  
PMID:18293375   PMID:18467435   PMID:18469139   PMID:18502759   PMID:18552658   PMID:18590691   PMID:18597865   PMID:18666320   PMID:18669936   PMID:18671941   PMID:18782533   PMID:18801338  
PMID:18827067   PMID:18832087   PMID:18832567   PMID:18841527   PMID:18922796   PMID:18977203   PMID:19008912   PMID:19115393   PMID:19125275   PMID:19208758   PMID:19220704   PMID:19231997  
PMID:19245789   PMID:19359426   PMID:19364764   PMID:19382214   PMID:19406747   PMID:19437499   PMID:19438508   PMID:19453943   PMID:19509289   PMID:19578119   PMID:19587145   PMID:19654000  
PMID:19720043   PMID:19726620   PMID:19726638   PMID:19744960   PMID:19816949   PMID:19850049   PMID:19899713   PMID:19911128   PMID:19916171   PMID:19920079   PMID:19926099   PMID:19933931  
PMID:20039316   PMID:20042609   PMID:20097715   PMID:20160126   PMID:20200966   PMID:20207740   PMID:20213470   PMID:20235220   PMID:20347065   PMID:20350589   PMID:20378540   PMID:20525067  
PMID:20535993   PMID:20563856   PMID:20577844   PMID:20685873   PMID:20849920   PMID:20942583   PMID:21076856   PMID:21162126   PMID:21241779   PMID:21279379   PMID:21343254   PMID:21402727  
PMID:21406500   PMID:21413931   PMID:21496647   PMID:21515376   PMID:21543511   PMID:21592969   PMID:21598309   PMID:21606872   PMID:21677284   PMID:21739215   PMID:21795542   PMID:21840378  
PMID:21854769   PMID:21867412   PMID:21924541   PMID:21940672   PMID:22080499   PMID:22104347   PMID:22172933   PMID:22228770   PMID:22341695   PMID:22351760   PMID:22393433   PMID:22413999  
PMID:22490886   PMID:22496359   PMID:22565577   PMID:22568219   PMID:22579999   PMID:22583947   PMID:22592456   PMID:22635104   PMID:22645024   PMID:22696074   PMID:22714676   PMID:22720172  
PMID:22729283   PMID:22735908   PMID:22739109   PMID:22752413   PMID:22797316   PMID:22797923   PMID:22805023   PMID:22820932   PMID:22865430   PMID:22964493   PMID:22995212   PMID:23016132  
PMID:23142791   PMID:23152492   PMID:23185594   PMID:23255067   PMID:23292283   PMID:23331186   PMID:23340251   PMID:23359486   PMID:23457189   PMID:23480228   PMID:23528977   PMID:23532711  
PMID:23584855   PMID:23658701   PMID:23681983   PMID:23709620   PMID:23721666   PMID:23745035   PMID:23774069   PMID:23843538   PMID:23865718   PMID:23963811   PMID:24006456   PMID:24029240  
PMID:24033831   PMID:24049436   PMID:24117217   PMID:24188094   PMID:24322591   PMID:24364912   PMID:24416413   PMID:24418087   PMID:24423253   PMID:24440782   PMID:24460314   PMID:24508636  
PMID:24530896   PMID:24562308   PMID:24617524   PMID:24617825   PMID:24673524   PMID:24750178   PMID:24808494   PMID:25036495   PMID:25136768   PMID:25152160   PMID:25162639   PMID:25226394  
PMID:25268143   PMID:25274047   PMID:25450576   PMID:25466885   PMID:25543525   PMID:25666965   PMID:25667201   PMID:25958232   PMID:26104971   PMID:26151354   PMID:26151859   PMID:26166810  
PMID:26187065   PMID:26286172   PMID:26330488   PMID:26434683   PMID:26499267   PMID:26596702   PMID:26702053   PMID:26762757   PMID:26924708   PMID:26994309   PMID:27090441   PMID:27167199  
PMID:27180072   PMID:27196416   PMID:27254005   PMID:27277332   PMID:27385628   PMID:27537370   PMID:28063218   PMID:28077319   PMID:28101820   PMID:28179125   PMID:28256809   PMID:28276453  
PMID:28279229   PMID:28668953   PMID:28684382   PMID:28843696   PMID:28963396   PMID:29031906   PMID:29080043   PMID:29149028   PMID:29151078   PMID:29167509   PMID:29226348   PMID:29572520  
PMID:29915198   PMID:30068974   PMID:30335903   PMID:30359321   PMID:30418079   PMID:30659610   PMID:30770724   PMID:31059193   PMID:31171766   PMID:31281852   PMID:31370244   PMID:31474338  
PMID:31531182   PMID:31607475   PMID:31733099   PMID:31861182   PMID:32116075   PMID:32691304   PMID:32713334   PMID:32880387   PMID:33402478   PMID:33560148   PMID:33799501   PMID:34209299  
PMID:34601167   PMID:34852642   PMID:35298717   PMID:35459135   PMID:36421043   PMID:36847937   PMID:37220673   PMID:37569325   PMID:38085649  


Genomics

Comparative Map Data
Igf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8724,169,608 - 24,249,446 (+)NCBIGRCr8
mRatBN7.2722,282,895 - 22,361,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl722,282,930 - 22,359,296 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx724,277,579 - 24,351,455 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,440,272 - 26,514,144 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0726,217,310 - 26,291,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,412,123 - 28,491,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,412,198 - 28,486,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,528,165 - 28,607,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,531,669 - 24,605,742 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,553,367 - 24,625,089 (+)NCBI
Celera719,453,213 - 19,527,075 (+)NCBICelera
RH 3.4 Map7116.9RGD
RH 3.4 Map7118.8RGD
Cytogenetic Map7q13NCBI
IGF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812102,395,874 - 102,481,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12102,395,874 - 102,481,744 (-)EnsemblGRCh38hg38GRCh38
GRCh3712102,789,652 - 102,874,341 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612101,313,806 - 101,398,454 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412101,292,143 - 101,376,791NCBI
Celera12102,453,601 - 102,538,345 (-)NCBICelera
Cytogenetic Map12q23.2NCBI
HuRef1299,849,028 - 99,933,911 (-)NCBIHuRef
CHM1_112102,756,305 - 102,841,104 (-)NCBICHM1_1
T2T-CHM13v2.012102,357,015 - 102,443,074 (-)NCBIT2T-CHM13v2.0
Igf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391087,694,127 - 87,772,909 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1087,694,127 - 87,772,904 (+)EnsemblGRCm39 Ensembl
GRCm381087,858,265 - 87,937,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1087,858,265 - 87,937,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv371087,321,801 - 87,399,792 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361087,289,200 - 87,361,600 (+)NCBIMGSCv36mm8
Celera1089,837,923 - 89,916,340 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.7NCBI
Igf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540537,512,201 - 37,582,152 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540537,505,830 - 37,582,152 (-)NCBIChiLan1.0ChiLan1.0
IGF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210110,469,849 - 110,552,651 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112110,466,247 - 110,549,042 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01299,986,887 - 100,066,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112103,385,911 - 103,463,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12103,385,911 - 103,462,177 (-)Ensemblpanpan1.1panPan2
IGF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11541,203,320 - 41,275,964 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1541,202,518 - 41,275,794 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1541,571,399 - 41,643,792 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01541,855,737 - 41,930,681 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1541,856,552 - 41,930,595 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11541,124,961 - 41,197,284 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01541,221,486 - 41,300,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01541,495,479 - 41,567,874 (-)NCBIUU_Cfam_GSD_1.0
Igf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494518,699,022 - 18,773,635 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649211,709,222 - 11,778,351 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649211,709,623 - 11,784,028 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl581,775,970 - 81,848,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1581,762,027 - 81,909,253 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2585,700,439 - 85,773,714 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IGF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11197,624,498 - 97,708,730 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1197,631,189 - 97,707,308 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037147,296,425 - 147,379,600 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247505,881,091 - 5,952,300 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247505,881,065 - 5,954,799 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Igf1
456 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI19245789
Mir1rno-miR-1-3pMirtarbaseexternal_infoELISAFunctional MTI (Weak)18801338
Mir320arno-miR-320-3pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI18986336
Mir206rno-miR-206-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI19245789

Predicted Target Of
Summary Value
Count of predictions:242
Count of miRNA genes:159
Interacting mature miRNAs:200
Transcripts:ENSRNOT00000005995, ENSRNOT00000038780
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat

Markers in Region
D7Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0728,526,489 - 28,528,806NCBIRnor5.0
RGSC_v3.4724,529,919 - 24,532,235RGDRGSC3.4
RGSC_v3.1724,551,120 - 24,551,317RGD
RH 3.4 Map7119.7RGD
RH 2.0 Map7125.5RGD
D7Mit23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,282,087 - 22,282,284 (+)MAPPERmRatBN7.2
Rnor_6.0728,411,379 - 28,411,575NCBIRnor6.0
Rnor_5.0728,527,421 - 28,527,617UniSTSRnor5.0
RGSC_v3.4724,530,850 - 24,531,046UniSTSRGSC3.4
RGSC_v3.1724,551,120 - 24,551,317RGD
Celera719,452,394 - 19,452,590UniSTS
RH 3.4 Map7118.5UniSTS
RH 3.4 Map7118.5RGD
RH 3.4 Map7119.7UniSTS
RH 2.0 Map7122.9RGD
Cytogenetic Map7q12-q13UniSTS
D7Rat226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,289,556 - 22,289,774 (+)MAPPERmRatBN7.2
Rnor_6.0728,418,847 - 28,419,064NCBIRnor6.0
Rnor_5.0728,534,889 - 28,535,106UniSTSRnor5.0
RGSC_v3.4724,538,317 - 24,538,534RGDRGSC3.4
RGSC_v3.4724,538,318 - 24,538,535UniSTSRGSC3.4
RGSC_v3.1724,558,588 - 24,558,805RGD
Celera719,459,862 - 19,460,079UniSTS
FHH x ACI Map75.8499RGD
FHH x ACI Map75.8499UniSTS
Cytogenetic Map7q12-q13UniSTS
RH142608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,340,188 - 22,340,354 (+)MAPPERmRatBN7.2
Rnor_6.0728,470,027 - 28,470,192NCBIRnor6.0
Rnor_5.0728,585,959 - 28,586,124UniSTSRnor5.0
RGSC_v3.4724,589,160 - 24,589,325UniSTSRGSC3.4
Celera719,510,662 - 19,510,827UniSTS
RH 3.4 Map7113.25UniSTS
Cytogenetic Map7q12-q13UniSTS
Igf1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,338,869 - 22,338,946 (+)MAPPERmRatBN7.2
Rnor_6.0728,468,708 - 28,468,784NCBIRnor6.0
Rnor_5.0728,584,640 - 28,584,716UniSTSRnor5.0
RGSC_v3.4724,587,841 - 24,587,917UniSTSRGSC3.4
Celera719,509,343 - 19,509,419UniSTS
Cytogenetic Map7q12-q13UniSTS
RH94801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,356,020 - 22,356,317 (+)MAPPERmRatBN7.2
Rnor_6.0728,485,860 - 28,486,156NCBIRnor6.0
Rnor_5.0728,601,792 - 28,602,088UniSTSRnor5.0
RGSC_v3.4724,604,993 - 24,605,289UniSTSRGSC3.4
Celera719,526,326 - 19,526,622UniSTS
Cytogenetic Map7q12-q13UniSTS
RH142569  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,356,132 - 22,356,294 (+)MAPPERmRatBN7.2
Rnor_6.0728,485,972 - 28,486,133NCBIRnor6.0
Rnor_5.0728,601,904 - 28,602,065UniSTSRnor5.0
RGSC_v3.4724,605,105 - 24,605,266UniSTSRGSC3.4
Celera719,526,438 - 19,526,599UniSTS
RH 3.4 Map7118.6UniSTS
Cytogenetic Map7q12-q13UniSTS
RH143798  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,347,751 - 22,347,936 (+)MAPPERmRatBN7.2
Rnor_6.0728,477,590 - 28,477,774NCBIRnor6.0
Rnor_5.0728,593,522 - 28,593,706UniSTSRnor5.0
RGSC_v3.4724,596,723 - 24,596,907UniSTSRGSC3.4
Celera719,518,056 - 19,518,240UniSTS
RH 3.4 Map7117.0UniSTS
Cytogenetic Map7q12-q13UniSTS
RH94417  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,338,672 - 22,338,853 (+)MAPPERmRatBN7.2
Rnor_6.0728,468,511 - 28,468,691NCBIRnor6.0
Rnor_5.0728,584,443 - 28,584,623UniSTSRnor5.0
RGSC_v3.4724,587,644 - 24,587,824UniSTSRGSC3.4
Celera719,509,146 - 19,509,326UniSTS
RH 3.4 Map7118.8UniSTS
Cytogenetic Map7q12-q13UniSTS
GDB:384821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,338,857 - 22,339,039 (+)MAPPERmRatBN7.2
Rnor_6.0728,468,696 - 28,468,877NCBIRnor6.0
Rnor_5.0728,584,628 - 28,584,809UniSTSRnor5.0
RGSC_v3.4724,587,829 - 24,588,010UniSTSRGSC3.4
Celera719,509,331 - 19,509,512UniSTS
Cytogenetic Map7q12-q13UniSTS
MARC_16386-16387:1017081416:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,355,650 - 22,356,461 (+)MAPPERmRatBN7.2
Rnor_6.0728,485,491 - 28,486,300NCBIRnor6.0
Rnor_5.0728,601,423 - 28,602,232UniSTSRnor5.0
RGSC_v3.4724,604,624 - 24,605,433UniSTSRGSC3.4
Celera719,525,957 - 19,526,766UniSTS
Cytogenetic Map7q12-q13UniSTS
Igf1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,282,087 - 22,282,284 (+)MAPPERmRatBN7.2
Rnor_6.0728,411,379 - 28,411,575NCBIRnor6.0
Rnor_5.0728,527,421 - 28,527,617UniSTSRnor5.0
RGSC_v3.4724,530,850 - 24,531,046UniSTSRGSC3.4
Celera719,452,394 - 19,452,590UniSTS
Cytogenetic Map7q12-q13UniSTS
Igf1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,282,040 - 22,282,309 (+)MAPPERmRatBN7.2
Rnor_6.0728,411,332 - 28,411,600NCBIRnor6.0
Rnor_5.0728,527,374 - 28,527,642UniSTSRnor5.0
RGSC_v3.4724,530,803 - 24,531,071UniSTSRGSC3.4
Celera719,452,347 - 19,452,615UniSTS
Cytogenetic Map7q12-q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 2 2
Medium 2 35 39 27 15 27 5 7 15 31 40 11 5
Low 1 8 16 12 4 12 3 4 59 4 1 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001082477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001082478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001082479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH002176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB751206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB761687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M17594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M81184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U05228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000005995   ⟹   ENSRNOP00000005995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl722,282,930 - 22,355,870 (+)Ensembl
Rnor_6.0 Ensembl728,412,220 - 28,485,710 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000038780   ⟹   ENSRNOP00000035899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl722,288,218 - 22,339,156 (+)Ensembl
Rnor_6.0 Ensembl728,412,198 - 28,486,609 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081822   ⟹   ENSRNOP00000073824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl728,412,198 - 28,486,609 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085680   ⟹   ENSRNOP00000070124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl722,285,060 - 22,356,770 (+)Ensembl
Rnor_6.0 Ensembl728,414,350 - 28,486,609 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118307   ⟹   ENSRNOP00000097781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl722,282,990 - 22,359,296 (+)Ensembl
RefSeq Acc Id: NM_001082477   ⟹   NP_001075946
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8724,172,532 - 24,244,244 (+)NCBI
mRatBN7.2722,285,060 - 22,356,770 (+)NCBI
Rnor_6.0728,414,350 - 28,486,609 (+)NCBI
Rnor_5.0728,528,165 - 28,607,747 (+)NCBI
RGSC_v3.4724,531,669 - 24,605,742 (+)RGD
Celera719,455,365 - 19,527,075 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001082478   ⟹   NP_001075947
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8724,170,380 - 24,244,244 (+)NCBI
mRatBN7.2722,282,908 - 22,356,770 (+)NCBI
Rnor_6.0728,412,198 - 28,486,609 (+)NCBI
Rnor_5.0728,528,165 - 28,607,747 (+)NCBI
RGSC_v3.4724,531,669 - 24,605,742 (+)RGD
Celera719,453,213 - 19,527,075 (+)RGD
Sequence:
RefSeq Acc Id: NM_001082479   ⟹   NP_001075948
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8724,170,380 - 24,244,244 (+)NCBI
mRatBN7.2722,282,908 - 22,356,770 (+)NCBI
Rnor_6.0728,412,198 - 28,486,609 (+)NCBI
Rnor_5.0728,528,165 - 28,607,747 (+)NCBI
RGSC_v3.4724,531,669 - 24,605,742 (+)RGD
Celera719,453,213 - 19,527,075 (+)RGD
Sequence:
RefSeq Acc Id: NM_178866   ⟹   NP_849197
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8724,172,532 - 24,244,244 (+)NCBI
mRatBN7.2722,285,060 - 22,356,770 (+)NCBI
Rnor_6.0728,414,350 - 28,486,609 (+)NCBI
Rnor_5.0728,528,165 - 28,607,747 (+)NCBI
RGSC_v3.4724,531,669 - 24,605,742 (+)RGD
Celera719,455,365 - 19,527,075 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241191   ⟹   XP_006241253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8724,170,360 - 24,249,446 (+)NCBI
mRatBN7.2722,282,911 - 22,361,972 (+)NCBI
Rnor_6.0728,412,168 - 28,491,815 (+)NCBI
Rnor_5.0728,528,165 - 28,607,747 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241193   ⟹   XP_006241255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8724,170,341 - 24,249,446 (+)NCBI
mRatBN7.2722,282,895 - 22,361,972 (+)NCBI
Rnor_6.0728,412,170 - 28,491,815 (+)NCBI
Rnor_5.0728,528,165 - 28,607,747 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241194   ⟹   XP_006241256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8724,170,774 - 24,249,446 (+)NCBI
mRatBN7.2722,283,290 - 22,361,972 (+)NCBI
Rnor_6.0728,412,555 - 28,491,815 (+)NCBI
Rnor_5.0728,528,165 - 28,607,747 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063262981   ⟹   XP_063119051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8724,169,608 - 24,249,446 (+)NCBI
RefSeq Acc Id: XM_063262982   ⟹   XP_063119052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8724,169,608 - 24,249,446 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001075946 (Get FASTA)   NCBI Sequence Viewer  
  NP_001075947 (Get FASTA)   NCBI Sequence Viewer  
  NP_001075948 (Get FASTA)   NCBI Sequence Viewer  
  NP_849197 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241253 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241255 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241256 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119051 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119052 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41214 (Get FASTA)   NCBI Sequence Viewer  
  AAA41215 (Get FASTA)   NCBI Sequence Viewer  
  AAA41385 (Get FASTA)   NCBI Sequence Viewer  
  AAA41386 (Get FASTA)   NCBI Sequence Viewer  
  AAA41387 (Get FASTA)   NCBI Sequence Viewer  
  AAA41388 (Get FASTA)   NCBI Sequence Viewer  
  AAA41389 (Get FASTA)   NCBI Sequence Viewer  
  AAA41390 (Get FASTA)   NCBI Sequence Viewer  
  AAH86374 (Get FASTA)   NCBI Sequence Viewer  
  BAA00604 (Get FASTA)   NCBI Sequence Viewer  
  CAA29436 (Get FASTA)   NCBI Sequence Viewer  
  CAA29480 (Get FASTA)   NCBI Sequence Viewer  
  CAA29481 (Get FASTA)   NCBI Sequence Viewer  
  EDM17020 (Get FASTA)   NCBI Sequence Viewer  
  EDM17021 (Get FASTA)   NCBI Sequence Viewer  
  EDM17022 (Get FASTA)   NCBI Sequence Viewer  
  EDM17023 (Get FASTA)   NCBI Sequence Viewer  
  EDM17024 (Get FASTA)   NCBI Sequence Viewer  
  EDM17025 (Get FASTA)   NCBI Sequence Viewer  
  EDM17026 (Get FASTA)   NCBI Sequence Viewer  
  EDM17027 (Get FASTA)   NCBI Sequence Viewer  
  EDM17028 (Get FASTA)   NCBI Sequence Viewer  
  EDM17029 (Get FASTA)   NCBI Sequence Viewer  
  EDM17030 (Get FASTA)   NCBI Sequence Viewer  
  EDM17031 (Get FASTA)   NCBI Sequence Viewer  
  EDM17032 (Get FASTA)   NCBI Sequence Viewer  
  EDM17033 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005995
  ENSRNOP00000005995.5
  ENSRNOP00000035899.5
  ENSRNOP00000070124
  ENSRNOP00000070124.1
  ENSRNOP00000097781
  ENSRNOP00000097781.1
GenBank Protein P08025 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_849197   ⟸   NM_178866
- Peptide Label: isoform b preproprotein
- UniProtKB: Q5RK13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001075947   ⟸   NM_001082478
- Peptide Label: isoform c preproprotein
- UniProtKB: F8WFZ5 (UniProtKB/TrEMBL),   A6IFM0 (UniProtKB/TrEMBL),   A6IFM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001075948   ⟸   NM_001082479
- Peptide Label: isoform d preproprotein
- UniProtKB: P08024 (UniProtKB/Swiss-Prot),   P08025 (UniProtKB/Swiss-Prot),   Q5RK13 (UniProtKB/TrEMBL),   A6IFL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001075946   ⟸   NM_001082477
- Peptide Label: isoform a preproprotein
- UniProtKB: A0A0G2JX40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241253   ⟸   XM_006241191
- Peptide Label: isoform X1
- UniProtKB: F8WFZ5 (UniProtKB/TrEMBL),   A6IFM0 (UniProtKB/TrEMBL),   A6IFM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241255   ⟸   XM_006241193
- Peptide Label: isoform X2
- UniProtKB: P08024 (UniProtKB/Swiss-Prot),   P08025 (UniProtKB/Swiss-Prot),   A6IFL5 (UniProtKB/TrEMBL),   Q5RK13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241256   ⟸   XM_006241194
- Peptide Label: isoform X3
- UniProtKB: Q5RK13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035899   ⟸   ENSRNOT00000038780
RefSeq Acc Id: ENSRNOP00000070124   ⟸   ENSRNOT00000085680
RefSeq Acc Id: ENSRNOP00000073824   ⟸   ENSRNOT00000081822
RefSeq Acc Id: ENSRNOP00000005995   ⟸   ENSRNOT00000005995
RefSeq Acc Id: ENSRNOP00000097781   ⟸   ENSRNOT00000118307
RefSeq Acc Id: XP_063119051   ⟸   XM_063262981
- Peptide Label: isoform X1
- UniProtKB: A6IFM0 (UniProtKB/TrEMBL),   F8WFZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119052   ⟸   XM_063262982
- Peptide Label: isoform X2
- UniProtKB: P08025 (UniProtKB/Swiss-Prot),   P08024 (UniProtKB/Swiss-Prot),   A6IFL5 (UniProtKB/TrEMBL)
Protein Domains
Insulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08025-F1-model_v2 AlphaFold P08025 1-153 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695134
Promoter ID:EPDNEW_R5645
Type:initiation region
Name:Igf1_1
Description:insulin-like growth factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5646  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0728,412,296 - 28,412,356EPDNEW
RGD ID:13695121
Promoter ID:EPDNEW_R5646
Type:multiple initiation site
Name:Igf1_2
Description:insulin-like growth factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5645  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0728,414,327 - 28,414,387EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2868 AgrOrtholog
BioCyc Gene G2FUF-34524 BioCyc
Ensembl Genes ENSRNOG00000004517 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005995.6 UniProtKB/TrEMBL
  ENSRNOT00000038780.7 UniProtKB/TrEMBL
  ENSRNOT00000085680 ENTREZGENE
  ENSRNOT00000085680.2 UniProtKB/TrEMBL
  ENSRNOT00000118307.1 UniProtKB/Swiss-Prot
Gene3D-CATH Insulin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7300903 IMAGE-MGC_LOAD
InterPro IGF-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like_growth_factor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_family UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24482 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105288 IMAGE-MGC_LOAD
NCBI Gene 24482 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR I UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR I UniProtKB/Swiss-Prot
  INSULIN-LIKE GROWTH FACTOR I UniProtKB/TrEMBL
  INSULIN-LIKE GROWTH FACTOR I UniProtKB/TrEMBL
Pfam Insulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Igf1 PhenoGen
PRINTS INSLNLIKEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSLNLIKEGF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INSULINFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INSULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004517 RatGTEx
SMART IlGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56994 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JX40 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UL72_RAT UniProtKB/TrEMBL
  A6IFL5 ENTREZGENE, UniProtKB/TrEMBL
  A6IFM0 ENTREZGENE, UniProtKB/TrEMBL
  A6IFM1 ENTREZGENE, UniProtKB/TrEMBL
  A6IFM2_RAT UniProtKB/TrEMBL
  A6IFM3_RAT UniProtKB/TrEMBL
  A6IFM5_RAT UniProtKB/TrEMBL
  A6IFM7_RAT UniProtKB/TrEMBL
  F8WFZ5 ENTREZGENE, UniProtKB/TrEMBL
  IGF1_RAT UniProtKB/Swiss-Prot
  P08024 ENTREZGENE
  P08025 ENTREZGENE
  Q5RK13 ENTREZGENE, UniProtKB/TrEMBL
  Q63261_RAT UniProtKB/TrEMBL
UniProt Secondary P08024 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Igf1  insulin-like growth factor 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs polyinosinic-polycytidylic acid [poly(IC)] is responsible for poly(IC) mediated glioma cell number caused by blockage in the G1 to S transition in the C6 cells 625705
gene_expression expressed mainly in the liver 68899
gene_expression expressed in testis 728976
gene_function binds insulin-like growth factor and has tyrosine kinase activity 61526
gene_function binds insulin-like growth factor and has tyrosine kinase activity 70266
gene_function mitogenic peptide 625705
gene_pathway activates the phosphatidylinositol 3-kinase mediated signaling pathway in pacreatic beta cells 625705
gene_process related to insulin but has a much higher growth-promoting activity 61526
gene_process related to insulin but has a much higher growth-promoting activity 70266
gene_process mediates cell proliferation by activating IGF-1 receptor 625705
gene_process active mitogen and potent inhibitor of cell death in pancreatic cells 625705
gene_process signaling plays a role in protective effect on pacreatic beta cells 625705
gene_regulation expression in GH4C1 cells is induced by 17 beta-estradiol (E2) and triiodothyronine (T3) 1358947
gene_transcript mRNA synthesized as a precursor in the rat testis which is then spliced 728976