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Gene: Igf1 (insulin-like growth factor 1) Rattus norvegicus
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Symbol: Igf1
Name: insulin-like growth factor 1
Description: Exhibits insulin-like growth factor receptor binding activity; molecular function regulator; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of cell death; and positive regulation of cell differentiation. Localizes to several cellular components, including the interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); congenital diaphragmatic hernia; folic acid deficiency anemia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1); PARTICIPATES IN altered insulin-like growth factor signaling pathway; cardiovascular system disease pathway; insulin-like growth factor signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IGF; IGF-I; insulin-like growth factor I; somatomedin
Orthologs:
Homo sapiens (human) : IGF1 (insulin like growth factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Igf1 (insulin-like growth factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igf1 (insulin like growth factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IGF1 (insulin like growth factor 1)
Canis lupus familiaris (dog) : IGF1 (insulin like growth factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igf1 (insulin like growth factor 1)
Sus scrofa (pig) : IGF1 (insulin like growth factor 1)
more info ...
Is Marker For: QTLs:   Bp102  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0728,412,123 - 28,491,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,412,198 - 28,486,609 (+)Ensembl
Rnor_5.0728,528,165 - 28,607,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,531,669 - 24,605,742 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1724,553,367 - 24,625,089 (+)NCBI
Celera719,453,213 - 19,527,075 (+)NCBICelera
Cytogenetic Map7q13NCBI
RH 3.4 Map7118.8RGD
RH 3.4 Map7116.9RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences