Igf1 (insulin like growth factor 1) - Rat Genome Database

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Gene: Igf1 (insulin like growth factor 1) Ictidomys tridecemlineatus
Analyze
Symbol: Igf1
Name: insulin like growth factor 1
RGD ID: 12721362
Description: ENCODES a protein that exhibits hormone activity (ortholog); insulin receptor binding (ortholog); insulin-like growth factor receptor binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); aging (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN altered insulin-like growth factor signaling pathway; cardiovascular system disease pathway; ceramide signaling pathway; ASSOCIATED WITH acne (ortholog); acoustic neuroma (ortholog); acromegaly (ortholog); FOUND IN alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog); cytoplasm (ortholog); exocytic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: insulin like growth factor 1, transcript variant X1; insulin like growth factor 1, transcript variant X2; insulin-like growth factor I
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494518,699,022 - 18,773,635 (+)NCBI
SpeTri2.0NW_00493649211,709,623 - 11,784,028 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acoustic neuroma  (ISO)
acromegaly  (ISO)
acute kidney failure  (ISO)
adenoma  (ISO)
Albuminuria  (ISO)
alcoholic neuropathy  (ISO)
alopecia  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cachexia  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Cockayne syndrome  (ISO)
colitis  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (ISO)
congenital hypothyroidism  (ISO)
congestive heart failure  (ISO)
corneal disease  (ISO)
Coronary Disease  (ISO)
coronary stenosis  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
Deafness  (ISO)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dwarfism  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial Mediterranean fever  (ISO)
Female Urogenital Diseases  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fetal Macrosomia  (ISO)
folic acid deficiency anemia  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
Head Injuries, Closed  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypothyroidism  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Insulin-Like Growth Factor I Deficiency  (ISO)
intellectual disability  (ISO)
Intervertebral Disc Displacement  (ISO)
kidney disease  (ISO)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (ISO)
Laron syndrome  (ISO)
Malocclusion  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Metabolic Bone Diseases  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
myopia  (ISO)
Nasal Polyps  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
non-alcoholic fatty liver disease  (ISO)
Noonan syndrome  (ISO)
osteoarthritis  (ISO)
Osteophytes  (ISO)
osteoporosis  (ISO)
Osteoporotic Fractures  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
PEHO syndrome  (ISO)
peripheral nervous system disease  (ISO)
Pituitary Neoplasms  (ISO)
Plaque, Atherosclerotic  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
Precocious Puberty  (ISO)
progeria  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pycnodysostosis  (ISO)
Reperfusion Injury  (ISO)
retinopathy of prematurity  (ISO)
rheumatic heart disease  (ISO)
Rhinosinusitis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sarcopenia  (ISO)
severe acute respiratory syndrome  (ISO)
Skin Neoplasms  (ISO)
Skull Fractures  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (ISO)
Sudden Hearing Loss  (ISO)
Thinness  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
vascular dementia  (ISO)
Wounds and Injuries  (ISO)
Zinc Deficiency  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
aging  (ISO)
blood vessel remodeling  (ISO)
bone development  (ISO)
bone mineralization involved in bone maturation  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
cardiac atrium development  (ISO)
cell activation  (ISO)
cell development  (ISO)
cell population proliferation  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to nicotine  (ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to Thyroglobulin triiodothyronine  (ISO)
chondroitin sulfate proteoglycan biosynthetic process  (ISO)
circadian rhythm  (ISO)
cranial suture morphogenesis  (ISO)
detection of mechanical stimulus involved in sensory perception  (ISO)
ERK1 and ERK2 cascade  (ISO)
exocrine pancreas development  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
female pregnancy  (ISO)
glial cell differentiation  (ISO)
inner ear development  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lung lobe morphogenesis  (ISO)
lung vasculature development  (ISO)
mammary gland development  (ISO)
memory  (ISO)
multicellular organism growth  (ISO)
muscle hypertrophy  (ISO)
myoblast differentiation  (ISO)
myoblast proliferation  (ISO)
myotube cell development  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of immune system process  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of neuroinflammatory response  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of oligodendrocyte apoptotic process  (ISO)
negative regulation of oocyte development  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
nervous system development  (ISO)
osteoblast differentiation  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
phosphatidylinositol-mediated signaling  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of calcineurin-NFAT signaling cascade  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of myelination  (ISO)
positive regulation of myoblast proliferation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of steroid hormone biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription regulatory region DNA binding  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of trophectodermal cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (ISO)
prostate gland epithelium morphogenesis  (ISO)
prostate gland growth  (ISO)
prostate gland stromal morphogenesis  (ISO)
protein kinase B signaling  (ISO)
protein stabilization  (ISO)
proteoglycan biosynthetic process  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cell population proliferation  (ISO)
regulation of establishment or maintenance of cell polarity  (ISO)
regulation of gene expression  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of protein metabolic process  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of translation  (ISO)
response to activity  (ISO)
response to caffeine  (ISO)
response to epidermal growth factor  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to growth hormone  (ISO)
response to heat  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to starvation  (ISO)
response to steroid hormone  (ISO)
response to thyroid hormone  (ISO)
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  (ISO)
type I pneumocyte differentiation  (ISO)
type II pneumocyte differentiation  (ISO)
water homeostasis  (ISO)
wound healing  (ISO)

References

Genomics

Comparative Map Data
Igf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494518,699,022 - 18,773,635 (+)NCBI
SpeTri2.0NW_00493649211,709,623 - 11,784,028 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12102,395,874 - 102,481,744 (-)EnsemblGRCh38hg38GRCh38
GRCh3812102,395,860 - 102,481,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712102,789,652 - 102,874,341 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612101,313,806 - 101,398,454 (-)NCBINCBI36hg18NCBI36
Build 3412101,292,143 - 101,376,791NCBI
Celera12102,453,601 - 102,538,345 (-)NCBI
Cytogenetic Map12q23.2NCBI
HuRef1299,849,028 - 99,933,911 (-)NCBIHuRef
CHM1_112102,756,305 - 102,841,104 (-)NCBICHM1_1
Igf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391087,694,127 - 87,772,909 (+)NCBIGRCm39mm39
GRCm39 Ensembl1087,694,127 - 87,772,904 (+)Ensembl
GRCm381087,858,265 - 87,937,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1087,858,265 - 87,937,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv371087,321,801 - 87,399,792 (+)NCBIGRCm37mm9NCBIm37
MGSCv361087,289,200 - 87,361,600 (+)NCBImm8
Celera1089,837,923 - 89,916,340 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.7NCBI
Igf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2722,282,895 - 22,361,972 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl722,282,930 - 22,359,296 (+)Ensembl
Rnor_6.0728,412,123 - 28,491,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,412,198 - 28,486,609 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,528,165 - 28,607,747 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,531,669 - 24,605,742 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1724,553,367 - 24,625,089 (+)NCBI
Celera719,453,213 - 19,527,075 (+)NCBICelera
RH 3.4 Map7118.8RGD
RH 3.4 Map7116.9RGD
Cytogenetic Map7q13NCBI
Igf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540537,512,201 - 37,582,152 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540537,505,830 - 37,582,152 (-)NCBIChiLan1.0ChiLan1.0
IGF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112103,385,911 - 103,463,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12103,385,911 - 103,462,177 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01299,986,887 - 100,066,773 (-)NCBIMhudiblu_PPA_v0panPan3
IGF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11541,203,320 - 41,275,964 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1541,202,518 - 41,275,794 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1541,571,399 - 41,643,792 (-)NCBI
ROS_Cfam_1.01541,855,737 - 41,930,681 (-)NCBI
UMICH_Zoey_3.11541,124,961 - 41,197,284 (-)NCBI
UNSW_CanFamBas_1.01541,221,486 - 41,300,498 (-)NCBI
UU_Cfam_GSD_1.01541,495,479 - 41,567,874 (-)NCBI
IGF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl581,775,970 - 81,848,037 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1581,762,027 - 81,909,253 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2585,700,439 - 85,773,714 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IGF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11197,624,498 - 97,708,730 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1197,631,189 - 97,707,308 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037147,296,425 - 147,379,600 (+)NCBIVero_WHO_p1.0
Igf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247505,881,065 - 5,954,799 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005322352   ⟹   XP_005322409
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494518,701,095 - 18,773,635 (+)NCBI
SpeTri2.0NW_00493649211,710,856 - 11,784,028 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005322353   ⟹   XP_005322410
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494518,699,034 - 18,773,635 (+)NCBI
SpeTri2.0NW_00493649211,709,623 - 11,784,028 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040279238   ⟹   XP_040135172
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494518,701,068 - 18,773,635 (+)NCBI
RefSeq Acc Id: XM_040279244   ⟹   XP_040135178
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494518,699,022 - 18,773,635 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005322410   ⟸   XM_005322353
- Peptide Label: isoform X4
- UniProtKB: A0A287CZX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005322409   ⟸   XM_005322352
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040135178   ⟸   XM_040279244
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040135172   ⟸   XM_040279238
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000015842 ENTREZGENE
Ensembl Protein ENSSTOP00000026895 ENTREZGENE
  ENSSTOP00000029785 ENTREZGENE
NCBI Gene Igf1 ENTREZGENE
UniProt A0A287CZX8 ENTREZGENE