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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:379896
Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Chemical ID: MESH:D015741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1increases expressionISOIGF1 (Homo sapiens)6480464CTDMetribolone results in increased expression of IGF1 mRNAPMID:25682698
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTD[Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] results in decreased expression of IGF1 mRNA; DDT affects the reaction [Metribolone results in increased expression of IGF1 mRNA]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in increased expression of IGF1 mRNA]PMID:25682698 PMID:26709203
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