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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:27641
Term: cycloheximide
Definition: A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.
Chemical ID: MESH:D003513
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1multiple interactionsISOIgf1 (Mus musculus)6480464CTDCycloheximide inhibits the reaction [IGF1 protein affects the metabolism of 1,2-diacylglycerol]PMID:2120207
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTDIGF1 protein inhibits the reaction [Cycloheximide results in decreased expression of CDKN1A protein]PMID:26687534
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