RGD Reference Report - Association of insulin-like growth factor-1 polymorphisms with high myopia in the Chinese population. - Rat Genome Database

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Association of insulin-like growth factor-1 polymorphisms with high myopia in the Chinese population.

Authors: Zhuang, W  Yang, P  Li, Z  Sheng, X  Zhao, J  Li, S  Yang, X  Xiang, W  Rong, W  Liu, Y  Zhang, F 
Citation: Zhuang W, etal., Mol Vis. 2012;18:634-44. Epub 2012 Mar 13.
RGD ID: 8548838
Pubmed: PMID:22509095   (View Abstract at PubMed)
PMCID: PMC3324364   (View Article at PubMed Central)

PURPOSE: The purpose of this study was to determine whether genetic variants in the insulin-like growth factor-1 (IGF-1) gene were associated with high myopia in the Chinese population. METHODS: A case-control association study of 421 unrelated Chinese patients with high myopia and 401 control subjects matched in ethnicity and gender was undertaken. Genomic DNA was prepared from peripheral blood. All individuals were genotyped for 7 tag single nucleotide polymorphisms (tSNPs) across the IGF-1 gene region. Genotypic distribution was tested for Hardy-Weinberg equilibrium. The genotype and allele frequencies were evaluated using the chi(2) tests. Bonferroni corrections for multiple comparisons were performed. RESULTS: The polymorphism of rs12423791 showed positive association with extreme myopia (p(allel)=0.006 and p(allel1 recessive model)=0.004, respectively) after Bonferroni correction for multiple testing and the haplotype GC of rs5742629-rs12423791 was also associated with extreme myopia (p=0.033) after 50,000 permutations for multiple comparisons. CONCLUSIONS: The polymorphism of rs12423791 in IGF-1 may be associated with extreme myopia in the Chinese population and should be investigated further.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IGF1Humanmyopia susceptibilityIAGP DNA:SNP more ...RGD 
Igf1Ratmyopia susceptibilityISOIGF1 (Homo sapiens)DNA:SNP more ...RGD 
Igf1Mousemyopia susceptibilityISOIGF1 (Homo sapiens)DNA:SNP more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1  (insulin-like growth factor 1)

Genes (Mus musculus)
Igf1  (insulin-like growth factor 1)

Genes (Homo sapiens)
IGF1  (insulin like growth factor 1)


Additional Information