IGF1 (insulin like growth factor 1) - Rat Genome Database

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Gene: IGF1 (insulin like growth factor 1) Homo sapiens
Symbol: IGF1
Name: insulin like growth factor 1
RGD ID: 70506
HGNC Page HGNC:5464
Description: Enables signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within cell activation. Located in extracellular space. Part of alphav-beta3 integrin-IGF-1-IGF1R complex and insulin-like growth factor ternary complex. Implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Biomarker of several diseases, including Henoch-Schoenlein purpura; artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); and eye disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: IGF; IGF-I; IGF-IA; IGF-IB; IGF1A; IGFI; insulin-like growth factor 1; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; mechano growth factor; MGF; somatomedin-C
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BW58_H   BW104_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3812102,395,874 - 102,481,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12102,395,874 - 102,481,744 (-)EnsemblGRCh38hg38GRCh38
GRCh3712102,789,652 - 102,874,341 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612101,313,806 - 101,398,454 (-)NCBINCBI36hg18NCBI36
Build 3412101,292,143 - 101,376,791NCBI
Celera12102,453,601 - 102,538,345 (-)NCBI
Cytogenetic Map12q23.2NCBI
HuRef1299,849,028 - 99,933,911 (-)NCBIHuRef
CHM1_112102,756,305 - 102,841,104 (-)NCBICHM1_1
T2T-CHM13v2.012102,357,015 - 102,441,796 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acne  (IDA,IEP)
acoustic neuroma  (IEP)
acromegaly  (EXP)
acute kidney failure  (EXP)
adenoma  (EXP)
Albuminuria  (IAGP)
alcoholic neuropathy  (ISO)
alopecia  (IEP)
Alzheimer's disease  (EXP,IAGP,IDA,IEP,ISO)
arteriosclerosis  (IEP)
autistic disorder  (EXP)
Brain Injuries  (IDA)
brain ischemia  (IMP,ISO)
breast cancer  (ISO)
Breast Neoplasms  (EXP)
Burns  (ISO)
Cachexia  (EXP)
Cardiomegaly  (EXP)
carotid artery disease  (IEP)
Carotid Artery Injuries  (ISO)
Chemical and Drug Induced Liver Injury  (EXP)
cholestasis  (EXP,ISO)
Cockayne syndrome  (ISO)
colitis  (EXP)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (IEP)
congenital hypothyroidism  (ISO)
congestive heart failure  (ISO)
corneal disease  (EXP)
Coronary Disease  (IDA)
coronary stenosis  (ISO)
Crohn's disease  (EXP)
cystic fibrosis  (IEP)
Deafness  (ISO)
demyelinating disease  (EXP)
diabetes mellitus  (IEP)
Diabetic Cardiomyopathies  (EXP)
Diabetic Foot  (IEP)
Diabetic Nephropathies  (IEP,ISO)
diabetic neuropathy  (IEP,ISO)
diabetic retinopathy  (IAGP,IEP)
Diaphragmatic Hernia  (EXP)
dilated cardiomyopathy  (IDA)
Drug-Related Side Effects and Adverse Reactions  (EXP)
Dwarfism  (IMP,ISO)
end stage renal disease  (EXP)
endometriosis  (EXP)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Liver Cirrhosis  (EXP,IDA,ISO)
familial Mediterranean fever  (IEP)
Female Urogenital Diseases  (EXP)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (IDA,ISO)
Fetal Macrosomia  (IEP)
folic acid deficiency anemia  (ISO)
granulomatosis with polyangiitis  (IEP)
Graves ophthalmopathy  (IEP)
Graves' disease  (IEP)
Growth Disorders  (IAGP)
head and neck squamous cell carcinoma  (EXP)
Head Injuries, Closed  (IEP)
Hearing Loss, Noise-Induced  (IEP)
Henoch-Schoenlein purpura  (IEP)
hepatocellular carcinoma  (EXP)
high grade glioma  (IEP)
Huntington's disease  (IDA,ISO)
Hyperalgesia  (EXP)
Hyperoxia  (IDA)
Hyperphagia  (ISO)
hypertension  (EXP,IEP,ISO)
hypertrophic cardiomyopathy  (IEP)
hypothyroidism  (ISO)
Hypoxia-Ischemia, Brain  (IDA,ISO)
Insulin-Like Growth Factor I Deficiency  (IAGP)
intellectual disability  (IAGP)
Intervertebral Disc Displacement  (ISO)
kidney disease  (EXP)
Knee Osteoarthritis  (IEP,ISO)
Kuhnt-Junius degeneration  (IEP)
Laron syndrome  (IEP)
Malocclusion  (ISO)
Mammary Neoplasms, Experimental  (EXP,ISO)
Metabolic Bone Diseases  (EXP,IDA,ISO)
microcephaly  (IAGP,IMP)
middle cerebral artery infarction  (EXP)
muscular atrophy  (EXP)
myocardial infarction  (IAGP,ISO)
Myocardial Ischemia  (EXP,IEP,ISO)
myopia  (IAGP)
Nasal Polyps  (IEP)
Neointima  (IAGP)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (EXP,IEP)
Nerve Degeneration  (EXP)
non-alcoholic fatty liver disease  (ISO)
Noonan syndrome  (IEP,ISO)
osteoarthritis  (IEP)
Osteophytes  (ISO)
osteoporosis  (ISO)
Osteoporotic Fractures  (IAGP,IEP,ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (IAGP)
pancreatic ductal carcinoma  (ISO)
PEHO syndrome  (IEP)
peripheral nervous system disease  (EXP)
Pituitary Neoplasms  (EXP)
Plaque, Atherosclerotic  (IDA)
polycystic ovary syndrome  (IEP)
Postmenopausal Osteoporosis  (IEP)
Precocious Puberty  (EXP)
progeria  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (EXP,ISO)
psoriasis  (IEP)
pulmonary fibrosis  (EXP)
pycnodysostosis  (IEP)
Reperfusion Injury  (ISO)
retinopathy of prematurity  (IEP,ISO)
rheumatic heart disease  (IEP)
Rhinosinusitis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sarcopenia  (IEP)
severe acute respiratory syndrome  (IEP)
Skin Neoplasms  (EXP,IMP)
Skull Fractures  (IEP)
Spontaneous Abortions  (EXP)
Stroke  (IEP,ISO)
Sudden Hearing Loss  (IDA)
Thinness  (IEP)
Tongue Neoplasms  (IEP)
transient cerebral ischemia  (ISO)
Turner syndrome  (IEP)
type 1 diabetes mellitus  (EXP,IDA,IEP)
type 2 diabetes mellitus  (IDA,ISO)
urinary bladder cancer  (EXP)
uveal melanoma  (IEP)
vascular dementia  (IEP,ISO)
Wounds and Injuries  (ISO)
Zinc Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-anisomycin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylphenanthrene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-nitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-nitrophenol  (ISO)
4-tert-Octylphenol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-(methylamino)isobutyric acid  (ISO)
aluminium atom  (EXP)
aluminium oxide  (EXP)
aluminium sulfate (anhydrous)  (EXP)
aluminium(0)  (EXP)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
astemizole  (EXP)
azathioprine  (EXP)
baicalein  (EXP)
belinostat  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzoyl peroxide  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bezafibrate  (EXP)
bicalutamide  (EXP)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bosentan  (EXP)
bromobenzene  (ISO)
bromochloroacetic acid  (ISO)
bucladesine  (EXP)
buspirone  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (ISO)
calcitriol  (EXP)
calcium atom  (ISO)
calcium silicate  (ISO)
calcium(0)  (ISO)
Candesartan cilexetil  (ISO)
cannabidiolic acid  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
capsiate  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
cetrorelix  (EXP)
CGP 52608  (EXP)
chelerythrine  (ISO)
chlormequat chloride  (ISO)
chloroacetic acid  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium atom  (ISO)
chromium(3+) trichloride  (ISO)
chrysin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
clozapine  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
corticosterone  (ISO)
cortisol  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
cyproterone acetate  (EXP)
D-glucose  (EXP)
D-mannitol  (EXP)
D-penicillamine  (EXP)
dantrolene  (EXP)
deguelin  (EXP)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenziodolium  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
dicoumarol  (EXP)
dieldrin  (ISO)
dienogest  (EXP)
diethyl malate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dihydrocapsaicin  (ISO)
Dimethyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dobutamine  (ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
endosulfan  (ISO)
enzalutamide  (EXP)
epoxiconazole  (ISO)
estriol  (EXP)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
felbamate  (ISO)
fenarimol  (ISO)
fenvalerate  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flavonol  (EXP)
fluoranthene  (EXP)
flutamide  (EXP,ISO)
fluvastatin  (EXP)
folpet  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (ISO)
furazolidone  (EXP)
furosemide  (ISO)
gabapentin  (ISO)
gadolinium trichloride  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
ginsenoside Rb1  (ISO)
Ginsenoside Rh4  (ISO)
glucose  (EXP)
glutathione  (ISO)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
griseofulvin  (ISO)
heptachlor  (ISO)
herbicide  (ISO)
hexachlorobenzene  (EXP,ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
ibuprofen  (ISO)
icariin  (ISO)
indometacin  (EXP,ISO)
irinotecan  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isoflavones  (EXP,ISO)
isoflurane  (ISO)
isoprenaline  (ISO)
isotretinoin  (EXP)
L-ascorbic acid 2-phosphate  (EXP)
L-ethionine  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (ISO)
leuprolide  (EXP)
levonorgestrel  (EXP)
lidocaine  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lornoxicam  (ISO)
lovastatin  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
maleic acid  (EXP)
maneb  (ISO)
manganese(II) chloride  (ISO)
masoprocol  (EXP)
melatonin  (ISO)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
metformin  (EXP,ISO)
methimazole  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (EXP)
mifepristone  (EXP,ISO)
MK-2206  (ISO)
monodansylcadaverine  (EXP)
monosodium L-glutamate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
nifedipine  (EXP)
nimesulide  (ISO)
nitrofen  (ISO)
nitroprusside  (EXP,ISO)
nonivamide  (ISO)
Nordihydrocapsaicin  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (ISO)
octreotide  (EXP)
okadaic acid  (ISO)
omeprazole  (ISO)
Osajin  (EXP)
oxaliplatin  (ISO)
p-menthan-3-ol  (EXP)
p-tert-Amylphenol  (ISO)
para-Cresidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pendimethalin  (ISO)
pentane-2,3-dione  (ISO)
pentetic acid  (ISO)
pentetrazol  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
picolinic acid  (ISO)
picropodophyllotoxin  (ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
polaprezinc  (EXP)
poly(I:C)  (ISO)
Pomiferin  (EXP)
potassium atom  (ISO)
potassium chloride  (ISO)
potassium dichromate  (ISO)
prazosin  (ISO)
prednisolone  (EXP)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
Ptaquiloside  (ISO)
puerarin  (EXP,ISO)
quercetin  (EXP,ISO)
quinidine  (EXP)
raloxifene  (EXP,ISO)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rivastigmine  (ISO)
Rosavin  (EXP)
rotenone  (EXP,ISO)
ruthenium red  (EXP)
rutin  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
shikimic acid  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Sodium salicylate  (ISO)
sophoraflavanone B  (ISO)
sorafenib  (EXP)
sphingosine 1-phosphate  (EXP)
staurosporine  (ISO)
streptozocin  (ISO)
succimer  (ISO)
superoxide  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetradecane  (ISO)
tetramethrin  (ISO)
tetrathiomolybdate(2-)  (EXP)
thalidomide  (EXP)
thimerosal  (EXP,ISO)
thioacetamide  (ISO)
thymidine  (EXP)
thyroxine  (ISO)
Tiron  (EXP)
titanium dioxide  (ISO)
topiramate  (ISO)
topotecan  (ISO)
tremolite asbestos  (ISO)
triadimefon  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trilostane  (EXP)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP)
undecane  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
wortmannin  (EXP,ISO)
zearalenone  (EXP)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (IMP)
aging  (ISO)
androgen receptor signaling pathway  (ISO)
blood vessel remodeling  (ISO)
bone development  (ISO)
bone mineralization involved in bone maturation  (IDA)
branching morphogenesis of an epithelial tube  (ISO)
cardiac atrium development  (ISO)
cell activation  (IDA)
cell development  (ISO)
cell population proliferation  (IBA,IMP,ISO)
cellular response to amyloid-beta  (IGI)
cellular response to dexamethasone stimulus  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to nicotine  (ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to Thyroglobulin triiodothyronine  (ISO)
cellular response to zinc ion starvation  (ISO)
cerebellar granule cell precursor proliferation  (ISO)
chondroitin sulfate proteoglycan biosynthetic process  (ISO)
circadian rhythm  (ISO)
cranial suture morphogenesis  (ISO)
detection of mechanical stimulus involved in sensory perception  (ISO)
epithelial to mesenchymal transition  (NAS)
ERK1 and ERK2 cascade  (IMP)
exocrine pancreas development  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
female pregnancy  (ISO)
glial cell differentiation  (ISO)
glycolate metabolic process  (TAS)
inner ear development  (ISO)
insulin-like growth factor receptor signaling pathway  (IBA,IMP,ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lung lobe morphogenesis  (ISO)
lung vasculature development  (ISO)
mammary gland development  (ISO)
memory  (ISO)
multicellular organism growth  (ISO)
muscle hypertrophy  (IMP)
muscle organ development  (TAS)
myoblast differentiation  (IDA)
myoblast proliferation  (IDA)
myotube cell development  (IDA)
negative regulation of amyloid-beta formation  (IGI)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (IBA,IMP,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IDA)
negative regulation of gene expression  (IDA)
negative regulation of immune system process  (ISO)
negative regulation of interleukin-1 beta production  (IGI)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of neuroinflammatory response  (IGI)
negative regulation of neuron death  (ISO)
negative regulation of oligodendrocyte apoptotic process  (ISO)
negative regulation of oocyte development  (IMP)
negative regulation of peptidyl-tyrosine phosphorylation  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISS)
negative regulation of smooth muscle cell apoptotic process  (IDA)
negative regulation of tumor necrosis factor production  (IGI)
negative regulation of vascular associated smooth muscle cell apoptotic process  (IMP)
nervous system development  (ISO)
osteoblast differentiation  (ISO)
phosphatidylinositol 3-kinase signaling  (IMP,ISO)
phosphatidylinositol-mediated signaling  (IDA)
positive regulation of activated T cell proliferation  (IDA)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of calcineurin-NFAT signaling cascade  (IDA)
positive regulation of cardiac muscle hypertrophy  (IDA,IMP)
positive regulation of cell growth  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IDA,IGI)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IBA,IDA,IMP)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA binding  (IDA)
positive regulation of DNA-templated transcription  (IDA,IMP)
positive regulation of epithelial cell proliferation  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of fat cell differentiation  (ISO)
positive regulation of fibroblast proliferation  (IDA)
positive regulation of gene expression  (IGI)
positive regulation of glial cell proliferation  (ISO)
positive regulation of glucose import  (IDA)
positive regulation of glycogen biosynthetic process  (IDA)
positive regulation of glycolytic process  (IDA)
positive regulation of glycoprotein biosynthetic process  (IMP)
positive regulation of insulin-like growth factor receptor signaling pathway  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of mitotic nuclear division  (IDA)
positive regulation of myelination  (ISO)
positive regulation of myoblast proliferation  (ISO)
positive regulation of osteoblast differentiation  (IDA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IBA,IDA,ISO)
positive regulation of protein kinase B signaling  (ISO,NAS)
positive regulation of protein secretion  (IMP)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of Ras protein signal transduction  (IDA)
positive regulation of smooth muscle cell migration  (IDA)
positive regulation of smooth muscle cell proliferation  (IDA)
positive regulation of steroid hormone biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription regulatory region DNA binding  (IDA)
positive regulation of trophectodermal cell proliferation  (IMP)
positive regulation of type B pancreatic cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
positive regulation of vascular endothelial cell proliferation  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (ISO)
prostate gland epithelium morphogenesis  (ISO)
prostate gland growth  (ISO)
prostate gland stromal morphogenesis  (ISO)
protein kinase B signaling  (IMP)
protein stabilization  (IMP)
proteoglycan biosynthetic process  (IDA,IMP)
Ras protein signal transduction  (TAS)
regulation of calcium ion transport  (ISO)
regulation of cell population proliferation  (ISO)
regulation of establishment or maintenance of cell polarity  (ISO)
regulation of gene expression  (IMP)
regulation of multicellular organism growth  (IEP)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of protein metabolic process  (ISO)
regulation of protein phosphorylation  (IBA,ISO)
regulation of translation  (ISO)
response to activity  (ISO)
response to caffeine  (ISO)
response to epidermal growth factor  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to growth hormone  (ISO)
response to heat  (IDA)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to starvation  (ISO)
response to steroid hormone  (ISO)
response to thyroid hormone  (ISO)
signal transduction  (IEA,TAS)
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  (IDA)
skeletal system development  (TAS)
type B pancreatic cell proliferation  (ISO)
type I pneumocyte differentiation  (ISO)
type II pneumocyte differentiation  (ISO)
water homeostasis  (ISO)
wound healing  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal facial shape  (IAGP)
Abnormality of femur morphology  (IAGP)
Abnormality of metabolism/homeostasis  (IAGP)
Aortic stiffness  (IAGP)
Attention deficit hyperactivity disorder  (IAGP)
Autosomal recessive inheritance  (IAGP)
Bilateral sensorineural hearing impairment  (IAGP)
Cafe-au-lait spot  (IAGP)
Clinodactyly  (IAGP)
Clinodactyly of the 5th finger  (IAGP)
Concave nasal ridge  (IAGP)
Congenital bilateral ptosis  (IAGP)
Congenital onset  (IAGP)
Congenital sensorineural hearing impairment  (IAGP)
Decreased body weight  (IAGP)
Delayed eruption of teeth  (IAGP)
Delayed skeletal maturation  (IAGP)
Failure to thrive  (IAGP)
Hyperactivity  (IAGP)
Hypoglycemia  (IAGP)
Hypogonadism  (IAGP)
Increased susceptibility to fractures  (IAGP)
Insulin resistance  (IAGP)
Intellectual disability  (IAGP)
Intellectual disability, mild  (IAGP)
Intrauterine growth retardation  (IAGP)
Low anterior hairline  (IAGP)
Low posterior hairline  (IAGP)
Microcephaly  (IAGP)
Micrognathia  (IAGP)
Motor delay  (IAGP)
Myopia  (IAGP)
Neonatal hyperbilirubinemia  (IAGP)
Osteopenia  (IAGP)
Osteoporosis  (IAGP)
Prelingual sensorineural hearing impairment  (IAGP)
Prominent forehead  (IAGP)
Ptosis  (IAGP)
Radial deviation of finger  (IAGP)
Reduced bone mineral density  (IAGP)
Sensorineural hearing impairment  (IAGP)
Severe intrauterine growth retardation  (IAGP)
Severe postnatal growth retardation  (IAGP)
Short attention span  (IAGP)
Short stature  (IAGP)
Single transverse palmar crease  (IAGP)
Small for gestational age  (IAGP)
Small placenta  (IAGP)
Truncal obesity  (IAGP)

References - curated
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42. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
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