Igf1 (insulin-like growth factor 1) - Rat Genome Database

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Gene: Igf1 (insulin-like growth factor 1) Mus musculus
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Symbol: Igf1
Name: insulin-like growth factor 1
RGD ID: 10765
MGI Page MGI
Description: Exhibits insulin receptor binding activity and insulin-like growth factor receptor binding activity. Involved in several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Localizes to exocytic vesicle and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including acne; artery disease (multiple); diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C730016P09Rik; Igf; Igf-; Igf-1; Igf-I; insulin-like growth factor I; somatomedin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391087,694,127 - 87,772,909 (+)NCBIGRCm39mm39
GRCm39 Ensembl1087,694,127 - 87,772,904 (+)Ensembl
GRCm381087,858,265 - 87,937,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1087,858,265 - 87,937,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv371087,321,801 - 87,399,792 (+)NCBIGRCm37mm9NCBIm37
MGSCv361087,289,200 - 87,361,600 (+)NCBImm8
Celera1089,837,923 - 89,916,340 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acne  (ISO)
acoustic neuroma  (ISO)
acromegaly  (ISO)
acute kidney failure  (ISO)
adenoma  (ISO)
Albuminuria  (ISO)
alcoholic neuropathy  (ISO)
alopecia  (ISO)
Alzheimer's disease  (IEP,ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cachexia  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Cockayne syndrome  (IEP)
colitis  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (ISO)
congenital hypothyroidism  (ISO)
congestive heart failure  (ISO)
corneal disease  (ISO)
Coronary Disease  (ISO)
coronary stenosis  (ISO)
Crohn's disease  (ISO)
cystic fibrosis  (ISO)
Deafness  (IMP)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (IDA,ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Dwarfism  (ISO)
end stage renal disease  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
familial Mediterranean fever  (ISO)
Female Urogenital Diseases  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fetal Macrosomia  (ISO)
folic acid deficiency anemia  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
Head Injuries, Closed  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Huntington's disease  (IDA,IEP,ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
Hyperphagia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypothyroidism  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Insulin-Like Growth Factor I Deficiency  (ISO)
intellectual disability  (ISO)
Intervertebral Disc Displacement  (ISO)
kidney disease  (ISO)
Knee Osteoarthritis  (IEP,ISO)
Kuhnt-Junius degeneration  (ISO)
Laron syndrome  (ISO)
Malocclusion  (ISO)
Mammary Neoplasms, Experimental  (IDA,ISO)
Metabolic Bone Diseases  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
myopia  (ISO)
Nasal Polyps  (ISO)
Neointima  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
non-alcoholic fatty liver disease  (ISO)
Noonan syndrome  (IEP,ISO)
osteoarthritis  (ISO)
Osteophytes  (ISO)
osteoporosis  (IEP,ISO)
Osteoporotic Fractures  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (IDA)
PEHO syndrome  (ISO)
peripheral nervous system disease  (ISO)
Pituitary Neoplasms  (ISO)
Plaque, Atherosclerotic  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
Precocious Puberty  (ISO)
progeria  (IEP)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pycnodysostosis  (ISO)
Reperfusion Injury  (IEP)
retinopathy of prematurity  (ISO)
rheumatic heart disease  (ISO)
Rhinosinusitis  (IEP)
Right Ventricular Hypertrophy  (ISO)
Sarcopenia  (ISO)
severe acute respiratory syndrome  (ISO)
Skin Neoplasms  (ISO)
Skull Fractures  (ISO)
Spontaneous Abortions  (ISO)
Stroke  (ISO)
Sudden Hearing Loss  (ISO)
Thinness  (ISO)
Tongue Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
vascular dementia  (ISO)
Wounds and Injuries  (IEP,ISO)
Zinc Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-methylphenanthrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2-nitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-tert-Octylphenol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-(methylamino)isobutyric acid  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (ISO)
amino acid  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
anandamide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
astemizole  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzoyl peroxide  (EXP)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
bosentan  (ISO)
bromobenzene  (ISO)
bromochloroacetic acid  (ISO)
bucladesine  (ISO)
buspirone  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcidiol  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Candesartan cilexetil  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
capsiate  (EXP)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
cetrorelix  (ISO)
chelerythrine  (ISO)
chlormequat chloride  (ISO)
chloroacetic acid  (EXP)
chlorohydrocarbon  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cholesterol  (ISO)
chromium atom  (ISO)
chromium(3+) trichloride  (EXP,ISO)
chrysin  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clozapine  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP)
corticosterone  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cyproconazole  (EXP)
cyproterone acetate  (ISO)
D-glucose  (ISO)
D-mannitol  (ISO)
D-penicillamine  (ISO)
dantrolene  (ISO)
DDE  (ISO)
DDT  (ISO)
Deguelin  (ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
dicoumarol  (ISO)
dieldrin  (ISO)
dienogest  (ISO)
diethyl malate  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydrocapsaicin  (EXP)
Dimethyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (ISO)
disodium selenite  (EXP)
diuron  (ISO)
dobutamine  (ISO)
doxorubicin  (EXP,ISO)
enalapril  (ISO)
endosulfan  (ISO)
enzalutamide  (ISO)
epoxiconazole  (EXP)
estriol  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
felbamate  (ISO)
fenarimol  (ISO)
fenvalerate  (EXP)
fipronil  (ISO)
flavonoids  (ISO)
flavonol  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
fluvastatin  (ISO)
folpet  (EXP)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
furazolidone  (ISO)
furosemide  (ISO)
gabapentin  (ISO)
gadolinium trichloride  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
ginsenoside Rb1  (ISO)
glucose  (ISO)
glutathione  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (EXP)
heptachlor  (ISO)
herbicide  (ISO)
hexachlorobenzene  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
icariin  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflavones  (EXP,ISO)
isoflurane  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP)
leuprolide  (ISO)
levonorgestrel  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
lornoxicam  (ISO)
lovastatin  (EXP)
LY294002  (EXP,ISO)
lycopene  (ISO)
maleic acid  (ISO)
maneb  (EXP)
manganese(II) chloride  (ISO)
masoprocol  (ISO)
melatonin  (EXP)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methimazole  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP)
naringin  (EXP,ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nifedipine  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
nitroprusside  (ISO)
nonivamide  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
octreotide  (ISO)
okadaic acid  (EXP)
omeprazole  (ISO)
Osajin  (ISO)
oxaliplatin  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
para-Cresidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
pendimethalin  (ISO)
pentane-2,3-dione  (ISO)
pentetic acid  (ISO)
pentetrazol  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidylcholine  (EXP)
picolinic acid  (ISO)
picropodophyllotoxin  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
polaprezinc  (ISO)
poly(I:C)  (EXP)
Pomiferin  (ISO)
potassium atom  (ISO)
potassium chloride  (ISO)
potassium dichromate  (ISO)
prazosin  (ISO)
prednisolone  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
propiconazole  (EXP)
Ptaquiloside  (EXP)
puerarin  (EXP,ISO)
quercetin  (EXP,ISO)
quinidine  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
rivastigmine  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
ruthenium red  (ISO)
rutin  (ISO)
SB 203580  (EXP)
serpentine asbestos  (EXP)
shikimic acid  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
Sodium salicylate  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
superoxide  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (ISO)
tetramethrin  (EXP)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thimerosal  (EXP,ISO)
thioacetamide  (ISO)
thymidine  (ISO)
thyroxine  (EXP)
Tiron  (ISO)
titanium dioxide  (EXP)
topiramate  (ISO)
topotecan  (ISO)
tremolite asbestos  (EXP)
trichostatin A  (EXP)
triclosan  (ISO)
trilostane  (ISO)
trimethyltin  (EXP)
triphenyl phosphate  (EXP)
triphenylstannane  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
wortmannin  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
aging  (ISO)
blood vessel remodeling  (IGI,IMP)
bone development  (ISO)
bone mineralization involved in bone maturation  (ISO)
branching morphogenesis of an epithelial tube  (IMP)
cardiac atrium development  (ISO)
cell activation  (ISO)
cell development  (IMP)
cell population proliferation  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to glucose stimulus  (IDA)
cellular response to insulin stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (IMP)
cellular response to nicotine  (ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to Thyroglobulin triiodothyronine  (ISO)
chondroitin sulfate proteoglycan biosynthetic process  (IDA)
circadian rhythm  (IEP)
cranial suture morphogenesis  (ISO)
detection of mechanical stimulus involved in sensory perception  (ISO)
ERK1 and ERK2 cascade  (ISO)
exocrine pancreas development  (IMP)
extrinsic apoptotic signaling pathway in absence of ligand  (IDA)
female pregnancy  (ISO)
glial cell differentiation  (IMP)
inner ear development  (IDA)
insulin-like growth factor receptor signaling pathway  (IDA,ISO)
lung alveolus development  (IGI,IMP)
lung development  (IGI)
lung lobe morphogenesis  (IGI,IMP)
lung vasculature development  (IGI,IMP)
mammary gland development  (IMP)
memory  (ISO)
multicellular organism growth  (IDA)
muscle hypertrophy  (ISO)
myoblast differentiation  (ISO)
myoblast proliferation  (ISO)
myotube cell development  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of androgen receptor signaling pathway  (IMP)
negative regulation of apoptotic process  (IDA,ISO)
negative regulation of cell population proliferation  (IGI,IMP)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of ERK1 and ERK2 cascade  (IGI)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of gene expression  (IDA,ISO)
negative regulation of immune system process  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of neuroinflammatory response  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of oligodendrocyte apoptotic process  (ISO)
negative regulation of oocyte development  (ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (IMP)
negative regulation of release of cytochrome c from mitochondria  (IDA)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
nervous system development  (IMP)
obsolete activation of MAPK activity  (ISO)
osteoblast differentiation  (IEP)
phosphatidylinositol 3-kinase signaling  (ISO)
phosphatidylinositol-mediated signaling  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of calcineurin-NFAT signaling cascade  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IGI,ISO)
positive regulation of cerebellar granule cell precursor proliferation  (IDA)
positive regulation of DNA binding  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of glycogen biosynthetic process  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of myelination  (IDA)
positive regulation of myoblast proliferation  (IMP)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IDA,ISO)
positive regulation of protein kinase B signaling  (IDA)
positive regulation of protein secretion  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of steroid hormone biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transcription regulatory region DNA binding  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of trophectodermal cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (IMP)
prostate gland epithelium morphogenesis  (IMP)
prostate gland growth  (IDA,IMP)
prostate gland stromal morphogenesis  (IMP)
protein kinase B signaling  (ISO)
protein stabilization  (ISO)
proteoglycan biosynthetic process  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cell population proliferation  (ISO)
regulation of establishment or maintenance of cell polarity  (IDA)
regulation of gene expression  (ISO)
regulation of intracellular steroid hormone receptor signaling pathway  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of nitric oxide biosynthetic process  (IMP)
regulation of protein metabolic process  (IGI)
regulation of protein phosphorylation  (IDA)
regulation of translation  (ISO)
response to activity  (ISO)
response to caffeine  (ISO)
response to epidermal growth factor  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to growth hormone  (ISO)
response to heat  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to starvation  (ISO)
response to steroid hormone  (ISO)
response to thyroid hormone  (ISO)
sensory perception of smell  (TAS)
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  (ISO)
type I pneumocyte differentiation  (IMP)
type II pneumocyte differentiation  (IMP)
water homeostasis  (IGI)
wound healing  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response waveform shape  (IAGP)
abnormal body size  (IAGP)
abnormal brain morphology  (IAGP)
abnormal branching of the mammary ductal tree  (IAGP)
abnormal cerebellar Purkinje cell layer  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear ganglion morphology  (IAGP)
abnormal cochlear nerve morphology  (IAGP)
abnormal corpus luteum morphology  (IAGP)
abnormal embryonic growth/weight/body size  (IAGP)
abnormal endometrial gland development  (IAGP)
abnormal endometrium morphology  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal femur morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal insulin-like growth factor I level  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal mature ovarian follicle morphology  (IAGP)
abnormal mitral cell morphology  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal olfactory bulb external plexiform layer morphology  (IAGP)
abnormal olfactory bulb layer morphology  (IAGP)
abnormal olfactory bulb mitral cell layer morphology  (IAGP)
abnormal otic capsule morphology  (IAGP)
abnormal postnatal growth/weight/body size  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal respiratory system morphology  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal superovulation  (IAGP)
abnormal tectorial membrane morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal white fat cell morphology  (IAGP)
absent type I pneumocytes  (IAGP)
atelectasis  (IAGP)
cochlear ganglion degeneration  (IAGP)
decreased birth body size  (IAGP)
decreased birth weight  (IAGP)
decreased body length  (IAGP)
decreased body mass index  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating growth hormone level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased diameter of femur  (IAGP)
decreased endometrial gland number  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased kidney weight  (IAGP)
decreased litter size  (IAGP)
decreased long bone epiphyseal plate size  (IAGP)
decreased motor neuron number  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased survivor rate  (IAGP)
decreased total body fat amount  (IAGP)
decreased tumor growth/size  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed bone ossification  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed inner ear development  (IAGP)
disproportionate dwarf  (IAGP)
endometrium hypoplasia  (IAGP)
fetal growth retardation  (IAGP)
fragile skeleton  (IAGP)
increased body length  (IAGP)
increased circulating growth hormone level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating insulin-like growth factor I level  (IAGP)
increased circulating leptin level  (IAGP)
increased growth hormone level  (IAGP)
increased neuron apoptosis  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased spleen weight  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased type II pneumocyte number  (IAGP)
increased urine potassium level  (IAGP)
increased urine sodium level  (IAGP)
increased ventricle muscle contractility  (IAGP)
infertility  (IAGP)
insensitivity to growth hormone  (IAGP)
maternal imprinting  (IAGP)
muscle hypoplasia  (IAGP)
myometrium hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ovary hypoplasia  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
primary atelectasis  (IAGP)
prolonged diestrus  (IAGP)
prolonged proestrus  (IAGP)
proportional dwarf  (IAGP)
reduced female fertility  (IAGP)
respiratory failure  (IAGP)
sensorineural hearing loss  (IAGP)
short estrus  (IAGP)
short femur  (IAGP)
slow postnatal weight gain  (IAGP)
small cochlear ganglion  (IAGP)
syndromic hearing loss  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thin epidermis  (IAGP)
thin epidermis stratum spinosum  (IAGP)
underdeveloped hair follicles  (IAGP)
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