RGD Reference Report - Independent alterations in the central and peripheral somatosensory pathways in rat diabetic neuropathy. - Rat Genome Database

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Independent alterations in the central and peripheral somatosensory pathways in rat diabetic neuropathy.

Authors: Piriz, J  Torres-Aleman, I  Nunez, A 
Citation: Piriz J, etal., Neuroscience. 2009 May 5;160(2):402-11. Epub 2009 Mar 3.
RGD ID: 2306687
Pubmed: PMID:19264110   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuroscience.2009.02.047   (Journal Full-text)

Peripheral and central diabetic neuropathies were studied in streptozotocin-diabetic rats, using behavioral, biochemical and electrophysiological techniques. Diabetic rats showed thermal hypoalgesia and decreasing motor nerve conduction velocity at 4 and 8 weeks of diabetes. In addition, amplitude of the evoked potential recorded in primary somatosensory cortex after stimulation of the sciatic nerve was markedly reduced at 8 weeks of diabetes. This decrease was accompanied by decreases in GluR2/3 AMPA receptor subunits. These changes seem to be specific to the somatosensory system and to originate in higher centers since they were not present in the hippocampus and were not observed at the level of gracilis nucleus. Insulin-like growth factor I (IGF-I) treatment reversed the reduced thermal sensitivity and peripheral nerve conduction velocity but did not reverse changes in the CNS, suggesting that once initiated, both anomalies may develop independently in this model of diabetic neuropathy. In conclusion, the results indicate that diabetes induces a wide spectrum of alterations in the central somatosensory system that are independent of the decreases in peripheral sensory transmission that could be responsible for the disturbances in somatosensory perception observed in diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diabetic neuropathy  ISOIgf1 (Rattus norvegicus)2306687; 2306687associated with Diabetes Mellitus and ExperimentalRGD 
diabetic neuropathy  IMP 2306687associated with Diabetes Mellitus and ExperimentalRGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1  (insulin-like growth factor 1)

Genes (Mus musculus)
Igf1  (insulin-like growth factor 1)

Genes (Homo sapiens)
IGF1  (insulin like growth factor 1)


Additional Information