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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1affects expressionISOIgf1 (Mus musculus)6480464CTDBenzo(a)pyrene affects the expression of IGF1 mRNAPMID:15037607
Igf1affects methylationISOIGF1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of IGF1 5' UTRPMID:27901495
Igf1decreases expressionISOIgf1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of IGF1 mRNAPMID:15034205 PMID:19770486 PMID:21569818
Igf1decreases expressionISOIGF1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of IGF1 mRNAPMID:32234424
Igf1decreases methylationISOIGF1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of IGF1 3' UTR; Benzo(a)pyrene results in decreased methylation of IGF1 promoterPMID:27901495
Igf1increases expressionISOIgf1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of IGF1 mRNAPMID:15894712 PMID:22610609
Igf1increases expressionISOIGF1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of IGF1 mRNAPMID:17879257
Igf1multiple interactionsISOIgf1 (Mus musculus)6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of IGF1 mRNA; AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of IGF1 mRNA]PMID:15034205 PMID:15894712
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of IGF1 mRNA; [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of IGF1 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of IGF1 mRNA; [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of IGF1 mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of IGF1 mRNA; Benzo(a)pyrene inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; IGF1 protein inhibits the reaction [Benzo(a)pyrene results in decreased phosphorylation of FOXO4 protein]; IGF1 protein inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP1 protein]; IGF1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of BECN1 protein]; IGF1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL18 protein]; IGF1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; IGF1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]; IGF1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]PMID:17690111 PMID:30726812
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