RGD Reference Report - Elevated serum heme oxygenase-1 and insulin-like growth factor-1 levels in patients with Henoch-Schonlein purpura. - Rat Genome Database

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Elevated serum heme oxygenase-1 and insulin-like growth factor-1 levels in patients with Henoch-Schonlein purpura.

Authors: Chen, T  Guo, ZP  Zhang, YH  Gao, Y  Liu, HJ  Li, JY 
Citation: Chen T, etal., Rheumatol Int. 2011 Mar;31(3):321-6. doi: 10.1007/s00296-009-1254-3. Epub 2009 Dec 16.
RGD ID: 10755701
Pubmed: PMID:20013271   (View Abstract at PubMed)
DOI: DOI:10.1007/s00296-009-1254-3   (Journal Full-text)

The aim of this study is to investigate the levels of heme oxygenase-1 (HO-1), insulin-like growth factor-1 (IGF-1) and oxidative stress parameters including malondialdehyde (MDA), total antioxidant capacity (T-AOC) and the activities of total superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), catalase (CAT) for exploring the correlations between these biological indexes and the clinical manifestations in Henoch-Schonlein purpura (HSP) patients. 36 patients with different phases of HSP and 16 age- and sex-matched controls were enrolled. MDA level, T-AOC and the activities of SOD, GSH-PX and CAT were measured by spectrophotometry. HO-1 and IGF-1 levels were detected by enzyme-linked immunosorbent assay. Significant higher MDA level, lower T-AOC, SOD, GSH-PX activities were shown in active phase of HSP, respectively, compared with those in early resolution phase of HSP (p < 0.001, <0.001, 0.017, <0.001, respectively) and the control subjects (p < 0.001, <0.001, 0.01, 0.008, respectively). HO-1 (both p < 0.001) and IGF-1 (p < 0.001, 0.009, respectively) levels in active phase and early resolution phase of HSP were significantly higher than those in normal controls. The changes of HO-1 and IGF-1 levels were coincident with overall clinical scores (r = 0.71, p < 0.001; r = 0.615, p < 0.001, respectively). The HO-1 level was found as positive correlation with MDA levels (r = 0.395, p = 0.017), but negative correlations with T-AOC (r = -0.409, p = 0.013) and SOD activities (r = -0.352, p = 0.035). HO-1 and IGF-1 were possibly involved in the pathogenesis of HSP; they could be the marker for evaluating the severity of the disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Henoch-Schoenlein purpura  IEP 10755701; 10755701protein:increased expression:serumRGD 
Henoch-Schoenlein purpura  ISOHMOX1 (Homo sapiens)10755701; 10755701protein:increased expression:serumRGD 
Henoch-Schoenlein purpura  ISOIGF1 (Homo sapiens)10755701; 10755701protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Hmox1  (heme oxygenase 1)
Igf1  (insulin-like growth factor 1)

Genes (Mus musculus)
Hmox1  (heme oxygenase 1)
Igf1  (insulin-like growth factor 1)

Genes (Homo sapiens)
HMOX1  (heme oxygenase 1)
IGF1  (insulin like growth factor 1)


Additional Information