RGD Reference Report - Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort. - Rat Genome Database

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Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort.

Authors: Metlapally, R  Ki, CS  Li, YJ  Tran-Viet, KN  Abbott, D  Malecaze, F  Calvas, P  Mackey, DA  Rosenberg, T  Paget, S  Guggenheim, JA  Young, TL 
Citation: Metlapally R, etal., Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4476-9. doi: 10.1167/iovs.09-4912. Epub 2010 Apr 30.
RGD ID: 8548828
Pubmed: PMID:20435602   (View Abstract at PubMed)
PMCID: PMC2941166   (View Article at PubMed Central)
DOI: DOI:10.1167/iovs.09-4912   (Journal Full-text)

PURPOSE: Evidence from human myopia genetic mapping studies (MYP3 locus), modulated animal models, and observations of glycemic control in humans suggests that insulin-like growth factor (IGF)-1 plays a role in the control of eye growth. This study was conducted to determine whether IGF-1 polymorphisms are associated with myopia in a large, international dataset of Caucasian high-grade myopia pedigrees. METHODS: Two hundred sixty-five multiplex families with 1391 subjects participated in the study. IGF-1 genotyping was performed with 13 selected tag single nucleotide polymorphisms (SNPs) using allelic discrimination assays. A family-based pedigree disequilibrium test (PDT) was performed to test for association. Myopia status was defined using sphere (SPH) or spherical equivalent (SE), and analyses assessed the association of (1) high-grade myopia (



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IGF1Humanmyopia susceptibilityIAGP DNA:SNPS: :rs10860860 more ...RGD 
Igf1Ratmyopia susceptibilityISOIGF1 (Homo sapiens)DNA:SNPS: :rs10860860 more ...RGD 
Igf1Mousemyopia susceptibilityISOIGF1 (Homo sapiens)DNA:SNPS: :rs10860860 more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1  (insulin-like growth factor 1)

Genes (Mus musculus)
Igf1  (insulin-like growth factor 1)

Genes (Homo sapiens)
IGF1  (insulin like growth factor 1)


Additional Information