Mir320a (microRNA 320a) - Rat Genome Database

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Gene: Mir320a (microRNA 320a) Rattus norvegicus
Analyze
Symbol: Mir320a
Name: microRNA 320a
RGD ID: 2325539
Description: Predicted to enable mRNA base-pairing translational repressor activity. Involved in several processes, including cellular response to hypoxia; negative regulation of mitochondrial membrane potential; and response to ischemia. Predicted to be located in extracellular space. Predicted to be part of RISC complex. Orthologous to human MIR320A (microRNA 320a); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,5-hexanedione; 2-methoxyethanol.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-320; Mir320; rno-mir-320
RGD Orthologs
Human
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21545,516,392 - 45,516,473 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,516,392 - 45,516,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,634,254 - 49,634,335 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01550,745,751 - 50,745,832 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01547,605,058 - 47,605,139 (+)NCBIRnor_WKY
Rnor_6.01552,134,276 - 52,134,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,134,276 - 52,134,357 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,857,793 - 55,857,874 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1545,195,518 - 45,195,599 (+)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
2. Micro RNA-320 as a novel potential biomarker in renal ischemia reperfusion. Güçlü A, etal., Ren Fail. 2016 Oct;38(9):1468-1475. doi: 10.1080/0886022X.2016.1227915. Epub 2016 Oct 19.
3. Inhibition of micro-ribonucleic acid-320 attenuates neurologic injuries after spinal cord ischemia. He F, etal., J Thorac Cardiovasc Surg. 2015 Aug;150(2):398-406. doi: 10.1016/j.jtcvs.2015.03.066. Epub 2015 May 14.
4. Knockdown of lncRNA MALAT1 attenuates acute myocardial infarction through miR-320-Pten axis. Hu H, etal., Biomed Pharmacother. 2018 Oct;106:738-746. doi: 10.1016/j.biopha.2018.06.122. Epub 2018 Jul 11.
5. Luteolin confers renoprotection against ischemia-reperfusion injury via involving Nrf2 pathway and regulating miR320. Kalbolandi SM, etal., Mol Biol Rep. 2019 Aug;46(4):4039-4047. doi: 10.1007/s11033-019-04853-0. Epub 2019 May 14.
6. miR-320a regulates cell proliferation and apoptosis in multiple myeloma by targeting pre-B-cell leukemia transcription factor 3. Lu Y, etal., Biochem Biophys Res Commun. 2016 May 13;473(4):1315-1320. doi: 10.1016/j.bbrc.2016.04.069. Epub 2016 Apr 14.
7. Downregulation of circulating miR-320a and target gene prediction in patients with diabetic retinopathy. Prado MSG, etal., BMC Res Notes. 2020 Mar 16;13(1):155. doi: 10.1186/s13104-020-05001-9.
8. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Ren XP, etal., Circulation. 2009 May 5;119(17):2357-2366. doi: 10.1161/CIRCULATIONAHA.108.814145. Epub 2009 Apr 20.
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. MiR-320a as a Potential Novel Circulating Biomarker of Arrhythmogenic CardioMyopathy. Sommariva E, etal., Sci Rep. 2017 Jul 6;7(1):4802. doi: 10.1038/s41598-017-05001-z.
11. The protective effect of microRNA-320 on left ventricular remodeling after myocardial ischemia-reperfusion injury in the rat model. Song CL, etal., Int J Mol Sci. 2014 Sep 29;15(10):17442-56. doi: 10.3390/ijms151017442.
12. Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1. Song CL, etal., Oncotarget. 2016 Jun 28;7(26):39740-39757. doi: 10.18632/oncotarget.9240.
13. MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1. Tian ZQ, etal., Cell Mol Biol Lett. 2018 Aug 28;23:41. doi: 10.1186/s11658-018-0105-1. eCollection 2018.
14. Down-regulation of miR-320 exerts protective effects on myocardial I-R injury via facilitating Nrf2 expression. Zhu XA, etal., Eur Rev Med Pharmacol Sci. 2019 Feb;23(4):1730-1741. doi: 10.26355/eurrev_201902_17135.
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:20386663   PMID:20403161   PMID:20417623   PMID:22925886   PMID:23185045   PMID:24161401   PMID:24825548   PMID:25858512   PMID:29551500   PMID:33485996  


Genomics

Comparative Map Data
Mir320a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21545,516,392 - 45,516,473 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,516,392 - 45,516,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,634,254 - 49,634,335 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01550,745,751 - 50,745,832 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01547,605,058 - 47,605,139 (+)NCBIRnor_WKY
Rnor_6.01552,134,276 - 52,134,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,134,276 - 52,134,357 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,857,793 - 55,857,874 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1545,195,518 - 45,195,599 (+)NCBICelera
Cytogenetic Map15p11NCBI
MIR320A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,244,966 - 22,245,037 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl822,244,962 - 22,245,043 (-)EnsemblGRCh38hg38GRCh38
GRCh37822,102,479 - 22,102,550 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,158,419 - 22,158,500 (-)NCBINCBI36Build 36hg18NCBI36
Celera821,064,808 - 21,064,889 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,644,669 - 20,644,750 (-)NCBIHuRef
CHM1_1822,304,138 - 22,304,219 (-)NCBICHM1_1
T2T-CHM13v2.0822,518,920 - 22,518,991 (-)NCBIT2T-CHM13v2.0
Mir320
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,680,950 - 70,681,031 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,680,950 - 70,681,031 (+)EnsemblGRCm39 Ensembl
GRCm381470,443,510 - 70,443,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,443,510 - 70,443,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,843,317 - 70,843,398 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1467,984,999 - 67,985,080 (+)NCBICelera
Cytogenetic Map14D2NCBI

Variants

.
Variants in Mir320a
1 total Variants
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Vimrno-miR-320-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Igf1rno-miR-320-3pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI18986336

Predicted Targets
Summary Value
Count of predictions:12545
Count of gene targets:7048
Count of transcripts:7574
Interacting mature miRNAs:rno-miR-320-3p, rno-miR-320-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 4 8 1 7 1 13 2
Below cutoff 1 3 1 1 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053752
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,516,392 - 45,516,473 (+)Ensembl
Rnor_6.0 Ensembl1552,134,276 - 52,134,357 (+)Ensembl
RefSeq Acc Id: NR_031945
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,516,392 - 45,516,473 (+)NCBI
Rnor_6.01552,134,276 - 52,134,357 (+)NCBI
Rnor_5.01555,857,793 - 55,857,874 (+)NCBI
Celera1545,195,518 - 45,195,599 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325539 AgrOrtholog
BioCyc Gene G2FUF-13218 BioCyc
Ensembl Genes ENSRNOG00000035629 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053752 ENTREZGENE
miRBase MI0000972 ENTREZGENE
NCBI Gene 100314065 ENTREZGENE
PhenoGen Mir320a PhenoGen
RNAcentral URS00003CF1AD RNACentral
  URS000042A57E RNACentral
  URS0000759B03 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir320a  microRNA 320a  Mir320  microRNA mir-320  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir320  microRNA mir-320      Symbol and Name status set to provisional 70820 PROVISIONAL