RGD Reference Report - Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat - Rat Genome Database

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Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat

Authors: Galli, J  Li, LS  Glaser, A  Ostenson, CG  Jiao, H  Fakhrai-Rad, H  Jacob, HJ  Lander, ES  Luthman, H 
Citation: Galli J, etal., Nat Genet 1996 Jan;12(1):31-7
RGD ID: 61082
Pubmed: PMID:8528247   (View Abstract at PubMed)
DOI: DOI:10.1038/ng0196-31   (Journal Full-text)

Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw19RatBody Weight Changes  IDA  RGD 
GK/KyoSweRatglucose intolerance  IAGP  RGD 
GK/KyoSweRathyperglycemia  IAGP  RGD 
GK/KyoSweRattype 2 diabetes mellitus MODEL:spontaneousIAGP  RGD 
Niddm1Rattype 2 diabetes mellitus  IDA  RGD 
Niddm2Rattype 2 diabetes mellitus  IDA  RGD 
Niddm3Rattype 2 diabetes mellitus  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F344/DuCrlRatdecreased susceptibility to non-insulin-dependent diabetes  IAGP compared to GK/KyoSweRGD 
GK/KyoSweRathyperglycemia  IAGP compared to F344/DuCrlRGD 
GK/KyoSweRatimpaired glucose tolerance  IAGP compared to F344/DuCrlRGD 
Niddm1Ratimpaired glucose tolerance  IDA  RGD 
Niddm2Ratimpaired glucose tolerance  QTM  RGD 
Niddm3Ratimpaired glucose tolerance  IDA  RGD 
Bw19Ratincreased body weight  IDA  RGD 
GK/KyoSweRatincreased body weight  IAGP compared to F344/DuCrlRGD 
Niddm1Ratincreased body weight  IDA  RGD 
Niddm2Ratincreased circulating glucose level  QTM  RGD 
Niddm3Ratincreased circulating glucose level  IDA  RGD 
GK/KyoSweRatincreased susceptibility to non-insulin-dependent diabetes  IAGP compared to F344/DuCrlRGD 

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Objects Annotated

Bw19  (Body weight QTL 19)
Niddm1  (Non-insulin dependent diabetes mellitus QTL 1)
Niddm2  (Non-insulin dependent diabetes mellitus QTL 2)
Niddm3  (Non-insulin dependent diabetes mellitus QTL 3)

F344/DuCrl  (NA)
F344/NRrrc  (NA)
GK/KyoSwe  (Goto Kakizaki)

Objects referenced in this article
Marker D7Mit23 D7Mit23 Rattus norvegicus
Marker D2Mit14 D2Mit14 Rattus norvegicus
Marker D2Mit15 D2Mit15 Rattus norvegicus
Marker D1Mit7 D1Mit7 Rattus norvegicus
Marker D10Mgh5 D10Mgh5 Rattus norvegicus
Marker D10Mgh6 D10Mgh6 Rattus norvegicus
QTL Bw17 Body weight QTL 17 Rattus norvegicus
Gene Igf1 insulin-like growth factor 1 Rattus norvegicus

Additional Information