RGD Reference Report - Insulin growth factor-1 protects against excitotoxicity in the rat striatum. - Rat Genome Database

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Insulin growth factor-1 protects against excitotoxicity in the rat striatum.

Authors: Escartin, Carole  Boyer, Frédéric  Bemelmans, Alexis-Pierre  Hantraye, Philippe  Brouillet, Emmanuel 
Citation: Escartin C, etal., Neuroreport. 2004 Oct 5;15(14):2251-4.
RGD ID: 12904970
Pubmed: PMID:15371744   (View Abstract at PubMed)

Recent findings demonstrated the neuroprotective effects of insulin-like growth factor 1 (IGF-1) in a cultured cell model of Huntington's disease. In the present study, we examined the potential neuroprotective effect of IGF-1 in vivo, in a rat model of Huntington's disease using the NMDA receptor agonist quinolinate. Continuous intracerebroventricular infusion of recombinant IGF-1 (0.25 microg/h for 2 days) in the rat brain, produced a significant 8-fold increase in striatal levels of the growth factor. Histological evaluation after intrastriatal injection of quinolinate showed that IGF-1 treatment significantly attenuated striatal degeneration. These results further support the therapeutic interest of IGF-1 in Huntington's disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IGF1HumanHuntington's disease treatmentIDA human protein in a rat modelRGD 
Igf1RatHuntington's disease treatmentISOIGF1 (Homo sapiens)human protein in a rat modelRGD 
Igf1MouseHuntington's disease treatmentISOIGF1 (Homo sapiens)human protein in a rat modelRGD 

Objects Annotated

Genes (Rattus norvegicus)
Igf1  (insulin-like growth factor 1)

Genes (Mus musculus)
Igf1  (insulin-like growth factor 1)

Genes (Homo sapiens)
IGF1  (insulin like growth factor 1)


Additional Information