GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Igf1 | multiple interactions | EXP | | 6480464 | CTD | IL17A protein promotes the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 protein] | PMID:31351185 | Igf1 | decreases expression | ISO | Igf1 (Mus musculus) | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 mRNA; 1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 protein | PMID:26254549 PMID:28268219 | Igf1 | decreases response to substance | ISO | IGF1 (Homo sapiens) | 6480464 | CTD | IGF1 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium | PMID:20064577 | Igf1 | multiple interactions | ISO | Igf1 (Mus musculus) | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]; SB 203580 inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]; TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 mRNA]; TGFBR1 protein promotes the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of IGF1 protein]] | PMID:26254549 | Igf1 | multiple interactions | ISO | IGF1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium]; IGF1 protein inhibits the reaction [SNCA protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]; IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]; IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK1 protein]; IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK3 protein] | PMID:15888489 PMID:20064577 | | ||||||||||||||||||||||
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