GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Igf1 | multiple interactions | EXP | | 6480464 | CTD | Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein]; Metformin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA] | PMID:26492952 PMID:36999408 | Igf1 | multiple interactions | ISO | Igf1 (Mus musculus) | 6480464 | CTD | Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein] | PMID:23927877 PMID:26497364 | Igf1 | multiple interactions | ISO | IGF1 (Homo sapiens) | 6480464 | CTD | [Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with Pioglitazone] results in decreased expression of IGF1 mRNA | PMID:21664031 PMID:32589349 | | ||||||||||||||||||||||
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