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Gene: Ada (adenosine deaminase) Rattus norvegicus
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Symbol: Ada
Name: adenosine deaminase
Description: Exhibits adenosine deaminase activity and purine nucleoside binding activity. Involved in several processes, including adenosine metabolic process; negative regulation of circadian sleep/wake cycle, non-REM sleep; and response to morphine. Localizes to the dendrite cytoplasm; extracellular space; and neuronal cell body. Used to study hypertension; peritonitis; and pulmonary edema. Biomarker of hyperglycemia; leptospirosis; lung disease; and trypanosomiasis. Human ortholog(s) of this gene implicated in adenosine deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (adenosine deaminase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (R)-noradrenaline; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adenosine aminohydrolase; MGC108610
Orthologs:
Homo sapiens (human) : ADA (adenosine deaminase)  HGNC  Alliance
Mus musculus (house mouse) : Ada (adenosine deaminase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ada (adenosine deaminase)
Pan paniscus (bonobo/pygmy chimpanzee) : ADA (adenosine deaminase)
Canis lupus familiaris (dog) : ADA (adenosine deaminase)
Sus scrofa (pig) : ADA (adenosine deaminase)
more info ...
Allele / Splice: AdaTn(sb-T2/Bart3)2.237Mcwi  
Genetic Models: F344-AdaTn(sb-T2/Bart3)2.237Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03160,115,840 - 160,139,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,115,842 - 160,139,947 (-)Ensembl
Rnor_5.03166,306,001 - 166,330,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,636,530 - 154,660,637 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13154,542,567 - 154,566,673 (-)NCBI
Celera3151,051,040 - 151,075,153 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ada
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2031
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.