Gene: Ada (adenosine deaminase) Rattus norvegicus
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Symbol: Ada
Name: adenosine deaminase
Description: ENCODES a protein that exhibits adenosine deaminase activity; purine nucleoside binding; zinc ion binding (ortholog); INVOLVED IN adenosine metabolic process; aging; histamine secretion; PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimental ; hyperglycemia; FOUND IN cytoplasm; dendrite cytoplasm; extracellular space; INTERACTS WITH (R)-noradrenaline; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate
AGR Description: Exhibits adenosine deaminase activity and purine nucleoside binding activity; involved in several processes, including adenosine metabolic process, aging, and histamine secretion; localizes to the dendrite cytoplasm, extracellular space, and neuronal cell body; used to study hypertension, peritonitis, and pulmonary edema; biomarker of hyperglycemia, leptospirosis, lung disease, and trypanosomiasis; orthologous to human ADA (adenosine deaminase).
Merged Description: Exhibits adenosine deaminase activity and purine nucleoside binding activity; involved in several processes, including adenosine metabolic process, aging, and histamine secretion; localizes to the dendrite cytoplasm, extracellular space, and neuronal cell body; used to study hypertension, peritonitis, and pulmonary edema; biomarker of hyperglycemia, leptospirosis, lung disease, and trypanosomiasis; orthologous to human ADA (adenosine deaminase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (R)-noradrenaline; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adenosine aminohydrolase; MGC108610
Orthologs:
Homo sapiens (human) : ADA (adenosine deaminase)  HGNC  Alliance
Mus musculus (house mouse) : Ada (adenosine deaminase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ada (adenosine deaminase)
Pan paniscus (bonobo/pygmy chimpanzee) : ADA (adenosine deaminase)
Canis lupus familiaris (dog) : ADA (adenosine deaminase)
Sus scrofa (pig) : ADA (adenosine deaminase)
more info ...
Allele / Splice: AdaTn(sb-T2/Bart3)2.237Mcwi  
Genetic Models: F344-AdaTn(sb-T2/Bart3)2.237Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03160,115,840 - 160,139,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03166,306,001 - 166,330,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,636,530 - 154,660,637 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13154,542,567 - 154,566,673 (-)NCBI
Celera3151,051,040 - 151,075,153 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ada
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2031
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.