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Gene: Fgf2 (fibroblast growth factor 2) Rattus norvegicus
Symbol: Fgf2
Name: fibroblast growth factor 2
Description: Exhibits fibroblast growth factor receptor binding activity. Involved in several processes, including paracrine signaling; positive regulation of ERK1 and ERK2 cascade; and positive regulation of cell population proliferation. Localizes to cytoplasm; extracellular space; and nucleus. Used to study pulmonary hypertension. Biomarker of bladder disease; decubitus ulcer; diabetic retinopathy; hypertension; and retinal vein occlusion. Human ortholog(s) of this gene implicated in several diseases, including corneal neovascularization; diabetic neuropathy; gastric ulcer; impotence; and prostate adenocarcinoma. Orthologous to human FGF2 (fibroblast growth factor 2); PARTICIPATES IN cerium oxide nanoparticle response pathway; fibroblast growth factor signaling pathway; glypican signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-colchicine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: angiogenesis promoting growth factor; basic fibroblast growth factor; bFGF; Fgf-2; HBGF-2; heparin binding growth factor; heparin-binding growth factor 2
Homo sapiens (human) : FGF2 (fibroblast growth factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Fgf2 (fibroblast growth factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fgf2 (fibroblast growth factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : FGF2 (fibroblast growth factor 2)
Canis lupus familiaris (dog) : FGF2 (fibroblast growth factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fgf2 (fibroblast growth factor 2)
Sus scrofa (pig) : FGF2 (fibroblast growth factor 2)
Chlorocebus sabaeus (African green monkey) : FGF2 (fibroblast growth factor 2)
Heterocephalus glaber (naked mole-rat) : Fgf2 (fibroblast growth factor 2)
more info ...
Is Marker For: Strains:   LEW  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
Celera2115,183,003 - 115,237,310 (+)NCBICelera
Cytogenetic Map2q25NCBI
RH 3.4 Map2677.29RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Fgf2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2609
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.