Fgf2 (fibroblast growth factor 2) - Rat Genome Database

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Gene: Fgf2 (fibroblast growth factor 2) Rattus norvegicus
Symbol: Fgf2
Name: fibroblast growth factor 2
RGD ID: 2609
Description: Enables fibroblast growth factor receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; paracrine signaling; and positive regulation of cell population proliferation. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Located in extracellular space. Used to study pulmonary hypertension. Biomarker of bladder disease; decubitus ulcer; hypertension; middle cerebral artery infarction; and retinal vascular disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (fibroblast growth factor 2); PARTICIPATES IN cerium oxide nanoparticle response pathway; fibroblast growth factor signaling pathway; glypican signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-colchicine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angiogenesis promoting growth factor; basic fibroblast growth factor; bFGF; Fgf-2; Fgf2a; fibroblast growth factor 2a; HBGF-2; heparin binding growth factor; heparin-binding growth factor 2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   LEW  
Candidate Gene For: Cm49
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82122,164,454 - 122,218,796 (+)NCBIGRCr8
mRatBN7.22120,236,328 - 120,290,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,236,328 - 120,291,221 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,799,241 - 126,853,523 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,911,739 - 124,966,029 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,540,703 - 119,594,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
Celera2115,183,003 - 115,237,310 (+)NCBICelera
RH 3.4 Map2677.29RGD
Cytogenetic Map2q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Animal Mammary Neoplasms  (ISO)
Arteriovenous Fistula  (ISO)
biliary tract disease  (ISO)
bladder disease  (IEP)
bone disease  (ISO)
Bone Fractures  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Cardiomegaly  (IEP,ISO)
cataract  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (IEP)
chronic ulcer of skin  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
decubitus ulcer  (IEP)
Delayed Hypersensitivity  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (IEP,ISO)
Diaphragmatic Hernia  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
esophageal cancer  (ISO)
essential thrombocythemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Eye Injuries  (IEP,ISO)
Femoral Fractures  (IEP)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
Gliosis  (ISO)
high grade glioma  (ISO)
Hypercholesterolemia  (ISO)
Hyperoxic Lung Injury  (IMP)
hypertension  (IEP)
Hypoglossal Nerve Injuries  (IEP)
impotence  (ISO)
Inflammation  (IEP,ISO)
Invasive Pulmonary Aspergillosis  (ISO)
Kaposiform Hemangioendothelioma  (ISO)
kidney disease  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
long QT syndrome  (ISO)
macular retinal edema  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (IEP)
multiple endocrine neoplasia type 1  (ISO)
Myocardial Ischemia  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neointima  (IEP)
neovascular inflammatory vitreoretinopathy  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
neurodevelopmental disorder with hearing loss, seizures, and brain abnormalities  (ISO)
Neurodevelopmental Disorders  (ISO)
Optic Nerve Injuries  (ISO)
oral submucous fibrosis  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinsonism  (ISO)
Penetrating Eye Injuries  (ISO)
periapical periodontitis  (ISO)
polyarteritis nodosa  (ISO)
Pregnancy in Diabetics  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
pterygium  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IMP,ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (IEP,ISO)
retinal vein occlusion  (IEP)
Spinal Cord Compression  (IEP)
Spinal Cord Injuries  (IEP)
transitional cell carcinoma  (ISO)
Tympanic Membrane Perforation  (IEP,ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (IEP)
urinary bladder cancer  (ISO)
Wound Infection  (ISO)
Wounds and Injuries  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
14,15-EET  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxyethyl methacrylate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydroxybenzaldehyde  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-fluorouracil  (ISO)
6-aminonicotinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alliin  (ISO)
alpha-D-galactose  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
bathocuproine disulfonic acid  (ISO)
BAY 60-6583  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcitonin gene-related peptide 1  (EXP)
Calphostin C  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
cerivastatin  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
chondroitin sulfate  (ISO)
cilazapril monohydrate  (EXP)
cilnidipine  (EXP)
cisplatin  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
dermatan sulfate  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (EXP)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
Erionite  (ISO)
etoposide  (ISO)
famotidine  (ISO)
fenoldopam  (EXP)
fenpyroximate  (ISO)
finasteride  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
furosemide  (EXP)
galactose  (EXP)
gamma-tocopherol  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
glucose  (EXP,ISO)
glycidol  (EXP)
gossypol  (ISO)
heparan sulfate  (ISO)
heparin  (EXP,ISO)
hexadecanoic acid  (ISO)
Hexadimethrine bromide  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
iloprost  (ISO)
imiquimod  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
irinotecan  (ISO)
Isradipine  (ISO)
kaempferol  (EXP)
kainic acid  (EXP)
lansoprazole  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
leukotriene B4  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
Mecamylamine  (EXP)
melittin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
MK-2206  (EXP)
monosodium L-glutamate  (ISO)
morphine  (ISO)
Morroniside  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
naloxone  (ISO)
naringin  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nifedipine  (ISO)
nitrofen  (EXP)
nitroprusside  (EXP,ISO)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
olanzapine  (EXP)
Oxadiazon  (ISO)
oxilofrine  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
permethrin  (EXP)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piroxicam  (ISO)
platycodin D  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
prostaglandin F2alpha  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH772984  (EXP)
scutellarin  (EXP)
serpentine asbestos  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Sodium oleate  (ISO)
Soman  (EXP)
Sucralfate  (ISO)
sucrose  (ISO)
suramin  (ISO)
Swertiamarin  (EXP)
tamoxifen  (ISO)
temozolomide  (EXP,ISO)
teniposide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
topotecan  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trifluoroacetic acid  (ISO)
triphenylstannane  (EXP,ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
water  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
angiogenesis involved in coronary vascular morphogenesis  (IMP)
animal organ morphogenesis  (IBA,IEA)
branching involved in ureteric bud morphogenesis  (ISO,ISS)
canonical Wnt signaling pathway  (ISO)
cell differentiation  (IBA,IEA)
cell migration involved in sprouting angiogenesis  (ISO)
cell population proliferation  (ISO)
cellular response to mechanical stimulus  (IEP)
cerebellar granule cell precursor proliferation  (ISO)
chondroblast differentiation  (ISO)
corticotropin hormone secreting cell differentiation  (ISO)
embryo development ending in birth or egg hatching  (IMP)
endothelial cell migration  (ISO)
endothelial cell proliferation  (ISO)
epithelial cell proliferation  (ISO)
ERK1 and ERK2 cascade  (ISO)
fibroblast growth factor receptor signaling pathway  (IBA,IEA,IPI,ISO)
glial cell differentiation  (ISO)
growth factor dependent regulation of skeletal muscle satellite cell proliferation  (ISO)
hyaluronan catabolic process  (ISO)
inner ear auditory receptor cell differentiation  (ISO)
lung development  (IBA,IEA,ISO)
lymphatic endothelial cell migration  (ISO)
mammary gland epithelial cell differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of stem cell proliferation  (ISO)
negative regulation of wound healing  (ISO)
neuroblast proliferation  (ISO)
neuroepithelial cell differentiation  (ISO)
organ induction  (ISO)
osteoblast differentiation  (ISO)
paracrine signaling  (IDA)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (ISO,ISS)
positive regulation of blood vessel endothelial cell migration  (ISO,ISS)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cardiac muscle cell proliferation  (IDA,ISO)
positive regulation of cell division  (IEA)
positive regulation of cell fate specification  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO,ISS)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of endothelial cell chemotaxis to fibroblast growth factor  (ISO)
positive regulation of endothelial cell migration  (IBA,IEA,ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell proliferation  (IBA,IEA,ISO)
positive regulation of epithelial tube formation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA,ISO)
positive regulation of gene expression  (IBA,IEA,ISO)
positive regulation of inner ear auditory receptor cell differentiation  (ISO)
positive regulation of lens fiber cell differentiation  (ISO,ISS)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuroepithelial cell differentiation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of sprouting angiogenesis  (ISO,ISS)
positive regulation of stem cell differentiation  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
regulation of cell cycle  (ISO)
regulation of endothelial cell chemotaxis to fibroblast growth factor  (ISO)
regulation of retinal cell programmed cell death  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to axon injury  (ISO)
stem cell development  (ISO)
stem cell differentiation  (ISO)
stem cell proliferation  (ISO)
substantia nigra development  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
wound healing  (IBA,IEA,ISO)

Cellular Component
cytoplasm  (IBA,IEA)
extracellular space  (IBA,IDA,IEA,ISO)
nucleus  (IBA,IEA)


References - curated
# Reference Title Reference Citation
1. Mechanical load induced by glass microspheres releases angiogenic factors from neonatal rat ventricular myocytes cultures and causes arrhythmias. Barac DY, etal., J Cell Mol Med. 2008 Oct;12(5B):2037-51. doi: 10.1111/j.1582-4934.2008.00193.x.
2. Proangiogenic growth factors potentiate in situ angiogenesis and enhance antifungal drug activity in murine invasive aspergillosis. Ben-Ami R, etal., J Infect Dis. 2013 Apr;207(7):1066-74. doi: 10.1093/infdis/jis940. Epub 2013 Jan 9.
3. Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy. Beranek M, etal., Diabetes Res Clin Pract. 2008 Feb;79(2):362-7. Epub 2007 Nov 7.
4. Cell surface heparan sulfate proteoglycans: target and partners of the basic fibroblast growth factor in rat Sertoli cells. Brucato S, etal., Eur J Biochem 2002 Jan;269(2):502-11.
5. Acidic and basic fibroblast growth factor messenger RNA and protein show increased expression in adult compared to developing normal and dystrophic rat retina. Bugra K and Hicks D, J Mol Neurosci. 1997 Aug;9(1):13-25.
6. Influence of maternal diabetes on placental fibroblast growth factor-2 expression, proliferation, and apoptosis. Burleigh DW, etal., J Soc Gynecol Investig. 2004 Jan;11(1):36-41.
7. Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. Cao W, etal., Exp Eye Res. 1997 Aug;65(2):241-8.
8. Functional components of basic fibroblast growth factor signaling that inhibit lung elastin gene expression. Carreras I, etal., Am J Physiol Lung Cell Mol Physiol 2001 Oct;281(4):L766-75.
9. Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders. Cassidy L, etal., Br J Ophthalmol. 1998 Feb;82(2):181-5.
10. The importance of vascular endothelial growth factor in the healing of acute tympanic membrane perforation. Cho KS, etal., Am J Otolaryngol. 2010 Sep-Oct;31(5):309-14. doi: 10.1016/j.amjoto.2009.03.005. Epub 2009 Jun 4.
11. Coordination of fibroblast growth factor receptor 1 (FGFR1) and fibroblast growth factor-2 (FGF-2) trafficking to nuclei of reactive astrocytes around cerebral lesions in adult rats.PG - 17-30 Clarke WE, etal., Mol Cell Neurosci 2001 Jan;17(1):17-30.
12. Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein. Claus P, etal., J Biol Chem 2003 Jan 3;278(1):479-85.
13. Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts. Delehedde M, etal., Biochem J 2002 Aug 15;366(Pt 1):235-44.
14. Growth factor expression in ophthalmic pterygia and normal conjunctiva. Detorakis ET, etal., Int J Mol Med. 2010 Apr;25(4):513-6.
15. Responses of reactive astrocytes containing S100beta protein and fibroblast growth factor-2 in the border and in the adjacent preserved tissue after a contusion injury of the spinal cord in rats: implications for wound repair and neuroregeneration. do Carmo Cunha J, etal., Wound Repair Regen. 2007 Jan-Feb;15(1):134-46.
16. Intranasal Calcitonin Gene-Related Peptide Protects Against Focal Cerebral Ischemic Injury in Rats Through the Wnt/β-Catenin Pathway. Du Z, etal., Med Sci Monit. 2018 Dec 7;24:8860-8869. doi: 10.12659/MSM.913777.
17. Sequence analysis of the fibroblast growth factor 2 gene from the spontaneously hypertensive and hypertrophic heart rats. Dwyer JP, etal., Clin Exp Hypertens 2004 Apr;26(3):209-18.
18. Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factors. Eckenstein FP, etal., Biochem Pharmacol. 1994 Jan 13;47(1):103-10.
19. Immunolocalization and temporal distribution of cytokine expression during the development of vein graft intimal hyperplasia in an experimental model. Faries PL, etal., J Vasc Surg. 1996 Sep;24(3):463-71.
20. A comparative study of recombinant human basic fibroblast growth factor (bFGF) and erythropoietin (EPO) in prevention of skin flap ischemic necrosis in rats. Fayazzadeh E, etal., Arch Iran Med. 2012 Sep;15(9):553-6. doi: 012159/AIM.008.
21. Keratinocyte growth factor-2 inhibits bacterial infection with Pseudomonas aeruginosa pneumonia in a mouse model. Feng N, etal., J Infect Chemother. 2016 Jan;22(1):44-52. doi: 10.1016/j.jiac.2015.10.005. Epub 2015 Nov 24.
22. Aortic coarctation hypertension induces fibroblast growth factor-2 immunoreactivity in the stimulated nucleus tractus solitarii. Fior-Chadi DR, etal., J Mol Histol. 2007 Aug;38(4):285-94. Epub 2007 Jun 12.
23. Gastric mucosal injury activates bFGF gene expression and triggers preferential translation of high molecular weight bFGF isoforms through CUG-initiated, non-canonical codons. Florkiewicz RZ, etal., Biochem Biophys Res Commun. 2011 Jun 10;409(3):494-9. doi: 10.1016/j.bbrc.2011.05.033. Epub 2011 May 11.
24. Expressions of the fibroblast growth factor family (FGF-1, -2 and -4) mRNA in endometrial cancers. Fujimoto J, etal., Tumour Biol. 1996;17(4):226-33.
25. Increased serum levels of basic fibroblast growth factor in patients with renal cell carcinoma. Fujimoto K, etal., Biochem Biophys Res Commun. 1991 Oct 15;180(1):386-92.
26. Prenatal stress elicits regionally selective changes in basal FGF-2 gene expression in adulthood and alters the adult response to acute or chronic stress. Fumagalli F, etal., Neurobiol Dis. 2005 Dec;20(3):731-7. Epub 2005 Jun 20.
27. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
28. Differential expression of fibroblast growth factor-2 and receptor by glial cells in experimental autoimmune encephalomyelitis (EAE) Gehrmann J, etal., Glia. 1996 Feb;16(2):93-100.
29. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
30. Strain-dependent anterior segment neovascularization following intravitreal gene transfer of basic fibroblast growth factor (bFGF). Gupta AR, etal., J Gene Med. 2001 May-Jun;3(3):252-9.
31. Time-dependent increase in basic fibroblast growth factor protein in limbic regions following electroshock seizures. Gwinn RP, etal., Neuroscience 2002;114(2):403-9.
32. A new method for closing tympanic membrane perforations using basic fibroblast growth factor. Hakuba N, etal., Laryngoscope. 2003 Aug;113(8):1352-5.
33. Alterations in protein tyrosine kinase pathways following retinal vein occlusion in the rat. Hayashi A, etal., Curr Eye Res. 1999 Mar;18(3):231-9.
34. Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat. Hellman U, etal., Cell Tissue Res. 2008 Jan 15;.
35. Increased levels of serum fibroblast growth factor-2 in diabetic pregnant women with retinopathy. Hill DJ, etal., J Clin Endocrinol Metab. 1997 May;82(5):1452-7.
36. High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF. Hoffmann AC, etal., J Gastrointest Surg. 2008 Oct;12(10):1674-81; discussion 1681-2. Epub 2008 Aug 13.
37. High basic fibroblast growth factor levels in nipple aspirate fluid are correlated with breast cancer. Hsiung R, etal., Cancer J. 2002 Jul-Aug;8(4):303-10.
38. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
39. Expression of fibroblast growth factor-2 in hypoglossal motoneurons is stimulated by peripheral nerve injury. Huber K, etal., J Comp Neurol. 1997 Jun 2;382(2):189-98.
40. Induction of KGF, basic FGF, and TGFalpha mRNA expression during healing of experimental TM perforations. Ishibashi T, etal., Acta Otolaryngol. 1998 Sep;118(5):701-4.
41. Inhibitory effect of TNP-470 on experimental choroidal neovascularization in a rat model. Ishida K, etal., Invest Ophthalmol Vis Sci. 1999 Jun;40(7):1512-9.
42. Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. Izikki M, etal., J Clin Invest. 2009 Mar;119(3):512-23. doi: 10.1172/JCI35070. Epub 2009 Feb 9.
43. Fibroblast growth factor receptor-1 and neonatal compensatory lung growth after exposure to 95% oxygen. Jankov RP, etal., Am J Respir Crit Care Med. 2003 Jun 1;167(11):1554-61. Epub 2003 Mar 5.
44. Vascular endothelial growth factor and basic fibroblast growth factor in exudative age-related macular degeneration and diffuse diabetic macular edema. Jonas JB and Neumaier M, Ophthalmic Res. 2007;39(3):139-42. Epub 2007 May 15.
45. Basic fibroblast growth factor in an animal model of spontaneous mammary tumor progression. Kao S, etal., Oncol Rep. 2012 Jun;27(6):1807-14. doi: 10.3892/or.2012.1710. Epub 2012 Mar 7.
46. Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats. Kawaguchi H, etal., Endocrinology. 1994 Aug;135(2):774-81.
47. Site-dependent angiogenic cytokine production in human tumor xenografts. Keyes KA, etal., Cytokine. 2003 Jan 21;21(2):98-104.
48. Angiogenic cytokines in serum and cutaneous lesions of patients with polyarteritis nodosa. Kikuchi K, etal., J Am Acad Dermatol. 2005 Jul;53(1):57-61.
49. Expression of acidic fibroblast growth factor and basic fibroblast growth factor in nasal polyps. Kim HJ, etal., Acta Otolaryngol. 2006 Jun;126(6):600-5.
50. Strain-dependent increases in retinal inflammatory proteins and photoreceptor FGF-2 expression in streptozotocin-induced diabetic rats. Kirwin SJ, etal., Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5396-404. Epub 2009 May 27.
51. Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. Konishi M, etal., J Biol Chem. 2000 Apr 21;275(16):12119-22.
52. Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. Kuniyasu H, etal., Int J Oncol. 2001 Oct;19(4):681-5.
53. Expressions of angiogenic factors in pancreatic ductal carcinoma: a correlative study with clinicopathologic parameters and patient survival. Kuwahara K, etal., Pancreas. 2003 May;26(4):344-9.
54. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
55. NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats. Lin N, etal., Am J Physiol Cell Physiol. 2011 Aug;301(2):C469-77. doi: 10.1152/ajpcell.00452.2010. Epub 2011 May 4.
56. Prognostic correlation of basic fibroblast growth factor and vascular endothelial growth factor in 1307 primary breast cancers. Linderholm BK, etal., Clin Breast Cancer. 2003 Dec;4(5):340-7.
57. Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophin. Liu X, etal., Glia. 1998 Dec;24(4):390-7.
58. Fibrin-based scaffold incorporating VEGF- and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice. Losi P, etal., Acta Biomater. 2013 Aug;9(8):7814-21. doi: 10.1016/j.actbio.2013.04.019. Epub 2013 Apr 17.
59. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. Messersmith DJ, etal., J Neurosci Res. 2000 Oct 15;62(2):241-56.
60. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
61. Expression of basic fibroblast growth factor and its receptor mRNA in retinal tissue following ischemic injury in the rat. Miyashiro M, etal., Graefes Arch Clin Exp Ophthalmol. 1998 Apr;236(4):295-300.
62. Effects of basic fibroblast growth factor on experimental diabetic neuropathy in rats. Nakae M, etal., Diabetes. 2006 May;55(5):1470-7.
63. Spatial and temporal gene expression for fibroblast growth factor type I receptor (FGFR1) during fracture healing in the rat. Nakajima A, etal., Bone. 2001 Nov;29(5):458-66.
64. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
65. Kit ligand and basic fibroblast growth factor interactions in the induction of ovarian primordial to primary follicle transition. Nilsson EE and Skinner MK, Mol Cell Endocrinol 2004 Feb 12;214(1-2):19-25.
66. Therapeutic effect of bFGF on retina ischemia-reperfusion injury. Niu YJ, etal., Chin Med J (Engl). 2004 Feb;117(2):252-7.
67. Basic fibroblast growth factor evokes a rapid glutamate release through activation of the MAPK pathway in cultured cortical neurons. Numakawa T, etal., J Biol Chem 2002 Aug 9;277(32):28861-9.
68. Acceleration of wound healing in healing-impaired db/db mice with a photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2. Obara K, etal., Wound Repair Regen. 2005 Jul-Aug;13(4):390-7.
69. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
70. Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor. Owczarek S, etal., FASEB J. 2010 Apr;24(4):1139-50. Epub 2009 Dec 1.
71. Hypercholesterolemia impairs angiogenesis in patients with breast carcinoma and, therefore, lowers the risk of metastases. Ozdemir BH, etal., Am J Clin Pathol. 2004 Nov;122(5):696-703.
72. Fibroblast growth factors and their specific binding sites in normal urothelium and transitional cell carcinoma (TCC) of the human bladder. Palcy S, etal., Cell Mol Biol (Noisy-le-grand). 1995 Jun;41(4):565-75.
73. Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3. Pandey J and Wendell DL, Mamm Genome. 2006 Jan;17(1):49-57. Epub 2006 Jan 13.
74. Peripheral monocytes from diabetic patients with coronary artery disease display increased bFGF and VEGF mRNA expression. Panutsopulos D, etal., J Transl Med. 2003 Oct 6;1(1):6.
75. High and low molecular weight fibroblast growth factor-2 increase proliferation of neonatal rat cardiac myocytes but have differential effects on binucleation and nuclear morphology. Evidence for both paracrine and intracrine actions of fibroblast growth factor-2. Pasumarthi KB, etal., Circ Res. 1996 Jan;78(1):126-36.
76. Polymorphisms in the promoter region of the basic fibroblast growth factor gene and proliferative diabetic retinopathy in Caucasians with type 2 diabetes. Petrovic MG, etal., Clin Experiment Ophthalmol. 2008 Mar;36(2):168-72. Epub 2008 Feb 13.
77. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
78. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
79. Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer. Polnaszek N, etal., Cancer Res. 2003 Sep 15;63(18):5754-60.
80. Suppression of smooth muscle cell proliferation after experimental PTFE arterial grafting: a role for polyclonal anti-basic fibroblast growth factor (bFGF) antibody. Randone B, etal., Eur J Vasc Endovasc Surg. 1998 Nov;16(5):401-7.
81. GOA pipeline RGD automated data pipeline
82. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
83. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
84. Assessment of the VEGF, bFGF, aFGF and IL8 angiogenic activity in urinary bladder carcinoma, using the mice cutaneous angiogenesis test. Rogala E, etal., Anticancer Res. 2001 Nov-Dec;21(6B):4259-63.
85. Controlled release of fibroblast growth factor 2 stimulates bone healing in an animal model of diabetes mellitus. Santana RB and Trackman PC, Int J Oral Maxillofac Implants. 2006 Sep-Oct;21(5):711-8.
86. Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury. Sapieha PS, etal., Mol Cell Neurosci. 2003 Nov;24(3):656-72.
87. Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. Satoh H, etal., Jpn J Pharmacol. 1997 Mar;73(3):229-41.
88. Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. Shimizu T, etal., JCI Insight. 2017 Jul 6;2(13). pii: 93187. doi: 10.1172/jci.insight.93187.
89. Endothelial cells overexpressing basic fibroblast growth factor (FGF-2) induce vascular tumors in immunodeficient mice. Sola F, etal., Angiogenesis. 1997;1(1):102-116.
90. Diabetic retinopathy: VEGF, bFGF and retinal vascular pathology. Song E, etal., Chin Med J (Engl). 2004 Feb;117(2):247-51.
91. Functional restoration using basic fibroblast growth factor (bFGF) infusion in Kainic acid induced cognitive dysfunction in rat: neurobehavioural and neurochemical studies. Srivastava N, etal., Neurochem Res. 2008 Jul;33(7):1169-77. Epub 2007 Oct 23.
92. Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders. Su WC, etal., Dig Dis Sci. 2001 Jul;46(7):1387-92.
93. Angiogenesis and angiogenic growth factors in middle ear cholesteatoma. Sudhoff H, etal., Am J Otol. 2000 Nov;21(6):793-8.
94. Effect of basic fibroblast growth factor incorporating gelatin microspheres on erectile function in the diabetic rat. Suetomi T, etal., J Urol. 2005 Apr;173(4):1423-8.
95. Fibroblast growth factor 2: roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury. Tanaka T, etal., Mol Vis. 2004 Jul 15;10:462-7.
96. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
97. Cellular uptake and activity of heparin functionalised cerium oxide nanoparticles in monocytes. Ting SR, etal., Biomaterials. 2013 Jun;34(17):4377-86. doi: 10.1016/j.biomaterials.2013.02.042. Epub 2013 Mar 7.
98. Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis. Tomanek RJ, etal., Circ Res. 2001 Jun 8;88(11):1135-41.
99. Clinical efficacy of basic fibroblast growth factor (bFGF) for diabetic ulcer. UCHI H, etal., Eur J Dermatol. 2009 Sep-Oct;19(5):461-8. Epub 2009 Jul 29.
100. Protection of the rat retina from ischemic injury by brain-derived neurotrophic factor, ciliary neurotrophic factor, and basic fibroblast growth factor. Unoki K and LaVail MM, Invest Ophthalmol Vis Sci. 1994 Mar;35(3):907-15.
101. Effect of anti-basic fibroblast growth factor (Anti-bFGF) on in vitro embryonic development in rat. Unur E, etal., Anat Histol Embryol. 2009 Aug;38(4):241-5. Epub 2009 May 19.
102. Expression of angiogenic growth factors in dural arteriovenous fistula. Uranishi R, etal., J Neurosurg. 1999 Nov;91(5):781-6.
103. Human mesenchymal stem cells modulate inflammatory cytokines after spinal cord injury in rat. Urdzíková LM, etal., Int J Mol Sci. 2014 Jun 25;15(7):11275-93. doi: 10.3390/ijms150711275.
104. Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts. Vasko R, etal., Am J Physiol Renal Physiol. 2009 Jun;296(6):F1452-63. Epub 2009 Mar 11.
105. Biologic and clinical significance of basic fibroblast growth factor immunostaining in breast carcinoma. Visscher DW, etal., Mod Pathol. 1995 Aug;8(6):665-70.
106. [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing] Wang HJ, etal., Fa Yi Xue Za Zhi. 2001 Nov;17(4):198-201, 204.
107. MicroRNA-155 inversely correlates with esophageal cancer progression through regulating tumor-associated macrophage FGF2 expression. Wang P, etal., Biochem Biophys Res Commun. 2018 Sep 5;503(2):452-458. doi: 10.1016/j.bbrc.2018.04.094. Epub 2018 Jun 30.
108. Expression and localization of basic fibroblast growth factor in diabetic rat prostate. Wang Z, etal., BJU Int. 2000 May;85(7):945-52.
109. Growth factors in the collateral circulation of chronic total coronary occlusions: relation to duration of occlusion and collateral function. Werner GS, etal., Circulation. 2004 Oct 5;110(14):1940-5. Epub 2004 Sep 27.
110. Fibroblast growth factors (FGF) in human myometrium and uterine leiomyomas in various stages of tumour growth. Wolanska M and Bankowski E, Biochimie. 2006 Feb;88(2):141-6. Epub 2005 Aug 22.
111. Overaccumulation of transforming growth factor-beta1 and basic fibroblast growth factor in lens epithelial cells of congenital cataract. Xiao Y, etal., Can J Ophthalmol. 2009 Apr;44(2):189-92. doi: 10.3129/i09-006.
112. Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats. Yamashita A, etal., J Immunol 2002 Jan 1;168(1):450-7.
113. Expression of basic fibroblast growth factor (FGF-2)-associated with tumour proliferation in human pancreatic carcinoma. Yamazaki K, etal., Virchows Arch. 1997 Aug;431(2):95-101.
114. The angiogenic peptide vascular endothelial growth factor-basic fibroblast growth factor signaling is up-regulated in a rat pressure ulcer model. Yang JJ, etal., Anat Rec (Hoboken). 2013 Aug;296(8):1161-8. doi: 10.1002/ar.22676. Epub 2013 Jun 6.
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116. Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor. Yang Y, etal., Biomaterials. 2011 Jun;32(18):4243-54. doi: 10.1016/j.biomaterials.2011.02.042. Epub 2011 Mar 12.
117. Expression of transforming growth factor beta1 gene, basic fibroblast growth factor gene and hydroxyproline in diabetes-induced bladder dysfunction in a rat model. Yongzhi L, etal., Neurourol Urodyn. 2008;27(3):254-9.
118. Diabetes can alter the signal transduction pathways in the lens of rats. Zatechka DS Jr, etal., Diabetes. 2003 Apr;52(4):1014-22.
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120. Increased basic fibroblast growth factor in plasma from multiple endocrine neoplasia type 1: relation to pituitary tumor. Zimering MB, etal., J Clin Endocrinol Metab. 1993 May;76(5):1182-7.
121. Basic fibroblast growth factor (bFGF, FGF-2) potentiates leukocyte recruitment to inflammation by enhancing endothelial adhesion molecule expression. Zittermann SI and Issekutz AC, Am J Pathol. 2006 Mar;168(3):835-46.
Additional References at PubMed
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Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr82122,164,454 - 122,218,796 (+)NCBIGRCr8
mRatBN7.22120,236,328 - 120,290,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,236,328 - 120,291,221 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,799,241 - 126,853,523 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,911,739 - 124,966,029 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,540,703 - 119,594,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
Celera2115,183,003 - 115,237,310 (+)NCBICelera
RH 3.4 Map2677.29RGD
Cytogenetic Map2q25NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384122,826,682 - 122,898,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,826,682 - 122,898,236 (+)EnsemblGRCh38hg38GRCh38
GRCh374123,747,837 - 123,819,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,967,313 - 124,038,840 (+)NCBINCBI36Build 36hg18NCBI36
Build 344124,105,467 - 124,176,995NCBI
Celera4121,130,707 - 121,202,234 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4119,474,437 - 119,545,817 (+)NCBIHuRef
CHM1_14123,724,372 - 123,795,895 (+)NCBICHM1_1
T2T-CHM13v2.04126,130,781 - 126,202,343 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39337,402,616 - 37,464,255 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,402,495 - 37,464,257 (+)EnsemblGRCm39 Ensembl
GRCm38337,348,477 - 37,410,106 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,348,346 - 37,410,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv37337,247,575 - 37,303,752 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,540,399 - 37,596,346 (+)NCBIMGSCv36mm8
Celera337,228,587 - 37,279,676 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.41NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542817,840,628 - 17,894,773 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542817,840,554 - 17,894,779 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v23120,604,078 - 120,675,314 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,869,886 - 120,941,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04115,005,136 - 115,076,369 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14126,149,750 - 126,220,774 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4126,149,813 - 126,214,942 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11917,403,288 - 17,463,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1916,994,661 - 17,463,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,610,808 - 17,690,535 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01917,510,798 - 17,588,734 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11917,466,635 - 17,533,082 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,745,360 - 17,822,472 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,217,074 - 18,293,705 (-)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl8101,278,885 - 101,343,916 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,278,877 - 101,344,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,489,442 - 108,508,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1770,089,394 - 70,157,423 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603749,060,630 - 49,133,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247773,268,953 - 3,321,145 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247773,268,674 - 3,321,424 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Fgf2
211 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:92
Interacting mature miRNAs:99
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22120,291,028 - 120,291,198 (+)MAPPERmRatBN7.2
Rnor_6.02124,134,489 - 124,134,658NCBIRnor6.0
Rnor_5.02143,742,426 - 143,742,595UniSTSRnor5.0
RGSC_v3.42123,947,492 - 123,947,661UniSTSRGSC3.4
Celera2115,237,678 - 115,237,847UniSTS
RH 3.4 Map2677.29UniSTS
Cytogenetic Map2q25UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2115,237,546 - 115,237,729UniSTS
RH 3.4 Map2667.5UniSTS
Cytogenetic Map2q25UniSTS

Related Rat Strains
The following Strains have been annotated to Fgf2


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 1 14 17 2 18 2 8 11 31 18 28 11 8
Below cutoff 2 23 16 15 1 15 43 15 9


RefSeq Acc Id: ENSRNOT00000023388   ⟹   ENSRNOP00000023388
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2120,236,328 - 120,291,221 (+)Ensembl
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119158   ⟹   ENSRNOP00000088479
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2120,267,741 - 120,291,221 (+)Ensembl
RefSeq Acc Id: NM_019305   ⟹   NP_062178
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr82122,164,454 - 122,218,796 (+)NCBI
mRatBN7.22120,236,328 - 120,290,673 (+)NCBI
Rnor_6.02124,081,072 - 124,134,133 (+)NCBI
Rnor_5.02143,689,407 - 143,742,070 (+)NCBI
RGSC_v3.42123,893,314 - 123,947,136 (+)RGD
Celera2115,183,003 - 115,237,310 (+)RGD
RefSeq Acc Id: NP_062178   ⟸   NM_019305
- UniProtKB: P13109 (UniProtKB/Swiss-Prot),   A0A7U3JW58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023388   ⟸   ENSRNOT00000023388
RefSeq Acc Id: ENSRNOP00000088479   ⟸   ENSRNOT00000119158

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13109-F1-model_v2 AlphaFold P13109 1-154 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691296
Promoter ID:EPDNEW_R1821
Type:single initiation site
Description:fibroblast growth factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.02124,081,170 - 124,081,230EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2609 AgrOrtholog
BioCyc Gene G2FUF-53305 BioCyc
Ensembl Genes ENSRNOG00000017392 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055002219 UniProtKB/Swiss-Prot
  ENSRNOG00060006887 UniProtKB/Swiss-Prot
  ENSRNOG00065008811 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023388 ENTREZGENE
  ENSRNOT00000023388.6 UniProtKB/Swiss-Prot
  ENSRNOT00000119158.1 UniProtKB/TrEMBL
  ENSRNOT00055003524 UniProtKB/Swiss-Prot
  ENSRNOT00060011282 UniProtKB/Swiss-Prot
  ENSRNOT00065014050 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54250 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF83 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fgf2 PhenoGen
  IL1HBGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017392 RatGTEx
  ENSRNOG00055002219 RatGTEx
  ENSRNOG00060006887 RatGTEx
  ENSRNOG00065008811 RatGTEx
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230999
UniProt A0A2U1_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fgf2  Fibroblast growth factor 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalizes with FGFR1 protein in transcriptionally active chormatin of astrocytes and has also been observed in the perinuclear region and cytoplasm of activated astrocytes in response to CNS injury 625526
gene_disease up-regulated in adjuvant-induced arthritis synovial joints 70481
gene_disease may function in rheumatoid arthritis joint disease to modulate disease progression 70481
gene_expression expressed in astrocytes and discrete neuronal populations in brain 625526
gene_expression expressed in many tissues including testis 628487
gene_function a FGF receptor 1 (FGFR1) ligand 625526
gene_pathway decreases elastin gene expression through activation of the ERK1/2, resulting in the translocation of ERK1/2, and causes the induction of Fra-1 mRNA and protein 628487
gene_process a potent gliogenic and neurotrophic factor that may be involved in the regulation of central nervous system (CNS) injury responses 625565
gene_process may be active in CNS injury responses like transformation of reactive astrocytes, angiogenesis, scar formation and promotion of neurotrophic activities 625526
gene_process negative regulator of elastin transcription in contact-inhibited fibroblast cultures 628487
gene_product 22, 21 and 18 kDa proteins 625526
gene_regulation increase in expression seen after brain injury 625526