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Gene: Fgf2 (fibroblast growth factor 2) Rattus norvegicus
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Symbol: Fgf2
Name: fibroblast growth factor 2
Description: Exhibits fibroblast growth factor receptor binding activity. Involved in several processes, including aging; paracrine signaling; and positive regulation of cell population proliferation. Localizes to the cytoplasm and nucleus. Used to study pulmonary hypertension. Biomarker of bladder disease; decubitus ulcer; diabetic retinopathy; hypertension; and retinal vein occlusion. Human ortholog(s) of this gene implicated in several diseases, including diabetic neuropathy; eye disease (multiple); gastric ulcer; impotence; and prostate adenocarcinoma. Orthologous to human FGF2 (fibroblast growth factor 2); PARTICIPATES IN cerium oxide nanoparticle response pathway; fibroblast growth factor signaling pathway; glypican signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (RS)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: angiogenesis promoting growth factor; basic fibroblast growth factor; bFGF; Fgf-2; HBGF-2; heparin binding growth factor; heparin-binding growth factor 2
Orthologs:
Homo sapiens (human) : FGF2 (fibroblast growth factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Fgf2 (fibroblast growth factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fgf2 (fibroblast growth factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : FGF2 (fibroblast growth factor 2)
Canis lupus familiaris (dog) : FGF2 (fibroblast growth factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fgf2 (fibroblast growth factor 2)
Sus scrofa (pig) : FGF2 (fibroblast growth factor 2)
more info ...
Is Marker For: Strains:   LEW  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
Celera2115,183,003 - 115,237,310 (+)NCBICelera
Cytogenetic Map2q25NCBI
RH 3.4 Map2677.29RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Fgf2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2609
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.