C1r (complement C1r) - Rat Genome Database

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Gene: C1r (complement C1r) Rattus norvegicus
Analyze
Symbol: C1r
Name: complement C1r
RGD ID: 1309091
Description: Predicted to enable several functions, including calcium ion binding activity; identical protein binding activity; and serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to be active in blood microparticle. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 1. Orthologous to human C1R (complement C1r); PARTICIPATES IN coagulation cascade pathway; complement system pathway; phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: complement C1r subcomponent; complement component 1, r subcomponent; LOC312705
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,412,718 - 157,423,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,412,692 - 157,423,484 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,635,374 - 163,646,172 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04159,418,283 - 159,429,081 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04158,064,480 - 158,075,420 (+)NCBIRnor_WKY
Rnor_6.04157,126,060 - 157,136,825 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,125,998 - 157,136,829 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,144,564 - 224,155,329 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,712,582 - 160,729,362 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14160,957,464 - 160,974,090 (+)NCBI
Celera4146,152,622 - 146,163,370 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dioxygen  (EXP)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
indinavir  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
medroxyprogesterone acetate  (ISO)
methidathion  (ISO)
methimazole  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
saquinavir  (ISO)
silicon dioxide  (ISO)
sodium dodecyl sulfate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Alterations of the Classic Pathway of Complement in Adipose Tissue of Obesity and Insulin Resistance. Zhang J, etal., Am J Physiol Endocrinol Metab. 2007 Jan 23;.
Additional References at PubMed
PMID:11823416   PMID:12477932   PMID:20178990   PMID:20970424   PMID:22516433   PMID:23533145   PMID:31749804  


Genomics

Comparative Map Data
C1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,412,718 - 157,423,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,412,692 - 157,423,484 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,635,374 - 163,646,172 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04159,418,283 - 159,429,081 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04158,064,480 - 158,075,420 (+)NCBIRnor_WKY
Rnor_6.04157,126,060 - 157,136,825 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,125,998 - 157,136,829 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,144,564 - 224,155,329 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,712,582 - 160,729,362 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14160,957,464 - 160,974,090 (+)NCBI
Celera4146,152,622 - 146,163,370 (+)NCBICelera
Cytogenetic Map4q42NCBI
C1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,080,219 - 7,092,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl127,080,214 - 7,092,540 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,187,523 - 7,245,041 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,132,347 - 7,136,184 (-)NCBINCBI36Build 36hg18NCBI36
Build 36127,057,768 - 7,058,863 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,132,345 - 7,136,184NCBI
Celera128,810,415 - 8,821,122 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,051,362 - 7,057,949 (-)NCBIHuRef
HuRef127,047,821 - 7,049,720 (-)NCBIHuRef
CHM1_1127,186,493 - 7,188,392 (-)NCBICHM1_1
CHM1_1127,240,180 - 7,244,018 (-)NCBICHM1_1
T2T-CHM13v2.0127,093,689 - 7,105,531 (-)NCBIT2T-CHM13v2.0
C1rb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,547,389 - 124,558,003 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,547,253 - 124,558,130 (+)EnsemblGRCm39 Ensembl
GRCm386124,570,430 - 124,581,044 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,570,294 - 124,581,171 (+)EnsemblGRCm38mm10GRCm38
MGSCv376124,520,448 - 124,531,062 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,535,681 - 124,546,793 (+)NCBIMGSCv36mm8
Celera6126,253,012 - 126,262,880 (+)NCBICelera
Cytogenetic Map6F2NCBI
C1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,652,308 - 4,660,304 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554134,652,156 - 4,660,897 (-)NCBIChiLan1.0ChiLan1.0
C1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,126,723 - 7,137,895 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,126,723 - 7,137,895 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0127,211,162 - 7,222,673 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
C1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,951,137 - 37,960,687 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,950,246 - 37,960,557 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,656,115 - 8,665,621 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,303,593 - 38,313,135 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,303,136 - 38,333,701 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,178,473 - 38,188,007 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,219,555 - 38,229,110 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,134,262 - 8,143,646 (-)NCBIUU_Cfam_GSD_1.0
C1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,041,423 - 102,052,228 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936709709,001 - 719,758 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,643,374 - 63,655,143 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,644,097 - 63,655,149 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
C1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,115,964 - 7,134,612 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,125,367 - 7,134,758 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660631,078,052 - 1,089,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,676,252 - 3,684,406 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,675,926 - 3,684,598 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C1r
164 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:81
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000056051
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4153031106158841762Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat

Markers in Region
RH128516  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,422,894 - 157,423,098 (+)MAPPERmRatBN7.2
Rnor_6.04157,136,237 - 157,136,440NCBIRnor6.0
Rnor_5.04224,154,741 - 224,154,944UniSTSRnor5.0
RGSC_v3.44160,728,774 - 160,728,977UniSTSRGSC3.4
Celera4146,162,782 - 146,162,985UniSTS
RH 3.4 Map41005.8UniSTS
Cytogenetic Map4q42UniSTS
RH142322  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,422,678 - 157,422,876 (+)MAPPERmRatBN7.2
Rnor_6.04157,136,021 - 157,136,218NCBIRnor6.0
Rnor_5.04224,154,525 - 224,154,722UniSTSRnor5.0
RGSC_v3.44160,728,558 - 160,728,755UniSTSRGSC3.4
Celera4146,162,566 - 146,162,763UniSTS
RH 3.4 Map41005.6UniSTS
Cytogenetic Map4q42UniSTS
RH140263  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,423,226 - 157,423,406 (+)MAPPERmRatBN7.2
Rnor_6.04157,136,569 - 157,136,748NCBIRnor6.0
Rnor_5.04224,155,073 - 224,155,252UniSTSRnor5.0
RGSC_v3.44160,729,106 - 160,729,285UniSTSRGSC3.4
Celera4146,163,114 - 146,163,293UniSTS
RH 3.4 Map41003.9UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 57 41 19 41 8 11 22 35 37 11 8
Low 14 52 4
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056051   ⟹   ENSRNOP00000052903
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,413,405 - 157,423,484 (+)Ensembl
Rnor_6.0 Ensembl4157,126,935 - 157,136,303 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078349   ⟹   ENSRNOP00000069123
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,412,692 - 157,423,483 (+)Ensembl
Rnor_6.0 Ensembl4157,125,998 - 157,136,829 (+)Ensembl
RefSeq Acc Id: NM_001134555   ⟹   NP_001128027
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24157,412,718 - 157,423,483 (+)NCBI
Rnor_6.04157,126,060 - 157,136,825 (+)NCBI
Rnor_5.04224,144,564 - 224,155,329 (+)NCBI
RGSC_v3.44160,712,582 - 160,729,362 (+)RGD
Celera4146,152,622 - 146,163,370 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128027 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98803 (Get FASTA)   NCBI Sequence Viewer  
  AAI68673 (Get FASTA)   NCBI Sequence Viewer  
  EDM01954 (Get FASTA)   NCBI Sequence Viewer  
  EDM01955 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001128027   ⟸   NM_001134555
- Peptide Label: precursor
- UniProtKB: B5DEH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069123   ⟸   ENSRNOT00000078349
RefSeq Acc Id: ENSRNOP00000052903   ⟸   ENSRNOT00000056051
Protein Domains
CUB   Peptidase S1   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DEH7-F1-model_v2 AlphaFold B5DEH7 1-707 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693383
Promoter ID:EPDNEW_R3906
Type:initiation region
Name:C1r_1
Description:complement C1r
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,126,063 - 157,126,123EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309091 AgrOrtholog
BioCyc Gene G2FUF-43093 BioCyc
Ensembl Genes ENSRNOG00000011796 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000052903.5 UniProtKB/TrEMBL
  ENSRNOP00000069123 ENTREZGENE
  ENSRNOP00000069123.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056051.5 UniProtKB/TrEMBL
  ENSRNOT00000078349 ENTREZGENE
  ENSRNOT00000078349.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7376270 IMAGE-MGC_LOAD
InterPro Complement_subcomponent_C1r UniProtKB/TrEMBL
  CUB_dom UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  sperma_CUB_dom UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:312705 UniProtKB/TrEMBL
MGC_CLONE MGC:112846 IMAGE-MGC_LOAD
NCBI Gene 312705 ENTREZGENE
PANTHER PTHR24255:SF25 UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PhenoGen C1r PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  SUSHI UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  Pept_Ser_Cys UniProtKB/TrEMBL
UniProt B5DEH7 ENTREZGENE, UniProtKB/TrEMBL
  D4A1T6_RAT UniProtKB/TrEMBL
  Q4G030_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 C1r  complement C1r  C1r  complement C1r subcomponent  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-15 C1r  complement C1r subcomponent  C1r  complement component 1, r subcomponent  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 C1r  complement component 1, r subcomponent  C1r_predicted  complement component 1, r subcomponent (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 C1r_predicted  complement component 1, r subcomponent (predicted)      Symbol and Name status set to approved 70820 APPROVED